公开(公告)号：WO2023011514A1

公开(公告)日：2023-02-09

申请号：PCT/CN2022/109906

申请日：2022-08-03

Applicant: VERSITECH LIMITED ,  THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： LIU, Yuan ,  SHEN, Yanting ,  SHUM, Anderson Ho Cheung ,  NUNES, Janine, K. ,  STONE, Howard, A.

IPC: A61L26/00 ,  A61L24/00

Abstract: Disclosed is a fiber-based hydrogel containing an aqueous hydrogel containing biocompatible microfibers having a high aspect ratio length to diameter suspended in water, the biocompatible microfibers mechanically interlocked. By simply adjusting the fiber aspect ratio, the fiber-based hydrogels can tune a considerable range of mechanical properties and drug release rates for clinical use. The fiber-based hydrogel has favorable biocompatibility and accelerated tissue regeneration ability demonstrated by a mice excision skin model.

公开(公告)号：WO2021207149A1

公开(公告)日：2021-10-14

申请号：PCT/US2021/025905

申请日：2021-04-06

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： MEZHERICHER, Maksym ,  STONE, Howard, A.

IPC: A61K31/137 ,  A61K47/02 ,  A61K47/10

Abstract: Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

公开(公告)号：WO2021102085A1

公开(公告)日：2021-05-27

申请号：PCT/US2020/061186

申请日：2020-11-19

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： MEZHERICHER, Maksym ,  STONE, Howard, A.

IPC: A61K9/00 ,  A61K9/12

Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter.