公开(公告)号：WO2021219897A1

公开(公告)日：2021-11-04

申请号：PCT/EP2021/061602

申请日：2021-05-03

Applicant: VACCIBODY AS

Inventor： FREDRIKSEN, Agnete, Brunsvik ,  SEKELJA, Monika ,  SCHJETNE, Karoline ,  NORHEIM, Gunnstein ,  STUBSRUD, Elisabeth

IPC: C07K14/165 ,  A61K39/12 ,  A61P31/14 ,  A61K39/00

Abstract: Disclosed is a vaccine comprising an immunologically effective amount of a polynucleotide comprising a nucleotide sequence encoding a targeting unit, a dimerization unit and an antigenic unit, wherein the antigenic unit comprises at least one betacoronavirus epitope. The vaccine is ideal for pandemic and epidemics as it can induce rapid, strong immune response with lower/fewer doses because the antigen is targeted to antigen presenting cells and the antigen is produced in the body.

公开(公告)号：WO2017118695A1

公开(公告)日：2017-07-13

申请号：PCT/EP2017/050206

申请日：2017-01-05

Applicant: VACCIBODY AS

Inventor： GRANUM, Stine ,  STUBSRUD, Elisabeth ,  FREDRIKSEN, Agnete Brunsvik

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K2039/53 ,  A61K2039/6031 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  A61K2039/70

Abstract: The present invention relates to an anticancer vaccine comprising polynucleotides or polypeptides, methods of treatment of cancer wherein such an anticancer vaccine is used as well as methods for producing the vaccine. The vaccine comprises a polynucleotide comprising a nucleotide sequenceencoding a targeting unit, a dimerization unit, a first linker and an antigenic unit, wherein said antigenic unit comprises n-1 antigenic subunits, each subunit comprising at least a part of a cancer neoepitope sequence and a second linker and said antigenic unit further comprising a final cancer neoepitope sequence, wherein n is an integer of from 3 to 50, or the vaccine comprises a polypeptide encoded by the polynucleotide or a dimeric protein consisting of two polypeptides encoded by the polynucleotide.

Abstract translation: 本发明涉及包含多核苷酸或多肽的抗癌疫苗，其中使用了所述抗癌疫苗的癌症治疗方法以及生产所述疫苗的方法。 疫苗包含含有编码靶向单元，二聚化单元，第一接头和抗原单元的核苷酸序列的多核苷酸，其中所述抗原单元包含n-1个抗原亚基，每个亚基包含至少一部分癌新表位序列和 第二接头和所述抗原单元进一步包含最终的癌新表位序列，其中n是3至50的整数，或者所述疫苗包含由所述多核苷酸编码的多肽或由所述多核苷酸编码的两个多肽组成的二聚体蛋白。 p>