利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

215 条记录 (耗时 0.024 秒)

    PRODUCING ALBUMIN IN CANNABACEAE PLANT PARTS
    2.
    发明申请
    PRODUCING ALBUMIN IN CANNABACEAE PLANT PARTS 审中-公开

    公开(公告)号：WO2022198094A1

    公开(公告)日：2022-09-22

    申请号：PCT/US2022/021027

    申请日：2022-03-18

    申请人： CALYXT, INC.

    发明人： CAMPBELL, Benjamin ,  LAPHAM, Rachelle

    IPC分类号： C12N15/82 ,  A61K38/38 ,  C07K14/76 ,  C12M1/00 ,  A01H5/00

    摘要： Example embodiments in accordance with the present disclosure are directed to methods for transforming a Cannabaceae plant part by exposing the Cannabaceae plant part to an expression construct comprising a nucleotide sequence encoding an albumin to transform the Cannabaceae plant part with the expression construct, and inducing production of the albumin in the transformed Cannabaceae plant part.

    TREGITOPE CONSTRUCTS USEFUL IN THE PREVENTION AND TREATMENT OF TYPE 1 DIABETES
    3.
    发明申请
    TREGITOPE CONSTRUCTS USEFUL IN THE PREVENTION AND TREATMENT OF TYPE 1 DIABETES 审中-公开

    公开(公告)号：WO2021195508A1

    公开(公告)日：2021-09-30

    申请号：PCT/US2021/024377

    申请日：2021-03-26

    申请人： EPIVAX, INC.

    发明人： DE GROOT, Anne ,  MARTIN, William

    IPC分类号： C07K14/00 ,  C07K7/08 ,  C07K14/76 ,  A61K38/00 ,  A61P3/10 ,  C07K14/74

    摘要： The present disclosure generally relates to novel Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes, with said modified peptides being capable of reacting with blood components to form such Tregitope-blood component conjugates. In aspects, the Tregitope-blood component conjugates include a blood component which acts as a carrier protein (e.g., albumin), and further include a modified polypeptide comprising one or more regulatory T cell epitopes (termed "Tregitopes"), the polypeptide having been modified by attaching a reactive moiety to the polypeptide that is capable of forming a bond (e.g., a covalent linkage) with a reactive functionality on the blood component. The present disclosure also relates to methods of using said Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes in the treatment and prevent of autoimmune disorders, such as type 1 diabetes.

    COMPOSITIONS AND METHODS FOR PREPARING FACTOR XA AND DERIVATIVES
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR PREPARING FACTOR XA AND DERIVATIVES 审中-公开

    公开(公告)号：WO2021026254A2

    公开(公告)日：2021-02-11

    申请号：PCT/US2020/045039

    申请日：2020-08-05

    申请人： PORTOLA PHARMACEUTICALS, INC.

    发明人： LU, Genmin

    IPC分类号： C07K19/00 ,  C12N9/50 ,  C12N9/64 ,  C07K14/76

    摘要： The present disclosure relates to protein sequences which can be used to generate factor Xa proteins and derivatives thereof. The protein sequences include a factor Xa light chain portion, a heavy chain catalytic domain portion, and an activation peptide C-terminal to the heavy chain catalytic domain portion. It is discovered that when an activation peptide (AP) is fused to the C-terminal end of the heavy chain of the factor Xa protein or derivative, the resulting protein can be more efficiently expressed, and the attachment of the activation peptide (AP) to the heavy chain does not affect the activity of the protein.

    還元型アルブミンの割合が増加した溶液の製造方法及び装置
    8.
    发明申请
    還元型アルブミンの割合が増加した溶液の製造方法及び装置 审中-公开

    公开(公告)号：WO2018092241A1

    公开(公告)日：2018-05-24

    申请号：PCT/JP2016/084088

    申请日：2016-11-17

    申请人： 学校法人藤田学園

    发明人： 大橋　篤

    IPC分类号： A61K38/00 ,  A61P1/16 ,  A61P3/02 ,  A61P29/00 ,  C07K14/76 ,  C12M1/12 ,  C12N1/00

    摘要： 還元型アルブミンの割合が増加したアルブミンを含む溶液の製造方法及び製造装置、並びにその製造方法を用いて製造される還元型アルブミンの割合が増加したアルブミンを含む溶液を提供する。（１）アルブミン含有溶液と、ＳＨ基を有する還元剤とを混合して、混合液を製造すること；及び（２）その混合液を透析して、還元型アルブミンの割合が増加したアルブミンを含む溶液を製造することを含み、（３）アルブミンの濃度を調節することを含んでよい、アルブミンを含む溶液の製造方法である。この方法によって製造されるアルブミンを含む溶液は、増加した還元型アルブミンの割合を長期間維持し得る。

    FUSION PROTEIN COMPRISING ALBUMIN AND A RETINOL-BINDING PROTEIN
    10.
    发明申请
    FUSION PROTEIN COMPRISING ALBUMIN AND A RETINOL-BINDING PROTEIN 审中-公开
    包含ALBUMIN和RETINOL-BINDING蛋白的融合蛋白

    公开(公告)号：WO2012118323A3

    公开(公告)日：2012-12-13

    申请号：PCT/KR2012001497

    申请日：2012-02-28

    申请人： UNIV KOREA RES & BUS FOUND ,  OH JUN SEO

    发明人： OH JUN SEO

    IPC分类号： C07K19/00 ,  A61K38/38 ,  C07K14/76 ,  C12N15/62 ,  C12N15/63

    CPC分类号： C07K14/76 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C07K2319/31

    摘要： The present invention relates to a fusion protein comprising albumin and a retinol-binding protein, which is useful in preventing or treating fibrotic diseases. The fusion protein, in which albumin and a retinol-binding protein (RBP) are bound together, induces the formation of cytoplasmic lipid droplets in stellate cells and returns the shape of activated stellate cells to the previous shape thereof before activation. Therefore, the fusion protein of the present invention may be effectively used in preventing or treating fibrotic diseases occurring in liver, pancreas, lungs, or the like.

    摘要翻译： 本发明涉及包含白蛋白和视黄醇结合蛋白的融合蛋白，其可用于预防或治疗纤维化疾病。 白蛋白和视黄醇结合蛋白（RBP）结合在一起的融合蛋白诱导星状细胞中细胞质脂滴的形成，并且在活化前将激活的星状细胞的形状返回到其先前的形状。 因此，本发明的融合蛋白可以有效地用于预防或治疗肝，胰腺，肺等中发生的纤维化疾病。