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    HEXYLAMINE SALTS AND METHODS OF USING HEXYLAMINE
    5.
    发明申请
    HEXYLAMINE SALTS AND METHODS OF USING HEXYLAMINE 审中-公开

    公开(公告)号：WO2020214841A1

    公开(公告)日：2020-10-22

    申请号：PCT/US2020/028566

    申请日：2020-04-16

    申请人： THERMOLIFE INTERNATIONAL, LLC

    发明人： KRAMER, Ronald ,  NIKOLAIDIS, Alexandros

    IPC分类号： C07C211/62 ,  C07C211/06 ,  C07C209/68 ,  C07C51/41 ,  C07C55/10 ,  C07C59/265 ,  C07C53/10 ,  C07C57/145 ,  C07C57/15 ,  C07C59/245 ,  A61K31/131 ,  A61K31/205 ,  A61P25/00 ,  A61P25/26 ,  A61P25/28 ,  A61P3/00

    摘要： Salts of hexylamine, for example, hexylamine succinate and tri-hexylamine citrate and their method of production are described. The disclosure also relates to compositions comprises hexyalmine and the use of hexylamine for for reducing appetite in a human subject, treating obesity in a human subject, preventing obesity in a human subject, preventing weight gain in a human subject, increasing fat loss in a human subject, treating an overweight human subject, increasing athletic performance in a human subject, increasing endurance in a human subject, increasing muscle strength in a human subject, improving cognitive function in a human subject, treating ADHD in a human subject, increasing sweating in a human subject, reducing reaction time of a human subject, increasing psychomotor vigilance of a human subject, enhancing memory in a human subject, increasing central nervous system activity in a human subject, and enhancing alertness, attention, concentration, and/or memory in a human subject.

    PROGRAMMABLE PHARMACEUTICAL COMPOSITIONS FOR CHRONO DRUG RELEASE
    7.
    发明申请
    PROGRAMMABLE PHARMACEUTICAL COMPOSITIONS FOR CHRONO DRUG RELEASE 审中-公开

    公开(公告)号：WO2019173384A1

    公开(公告)日：2019-09-12

    申请号：PCT/US2019/020815

    申请日：2019-03-05

    申请人： KASHIV PHARMA LLC

    发明人： SHAH, Navnit H. ,  PHUAPRADIT, Wantanee ,  DESAI, Dipen ,  VAKA, Siva Ram Kiran

    IPC分类号： A61K9/24 ,  A61K9/00 ,  A61K31/00 ,  A61P25/20 ,  A61P25/26

    摘要： The present disclosure provides programmable osmotic-controlled oral compositions providing delayed release of a therapeutically acceptable amount of a drug, hi certain embodiments, the programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, and volume of gastric fluid. The programmable osmotic-controlled oral compositions of the disclosure comprise a multilayer core comprising a drug for controlled release, wherein the core is coated with a semipermeable membrane comprising an orifice and, optionally, an immediate release coating, comprising a drug for immediate release, over the semipermeable membrane. The multilayered core comprises a pull layer containing the drug and a push layer. The pull layer comprises at least two layers: a placebo layer for providing a desired lag time for the drug release; and an active layer containing the drug and providing a delayed controlled release of the drug. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm, e.g., that matches the human circadian rhythm of a condition's symptoms and/or of the individual being treated in the application of the therapy to optimize therapeutic outcome and minimize side effects.

    ケイ酸カルシウムを含有するアクリル系貼付剤
    8.
    发明申请
    ケイ酸カルシウムを含有するアクリル系貼付剤 审中-公开

    公开(公告)号：WO2019167695A1

    公开(公告)日：2019-09-06

    申请号：PCT/JP2019/005829

    申请日：2019-02-18

    申请人： 久光製薬株式会社

    发明人： 田中　亮 ,  小南　和也 ,  内田　尚志 ,  島　滝登

    IPC分类号： A61K47/02 ,  A61K9/70 ,  A61K31/4458 ,  A61K47/32 ,  A61P25/26

    摘要： 本発明の課題は、物性や濃度に拘らず、包材中あるいは貼付中のコールドフローを抑制し、保管中の貼付剤における薬物の安定維持と長期間に亘る適切な投与形態の維持によって、持続的に十分な薬効を得られる、取り扱いに優れたアクリル系粘着基剤を含む貼付剤を提供することにある。本発明は、支持体層および粘着剤層を備える貼付剤であって、粘着剤層が、薬物、アクリル系粘着基剤およびケイ酸カルシウムを含有する、前記貼付剤、ならびに、その製造方法に関する。

    NICOTINE-CONTAINING CHEWING GUM COMPOSITIONS
    9.
    发明申请
    NICOTINE-CONTAINING CHEWING GUM COMPOSITIONS 审中-公开

    公开(公告)号：WO2018219650A1

    公开(公告)日：2018-12-06

    申请号：PCT/EP2018/062749

    申请日：2018-05-16

    申请人： ENORAMA PHARMA AB

    发明人： RUDRARAJU, Varma ,  RAJESH, Yelchuri

    IPC分类号： A61K9/68 ,  A61K31/465 ,  A61P25/26

    摘要： The present invention relates to nicotine-containing chewing gum compositions and the method of preparing the same. The present invention provides improved and stable nicotine-containing chewing gum compositions for use in nicotine replacement therapy, which provide rapid nicotine release in the oral cavity and effectively satisfy the craving that most smokers experience.