公开(公告)号：WO2014140176A1

公开(公告)日：2014-09-18

申请号：PCT/EP2014/054961

申请日：2014-03-13

Applicant: VACCIBODY AS

Inventor： BREKKE, Ole Henrik ,  LINDEBERG, Mona Mari ,  FREDRIKSEN, Agnete Brunsvik

IPC: C07K16/28 ,  A61K39/395

CPC classification number: C07K16/2833 ,  A61K39/3955 ,  C07K14/005 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16034 ,  C12N2710/16631

Abstract: The present invention relates to therapeutic compounds, such as vaccines against avian diseases and in particular to DNA vaccines. The invention further relates to protein construct encoding homodimeric peptides, which peptides may be released from a DNA vaccine or used separately. Further described are pharmaceutical formulations, host cells and methods for producing the vaccines, as well as methods for the treatment or prevention of various diseases in animals, such as avians, such as cancers and infectious diseases.

Abstract translation: 本发明涉及治疗性化合物，例如针对禽类疾病的疫苗，特别是DNA疫苗。 本发明还涉及编码同二聚体肽的蛋白质构建体，该肽可以从DNA疫苗中释放或分开使用。 进一步描述的是药物制剂，宿主细胞和用于生产疫苗的方法，以及用于治疗或预防动物诸如禽类如癌症和感染性疾病的各种疾病的方法。

公开(公告)号：WO2013092875A1

公开(公告)日：2013-06-27

申请号：PCT/EP2012/076404

申请日：2012-12-20

Applicant: VACCIBODY AS

Inventor： BREKKE, Ole Henrik ,  FREDRIKSEN, Agnete Brunsvik ,  AREFFARD, Ali ,  LINDEBERG, Mona Mari

IPC: A61K39/00 ,  C07K16/44 ,  A61K39/12 ,  C07K14/52 ,  C07K16/00 ,  A61P35/00

CPC classification number: A61K39/39575 ,  A61K39/0011 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/6031 ,  A61K2039/6056 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/523 ,  C07K16/084 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/735 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/20071 ,  C12N2800/22

Abstract: The present invention relates to therapeutic compounds, such as vaccines against human papillomavirus (HPV) and in particular to DNA vaccines against HPV16 or HPV18. The invention further relates to protein construct encoding homodimeric peptides, which peptides may be released from a DNA vaccine or used separately. Further described are pharmaceutical formulations, host cells and methods for producing the vaccines, as well as methods for the treatment of various HPV induced diseases, such as cancers and infectious diseases by application.

Abstract translation: 本发明涉及治疗性化合物，例如针对人乳头瘤病毒（HPV）的疫苗，特别涉及针对HPV16或HPV18的DNA疫苗。 本发明还涉及编码同二聚体肽的蛋白质构建体，该肽可以从DNA疫苗中释放或分开使用。 进一步描述了用于生产疫苗的药物制剂，宿主细胞和方法，以及通过应用治疗各种HPV诱导的疾病如癌症和感染性疾病的方法。