公开(公告)号：WO2018100484A1

公开(公告)日：2018-06-07

申请号：PCT/IB2017/057437

申请日：2017-11-28

Applicant: UNIVERSITY OF KWAZULU-NATAL

Inventor： KARUNANIDHI, Sivanandhan ,  CHANDRASEKARAN, Balakumar ,  KARPOORMATH, Rajshekhar ,  KAJEE, Afsana

IPC: A61K31/416 ,  A61K31/655 ,  A61P31/00

Abstract: A compound having the general formula (I) or (II), in which R, R1, R2 and R3 are as described herein, or a pharmaceutically acceptable salt thereof, is provided. An associated method for treating a mycobacterial infection is also provided.

公开(公告)号：WO2022018651A2

公开(公告)日：2022-01-27

申请号：PCT/IB2021/056583

申请日：2021-07-21

Applicant: UNIVERSITY OF KWAZULU-NATAL

Inventor： KARPOORMATH, Rajshekhar ,  SAYYAD, Nisar

IPC: C07D263/12 ,  C07D273/04 ,  C07D265/10 ,  C07D273/00

Abstract: The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.