公开(公告)号：WO2021026387A2

公开(公告)日：2021-02-11

申请号：PCT/US2020/045268

申请日：2020-08-06

申请人： XENCOR, INC.

发明人： BERNETT, Matthew ,  DESJARLAIS, John ,  CHANG, Eric

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/3069 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/624

摘要： Novel Heterodimeric IgG-Like Bispecific Antibodies (HILBAs) are provided herein. Such bispecific antibodies are similar to IgG in structure and, thus, do not exhibit a limited half-life like previous antibody fragment-based bispecifics. Moreover, such heterodimeric IgG-like bispecific antibodies advantageously do not entail complicated generation methods such as Fab arm exchange and common light chain methods. Unlike canonical IgG antibodies, the HILBAs described herein include at least one monomer that is from N- to C-terminus: a VH-scFv linker- VL-CL-domain linker-CH 1 -hinge - CH2-CH3.

公开(公告)号：WO2020172631A2

公开(公告)日：2020-08-27

申请号：PCT/US2020/019363

申请日：2020-02-21

申请人： XENCOR, INC.

发明人： MOORE, Gregory ,  VARMA, Rajat ,  KIM, Yoon, Kyung ,  RASHID, Rumana ,  CHANG, Eric ,  NISTHAL, Alex ,  DIAZ, Juan ,  BERNETT, Matthew ,  HEDVAT, Michael

摘要： The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CDS and NKG2D.

公开(公告)号：WO2020132646A1

公开(公告)日：2020-06-25

申请号：PCT/US2019/068167

申请日：2019-12-20

申请人： XENCOR, INC.

发明人： BERNETT, Matthew ,  DESJARLAIS, John, R. ,  VARMA, Rajat ,  MOORE, Gregory ,  DIAZ, Juan ,  NISTHAL, Alex ,  LIU, Ke ,  RASHID, Rumana ,  CHANG, Eric

IPC分类号： A61P35/00 ,  C07K14/54 ,  C07K14/715 ,  C07K16/28 ,  C07K19/00 ,  C12N15/63

摘要： The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-l5/IL-l5Rα Fc fusion protein and an NKG2D antigen binding domain Fc fusion proteins.