公开(公告)号：WO2015170984A1

公开(公告)日：2015-11-12

申请号：PCT/NL2015/050323

申请日：2015-05-08

Applicant: UNIVERSITEIT UTRECHT HOLDING B.V.

Inventor： HAAGSMAN, Hendrik Peter ,  VAN DIJK, Albert ,  VELDHUIZEN, Edwin Johannes Adrianus

IPC: C07K4/12 ,  C07K7/08 ,  C07K14/465 ,  A61K38/17

CPC classification number: C07K14/465 ,  A61K38/00

Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retro-inverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.

Abstract translation: 本发明提供CATH2或CMAP27的新衍生物，其为导管素之一。 这些衍生物包括N-末端截短的肽，环肽，CATH2的D-氨基酸变体及其截短的衍生物，反转和反转式CATH2衍生物。 这些衍生物作为抗感染剂，疫苗，尤其是在ovo应用中是有用的。 此外，对于上述衍生物以及已知的C末端截短衍生物，已经描述了对预防性治疗特别有利的新的免疫活化功能。

公开(公告)号：WO2022131922A1

公开(公告)日：2022-06-23

申请号：PCT/NL2021/050776

申请日：2021-12-17

Applicant: UNIVERSITEIT UTRECHT HOLDING B.V.

Inventor： HAAGSMAN, Hendrik Peter ,  VAN DIJK, Albert ,  VELDHUIZEN, Edwin Johannes Adrianus

IPC: A61K38/10 ,  A61K38/17 ,  A61K39/00 ,  A61P31/00 ,  A61P31/04 ,  A61K39/39

Abstract: The invention relates to methods for activating, inducing or promoting innate immune memory in a subject in need thereof comprising administering to the subject CATH2 or a derivative thereof. The invention further relates to methods of improving antimicrobial treatment in a subject in need thereof comprising administering to the subject CATH2 or a derivative thereof and to a use of CATH2 or a derivative thereof as an adjuvant for a pathogen-specific vaccine.

公开(公告)号：WO2018197445A1

公开(公告)日：2018-11-01

申请号：PCT/EP2018/060402

申请日：2018-04-24

Applicant: UNIVERSITEIT UTRECHT HOLDING B.V. ,  UMC UTRECHT HOLDING B.V.

Inventor： VAN EIJK, Marinus ,  VAN DIJK, Albert ,  HAAGSMAN, Hendrik Peter ,  VAN DER ENT, Cornelis Korstiaan

IPC: C07K7/08 ,  C07K14/00 ,  A61K38/10

Abstract: The invention relates to the field of antibiotics, more specifically to peptide antibiotics, such as antimicrobial peptides and their use in the treatment of diseases associated with microbial infections. In particular, the invention provides a peptide with antimicrobial activity comprising an amino acid sequence RRWVQRWIRRWR (SEQ ID NO: 24) or an analogue thereof.

公开(公告)号：WO2022169364A1

公开(公告)日：2022-08-11

申请号：PCT/NL2022/050057

申请日：2022-02-04

Applicant: UNIVERSITEIT UTRECHT HOLDING B.V.

Inventor： SCHEENSTRA, Maaike Riena ,  VAN HARTEN, Roeland Maarten ,  HAAGSMAN, Hendrik Peter ,  VAN DIJK, Albert ,  VELDHUIZEN, Edwin Johannes Adrianus

IPC: C07K14/465 ,  A61K38/00 ,  A61P31/04 ,  C07K14/47 ,  A61P11/00 ,  C07K14/435

Abstract: The invention relates to methods for inhibiting S. suis comprising administering to CATH2 or a derivative thereof and to methods for the treatment or prevention of a S. suis infection in a subject in need thereof, comprising administering CATH2 or a derivative thereof to the subject.