公开(公告)号：WO2014189738A3

公开(公告)日：2015-05-28

申请号：PCT/US2014038027

申请日：2014-05-15

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL O ,  MICHIENZI JOSEPH D ,  MURPHY JAMES P

IPC: G01N30/38

CPC classification number: G01N30/30 ,  B01D15/161 ,  B01D15/40 ,  G01N30/16 ,  G01N30/32 ,  G01N30/34 ,  G01N30/7213 ,  G01N30/84 ,  G01N2030/3038

Abstract: A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.

Abstract translation: 色谱系统包括分离柱，其将由可压缩流动相流携带的样品分离成分析物，以及与分离塔流体连通的分离器，以将可压缩流动相流接收并分成第一和第二流动相流，根据 分流比。 热调制变量限制器耦合在分路器和检测器之间。 限流器从分流器接收第一流动相流，并且具有与第一流动相流热连通的温度元件以与其进行热量交换。 与节流器连通的控制器动态地调节限流器的温度元件的温度设置，以调节热调节的可变节流器和第一流动相流之间的热交换，以便在整个色谱运行期间保持分流比恒定 。

公开(公告)号：WO2013032834A3

公开(公告)日：2014-05-08

申请号：PCT/US2012051976

申请日：2012-08-23

Applicant: WATERS TECHNOLOGIES CORP ,  MICHIENZI JOSEPH D

Inventor： MICHIENZI JOSEPH D

IPC: B01D15/08

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a chromatography a chromatography apparatus that includes a microfluidic substrate, a coupler and a sealing fitting. The microfluidic substrate can include one or more chromatography columns, such as analytical columns or trap columns, and an inlet in communication with the one or more chromatography columns. The coupler is diffusion bonded to the surface of the microfluidic substrate so that an opening in the coupler is aligned to the inlet in the microfluidic substrate. The sealing fitting includes a heat-resistant sealant disposed in the opening of the coupler and in contact with the surface of the substrate. The coupler and sealing fitting enable a compact fluid-tight connection to the inlet of the microfluidic substrate that exhibits high tensile and torsional strength, and does not require the use of adhesives.

Abstract translation: 描述了一种色谱分离装置，其包括微流体基板，耦合器和密封配件。 微流体底物可以包括一个或多个色谱柱，例如分析柱或捕集柱，以及与一个或多个色谱柱连通的入口。 耦合器扩散接合到微流体衬底的表面，使得耦合器中的开口与微流体衬底中的入口对准。 密封配件包括设置在耦合器的开口中并与衬底的表面接触的耐热密封剂。 联接器和密封配件能够实现紧凑的流体密封连接到微流体衬底的入口，其显示出高的拉伸和扭转强度，并且不需要使用粘合剂。