公开(公告)号：WO2021133916A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066858

申请日：2020-12-23

Applicant: ABBOTT LABORATORIES

Inventor： BERG, Michael G. ,  FORBERG, Kenn ,  MEYER, Todd V. ,  LUK, Ka-Cheung

IPC: C07K14/085 ,  C12Q1/70 ,  G01N33/569 ,  C07K14/005 ,  C12N2720/00021 ,  C12N2720/00022 ,  C12N7/00 ,  C12Q1/701 ,  G01N2333/005

Abstract: Provided herein are compositions, methods, and kits for detecting human picobirnavirus (PBV). In certain embodiments, provided herein are PBV specific nucleic acid probes and primers, and methods for detecting PBV nucleic acid.

公开(公告)号：WO2022264035A1

公开(公告)日：2022-12-22

申请号：PCT/IB2022/055508

申请日：2022-06-14

Applicant: FERRING B.V.

Inventor： WANNERBERGER, Kristin ,  SULAKVELIDZE, Alexander

IPC: A61K35/76 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K36/06 ,  A61K39/00 ,  A61P1/00 ,  A61P31/04 ,  G01N33/50 ,  A61K2035/115 ,  C12Q1/18 ,  G01N2333/005

Abstract: Described herein are bacteriophages that infect and lyse Vancomycin-Resistant Enterococci (VRE). The bacteriophages are useful, for example, for the prophylactic or therapeutic treatment of subjects infected with Enterococci, including VRE, or who are at risk of infection by Enterococci, including VRE, and for other uses described herein.

公开(公告)号：WO2021262019A1

公开(公告)日：2021-12-30

申请号：PCT/PL2021/050047

申请日：2021-06-28

Applicant: PROTEON PHARMACEUTICALS S.A.

Inventor： DASTYCH, Jarosław ,  WÓJCIK, Ewelina A. ,  MASZEWSKA, Agnieszka ,  STAŃCZYK, Małgorzata ,  PĘKALA, Anna ,  ŚMIGIELSKA, Edyta ,  WOJDA, Ewelina ,  KAZIMIERCZAK, Joanna ,  GUZIŃSKI, Arkadiusz ,  ANDRYSIAK, Justyna ,  WIGNER, Paulina

IPC: A61K35/76 ,  C12N7/00 ,  C12Q1/18 ,  A61P31/04 ,  C12N2795/00021 ,  C12N2795/00032 ,  C12N2795/00051 ,  G01N2333/005

Abstract: The formation method was revealed of a bacteriophage synergistic composition intended to prevent and combat infections of livestock, including but not limited to poultry, with pathogenic bacteria strains sensitive to the phages.

公开(公告)号：WO2022003184A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068402

申请日：2021-07-02

Applicant: INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

Inventor： MEYER, Björn ,  VIGNUZZI, Marco

IPC: C07K14/435 ,  C12N9/50 ,  C12Q1/37 ,  C07K14/43504 ,  C07K2319/50 ,  C07K2319/60 ,  C12N9/503 ,  G01N2333/005 ,  G01N33/542

Abstract: The invention relates to novel means and processes for the detection of a virus in a biological sample comprising cells infected by the virus. In particular, the invention relates to a fluorescent reporter protein designed as a recombinant inactive form of flipGFP suitable for specific activation by viral components in particular by viral proteins, such as viral protease, wherein the viral component recognizes a cleavage site inserted in the recombinant flipGFP. The fluorescent reporter protein is suitable for use in an in vitro method of detection of virus infection in a biological sample when the virus is related to the viral components activating the inactive form of flipGFP into an active fluorescent flipGFP in a biological sample, especially a sample comprising cells, in particular unaltered cells.

公开(公告)号：WO2021256868A1

公开(公告)日：2021-12-23

申请号：PCT/KR2021/007593

申请日：2021-06-17

Applicant: 가톨릭대학교 산학협력단 ,  서강대학교산학협력단

Inventor： 채현석 ,  조규만

IPC: G01N15/14 ,  G01N33/569 ,  G01N15/10 ,  G01N15/1434 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/1454 ,  G01N2333/005 ,  G01N33/56983

Abstract: 본 명세서는 타겟 바이러스에 특이적인 연속된 펄스를 갖는 레이저를 조사하고, 이 레이저가 조사된 검체에 광을 통과한 후 분광학적 특성 변화를 이용하여 바이러스 존재여부를 진단하는 바이러스 진단 장치를 개시한다.

公开(公告)号：WO2021222723A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/030127

申请日：2021-04-30

Applicant: LABORATORY CORPORATION OF AMERICA HOLDINGS

Inventor： BROWN, Matthew J. ,  NGUYEN, Minh Mindy Bao ,  ERICKSON, Stephen ,  GIL, Jose

IPC: G01N33/543 ,  G01N33/569 ,  G01N2333/005 ,  G01N2333/31 ,  G01N2800/44 ,  G01N33/56911 ,  G01N33/56938 ,  G01N33/68

Abstract: Disclosed are compositions, methods and systems for detecting MRSA, for example MRSA nasal colonization. In certain embodiments, the methods use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms to detect MRSA. The methods for detecting MRSA may include preparing an assay comprising a selective agent and a cocktail comprising at least two different types of recombinant bacteriophages, incubating the sample in the assay, capturing an indicator protein product, and detecting an indicator protein product produced by the recombinant bacteriophage, wherein positive detection of the indicator protein product indicates that MRSA is present in the sample.