公开(公告)号：WO2016049772A1

公开(公告)日：2016-04-07

申请号：PCT/CA2015/050992

申请日：2015-10-02

Applicant: UNIVERSITY OF OTTAWA

Inventor： FIGEYS, Daniel ,  STINTZI, Alain ,  MACK, David R. ,  CHIANG, Cheng-Kang ,  STARR, Amanda Elizabeth

IPC: G01N33/48 ,  A61K45/00 ,  A61P1/00 ,  G01N33/53 ,  G01N33/543

CPC classification number: G01N33/6893 ,  A61K45/06 ,  G01N2333/47 ,  G01N2333/902 ,  G01N2333/91142 ,  G01N2333/914 ,  G01N2800/065

Abstract: There is provided protein biomarkers and methods for their use in diagnosing and treating Inflammatory Bowel Disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) as well as methods for assessing the severity of the diseases.

Abstract translation: 提供了用于诊断和治疗炎症性肠病（IBD），溃疡性结肠炎（UC）和克罗恩病（CD）的蛋白质生物标志物和方法以及评估疾病严重程度的方法。

公开(公告)号：WO2018227295A1

公开(公告)日：2018-12-20

申请号：PCT/CA2018/050716

申请日：2018-06-14

Applicant: UNIVERSITY OF OTTAWA

Inventor： FIGEYS, Joseph Michel Daniel ,  STINTZI, Alain Christophe ,  MACK, David R. ,  STARR, Amanda Elizabeth ,  DEEKE, Shelley A.

IPC: G01N33/48 ,  A61B5/00 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N33/573

CPC classification number: G01N33/6893 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G01N33/573 ,  G01N2800/065 ,  G01N2800/52

Abstract: A method for determining a presence of inflammatory bowel disease in a subject. The method involves providing a gut sample obtained from a subject; measuring a level in said gut sample of one or more proteins, wherein said one or more proteins comprises at least one of: leukotriene A-4 hydrolase, catalase, transketolase, thioredoxin domain containing protein 17, vasodilator-stimulated phosphoprotein and thymosin beta-10; and comparing said measured level of each of said one or more proteins to a corresponding protein level for a normal subject. A method for determining a presence of pancolitis in a subject with ulcerative colitis is also provided.