公开(公告)号：WO2017158142A1

公开(公告)日：2017-09-21

申请号：PCT/EP2017/056346

申请日：2017-03-17

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： KUMAR-SINGH, Samir ,  BIELEN, Kenny ,  GOOSENS, Herman ,  JORENS, Philippe ,  MALTHOTRA-KUMAR, Surbhi ,  'S JONGERS, Bart

IPC: G01N33/68

CPC classification number: G01N33/6869 ,  G01N2333/56 ,  G01N2800/12 ,  G01N2800/50

Abstract: The present invention relates to the field of ventilator-associated pneumonia, caused by mechanical ventilation of a subject. In particular, it relates to the identification of subjects at risk of developing ventilator-associated pneumonia upon mechanical ventilation of said subject; wherein the identification of said subjects being at risk of developing VAP is based on the determination of one or more interleukins. The present invention also relates to the use of interleukin-reducing compounds for reducing the severity and/or progression of ventilator associated pneumonia in a subject being mechanically ventilated.

Abstract translation: 呼吸机相关肺炎的领域本发明涉及由对象的机械通气引起的呼吸机相关肺炎的领域。 特别涉及识别在所述受试者机械通气时有风险产生呼吸机相关性肺炎的受试者; 其中所述受试者处于发生VAP的风险中的鉴定基于一种或多种白细胞介素的确定。 本发明还涉及白细胞减少化合物用于降低机械通气的受试者中呼吸机相关肺炎的严重程度和/或进展的用途。