公开(公告)号：WO2022178454A2

公开(公告)日：2022-08-25

申请号：PCT/US2022/017382

申请日：2022-02-22

申请人： APEEL TECHNOLOGY, INC.

发明人： FAUST, Gregory ,  HEGEL, Cody ,  GAUDIOSO, Matthew Dominick ,  BRODBECK, Erich

IPC分类号： B01F23/41 ,  B01F23/43 ,  B01F23/70 ,  B01F27/93 ,  B01F27/192 ,  B01F27/2121 ,  B01F27/1152 ,  B01F25/50 ,  B01F23/40 ,  B01F35/21 ,  B01F33/501 ,  B01F35/22 ,  B01F35/13 ,  B01F2035/99 ,  B01F2101/06 ,  B01F2215/044 ,  B01F2215/045 ,  B01F2215/0472 ,  B01F23/4146 ,  B01F23/49 ,  B01F23/51 ,  B01F23/53 ,  B01F23/56 ,  B01F23/59 ,  B01F23/711 ,  B01F27/113 ,  B01F27/1153 ,  B01F27/17 ,  B01F27/2712 ,  B01F27/911 ,  B01F33/5013 ,  B01F35/2113 ,  B01F35/2115 ,  B01F35/213 ,  B01F35/2131 ,  B01F35/2132 ,  B01F35/2209 ,  B01F35/2215 ,  B01F35/2217 ,  B01F35/2218 ,  B01F35/92

摘要： The subject matter of this specification can be embodied in, among other things, a mixing system (100) that includes a heating assembly (300) configured to heat liquid, and a mixing assembly (400) including a tank (240) defining a cavity and configured to retain liquid, an inlet in fluidic communication with the cavity and configured to receive liquid from the heating assembly, a mixing impeller assembly configured to mix contents of the cavity, an actuator configured to actuate the mixing impeller assembly to mix contents of the cavity, and an outlet (140) in fluidic communication with the cavity and having a valve configured to selectively prevent and permit egress of contents of the cavity.

公开(公告)号：WO2023283320A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/036336

申请日：2022-07-07

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： MANIRUZZAMAN, Mohammed ,  WANG, Jiawei ,  AGHDA, Niloofar Heshmati ,  ZHANG, Yu

IPC分类号： B05B1/02 ,  A61K9/107 ,  B29C64/10 ,  B01F23/40 ,  A61K9/16 ,  B01F23/4146 ,  A61K35/00 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1694 ,  B29C64/106 ,  B33Y10/00 ,  B33Y80/00

摘要： Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.