IN-VITRO SENSOR USING A TETRAPOLAR IMPEDANCE MEASUREMENT
    1.
    发明申请
    IN-VITRO SENSOR USING A TETRAPOLAR IMPEDANCE MEASUREMENT 审中-公开
    体外传感器使用四分体阻抗测量

    公开(公告)号:WO2017106560A1

    公开(公告)日:2017-06-22

    申请号:PCT/US2016/067028

    申请日:2016-12-15

    摘要: Systems, methods, and devices are provided for determining an impedance measurement of a sample of fluid on a test strip having a base layer, at least two drive electrodes disposed on the base layer and in electrical communication with a current-source (I ac ) for flowing an AC current provided by the current-source (I ac ) through a fluid sample between the at least two drive electrodes, and at least two sense electrodes disposed on the base layer and positioned between the at least two drive electrodes, each of the at least two sense electrodes configured for measuring a difference in an AC potential therebetween to determine an impedance measurement of the fluid sample between the at least two sense electrodes.

    摘要翻译: 提供用于确定测试条上的流体样本的阻抗测量的系统,方法和设备,所述测试条具有基础层,至少两个驱动电极,所述至少两个驱动电极设置在基础层上并与 用于使电流源(I ac)提供的AC电流流过至少两个驱动电极之间的流体样本的电流源(I ac),以及 至少两个感测电极,所述至少两个感测电极设置在所述基底层上并且位于所述至少两个驱动电极之间,所述至少两个感测电极中的每一个被配置用于测量其间的AC电势差,以确定所述流体样本之间的阻抗测量值, 至少两个感应电极。

    TEST STRIP AND METHOD TO DETERMINE TEST STRIP COMPATIBILITY
    2.
    发明申请
    TEST STRIP AND METHOD TO DETERMINE TEST STRIP COMPATIBILITY 审中-公开
    测试条和测定条带兼容性的方法

    公开(公告)号:WO2016097054A3

    公开(公告)日:2016-09-29

    申请号:PCT/EP2015080094

    申请日:2015-12-16

    申请人: CILAG GMBH INT

    IPC分类号: G01N27/327

    摘要: An analyte measurement system is disclosed herein. The analyte measurement system includes a test strip. The test strip includes at least two electrodes spaced apart in a reaction chamber, one of said electrodes including a conductive material having a coating applied thereupon. The analyte measurement system also includes an analyte measurement device. The analyte measurement device includes a strip port having connectors configured to coupled to the electrodes of the test strip. The applied coating enables a capacitance value of the test strip to be measured in order to determine compatibility of the test strip with the analyte measurement device.

    摘要翻译: 本文公开了分析物测量系统。 分析物测量系统包括测试条。 测试条包括在反应室中间隔开的至少两个电极,所述电极中的一个包括具有施加在其上的涂层的导电材料。 分析物测量系统还包括分析物测量装置。 分析物测量装置包括具有被配置为耦合到测试条的电极的连接器的带状端口。 所施加的涂层使得能够测量测试条的电容值,以便确定测试条与分析物测量装置的相容性。

    METHOD FOR CALIBRATING A DEVICE FOR MEASURING THE CONCENTRATION OF CREATININE
    3.
    发明申请
    METHOD FOR CALIBRATING A DEVICE FOR MEASURING THE CONCENTRATION OF CREATININE 审中-公开
    用于校准用于测量CREATININE浓度的装置的方法

    公开(公告)号:WO2016097078A1

    公开(公告)日:2016-06-23

    申请号:PCT/EP2015/080131

    申请日:2015-12-17

    发明人: KJAER, Thomas

    IPC分类号: G01N27/327

    摘要: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Cm in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Cm.

    摘要翻译: 一种校准用于使用一种或多种校准溶液测量肌酸酐浓度的装置的方法,所述方法包括:在所述一种或多种校准溶液的肌酸,Cr和/或肌酸酐Crn的初始时间接收浓度; 在结束时间接收测量装置的输出; 使用温度模型计算结束时间的校准溶液中的Cr和/或Cm的浓度,其中温度模型指示校准溶液的温度从初始时间到结束时间的变化; 并确定测量装置的输出与计算出的Cr和/或Cm浓度之间的关系。

    ANALYTE MEASUREMENT
    4.
    发明申请
    ANALYTE MEASUREMENT 审中-公开
    分析测量

    公开(公告)号:WO2016092276A1

    公开(公告)日:2016-06-16

    申请号:PCT/GB2015/053736

    申请日:2015-12-07

    IPC分类号: G01N27/327

    摘要: A method for configuring a device to determine a concentration of an analyte, the method using a plurality of m fluid samples, each fluid sample of the m fluid samples having a corresponding known analyte concentration, the method comprising: for each fluid sample of the m fluid samples: generating an output signal from the fluid sample; recording values of the output signal over time; and modelling at least a subset of the recorded values of the output signal using n basis functions to obtain n coefficients, each coefficient being associated with a corresponding basis function, the n basis functions and n coefficients representing the output signal for the subset; performing a statistical analysis of the mxn coefficients and corresponding known analyte concentrations to determine a set of n parameters from which an analyte concentration can be estimated based on a set of n coefficients obtained for a fluid sample for which the analyte concentration is unknown; and storing the set of n parameters in a memory of one or more devices.

    摘要翻译: 一种用于配置装置以确定分析物的浓度的方法,所述方法使用多个m个流体样品,所述m个流体样品的每个流体样品具有相应的已知分析物浓度,所述方法包括:对于m的每个流体样品 流体样品:从流体样品产生输出信号; 随时间记录输出信号的值; 以及使用n个基函数对所述输出信号的记录值的至少一个子集进行建模以获得n个系数,每个系数与相应的基函数相关联,所述n个基函数和n个系数表示该子集的输出信号; 对mxn系数和相应的已知分析物浓度进行统计分析,以确定一组n个参数,从而可以基于为分析物浓度未知的流体样品获得的一组n个系数来估计分析物浓度; 以及将一组n个参数存储在一个或多个设备的存储器中。

    INTERFERENCE COMPENSATING TWO ELECTRODES TEST STRIP
    5.
    发明申请
    INTERFERENCE COMPENSATING TWO ELECTRODES TEST STRIP 审中-公开
    干扰补偿两个电极测试条

    公开(公告)号:WO2016030346A2

    公开(公告)日:2016-03-03

    申请号:PCT/EP2015/069393

    申请日:2015-08-25

    IPC分类号: C12Q1/00

    摘要: The present invention relates to a method of detecting at least one analyte in a test sample, said method comprising the steps of a) contacting said test sample (i) to an active chemistry matrix (116) changing at least one electrochemical property dependent on an enzymatic activity active in the presence of said analyte, said active chemistry matrix contacting a first electrode (112); and (ii) to an inactive chemistry matrix (118), said inactive chemistry matrix contacting a second electrode (114), b) closing an electrical circuit including said first electrode(112), said second electrode (114), and said active chemistry matrix (116) and inactive chemistry matrix (118), followed by determining a first value of said at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of said at least one electrochemical property, and d) detecting said at least one analyte based on said first value and on said second value. Moreover, the present invention relates to a test device and to a test system adapted to make use of the method of the present invention. The present invention further relates to a sensor element (110) for determining at least one analyte, comprising a pair of electrodes (112, 114) and at least an active and an inactive chemistry matrix (116, 118), said active chemistry matrix (116) changing at least one electrochemical property dependent on an enzymatic activity active in the presence of said analyte, (i) wherein said pair of electrodes (112, 114) consists of two electrodes electrically insulated from other electrodes, (ii) wherein said active chemistry matrix (116) comprises said enzymatic activity and wherein said inactive chemistry matrix (118) does not comprise said enzymatic activity, and (iii) wherein a first electrode (112) of said pair of electrodes contacts said active chemistry matrix (116) and wherein a second electrode (114) of said pair of electrodes contacts said inactive chemistry matrix (118).

    摘要翻译: 本发明涉及检测测试样品中至少一种分析物的方法,所述方法包括以下步骤:a)将所述测试样品(i)与活性化学基质(116)接触,以改变 至少一种取决于在所述分析物存在下有活性的酶活性的电化学性质,所述活性化学基质接触第一电极(112); 和(ii)非活性化学基质(118),所述非活性化学基质接触第二电极(114),b)闭合包括所述第一电极(112),所述第二电极(114)和所述活性化学物质 矩阵(116)和非活性化学基质(118),然后确定所述至少一种电化学性质的第一值,c)反转b)的电路的电极性,随后确定所述至少一种 电化学性质,和d)基于所述第一值和所述第二值检测所述至少一种分析物。 此外,本发明涉及适用于利用本发明的方法的测试装置和测试系统。 本发明进一步涉及用于确定至少一种分析物的传感器元件(110),其包括一对电极(112,114)以及至少一个活性化学基质(116,118),所述活性化学基质( (i)其中所述一对电极(112,114)由与其他电极电绝缘的两个电极组成,(ii)其中所述活性物质在所述分析物存在下活化, (116)包括所述酶活性,并且其中所述非活性化学基质(118)不包含所述酶活性,并且(iii)其中所述电极对的第一电极(112)接触所述活性化学基质(116),和 其中所述电极对的第二电极(114)接触所述非活性化学基质(118)。

    ANALYTE CONCENTRATION MEASUREMENT
    6.
    发明申请
    ANALYTE CONCENTRATION MEASUREMENT 审中-公开
    分析浓度测量

    公开(公告)号:WO2016005743A1

    公开(公告)日:2016-01-14

    申请号:PCT/GB2015/051973

    申请日:2015-07-08

    发明人: LIU, Zuifang

    IPC分类号: G01N27/327 G01N27/49

    CPC分类号: G01N27/3274

    摘要: A method of determining analyte concentration uses a redox reaction in an electrochemical cell that has at least two electrodes, one of which is a working electrode, at least one electrode being exposed to at least one redox mediator. The method uses at least one cycle of pulses, each cycle having at least a first potential and a second potential. The method comprises applying a first potential to initiate an accumulation phase that forces accumulation of a mediator concentration gradient at or close to the working electrode with a concentration that decreases towards the bulk solution, applying a second potential to initiate a measurement phase and deplete the established mediator concentration gradient at the working electrode, measuring current associated with the second potential of each cycle, and using the measured current to determine analyte concentration. In this way, the effects of diffusion interfering factors (DIF), especially haematocrit (Hct) can be mitigated.

    摘要翻译: 确定分析物浓度的方法使用具有至少两个电极的电化学电池中的氧化还原反应,其中一个电极是工作电极,至少一个电极暴露于至少一个氧化还原介体。 该方法使用至少一个脉冲周期,每个周期具有至少第一电势和第二电位。 该方法包括施加第一电位以启动积累阶段,其强制在工作电极处或附近的介体浓度梯度的累积,其浓度朝向本体溶液减小,施加第二电位以启动测量阶段并耗尽建立的 在工作电极处的介体浓度梯度,测量与每个循环的第二电位相关的电流,并使用测量的电流来确定分析物浓度。 以这种方式,可以减轻扩散干扰因子(DIF),特别是血细胞比容(Hct)的影响。

    휴대용 혈당 측정기
    7.
    发明申请
    휴대용 혈당 측정기 审中-公开
    便携式血糖测量装置

    公开(公告)号:WO2015178737A1

    公开(公告)日:2015-11-26

    申请号:PCT/KR2015/005207

    申请日:2015-05-22

    IPC分类号: G01N33/66 A61B5/145

    摘要: 본 발명은 휴대용 혈당 측정기에 관한 것으로, 케이스의 일측면에 외부 온도 변화에 따라 신속하게 온도 변화하는 온도 측정 매개체를 외부 노출되게 장착하고, 온도 측정 매개체의 온도를 적외선 온도 센서로 비접촉 방식으로 측정하며, 측정된 온도를 고려하여 혈당 측정 결과를 산출함으로써, 실제 혈당 측정 환경의 외부 온도를 정확하게 반영할 수 있어 혈당 측정 결과의 정확도를 향상시킬 수 있고, 온도 측정 매개체를 케이스와는 독립적으로 외부 온도에 민감하게 반응하도록 구성함으로써, 외부 온도 변화에 따른 온도 측정 매개체의 온도 변화가 신속 정확하게 이루어지고, 이에 따라 더욱 정확한 온도 측정이 가능하고 이로 인해 더욱 정확하게 혈당 측정 결과를 산출할 수 있는 휴대용 혈당 측정기를 제공한다.

    摘要翻译: 便携式血糖测定装置技术领域本发明涉及便携式血糖值测定装置,其特征在于,提供一种便携式血糖值测定装置,其以外部暴露的方式设置有温度随温度变化而变化的温度测量介质, 以非接触方式用红外线温度传感器测量温度测量介质的温度,并且通过考虑所测量的温度来计算血糖测量结果,以便准确地反映实际的血糖测量环境的外部温度,例如 可以提高血糖测量结果的准确性; 并且允许温度测量介质被配置为独立于壳体对外部温度敏感地响应,使得温度测量介质的温度根据外部温度的变化快速且准确地改变,以便测量 温度更准确,从而更准确地计算血糖测量结果。

    生体情報測定装置および生体情報測定装置の制御方法
    8.
    发明申请
    生体情報測定装置および生体情報測定装置の制御方法 审中-公开
    生物信息测量装置和控制生物信息测量装置的方法

    公开(公告)号:WO2015141510A1

    公开(公告)日:2015-09-24

    申请号:PCT/JP2015/056845

    申请日:2015-03-09

    IPC分类号: G01N27/28 G01N27/26 G01N33/66

    摘要: 本発明は、生体情報測定装置に関するもので、適切な測定を行うことを目的とする。そしてこの目的を達成するために本発明の生体情報測定装置(1)は、本体ケース(2)と、コネクタ(8)と、測定部(9)と、カバー(15)と、外気温度測定部(20)と、を備える。本体ケース(2)は、センサ(4)が装着されるセンサ装着口(3)を有する。コネクタ(8)は、本体ケース(2)内でセンサ装着口(3)の奥側に設けられセンサ装着口(3)に装着されるセンサ(4)と電気的に接続される。測定部(9)は、コネクタ(8)に電気的に接続されている。カバー(15)は、本体ケース(2)の表面に設けられセンサ装着口(3)を開閉自在に覆う。外気温度測定部(20)は、本体ケース(2)の表面に設けられ本体ケース(2)の外気温度を測定する。カバー(15)は、センサ装着口(3)と共に外気温度測定部(20)を覆う。

    摘要翻译: 本发明涉及一种生物信息测量装置,其目的是适当的测量。 为了达到这个目的,该生物信息测量装置(1)具有主体壳体(2),连接器(8),测量单元(9),盖(15)和外部温度测量单元 20)。 主体壳体(2)具有插入传感器(4)的传感器插入口(3)。 连接器(8)设置在传感器插入口(3)的后侧的主体壳体(2)的内部,与插入传感器插入口(3)的传感器(4)电连接。 测量单元(9)电连接到连接器(8)。 盖体(15)设置在主体壳体(2)的表面上,可开闭地覆盖传感器插入口(3)。 外部温度测量单元(20)设置在主体壳体(2)的表面上,并且测量主体壳体(2)外部的空气的温度。 盖(15)与传感器插入口(3)一起覆盖外部温度测量单元(20)。

    BIOSENSOR CALIBRATION CODING SYSTEMS AND METHODS
    9.
    发明申请
    BIOSENSOR CALIBRATION CODING SYSTEMS AND METHODS 审中-公开
    生物传感器校准编码系统和方法

    公开(公告)号:WO2015134779A1

    公开(公告)日:2015-09-11

    申请号:PCT/US2015/019020

    申请日:2015-03-05

    发明人: GOFMAN, Igor

    IPC分类号: G01N33/487

    摘要: A test sensor (100) for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area (128) and a port-insertion region (126). A first row of optically transparent (132) and non-transparent positions forms a calibration code pattern (130) disposed within a first area of the port-insertion region (126). A second row of optically transparent (142) and non-transparent positions forms a synchronization code pattern (140) disposed within a second area of the port-insertion region (126). The second area is different from the first area. The synchronization code pattern (140) corresponds to the calibration code pattern (130) such that the synchronization code pattern (140) provides synchronization of the serial calibration code pattern (130) during insertion of the port- insertion region (126) into the receiving port of the analyte meter.

    摘要翻译: 用于确定生物流体中的分析物浓度的测试传感器(100)包括包括流体接收区域(128)和端口插入区域(126)的条带。 光学透明(132)和非透明位置的第一行形成设置在端口插入区域(126)的第一区域内的校准码图案(130)。 光学透明(142)和非透明位置的第二行形成设置在端口插入区域(126)的第二区域内的同步码图案(140)。 第二个区域与第一个区域不同。 同步代码模式(140)对应于校准代码模式(130),使得同步码模式(140)在将端口插入区域(126)插入到接收器期间时提供串行校准码模式(130)的同步 分析仪的端口。

    TEST STRIP RESISTANCE CHECK
    10.
    发明申请
    TEST STRIP RESISTANCE CHECK 审中-公开
    检测条纹检查

    公开(公告)号:WO2015044406A1

    公开(公告)日:2015-04-02

    申请号:PCT/EP2014/070757

    申请日:2014-09-29

    发明人: ELDER, David

    IPC分类号: G01N27/327 G01N33/487

    摘要: A system for determining usability of an analytical test strip having two electrodes connected in series with a sample cell includes a test meter configured to receive the test strip. The sample cell receives a fluid sample, the sample cell with the received fluid sample having a frequency-dependent impedance. A microprocessor and circuit in the test meter cause application of an AC waveform across the sample cell via the electrodes upon detection of sample in the sample cell and concurrently measure of a current through the electrodes. The AC waveform has a frequency at which the characteristic impedance is substantially zero. The measured current is inversely proportional to a series resistance of the two electrodes. A hand-held test meter and a method for determining usability of an analytical test strip are also described.

    摘要翻译: 用于确定具有与样品池串联连接的两个电极的分析测试条的可用性的系统包括配置成接收测试条的测试计量器。 样品池接收流体样品,所接收的流体样品的样品池具有频率依赖阻抗。 测试仪中的微处理器和电路在检测到样品池中的样品并同时测量通过电极的电流时,通过电极通过样品池施加AC波形。 AC波形具有特性阻抗基本上为零的频率。 测量的电流与两个电极的串联电阻成反比。 还描述了手持测试仪和用于确定分析测试条的可用性的方法。