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    PROCESSES FOR THE PREPARATION OF HIGHLY PURE 3-(2-SUBSTITUTED VINYL) CEPHALOSPORIN
    3.
    发明申请
    PROCESSES FOR THE PREPARATION OF HIGHLY PURE 3-(2-SUBSTITUTED VINYL) CEPHALOSPORIN 审中-公开
    制备高纯3-（2-取代乙烯基）头孢菌素的方法

    公开(公告)号：WO2005044824A3

    公开(公告)日：2005-07-14

    申请号：PCT/IB2004003571

    申请日：2004-11-01

    Applicant: RANBAXY LAB LTD ,  KUMAR YATENDRA ,  PRASAD MOHAN ,  SINGH KAPTAN ,  PRASAD ASHOK ,  RICHHARIYA SANTOSH

    Inventor： KUMAR YATENDRA ,  PRASAD MOHAN ,  SINGH KAPTAN ,  PRASAD ASHOK ,  RICHHARIYA SANTOSH

    IPC: C07D501/00 ,  C07D501/24 ,  A61K31/545 ,  A61P31/00

    CPC classification number: C07D501/24

    Abstract: The present invention relates to a process for preparation of highly pure amorphous and crystalline forms of cefditoren pivoxil and pharmaceutical compositions comprising highly pure amorphous and crystalline forms of cefditoren pivoxil. The present invention also relates to a method of treating infections using highly pure amorphous and crystalline forms of cefditoren pivoxil. The highly pure cefditoren pivoxil has a purity greater than 98.5% and contains less than 1.0% of the E-isomer impurity and less than 1 % of the Delta ­isomer impurity.

    Abstract translation: 本发明涉及制备高纯度无定形和晶体形式的头孢托仑匹酯的方法以及包含高纯度无定形和晶体形式的头孢托仑匹酯的药物组合物。 本发明还涉及使用高纯度无定形和晶体形式的头孢托仑匹酯治疗感染的方法。 高纯度头孢托仑匹酯具有大于98.5％的纯度并且包含小于1.0％的E-异构体杂质和小于1％的δ2异构体杂质。

    CEPHEM COMPOUNDS AND ESBL-DETECTING REAGENTS CONTAINING THE SAME
    4.
    发明申请
    CEPHEM COMPOUNDS AND ESBL-DETECTING REAGENTS CONTAINING THE SAME 审中-公开
    CEPHEM化合物和含有其的ESBL检测试剂

    公开(公告)号：WO02024707A1

    公开(公告)日：2002-03-28

    申请号：PCT/JP2001/008235

    申请日：2001-09-21

    IPC: C07D501/00 ,  C07D501/14 ,  C07D501/24 ,  G01N21/78 ,  G01N21/77 ,  G01N31/22 ,  G01N33/569

    CPC classification number: C07D501/00 ,  G01N21/78

    Abstract: Cephem compounds of the general formula (I) or their pharmaceutically acceptable salts: (I) wherein R1 and R2 are each independently hydrogen, nitro, or cyano; R3 is optionally carboxylated C1-6 alkyl; R4 is hydrogen or amino; and X is S- or SO-, with the proviso that the cases wherein both of R1 and R2 are simultaneously hydrogen are excepted.

    Abstract translation: 通式（I）的头孢烯化合物或其药学上可接受的盐：（I）其中R 1和R 2各自独立地为氢，硝基或氰基; R3任选地是羧基化的C 1-6烷基; R4是氢或氨基; 并且X是S-或SO-，条件是其中R 1和R 2都同时为氢的情况除外。

    NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME
    5.
    发明申请
    NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME 审中-公开
    新型CEPHOROSPORIN化合物及其制备方法

    公开(公告)号：WO02004464A1

    公开(公告)日：2002-01-17

    申请号：PCT/KR2001/001027

    申请日：2001-06-14

    IPC: C07D519/06 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/14 ,  C07D501/20 ,  C07D501/24 ,  C07D501/52

    CPC classification number: C07D501/00 ,  Y02P20/55

    Abstract: The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition containing the compound and to a process for preparing the compound.

    Abstract translation: 本发明涉及一种新颖的头孢菌素化合物及其药学上可接受的无毒盐，生理上可水解的酯，水合物，溶剂合物或异构体，其含有该化合物的药物组合物及其制备方法。

    INTERMEDIATES FOR AND SYNTHESIS OF 3-METHYLENE CEPHAMS
    7.
    发明申请
    INTERMEDIATES FOR AND SYNTHESIS OF 3-METHYLENE CEPHAMS 审中-公开
    3-甲基苯酚的中间体和合成

    公开(公告)号：WO01060828A1

    公开(公告)日：2001-08-23

    申请号：PCT/US2001/004410

    申请日：2001-02-10

    IPC: C07D205/095 ,  C07D403/04 ,  C07D501/00 ,  C07D501/08 ,  C07D501/14 ,  C07D501/22 ,  C07D501/24

    CPC classification number: C07D403/04 ,  C07D205/095 ,  C07D501/00 ,  Y02P20/55

    Abstract: The present invention relates to novel processes for the preparation of 3-methylenecephams. More specifically, the present invention relates in part to the intramolecular cyclization of penicillin sulfoxide derived monocyclic azetidinone derivatives either thermally or with lanthanide metal salt catalysts.

    Abstract translation: 本发明涉及制备3-亚甲基脑炎的新方法。 更具体地说，本发明部分地涉及青霉素亚砜衍生的单环氮杂环丁酮衍生物与镧系元素金属盐催化剂的分子内环化。

    CRYSTALLOGRAPHICALLY STABLE AMORPHOUS CEPHALOSPORIN COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME
    9.
    发明申请
    CRYSTALLOGRAPHICALLY STABLE AMORPHOUS CEPHALOSPORIN COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME 审中-公开
    晶体稳定的无定形酚酞组合物及其制备方法

    公开(公告)号：WO99034832A1

    公开(公告)日：1999-07-15

    申请号：PCT/JP1999/000020

    申请日：1999-01-07

    IPC: A61K9/14 ,  A61K31/545 ,  A61K31/546 ,  A61K47/38 ,  A61P31/00 ,  C07D501/00 ,  C07D501/24

    CPC classification number: C07D501/00 ,  A61K9/146 ,  A61K31/545 ,  A61K31/546 ,  Y10S514/96

    Abstract: Yellow and powdery compositions consisting of particles composed of a homogeneous mixture of amorphous cefditoren pivoxil with a water-soluble polymer additive and being orally administrable. These compositions can be obtained by dissolving the amorphous cefditoren pivoxil and the water-soluble polymer in an aqueous solution of an acid, neutralizing, coprecipitating, and then drying the thus obtained precipitate followed by the recovery of the product.

    Abstract translation: 由由无定形头孢托仑匹酯与水溶性聚合物添加剂的均匀混合物组成的颗粒组成的黄色和粉末组合物并且可口服施用。 这些组合物可以通过将无定形头孢托仑匹酯和水溶性聚合物溶解在酸的水溶液中，中和，共沉淀，然后干燥所得沉淀物，然后回收产物来获得。

    GLUTARYL 7-ACA DERIVATIVES AND PROCESSES FOR OBTAINING THEM
    10.
    发明申请
    GLUTARYL 7-ACA DERIVATIVES AND PROCESSES FOR OBTAINING THEM 审中-公开
    GLUTARYL 7-ACA衍生物及其制备方法

    公开(公告)号：WO1995035020A2

    公开(公告)日：1995-12-28

    申请号：PCT/EP1995002802

    申请日：1995-07-17

    Applicant: ANTIBIOTICOS S.P.A. ,  SOGLI, Loris ,  LONGONI, Davide ,  POZZI, Giovanni ,  SIVIERO, Enrico ,  TERRASSAN, Daniele, Mario ,  BERNASCONI, Ermanno ,  SALTO, Francisco

    Inventor： ANTIBIOTICOS S.P.A.

    IPC: C07D501/04 ,  C07D501/00 ,  C07D501/14 ,  C07D501/16 ,  C07D501/20 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/59

    CPC classification number: C07D501/00

    Abstract: There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom; a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by at least a linear or branched C1-C4 alkyl or alkoxy group or a nitro group; a silyl substituted by at least a linear or branched, unsubstituted or substituted C1-C4 alkyl group; n is 0 or 1; and Y is a radical of formula (II), wherein A is H, OH, Cl, CH2, CH2X, where X is F, Cl, Br, I, OH or OR' and R' is COCH3 or a linear or branched, unsubstituted or substituted C1-C4 alkyl group and ... represents a single or a double bond, with the proviso that when n=0 and R is H, R' is not a methyl group; and processes for obtaining them.

    Abstract translation: 公开了新的式（I）化合物，其中R是：氢原子; 直链或支链C 1 -C 4烷基，未被取代或被至少一个苯基或至少一个氢原子取代; 被至少一个直链或支链的C 1 -C 4烷基或烷氧基或硝基取代的苄基; 由至少一个直链或支链的未取代或取代的C 1 -C 4烷基取代的甲硅烷基; n为0或1; 并且Y是式（II）的基团，其中A是H，OH，Cl，CH 2，CH 2 X，其中X是F，Cl，Br，I，OH或OR'，R'是COCH 3或直链或支链， 未取代或取代的C 1 -C 4烷基，且 - 表示单键或双键，条件是当n = 0且R为H时，R'不为甲基; 以及获得它们的过程。

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