公开(公告)号：WO2022003361A1

公开(公告)日：2022-01-06

申请号：PCT/GB2021/051677

申请日：2021-07-01

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED

发明人： ISALAN, Mark ,  MIELCAREK, Michal

IPC分类号： C12N15/861 ,  C07K14/005 ,  A61K38/00 ,  A61K48/005 ,  A61P25/00 ,  C07K14/4702 ,  C07K2319/02 ,  C07K2319/10 ,  C07K2319/715 ,  C07K2319/73 ,  C07K2319/81 ,  C12N2710/16622 ,  C12N2750/14143

摘要： Disclosed herein are polypeptides for use in treating diseases associated with pathogenic genomic repeat sequences, such as neurological disorders. Also disclosed are nucleic acid molecules and vectors that encode such polypeptides. Therapeutic uses and methods for treating such diseases are also disclosed; in particular, therapeutic uses and methods comprising complementary pairs and combinations of therapeutic polypeptides, nucleic acids or vectors. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro.

公开(公告)号：WO2022003362A1

公开(公告)日：2022-01-06

申请号：PCT/GB2021/051678

申请日：2021-07-01

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED

发明人： ISALAN, Mark ,  MIELCAREK, Michal

IPC分类号： C07K14/005 ,  C12N15/861 ,  A61K38/00 ,  A61K48/005 ,  A61P25/00 ,  C07K14/4702 ,  C07K2319/02 ,  C07K2319/10 ,  C07K2319/715 ,  C07K2319/73 ,  C07K2319/81 ,  C12N2710/16622 ,  C12N2750/14143

摘要： Disclosed herein are polypeptides for use in treating diseases associated with pathogenic genomic repeat sequences, such as neurological disorders. Also disclosed are nucleic acid molecules and vectors that encode such polypeptides. Therapeutic uses and methods for treating such diseases are also disclosed; in particular, therapeutic uses and methods comprising complementary pairs and combinations of therapeutic polypeptides, nucleic acids or vectors. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro.

公开(公告)号：WO2022003363A1

公开(公告)日：2022-01-06

申请号：PCT/GB2021/051679

申请日：2021-07-01

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED

发明人： ISALAN, Mark ,  MIELCAREK, Michal

IPC分类号： C07K14/005 ,  C12N15/861 ,  C07K14/47 ,  A61K38/00 ,  A61P25/00 ,  A61K48/005 ,  C07K14/4702 ,  C07K2319/02 ,  C07K2319/10 ,  C07K2319/715 ,  C07K2319/73 ,  C07K2319/81 ,  C12N2710/16622 ,  C12N2750/14143

摘要： Disclosed herein are polypeptides for use in treating diseases. Therapeutic uses and methods for treating diseases are also disclosed. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro.

公开(公告)号：WO2021136841A2

公开(公告)日：2021-07-08

申请号：PCT/EP2020/088091

申请日：2020-12-31

申请人： PEPTINOV ,  CONSERVATOIRE NATIONAL DES ARTS ET METIERS

发明人： AZOULAI, René ,  CASSARD, Xavier ,  SALLES, Jean-Pierre ,  ZAGURY, Jean-François

IPC分类号： A61K38/17 ,  A61K38/20 ,  A61P29/00 ,  A61K2039/505 ,  A61K38/1793 ,  A61K38/204 ,  C07K14/4705 ,  C07K16/248 ,  C07K2319/00 ,  C07K2319/71 ,  C07K2319/715 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/003 ,  C12N9/88 ,  C12Y105/01003 ,  C12Y402/01001

摘要： La présente invention concerne un agent anti-IL-6 pour une utilisation dans une méthode de prévention ou de traitement de la douleur post-opératoire chez un individu.