公开(公告)号：WO2022249069A1

公开(公告)日：2022-12-01

申请号：PCT/IB2022/054864

申请日：2022-05-25

Applicant: VYLUMA INC.

Inventor： JAIN, Harshil H. ,  ATTLURI, Hari A. ,  CHANDLER, Simon P. ,  HINGORANI, Tushar ,  SOPPIMATH, Kumaresh

IPC: A61K9/00 ,  A61K9/08 ,  A61K47/12 ,  A61K31/27 ,  A61K31/4178 ,  A61K31/498 ,  A61K31/55 ,  A61K45/06 ,  A61P27/02

Abstract: A topical ophthalmological formulation comprises carbachol at a low concentration that effects reduction in pupil diameter over time when repeatedly administered over at least a week. Such formulations are particularly beneficial where carbachol is the sole active agent in the treatment of presbyopia and night vision disturbance. Such and other formulations may also comprise modified carbachol exhibiting improved delivery to the pupillary muscle and will (further) beneficially reduce the required quantity of active agent while still producing a desired pupil size for a predetermined period of time. Moreover, such compositions may not require combination with a penetration enhancer, such as benzalkonium chloride, and will as such be better tolerated.

公开(公告)号：WO2022197633A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020246

申请日：2022-03-14

Applicant: VYLUMA INC.

Inventor： SOPPIMATH, Kumaresh ,  HINGORANI, Tushar ,  ATTLURI, Hari A.

IPC: A61K9/00 ,  A61K47/38 ,  A61K31/46 ,  A61P27/02 ,  A61J1/14

Abstract: A sterile multi-dose ophthalmic consumer product, and especially a multi-dose low- concentration atropine eye drop container is disclosed having desirable atropine stability, low loss of viscosity, and low levels of total impurities leached from the container even after extended storage in the container.

公开(公告)号：WO2021236671A1

公开(公告)日：2021-11-25

申请号：PCT/US2021/033008

申请日：2021-05-18

Applicant: VYLUMA INC.

Inventor： LIPMAN, Jack Martin ,  HINGORANI, Tushar ,  SOPPIMATH, Kumaresh

IPC: A61K31/27 ,  A61K31/14 ,  A61K47/18 ,  A61P27/02

Abstract: Ophthalmic formulations for acute and transient treatment of night vision disturbance syndrome (NVD) are presented. Preferred formulations comprise carbachol at very low concentrations that were demonstrated to unexpectedly provide an acute and transient therapeutic effect for a desirable magnitude and period of time.

公开(公告)号：WO2022183051A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017997

申请日：2022-02-25

Applicant: VYLUMA INC.

Inventor： LIPMAN, Jack Martin ,  SOPPIMATH, Kumaresh ,  HINGORANI, Tushar

IPC: A61K31/197 ,  A61P25/04 ,  A61P27/02 ,  A61P29/00

Abstract: The present disclosure is directed to novel ophthalmic formulations comprising a gabapentinoid and methods for treating corneal pain using said formulations.

公开(公告)号：WO2022039887A1

公开(公告)日：2022-02-24

申请号：PCT/US2021/043061

申请日：2021-07-23

Applicant: VYLUMA INC.

Inventor： LIPMAN, Jack Martin ,  SOPPIMATH, Kumaresh ,  HINGORANI, Tushar

IPC: A61K31/439 ,  A61K31/4409 ,  A61K47/38

Abstract: Ophthalmic formulations for treatment of night vision disturbance syndrome (NVD) are presented and preferably comprise brimonidine, rivastigmine, and/or galantamine at very low concentrations. Such formulations unexpectedly provided acute and transient therapeutic effect to alleviate one or more symptoms associated with NVD.