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121. Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease

申请号: US11529720

申请日: 2006-09-26

公开（公告）号: US20090092588A1

公开（公告）日: 2009-04-09

发明人: Steven Stice; Jose Cibelli; James Robl; Paul Golueke; F. Abel Ponce De Leon; D. Joseph Jerry

Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.

122. Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease

申请号: US10818486

申请日: 2004-04-05

公开（公告）号: US20050074439A1

公开（公告）日: 2005-04-07

发明人: Steven Stice; Jose Cibelli; James Robl

123. Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease

申请号: US09534500

申请日: 2000-03-24

公开（公告）号: US20020073439A1

公开（公告）日: 2002-06-13

发明人: Steven L. Stice; Jose Cibelli; James M. Robl

124. Cloned ungulate embryos and animals, use of cells tissues and organs thereof for transplantation therapies including parkinson's disease

申请号: US10260020

申请日: 2003-03-21

公开（公告）号: US20040120934A1

公开（公告）日: 2004-06-24

发明人: Steven Stice; Jose Cibelli; James M. Robl; Paul Golueke; F. Abel Ponce de Leon; D. Joseph Jerry

125. ENRICHED PAG-55 FRACTION AND METHODS FOR EARLY DETECTION OF PREGNANCY IN UNGULATE ANIMALS

申请号: EP05856658.9

申请日: 2005-04-27

公开（公告）号: EP1756584A2

公开（公告）日: 2007-02-28

发明人: MATHIALAGAN, Nagappan; MCGRATH, Michael; SCHENKEL, Robert

Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immu1ogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with fewl false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.

126. TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF

申请号: EP03783271.4

申请日: 2003-11-10

公开（公告）号: EP1563084A2

公开（公告）日: 2005-08-17

发明人: ROBL, James; KUROIWA, Yoshimi; COLLAS, Philippe; SULLIVAN, Eddie; KASINATHAN, Poothappillai; TOMIZUKA, Kazuma401, RM2 Takasaki; ISHIDA, Isao352-6 Kushihashi

The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.

127. EXPRESSION OF XENOGENOUS (HUMAN) IMMUNOGLOBULINS IN CLONED, TRANSGENIC UNGULATES

申请号: EP01273248

申请日: 2001-11-16

公开（公告）号: EP1343880A4

公开（公告）日: 2005-03-16

发明人: ROBL JAMES M; GOLDSBY RICHARD A; FERGUSON STACY E; KUROIWA YOSHIMI; TOMIZUKA KAZUMA; ISHIDA ISAO; OSBORNE BARBARA A

The present invention relates to the production of a trangenic bovine which comprises a genetic modification that resulrs in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.

128. Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease

申请号: US09845352

申请日: 2001-05-01

公开（公告）号: US20010039667A1

公开（公告）日: 2001-11-08

发明人: Steven L. Stice; Jose Cibelli; James M. Robl

129. Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease

申请号: US10809556

申请日: 2004-03-25

公开（公告）号: US20040180041A1

公开（公告）日: 2004-09-16

发明人: Steven L. Stice; Jose Cibelli; James M. Robl

130. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals

申请号: EP01115354.1

申请日: 1994-12-23

公开（公告）号: EP1149898A2

公开（公告）日: 2001-10-31

发明人: Stice, Steven, L.; Strelchenko, Nick; Betthauser, Jeff; Scott, Brett; Jurgella, Gail

The use of embryonic stem (ES) cells as donor nuclei for nuclear transfer (NT) procedures is provided. The method provides for the production of ES cell derived NT embryos. The use of ES cell derived NT embryos for producing chimeric non-human animals, preferably ungulates is also provided. Additionally, the use of transgenic ES cells as nuclear donors to provide transgenic embryos and transgenic offspring is taught.

131. ungulate EMBRYONIC STEM CELLS AS NUCLEAR DONORS AND NUCLEAR TRANSFER TECHNIQUES TO PRODUCE CHIMERIC AND TRANSGENIC ANIMALS

申请号: EP95907932.8

申请日: 1994-12-23

公开（公告）号: EP0739412B1

公开（公告）日: 2002-02-27

发明人: STICE, Steven L.; STRELCHENKO, Nick; BETTHAUSER, Jeff; SCOTT, Brett; JURGELLA, Gail

132. Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines

申请号: EP07253688.1

申请日: 2007-09-18

公开（公告）号: EP1927859B1

公开（公告）日: 2011-12-14

发明人: Pellegrini, Franklin L.; Carter, Scott D.

133. Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines

申请号: EP07253688.1

申请日: 2007-09-18

公开（公告）号: EP1927859A1

公开（公告）日: 2008-06-04

发明人: Pellegrini, Franklin L.; Carter, Scott D.

A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bleeding in horses. Fecal droppings from a horse to be tested are placed in a container together with a buffered liquid solution and mixed thoroughly, following which several drops of liquid from the container are placed into a test kit. Visual markers in the test kits signify the detection of the indicators equine hemoglobin and equine albumin, which are respectively indicative of the presence of gastric and/or colonic ulcers or bleeding.

134. Unactivated oocytes in nuclear transfer to produce cultured inner cell mass cells and ungulates

申请号: US09989126

申请日: 2001-11-21

公开（公告）号: US07332648B2

公开（公告）日: 2008-02-19

发明人: Keith Henry Stockman Campbell; Ian Wilmut

A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.

135. Shoe system for hoofed animals, stud for such a shoe system and a method for studding a shoe

申请号: EP05110483.4

申请日: 2005-11-08

公开（公告）号: EP1782688A1

公开（公告）日: 2007-05-09

发明人: Melin, Per; Huggert, Mia

A shoe system for a hoofed animal comprises a shoe (1) having a wear side, which in use faces a surface supporting the animal, and a detachable stud. The system comprises fixing means for fixing the stud to the shoe (1). The fixing means comprising a recess (5) in the wear side and a fixing protrusion on the stud, which is sized and adapted for being received in the recess (5). The fixing means further comprises a pin hole (6a, 6b) in the shoe (1) which is open into said recess (5), and a corresponding pin hole in the fixing protrusion, whereby the stud is lockable relative to the shoe (1) by a locking pin insertable into said pin holes (6a, 6b).

136. 稳定的多能牛胚胎干细胞的高效衍生

申请号: CN202410843746.2

申请日: 2019-01-11

公开（公告）号: CN118652837A

公开（公告）日: 2024-09-17

发明人: 帕布罗·胡安·罗斯; 亚宁娜·博格里奥蒂; 玛塞拉·维拉利诺; 胡安·卡洛斯·伊斯皮萨·贝尔蒙特; 吴军

本公开提供了有蹄类动物胚胎干细胞(ESC)，其衍生自来自胚胎的植入前胚泡或多能细胞的内细胞团。从农业和生物医学的角度来看，从家养有蹄类动物中衍生出稳定的ESC对基因组测试和选择、基因工程、以及为研究人类疾病提供实验工具非常重要。牛是通常用于食品和生物反应器的最重要的家养有蹄类动物之一。

137. 稳定的多能牛胚胎干细胞的高效衍生

申请号: CN201980007033.X

申请日: 2019-01-11

公开（公告）号: CN111566202A

公开（公告）日: 2020-08-21

发明人: 帕布罗·胡安·罗斯; 亚宁娜·博格里奥蒂; 玛塞拉·维拉利诺; 胡安·卡洛斯·伊斯皮萨·贝尔蒙特; 吴军

本公开提供了有蹄类动物胚胎干细胞（ESC），其衍生自来自胚胎的植入前胚泡或多能细胞的内细胞团。从农业和生物医学的角度来看，从家养有蹄类动物中衍生出稳定的ESC对基因组测试和选择、基因工程、以及为研究人类疾病提供实验工具非常重要。牛是通常用于食品和生物反应器的最重要的家养有蹄类动物之一。

138. 转基因动物及其用途

申请号: CN200580020535.4

申请日: 2005-04-21

公开（公告）号: CN101014715A

公开（公告）日: 2007-08-08

发明人: J·罗布尔; Y·库罗伊瓦; P·卡西纳坦; I·伊施达; K·托米祖卡

总体而言，本发明涉及基因修饰的非人类哺乳动物(例如牛和其他有蹄类动物)以及产生这些哺乳动物的方法。具体而言，本发明涉及内源性IgM重链和/或朊病毒蛋白质水平降低的转基因有蹄类动物。