公开(公告)号：WO2014052989A3

公开(公告)日：2014-07-24

申请号：PCT/US2013062773

申请日：2013-09-30

Applicant: VIBRANT HOLDINGS LLC

Inventor： RAJASEKARAN JOHN J ,  JAYARAMAN VASANTH ,  WANG TIANHAO ,  BEI KANG ,  KRISHNAMURTHY HARI KRISHNAN

IPC: G01N33/543

CPC classification number: G01N33/54366 ,  C40B40/06 ,  C40B40/10 ,  G01N33/54386 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/00168

Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

Abstract translation: 本文公开了制剂，底物和阵列。 本文还公开了制备和使用制剂，基底和阵列的方法。 还公开了用于鉴定可用于疾病的诊断和治疗的肽序列的方法，以及使用肽序列诊断和治疗疾病例如乳糜泻的方法。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。

公开(公告)号：WO2014078606A3

公开(公告)日：2014-08-07

申请号：PCT/US2013070207

申请日：2013-11-14

Applicant: VIBRANT HOLDINGS LLC

Inventor： RAJASEKARAN JOHN J ,  JAYARAMAN VASANTH ,  WANG TIANHAO ,  BEI KANG ,  KRISHNAMURTHY HARI KRISHNAN

IPC: C09K11/64 ,  C07C211/62 ,  G01N33/68

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  B01J2219/00637 ,  B01J2219/00711 ,  B01J2219/00725 ,  C40B50/18 ,  G01N33/6842

Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

Abstract translation: 本文公开了配制剂，基质和阵列。 在某些实施方案中，基底和阵列包含用于聚合物或生物分子的合成和附着的多孔层。 本文还公开了用于制造和使用制剂，基底和阵列（包括多孔阵列）的方法。 本文还公开了用于一步偶联的制剂和方法，例如用于合成N-> C取向的肽。 在一些实施方案中，本文公开了用于生物分子与基质高效偶联的制剂和方法。

公开(公告)号：WO2014127328A3

公开(公告)日：2014-10-09

申请号：PCT/US2014016737

申请日：2014-02-17

Applicant: VIBRANT HOLDINGS LLC

Inventor： RAJASEKARAN JOHN J ,  JAYARAMAN VASANTH ,  WANG TIANHAO ,  BEI KANG ,  KRISHNAMURTHY HARI KRISHNAN

IPC: G01N33/53 ,  C12Q1/28

CPC classification number: G01N33/582 ,  G01N21/66 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581

Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

Abstract translation: 本文公开了配制剂，基质和阵列。 本文还公开了用于制造和使用制剂，基底和阵列的方法。 还公开了鉴定可用于诊断和治疗病症的肽序列的方法，以及使用该肽序列诊断和治疗病症例如乳糜泻的方法。 在某些实施方案中，基底和阵列包含用于聚合物或生物分子的合成和附着的多孔层。