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公开(公告)号：WO2016196183A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034298
申请日：2016-05-26
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe
CPC classification number: G01N33/5038 , B01D15/08 , G01N24/14 , G01N30/72 , G01N30/8617 , G01N30/8675 , G01N2570/00 , G06F19/12 , G06F19/18 , G06F19/24 , G06F19/703
Abstract: The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples. In particular, the present disclosure relates to a method and apparatus to increase the confidence of metabolite identification in metabolomics, such as in untargeted metabolomics data, using various statistical tools, such as over representation and enrichment analysis.
Abstract translation: 本公开涉及用于鉴定复杂生物样品中代谢途径和代谢物的方法和装置。 特别地，本公开涉及使用各种统计工具（例如过度表征和浓缩分析）来增加代谢组学中代谢物学的置信度的方法和装置，例如在非靶向代谢组学数据中。
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2.发明申请MONITORING RADIATION EXPOSURE AND RADIOSENSITIVITY USING AMBIENT IONIZATION MASS SPECTROMETRY 审中-公开环境电离质谱法监测辐射暴露和辐射灵敏度
公开(公告)号：WO2018009700A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040950
申请日：2017-07-06
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe
Abstract: The present disclosure relates to methods and apparatus for determining the effects of radiation exposure on a subject. In particular, the present disclosure relates to the use of surface desorption ionization mass spectrometry methods and apparatus to determine and quantify radiation exposure effects. The method and apparatus can determine the maximum radiation exposure of a subject, can monitor in real-time the radiation exposure and radio sensitivity of a subject, can allow for the preparation of personalized treatment against radiation exposure, and can reduce the incidence of secondary cancer.
Abstract translation: 本公开涉及用于确定辐射暴露对受试者的影响的方法和装置。 具体而言，本公开涉及使用表面解吸电离质谱方法和装置来确定和量化辐射暴露效应。 该方法和设备可以确定受试者的最大辐射暴露，可以实时监测受试者的辐射暴露和放射敏感性，可以允许制备针对放射暴露的个性化治疗，并且可以减少继发性癌症的发生率
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Patent Agency Ranking
公开(公告)号：WO2016168391A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027409
申请日：2016-04-14
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe
CPC classification number: G01N30/72 , G01N33/50 , G01N33/5038 , G01N33/6848 , G01N2458/15 , G01N2560/00 , H01J49/0036 , H01J49/0045 , H01J49/40
Abstract: The present disclosure relates to structural elucidation of isotopically labeled analytes using chromatography-MS and data-independent acquisition. The present disclosure can be used for rapid screening of analytes, such as the metabolome, including the simultaneous collection of both qualitative and quantitative information of known and unknown analytes.
Abstract translation: 本公开涉及使用色谱-MS和数据无关获取的同位素标记的分析物的结构解释。 本公开可用于快速筛选分析物，如代谢组，包括同时收集已知和未知分析物的定性和定量信息。
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4.发明申请METHOD OF USING CHEMICAL TAGS TO IMPROVE THE IDENTIFICATION, QUANTIFICATION AND SPATIAL LOCALIZATION OF COMPONENTS IN A SAMPLE 审中-公开使用化学标签改进样品中组分的鉴定，定量和空间定位的方法
公开(公告)号：WO2017143158A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018327
申请日：2017-02-17
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe , BROUSMICHE, Darryl, W.
CPC classification number: G06F19/16 , G01N27/4473 , G01N27/622 , G01N30/7266 , G01N2030/067
Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.
Abstract translation: 本公开涉及使用具有两个或更多个用于电离的位点的化学标签以改进来自复杂混合物的感兴趣组分的定量和鉴定的方法。 该方法依赖于首先使样品中的一种或多种组分与具有两个或多个用于电离的位点的化学标签选择性反应，然后基于电荷状态分离组分，最后表征每种组分以鉴定它们。 另外公开了可用作公开方法中的化学标签的化合物。
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公开(公告)号：WO2016196179A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034288
申请日：2016-05-26
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe , MASON, Donald , BALOGH, Michael
Abstract: The present disclosure relates generally to methods and apparatus for determining essential nutrients and the ratio of essential nutrients in a sample. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay essential nutrients and ratios thereof, e.g., omega-6/omega-3 ratios.
Abstract translation: 本公开一般涉及用于确定样品中必需营养物质和必需营养物质比例的方法和装置。 特别地，本公开内容涉及表面解吸电离 - 质谱法方法和装置用于测定必需营养物质及其比例，例如ω-6 /ω-3比例。
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公开(公告)号：WO2018005948A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/040256
申请日：2017-06-30
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe , GEROMANOS, Scott
Abstract: The present disclosure generally relates to methods for determining chemical class compositions present in a sample using collision cross-section fragment ion values.
Abstract translation: 本公开一般涉及使用碰撞截面碎片离子值确定样品中存在的化学类别组成的方法。
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7.发明申请MASS SPECTROMETRY WITH QUADRUPOLE AND ION MOBILITY SEPARATION CAPABILITIES 审中-公开具有四分之一和离子移动分离能力的质谱分析
公开(公告)号：WO2016196181A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034293
申请日：2016-05-26
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： ASTARITA, Giuseppe , GEROMANOS, Scott
CPC classification number: B01D15/40 , B01D15/305 , G01N30/72 , G01N30/78 , H01J49/00 , G01N27/622
Abstract: The present disclosure relates generally to metabolomics and lipidomics, and to the analysis of metabolite and lipids in simple and complex mixtures. More specifically, the present disclosure relates to a mass spectrometry system using data independent acquisition and having quadrupole and ion mobility separation capabilities for the identification and quantification of metabolites and lipids. In some embodiments, an optional chromatographic separation can also be included.
Abstract translation: 本公开一般涉及代谢组学和脂质组学，以及简单和复杂混合物中代谢物和脂质的分析。 更具体地，本公开涉及使用数据独立获取并具有用于鉴定和定量代谢物和脂质的四极和离子迁移率分离能力的质谱系统。 在一些实施方案中，也可以包括任选的色谱分离。
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