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公开(公告)号：WO2023047368A1
公开(公告)日：2023-03-30
申请号：PCT/IB2022/059058
申请日：2022-09-24
发明人： SHARMA, Shalini , KATRODIYA, Hetal
摘要： The present invention relates to an improved method of quantification and/or estimation of purity of antibody or fusion protein from a protein mixture containing impurity by providing long term sample stability. The invention provides a stable protein solution comprising antibody having reduce formation of Fab and Fc related impurities.
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公开(公告)号：WO2023016890A1
公开(公告)日：2023-02-16
申请号：PCT/EP2022/071826
申请日：2022-08-03
IPC分类号： C07K14/315 , C12P21/02 , C12P21/06
摘要： The present invention relates to a novel method for producing a recombinant collagen-like protein (CLP).
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公开(公告)号：WO2023278317A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035110
申请日：2022-06-27
申请人： AIR PROTEIN, INC.
发明人： REED, John , ROBERTSON, Dan
IPC分类号： C12N1/06 , C12N5/077 , C12N1/20 , C12N2500/72 , C12N2500/99 , C12N2501/998 , C12N5/0031 , C12N5/06 , C12N5/0602 , C12P17/12 , C12P17/167 , C12P19/42 , C12P21/06 , C12P7/625 , C12Y304/00
摘要： A protein hydrolysate composition derived from a microorganism, such as a chemoautotrophic microorganism, and methods of preparing and using the same are provided. The protein hydrolysate composition may be produced sustainably through fixation of carbon dioxide from biogenic or atmospheric sources. The protein hydrolysate composition finds use in supplementing culture media for serum-free culturing of animal cells as well as for growing other types of cells such as probiotics and lactic acid bacteria. Thus, the present disclosure provides sustainable, humane processes for culturing cells for pharmaceutical and nutraceutical application as well as for human consumption as a food ingredient or product, including cultured meat.
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公开(公告)号：WO2022245902A2
公开(公告)日：2022-11-24
申请号：PCT/US2022/029775
申请日：2022-05-18
IPC分类号： C12N15/52 , C12N9/00 , C12N5/10 , C12N9/93 , C12P21/06 , C12Y601/01001 , C12Y601/01004
摘要： Aminoacyl-tRNA synthetase (aaRS) characteristics such as solubility and specificity are known to play key roles for individual applications, but it is not yet clear how best to evolve aaRS to address those needs. Thus, there is a need for aminoacyl-tRNA synthetases with improved characteristics. The invention provides aminoacyl-tRNA synthetases, compositions thereof, and methods for use thereof. Preferably, the invention features in vitro methods of producing a protein containing a noncanonical amino acid. Methods include contacting an in vitro translation system or contacting a cell with an expression vector with a Tyrosyl-tRNA Synthetase (TyrRS) polypeptide or a functional fragment thereof, comprising an alteration at an amino acid position Y37.
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公开(公告)号：WO2022202985A1
公开(公告)日：2022-09-29
申请号：PCT/JP2022/013912
申请日：2022-03-24
申请人： 森永乳業株式会社 , 国立大学法人京都大学
IPC分类号： C07K7/06 , A23L33/18 , A61K38/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07K1/12 , C12P21/06
摘要： 日常的に気軽に摂取可能で副作用が少ない、各種作用を有するペプチド、及び該ペプチドを有効成分として含有する組成物を提供すること。 下記（ａ）又は（ｂ）のアミノ酸配列からなる、ペプチドを提供する。 （ａ）配列番号１（Ａｓｎ－Ｌｅｕ－Ｐｒｏ－Ｐｒｏ－Ｌｅｕ－Ｔｈｒ）に記載のアミノ酸配列 （ｂ）配列番号１に記載のアミノ酸配列において、１若しくは数個のアミノ酸が置換、欠失、又は付加されたアミノ酸列 また、前記ペプチドを有効成分として含有する組成物も提供する。
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公开(公告)号：WO2022191303A1
公开(公告)日：2022-09-15
申请号：PCT/JP2022/010765
申请日：2022-03-11
IPC分类号： A23J3/00 , A23J3/34 , C12P13/12 , A23L27/00 , C12N9/10 , C12N9/52 , C12N9/54 , C12N9/58 , C12N9/62 , C12N9/80 , C12P21/06 , A23L33/175 , A23L33/18 , A23L33/185
摘要： 本発明の課題は、食品分野（食品用途）への利用にも適した、タンパク質からシステインを生成するための実用的な手段を提供することである。本発明によれば、タンパク質材料にγ－グルタミルペプチド加水分解酵素、糸状菌由来プロテアーゼ及び細菌プロテアーゼを作用させる工程を含む、システイン含有タンパク質分解物の製造方法が提供される。
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公开(公告)号：WO2022156190A1
公开(公告)日：2022-07-28
申请号：PCT/CN2021/111448
申请日：2021-08-09
申请人： 南方海洋科学与工程广东省实验室（湛江） , 广东医科大学
摘要： 本发明提供一种降压肽、经聚乙二醇修饰的降压肽及其制备方法。本发明的降压肽包含至少一种如SEQ ID NO.1-SEQ ID NO.6所示的多肽序列。本发明的多肽是首次从沙虫中分离纯化得到，实验结果表明该多肽具有降压效果，可用于制备降压药物。
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公开(公告)号：WO2022119557A1
公开(公告)日：2022-06-09
申请号：PCT/US2020/062734
申请日：2020-12-01
发明人： TOOPCHAM, Tidarat
摘要： The present disclosure provides fish-derived peptides with ACE inhibitory activity by hydrolyzing fish meat using the alkaline protease subtilisin, and methods of producing peptide isolates comprising the fish-derived peptides. The present disclosure also provides pharmaceutical products, dietary supplements, and functional foods including the peptide isolates, and method of lowering blood pressure of a subject by administering to the subject one or more of the fish- derived peptides.
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公开(公告)号：WO2022099119A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/058430
申请日：2021-11-08
发明人： MOCK, Jee Young
摘要： The invention relates to fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and engineered T cell receptors comprising same. Specifically, the disclosure provides an engineered T Cell Receptor (TCR), comprising a first TCR subunit comprising a first transmembrane domain and a second TCR subunit comprising a second transmembrane domain, wherein the first transmembrane domain comprises a positively charged amino acid residue and the second transmembrane domain comprises a negatively charged amino acid residue, and wherein the interaction of the positively charged amino acid residue and the negatively charged amino acid residue specifically promote the formation of the engineered TCR receptor.
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