公开(公告)号：WO2022099284A1

公开(公告)日：2022-05-12

申请号：PCT/US2021/072234

申请日：2021-11-04

Applicant: YOUNG BIOPHARMA, LLC

Inventor： SHEN, Young ,  LIU, Junke

IPC: A61K31/05 ,  A61K31/327 ,  C07C215/46 ,  C07C409/00 ,  C07C409/40

Abstract: The present invention provides compositions comprising compounds having formulas (I), (II) or (III): and additionally provides methods for the use thereof in the treatment of various disorders including neurological disorders, cancer, diabetes, and obesity, wherein R1-R7, X, A, and Q in (I), R1-R15 in (II) and R1-R15 in (III) are as defined herein. In certain embodiments, methods for the treatment of various disorders including pain and cancer comprise topically, locally or systemically (e.g., IV, IP or orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formulas (I), (II) or (III).