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公开(公告)号：WO2022146028A1
公开(公告)日：2022-07-07
申请号：PCT/KR2021/020167
申请日：2021-12-29
Applicant: 주식회사 아모그린텍
Abstract: 배지로부터 기포를 제거하기 위한 기포제거장치가 제공된다. 본 발명의 예시적인 실시예에 따른 배지로부터 기포를 제거하기 위한 기포제거장치는 배지로부터 기포를 제거하기 위한 장치로서, 상기 배지를 일정량 저장하기 위한 내부공간과, 외부로부터 상기 내부공간으로 상기 배지가 유입되는 유입구 및 상기 내부공간에서 기포가 제거된 상태의 배지를 외부로 배출되는 유출구를 포함하는 하우징; 및 상기 하우징을 바닥면으로부터 일정높이 이격된 상태로 유지할 수 있도록 상기 하우징에 결합되는 지지부;를 포함하고, 상기 내부공간은 상기 배지가 일정량 채워지는 제1공간과 상기 제1공간의 상부에 위치하면서 상기 배지가 채워지지 않는 제2공간을 포함하며, 상기 제1공간 및 제2공간은 외부로부터 상기 유입구를 통해 상기 내부공간으로 유입된 상기 배지의 수위를 통해 구분된다.
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2.发明申请
公开(公告)号：WO2022127952A1
公开(公告)日：2022-06-23
申请号：PCT/CZ2021/050153
申请日：2021-12-17
Applicant: CESKA ZEMEDELSKA UNIVERZITA V PRAZE
Inventor： SVEHLA, Pavel , MICHAL, Pavel , TLUSTOS, Pavel
Abstract: The present invention relates to a multi-chamber nitrification reactor for fugate processing, which comprises a tank which comprises at least three separate chambers (S1, S2, S3), wherein the chambers have mutually different volumes, and wherein said tank further comprises an air distribution device (G) connected to a source of compressed air; a measuring and control unit (D) located outside the tank; an inlet (A) for raw fugate into each of the tank chambers (S1, S2, S3); an outlet (B) for the nitrified fugate from each of the tank chambers (S1, S2, S3); a probe (C) for measuring pH, located inside each chamber (S1, S2, S3) and connected to the measuring and control unit (D); a probe (C') for measuring the O2 concentration, located inside each chamber (S1, S2, S3) and connected to the measuring and control unit (D); an inlet for a defoamer in each of the chambers (S1, S2, S3), connected to a pump connected to a container (F) for defoamer; a neutralization station (E), located outside the tank, comprising a tank for the pH adjusting agent and a pump, said neutralization station (E) being connected to each chamber (S1, S2, S3) by an inlet for the pH adjusting agent; wherein the pump, and the air distribution device (G) are connected to the measuring and control unit (D) by feedback. The present invention further relates to a method of the start-up of the multi-chamber nitrification reactor into full scale operation, and to the use of the nitrification reactor for nitrification of fugate from biogas plants.
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3.发明申请
公开(公告)号：WO2022127951A1
公开(公告)日：2022-06-23
申请号：PCT/CZ2021/050152
申请日：2021-12-17
Applicant: CESKA ZEMEDELSKA UNIVERZITA V PRAZE
Inventor： SVEHLA, Pavel , MICHAL, Pavel , TLUSTOS, Pavel
Abstract: The present invention relates to the development and functioning of a device for cultivation of nitrifying biomass, capable of processing fugate by nitrification in order to use the produced biomass to innoculate a large-volume nitrification reactor capable of processing the entire production of fugate within the given biogas plant, or its required part. The device comprises a tank (1) comprising at least one aeration element (2) connected to a source (3) of compressed air; a measuring and control unit (8) located outside the tank (1); an inlet (4) for substrate located in the lower third of the tank (1) height; an outlet (5) for nitrifying biomass, preferably located in the upper third of the tank (1) height, preferably located at the level of the liquid in the tank (1); a probe (6) for measuring pH, located inside the tank (1) and connected to the measuring and control unit (8); a probe (7) for measuring the O2 concentration, located inside the tank (1) and connected to the measuring and control unit (8); an inlet (9) for pH adjusting agent connected to a pump (10) connected to the pH adjusting agent tank; an inlet (12) for defoamer connected to the defoamer container (13); wherein the pump (10) and the aeration element (2) are connected to the measuring and control unit (8) by feedback. The present invention further relates to a method for cultivating nitrifying biomass in the device described above, and to the use thereof.
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公开(公告)号：WO2011098204A1
公开(公告)日：2011-08-18
申请号：PCT/EP2011/000186
申请日：2011-01-18
Applicant: SARTORIUS STEDIM BIOTECH GMBH , RIECHERS, Daniel
Inventor： RIECHERS, Daniel
Abstract: Die Erfindung bezieht sich auf ein Bioreaktorbehälter mit einem optischen Schaumsensor (36), der eine Schaumanlagefläche zur Anlage des zu detektierenden Schaums aufweist. Die Erfindung zeichnet sich dadurch aus, dass die Schaumanlagefläche eine Innenseite eines für Licht des sichtbaren und des ultravioletten Spektralbereichs transparenten Fensters (38) in einer Außenwand des Bioreaktorbehälters (10) ist und dass eine Außenseite des Fensters (38) mit einer Beleuchtungs- und Detektionseinheit (52) gekoppelt ist, die wenigstens eine erste Lichtquelle (56) sichtbaren Lichtes und wenigstens einen Photodetektor (58), mittels dessen in dem Bioreaktorbehälter (10) reflektiertes Licht der ersten Lichtquelle (56) detektierbar ist, umfasst. Die Schaumanlagefläche ist mit einer durch Photoaktivierung mittels ultravioletten Lichtes superhydrophilisierbaren Titandioxidbeschichtung (44) versehen und die Beleuchtungsund Detektionseinheit (52) umfasst wenigstens eine zweite Lichtquelle (66) für ultraviolettes Licht.
Abstract translation: 本发明涉及一种具有泡沫光学传感器（36），其具有用于待检测的泡沫接触泡沫接触表面的生物反应器容器中。 本发明的特征在于，所述泡沫接触表面的用于在生物反应器容器（10）的外壁上的可见光和紫外光谱区的透明窗（38）的光的内侧和所述窗口（38）与照明和检测单元的外侧 （52）被耦合到所述至少一个第一光源（56），可见光和至少一个光电探测器（58），借助于反射，其在生物反应器容器（10）从所述第一光源（56）的光可检测的，包括。 泡沫接触表面由紫外线二氧化钛涂层（44）和所述照明和检测部（52）的装置设置有通过光活化一个superhydrophilisierbaren包括至少一个第二光源（66），以紫外线。
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公开(公告)号：WO2022178508A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/070675
申请日：2022-02-16
Applicant: NIRRIN TECHNOLOGIES, INC.
Inventor： HASSELL, Bryan A.
Abstract: A foam sensor device is used for monitoring foam within a vessel. The sensor (e.g. accelerometer) is encapsulated inside a water-tight, sterilizable, shell, which floats on a liquid contained. In one example, the foam sensor device includes an accelerometer for detecting and measuring rotation and movement of the foam sensor device and generates movement data based on the detected movement. During a learning or calibration process, sensor data (e.g., movement data) from the foam sensor device is analyzed and classified using machine learning and/or signal processing methods to extract features indicative of different possible foam statuses, including varying levels of foam, or no foam and generate models for the different statuses. During normal operation, the foam sensor device transmits sensor data to an analyzer containing the pre-calibrated models, which determines whether there is foam or not. Based on the foam status, a pump controller adds anti-foam solution.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2021087434A1
公开(公告)日：2021-05-06
申请号：PCT/US2020/058490
申请日：2020-11-02
Applicant: LOCUS IP COMPANY, LLC
Inventor： ALIBEK, Ken , CALLOW, Nicholas , DIXON, Tyler , KRAVTSOV, Sergey
Abstract: The subject invention provides systems, apparatuses and methods for cultivating microorganisms and for producing microbial metabolites on a large scale. Specifically, in certain embodiments, a system comprising three separate, but connected, vessels is provided, wherein a first vessel serves as a feed tank for supplying nutrient medium to a second vessel, said second vessel serving as a submerged fermentation reactor; and wherein a third vessel serves as a collection container into which foam containing microbial growth by-products is transferred from the second vessel.
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公开(公告)号：WO2021015587A1
公开(公告)日：2021-01-28
申请号：PCT/KR2020/009785
申请日：2020-07-24
Applicant: 주식회사 프록스엔렘
Inventor： 조양래
Abstract: 본 발명은 거품을 농축하고 배양액을 회수하기 위한 제1 및 제2 공기 주입관, 거품 센싱부 및 거품 배출부가 구비된 바이오 계면활성제 생산 장치에 관한 것으로, 상기 바이오 계면활성제 생산 장치는 거품 센싱부, 제1 및 제2 공기 주입관을 구비함으로써 거품의 양 및 농축을 조절하여 고농축된 거품을 수득할 수 있으며, 거품 배출부를 구비함으로써 미생물 배양 시 발생하는 거품이 넘치거나 배양액이 거품과 함께 배출되는 현상을 막아 배양액의 손실을 줄일 수 있을 뿐만 아니라 본 발명에 따른 바이오 계면활성제 생산 장치를 이용하여 미생물을 배양할 경우, 배양균을 보호할 수 있으며, 수거된 거품에 존재하는 일부 세포들을 제거하여 계면활성제를 생산하는 기간을 연장 가능하게 함으로써 바이오 계면활성제의 생산 효율을 향상시킬 수 있다.
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公开(公告)号：WO2018044748A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/048793
申请日：2017-08-28
Applicant: GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB
Inventor： GEBAUER, Klaus , LE GREVES, Pierre , PRIS, Andrew , CAN, Ali , VASI, Jozsef , EHRING, Hanno , HEIDARI, Esmaeil , PETROCELLI, Sam
Abstract: A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.
Abstract translation: 用于检测反应堆容器中的泡沫水平的装置和方法监视由监视定位在反应堆容器内的至少一个光源的照相机检测到的光的强度或光的移动 或通过反应器容器可见。
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公开(公告)号：WO2015185923A1
公开(公告)日：2015-12-10
申请号：PCT/GB2015/051613
申请日：2015-06-02
Applicant: ACD PHARMACEUTICALS AS , GARDINER, Stephen
Inventor： KLEPPEN, Hans Petter , BÅRDSEN, Eirik , MARTÍNEZ, Juan José Jiménez
CPC classification number: C12M21/04 , C12M21/08 , C12M21/14 , C12M23/02 , C12M23/06 , C12M23/34 , C12M27/00 , C12M29/08 , C12M29/20 , C12M41/02
Abstract: The present invention relates to the field of fermentation. In particular, the present invention relates to a method and apparatus for production of products by use of living cells or active components derived from such cells using a bioreactor having a built in gas distributor and a specific system/device for handling foam formed in the process. The invention also relates to a bioreactor comprising: a reaction chamber having a fermentation zone and a foam settling zone, wherein the reaction chamber is arranged such that the foam settling zone is spaced from or physically separated from the fermentation zone so as to reduce the effect of activity in the fermentation zone on foam in the settling zone. The separation of the fermentation zone from the activity of the fermentation zone encourages settling of the foam. The invention also provides a method of forming a bioreactor comprising: overlapping two flat, flexible sheets of material; and causing said two sheets to adhere to each other in selected areas so as to define a reaction chamber. This is a particularly cost-effective way to produce a single use, disposable reactor.
Abstract translation: 本发明涉及发酵领域。 特别地，本发明涉及使用具有内置气体分配器的生物反应器和用于处理在该方法中形成的泡沫的特定系统/装置，使用来自这种细胞的活细胞或活性成分来生产产品的方法和装置 。 本发明还涉及一种生物反应器，包括：具有发酵区和泡沫沉淀区的反应室，其中反应室被布置成使得泡沫沉降区与发酵区隔开或物理上与发酵区隔开，以便降低效果 在发酵区的泡沫在沉降区的活动。 发酵区域与发酵区域的活性分离有助于泡沫沉降。 本发明还提供了一种形成生物反应器的方法，包括：重叠两个平的，柔性的材料片; 并使所述两片在所选择的区域中彼此粘合以限定反应室。 这是生产单次使用的一次性反应器的特别具有成本效益的方法。
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公开(公告)号：WO2021170259A1
公开(公告)日：2021-09-02
申请号：PCT/EP2020/079148
申请日：2020-10-16
Applicant: SARTORIUS STEDIM BIOTECH GMBH
Inventor： PREDIGER, Andreas , GÖTEMANN, Sina , LEUPOLD, Marco , SCHOLZ, Jochen
IPC: C12M1/21
Abstract: System (100) zum Erfassen zumindest eines Vorhandenseins von Schaum (92, 93) eines Mediums (9) in einer Bioreaktoranlage (50), wobei das System (100) umfasst: - eine Bioreaktoranlage (50) mit zumindest einem Einwegbehälter (1) zum Aufnehmen des Mediums (9), das den Schaum (92, 93) aufweisen kann; und - zumindest zwei kapazitive Sensoreinheiten (10A, 10B), die an zumindest zwei unterschiedlichen Anordnungspositionen (A1-A3; B1-B6) der Bioreaktoranlage (50) angebracht sind, wobei die kapazitiven Sensor-Einheiten (10A, 10B) jeweils zumindest ein Elektrodensystem (19) für eine kapazitive Messung aufweisen und das Vorhandensein von Schaum (92, 93) an den zumindest zwei Anordnungspositionen (A1-A3; B1-B6) auf Basis der kapazitiven Messung erfassen können; und wobei die kapazitive Sensor-Einheiten (10A, 10B) dazu ausgelegt sind, erfasste Daten betreffend das Vorhandensein von Schaum (92, 93) an zumindest eine Kontrolleinheit (14) zum Kontrollieren, Steuern und/oder Regeln einer Schaumbildung (9) in der Bioreaktoranlage (50) auf deren Basis zu übermitteln.
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