US08004161B2
A multilayered piezoelectric element and a method of producing the multilayered piezoelectric element are disclosed. The multilayered piezoelectric element is made of piezoelectric ceramic layers and electrode formation layers which are alternately laminated. The piezoelectric ceramic layers are made of crystal oriented ceramic as polycrystalline material. The crystal oriented ceramic is made mainly of an isotropic perovskite type compound in which the specific {100} crystal plane of each of crystal grains that form the polycrystalline material is oriented. The electrode formation layers have electrode parts forming inner electrodes containing a conductive metal. The isotropic perovskite type compound is expressed by a general formula (1): [Agh{Lix(K1-yNay)1-x}1-h]j(Nb1-z-wTazSbw)O3-k (1), where 0≦x≦0.2, 0≦y≦1, 0≦z≦0.4, 0≦w≦0.2, x+z+w>0, 0
US08004154B2
The invention relates to a piezoelectric actuation structure including at least one strain gauge and at least one actuator produced from a stack on the surface of a substrate of at least one layer of piezoelectric material arranged between a bottom electrode layer and a top electrode layer, at least a portion of the stack forming the actuator being arranged above a cavity produced in the substrate, characterized in that the strain gauge is a piezoresistive gauge located in the top electrode layer and/or the bottom electrode layer, the layer or layers including electrode discontinuities making it possible to produce said piezoresistive gauge. The invention also relates to a method for producing such a structure.
US08004150B2
An ultrasonic actuator may be provided in which generation of a stress is prevented in the connection face of the piezoelectric element between the electrodes and the conductive members. The ultrasonic actuator includes a piezoelectric element (P1) and flexible cables (F1). The piezoelectric element (P1) includes: a piezoelectric layer (1); a power supply electrode (2) provided on a principal surface of the piezoelectric layer (1); a counter electrode (3) provided to face the power supply electrode (2) with the piezoelectric layer (1) interposed therebetween; a power supply external electrode (4) which is provided on a short-side surface of the piezoelectric element (P1), and is electrically coupled to the power supply electrode (2); and a counter external electrode (5) which is provided on a short-side surface of the piezoelectric element (P1), and is electrically coupled to the counter electrode (3). The flexible cables (F1) include a first flexible cable (F11) connected to the power supply external electrode (4), and a second flexible cable (F12) connected to the counter external electrode (5).
US08004149B2
A motor which includes two drive elements, especially piezoelectric bending actuators, having effective directions that are perpendicular to each other. These actuators act upon a drive ring to thereby rotate a shaft. Two tension-compression bars, which are parallel to an effective direction, are connected to the drive ring, have respective joints at their ends and are connected to the ends of a diagonal bar, relative to which the ring can be displaced in the other effective direction. The diagonal bar itself can be displaced relative to fixing elements to an effective direction via a diagonal suspension. The drive is compact, having actuators that are non-radially hinged to the ring.
US08004148B2
A surface acoustic wave element includes: a diamond layer; an alumina nitride layer provided on the diamond layer; a silicon oxide layer provided on the alumina nitride layer; and a pair of electrodes provided between the alumina nitride layer and the silicon oxide layer, the electrodes applying a voltage to the alumina nitride layer. If a thickness of the alumina nitride layer is represented by H1, a thickness of the silicon oxide layer is represented by H2, a wavelength of a surface acoustic wave is represented by λ, x is defined as x=2πH1/λ, and y is defined as y=2πH2/λ, (x, y) meets all of the following formulas 1 to 4 below. That is, the formula 1 is y≦0.750×x+0.325; the formula 2 is y≦−0.300×x+1.690; the formula 3 is y≧−0.500×x+0.950; and the formula 4 is y≧0.700×x−0.610.
US08004147B2
The invention relates to waveguide components based on acoustic surface waves, comprising at least one interdigital converter for exciting acoustic surface waves in a piezoelectric substrate or a piezoelectric layer. The object of the invention is to change known waveguide components, comprising at least one interdigital converter for exciting acoustic surface waves in a piezoelectric substrate or a piezoelectric layer, such that no reflectors are necessary with an otherwise equivalent function. The inventive waveguide components are characterized in that the interdigital converter(s) a) is or are disposed at a defined distance over the piezoelectric substrate or the piezoelectric layer for exciting wave fields, or b) is or are in contact with the piezoelectric substrate or the piezoelectric layer, wherein in version a) the piezoelectric substrate is designed as a ring and the piezoelectric layer is designed as a circular region. In case of version b), the interdigital converter and/or the piezoelectric layer form circular regions. The components can be used for example as resonators, filters, oscillators and sensors.
US08004140B2
An internal permanent magnet (IPM) machine is provided. The IPM machine includes a stator assembly and a stator core. The stator core also includes multiple stator teeth. The stator assembly is further configured with stator windings to generate a stator magnetic field when excited with alternating currents and extends along a longitudinal axis with an inner surface defining a cavity. The IPM machine also includes a rotor assembly and a rotor core. The rotor core is disposed inside the cavity and configured to rotate about the longitudinal axis. The rotor assembly further includes a shaft. The shaft further includes multiple protrusions alternately arranged relative to multiple bottom structures provided on the shaft. The rotor assembly also includes multiple stacks of laminations disposed on the protrusions and dovetailed circumferentially around the shaft. The rotor assembly further includes multiple pair of permanent magnets for generating a magnetic field, which magnetic field interacts with the stator magnetic field to produce a torque. The multiple pair of permanent magnets are disposed between the stacks. The rotor assembly also includes multiple middle wedges mounted between each pair of the multiple permanent magnets.
US08004135B2
An integrated electric motor and controller assembly includes a motor, a controller mounted to the motor, and a sensor device disposed at an interface between the motor and the controller. The sensor device includes a sensor disposed at the controller and a magnet disposed at the motor. An alignment structure is provided at the interface between the motor and the controller for positioning the sensor relative to the magnet when the controller is mounted to the motor. The magnet is recessed in the motor and the sensor is protected by a controller housing of the controller. This arrangement has the advantages of protecting the sensor device from damage during shipment and assembly and providing a quick assembly and connection of the sensor device to the motor and the controller.
US08004122B2
A power converter controller is operable to control power provided to a load circuit coupled between a first voltage supply terminal and a first switching element by controlling the first switching element and to control power provided to an energy storage element coupled to the first switching element. The energy storage element is operable to provide a power supply. A first control terminal couples to a control input of the first switching element. A first load terminal couples to the first switching element and the charge storing element. A second switching element couples between the first load terminal and a second voltage supply terminal. Timing logic is operable to selectively provide a control signal at the first control terminal to control the first switching element and to selectively control the second switching element to supply power to the load circuit during a load powering phase by enabling the first and second switching elements, charge the energy storage element during a bootstrap charging phase by enabling the first switching element and disabling the second switching element, and allowing the load circuit to operate in isolation during a passive phase by disabling at least the first switching element.
US08004118B2
A power transmission control device provided in a power transmitting device of a non-contact power transmission system includes a driver control circuit that controls a power transmitting driver that drives a primary coil, a load state detection circuit that detects a power-receiving-side load state, and a control circuit that controls the driver control circuit. The control circuit performs a foreign object detection process based on load state detection information from the load state detection circuit after receiving ID authentication information from a power receiving device, and starts normal power transmission to the power receiving device after performing the foreign object detection process.
US08004117B2
A converter circuit providing multiple current bypass routes between the output leads to provide reliability in a series connection of several converters. If the converter malfunctions due to component failure, the current bypass routes provide a path for the current that views the malfunctioning converter as substantially a short. Diodes prevent backflow into the power source connected to the converter. Redundancy is provided in the bypass portions of the converter circuit that provides alternate parallel paths in case a defective component in one of the paths opens the circuit along that path. In one example, the converter is implemented as a buck plus boost converter where either the buck or the boost portion or both are operative responsive to a controller controlling the switches of both portions. Most of the converter circuit may be implemented in an integrated circuit.
US08004115B2
An automatic transfer switch for automatically switching an electrical load between two power sources that includes a switch module containing circuitry for facilitating the switching function, and having two attached input cables and one attached output receptacle. The switch module may be mounted directly on or adjacent to the back of a piece of rack-mounted equipment, thereby minimizing the probability of a power failure between the switch and the equipment. The switch is relatively small, requires no mounting space within a rack, and requires minimal cord lengths.
US08004113B2
Solar power tracking techniques are described herein. In one aspect of the invention, a solar power tracking apparatus includes, but is not limited to, a voltage converter and a controller coupled to the voltage converter. The voltage converter includes an input capable of being coupled to a solar power source and an output capable of being coupled to an electronic load, such as, for example, a portable electronic device. The voltage converter is configured to monitor or detect an amount of power drawn by the electronic load at the output of the voltage converter. In response to the monitored power drawn, the controller is configured to control the voltage converter to reduce amount of power to be drawn subsequently if the monitored amount of power exceeds a predetermined threshold. As a result, the output voltage from the solar power source is maintained within a predetermined range. Other methods and apparatuses are also described.
US08004107B2
A direct drive generator for a wind turbine is provided. The direct drive generator includes a stator arrangement and a rotor arrangement. The stator arrangement and/or the rotor arrangement include an at least partly flexible front and/or rear endplate. The endplate is at least partly made of fiberglass.
US08004105B2
The present invention relates to a wave energy conversion device (1), for use in relatively shallow water, which has a base portion (2) for anchoring to the bed of a body of water (6) and an upstanding flap portion (8) pivotally connected (12) to the base portion. The flap portion is biased to the vertical and oscillates, backwards and forwards about the vertical in response to wave motion acting on its faces. Power extraction means extract energy from the movement of the flap portion. When the base portion (2) is anchored to the bed of a body of water (6) with the flap portion (8) facing the wave motion, the base portion (2) and the flap portion (8) extend vertically through at least the entire depth of the water, to present a substantially continuous surface to the wave motion throughout the full depth of water from the wave crest to the sea bed. A plurality of devices can be interconnected to form one system. The distance between the plurality of flaps is dependent on the wavelength.
US08004102B2
The present invention provides a method and apparatus for generating refrigeration in a process operating at sub-ambient temperatures in which the refrigeration is generated by a turboexpander. The turboexpander is coupled to a generator controlled so that its speed is maintained at a setpoint through electromagnetic braking and its power output is maintained at line matching voltage and frequency. The speed control of the generator therefore, also controls the speed of the turboexpander. The setpoint is calculated to be equal to a product of an operational efficiency parameter, U/Co, and a square root of twice the enthalpy drop in the flow passing through the turboexpander divided by a product of pi and a diameter of an impeller employed within the turboexpander.
US08004092B2
The invention provides a semiconductor chip comprising an interconnecting structure over said passivation layer. The interconnecting structure comprises a first contact pad connected to a second contact pad exposed by an opening in a passivation layer. A metal bump is on the first contact pad and over multiple semiconductor devices, wherein the metal bump has more than 50 percent by weight of gold and has a height of between 8 and 50 microns.
US08004089B2
On the lower surface of a semiconductor construct having an external connection electrode, there are formed an insulating film having a planar size greater than that of the semiconductor construct, and a metal layer and a mask metal layer having a connection pad portion in which a first opening corresponding to the external connection electrode is formed. A laser beam is applied using the mask metal layer as a mask, and a second opening is thereby formed in a part of the insulating film corresponding to the external connection electrode. Then, a connection conductor is formed to connect a wiring line to the external connection electrode via the second opening of the insulating film.
US08004079B2
A chip package structure includes a substrate, a chip, a thermal conductive layer, a plurality of signal contacts, and a molding compound. The substrate includes a plurality of first thermal conductive vias, a connecting circuit, and a plurality of signal vias electrically connected to the connecting circuit, and the substrate has a chip disposing region. The chip is disposed on the chip disposing region of the substrate and electrically connected to the signal vias through the connecting circuit. The thermal conductive layer is disposed over the substrate, connected to the first thermal conductive vias, and located above the chip disposing region. Besides, the thermal conductive layer has first openings exposing the signal vias. The signal contacts are respectively disposed in the first openings and connected to the signal vias. The molding compound encapsulates the chip.
US08004075B2
Use of Pb-free solder has become essential due to the environmental problem. A power module is formed by soldering substrates with large areas. It is known that in Sn-3Ag-0.5Cu which hardly creeps and deforms with respect to large deformation followed by warpage of the substrate, life is significantly shortened with respect to the temperature cycle test, and the conventional module structure is in the situation having difficulty in securing high reliability. Thus, the present invention has an object to select compositions from which increase in life can be expected at a low strain rate. In Sn solder, by doping In by 3 to 7% and Ag by 2 to 4.5%, the effect of delaying crack development at a low strain rate is found out, and as a representative composition stable at a high temperature, Sn-3Ag-0.5Cu-5In is selected. Further, for enhancement of reliability, a method for partially coating a solder end portion with a resin is shown.
US08004067B2
A semiconductor apparatus includes: a substrate of single crystal silicon; a first device formed in a first region of a surface of the substrate; a first interlayer insulating film formed on the substrate; a polycrystalline silicon layer formed in a second region on the first interlayer insulating film; a second device formed in the polycrystalline silicon layer; a second interlayer insulating film formed on the first interlayer insulating film, the second interlayer insulating film covering the polycrystalline silicon layer; and a pad formed in a third region on the second interlayer insulating film. The second region includes at least part of a directly overlying zone of the first region. The third region includes at least part of a region which is the directly overlying zone of the first region and a directly overlying zone of the second region.
US08004051B2
One embodiment relates to an integrated circuit that includes a lateral trench MOSFET disposed in a semiconductor body. The lateral trench MOSFET includes source and drain regions having a body region therebetween. A gate electrode region is disposed in a trench that extends beneath the surface of the semiconductor body at least partially between the source and drain. A gate dielectric separates the gate electrode region from the semiconductor body. In addition, a field plate region in the trench is coupled to the gate electrode region, and a field plate dielectric separates the field plate region from the semiconductor body. Other integrated circuits and methods are also disclosed.
US08004050B2
A semiconductor device is disclosed, which comprises a gate electrode having a laminated structure of a polycrystalline silicon film or a polycrystalline germanium film containing arsenic and a first nickel silicide layer formed in sequence on an element forming region of a semiconductor substrate through a gate insulating film, a sidewall insulating film formed on a side surface of the gate electrode, source/drain layers containing arsenic formed in the element forming region at both side portions of the gate electrode, and second nickel silicide layers formed on the source/drain layers, wherein a peak concentration of arsenic contained in the gate electrode is at least 1/10 of a peak concentration of arsenic contained in the source/drain layers.
US08004037B2
A surface between gate electrodes in an MOS gate structure is patterned so that missing portions are partially provided in surfaces of n+ emitter regions to thereby enlarge surface areas of p+ contact regions surrounded by the surfaces of the n+ emitter regions. In this manner, a highly reliable MOS type semiconductor device is provided which is improved in breakdown tolerance by suppressing an increase in the gain of a parasitic transistor caused by photo pattern defects produced easily in accordance with minute patterning in a process design rule.
US08004035B2
A dual stress liner manufacturing method and device is described. Overlapping stress liner layers of opposite effect (e.g., tensile versus compression) may be deposited over portions of the device, and the uppermost overlapping layer may be polished down in a process that uses the bottom overlapping layer as a stopper. An insulating film may be deposited on the stress liner layers before the polishing, and another insulating film may be deposited above the first insulating film after the polishing. Contacts may be formed such that the contacts need only penetrate one stress liner layer to reach a transistor well or gate structure.
US08004022B2
A field effect transistor includes a GaN epitaxial substrate, a gate electrode formed on an electron channel layer of the substrate, and source and drain electrodes arranged spaced apart by a prescribed distance on opposite sides of the gate electrode. The source and drain electrodes are in ohmic contact with the substrate. At an upper portion of the gate electrode, a field plate is formed protruding like a visor to the side of drain electrode. Between the electron channel layer of the epitaxial substrate and the field plate, a dielectric film is formed. The dielectric film is partially removed at a region immediately below the field plate, to be flush with a terminal end surface of the field plate. The dielectric film extends from a lower end of the removed portion to the drain electrode, to be overlapped on the drain electrode.
US08004010B2
In a semiconductor device with a shared contact, a gate electrode is formed via a gate insulating film on a semiconductor substrate and a sidewall insulating film is formed on both side faces of the gate electrode. At least one of the surface parts of the semiconductor substrate adjacent to both sides of the gate electrode is removed beyond the lower part of the sidewall insulating film and to the underside of the gate electrode. Then, the gate insulating film exposed in the remove part is removed. An impurity-doped semiconductor layer is formed in the part where the semiconductor substrate and the gate insulating film have been removed.
US08004001B2
A semiconductor device for light emission having a plurality of epitaxial layers with an n-type layer for light emission and a p-type layer for light reflection. The p-type layer has at least one seed layer for an outer layer of a conductive metal. The at least at least one seed layer is a material for providing a buffer for differential thermal expansion of the outer layer and the light reflecting layer.
US08003999B2
Disclosed is an organic light emitting device which includes a substrate; a encapsulation substrate, an organic light emitting unit interposed between the substrate and the encapsulation substrate. A water vapor absorption material-containing transparent sealant layer covers the organic light emitting unit. The sealant layer includes a transparent sealant having a water vapor transmission rate (WVTR) of about 20 g/m2·day or less and a water vapor absorption material having an average particle size of about 100 nm or less.
US08003998B2
A light-emitting diode arrangement is disclosed, comprising at least one light-emitting diode (LED) chip with a radiation decoupling surface through which a large portion of the electromagnetic radiation generated in the LED chip exits in a main direction of emission; a housing laterally surrounding the LED chip; and a reflective optic disposed after the radiation decoupling surface in the main direction of emission. The LED arrangement is particularly well suited for use in devices such as camera-equipped cell phones, digital cameras or video cameras.
US08003996B2
The present invention relates to a semiconductor component and an associated production method, said component emitting at least two defined wavelengths with a defined intensity ratio. It is an object of the present invention to specify an optical semiconductor component and an associated production method, said component emitting at least two defined wavelengths with a defined intensity ratio. In this case, the intention is that both the wavelengths and the intensity ratio can be set extremely precisely. The semiconductor component according to the invention has a substrate (8), a first charge carrier barrier layer (7) arranged on the substrate (8), a photoluminescent layer (6) arranged on the first charge carrier barrier layer (7), a second charge carrier barrier layer (5) arranged on the photoluminescent layer (6), and an active electroluminescent layer (4) composed of at least one inorganic semiconductor and arranged on the second charge carrier barrier layer (5), wherein the photoluminescent layer (6) absorbs at least part of the light emitted by the electroluminescent layer (4), and an at least partly transparent contact layer (1) arranged on the active electroluminescent layer (4) is furthermore provided.
US08003988B2
A thin film transistor array panel comprises a repair line disposed in a peripheral area of a display area and being configured to repair when at least one of a gate line and a data line are disconnected, and a detour line disposed in the peripheral area and comprising at least one resistor having higher resistance than a remaining portion of the detour line, wherein both ends of the detour line are connected to the repair line to protect the array panel.
US08003984B1
Techniques are provided for forming die on wafers with large area test structures between primary die. A reticle is used to pattern each die. The pattern on the reticle forms a primary die and test structures in scribelines that abut edges of the die. A reticle can be used to form additional test structures that are separated from the primary die. A gap is formed between the additional test structures and the primary die in each exposure. In subsequent exposures, test structures for adjacent die are formed in the gaps between the previously formed primary die and their additional test structures. These techniques are used to provide larger test structure area between each primary die. A blade can be used to block portions of the reticle that form the additional test structures. The reticle can then be used to pattern die with smaller test structures during high volume chip production.
US08003976B2
An organic light-light conversion device excellent in device characteristics, comprising a light sensing unit having a layer including a photo-conductive organic semiconductor developing a photo-current multiplication phenomenon by light irradiation, and a light emitting unit having a layer including an electroluminescent organic semiconductor emitting light by current injection, characterized in that at least one of the photo-conductive organic semiconductor and an electroluminescent organic semiconductor is polymer semiconductor. An imaging intensifier consisting of a plurality of arranged above organic light-light conversion devices. An optical sensor provided with a means of measuring and outputting voltages applied to the above organic light-light conversion device and to the opposite ends of a layer including the electroluminescent organic semiconductor.
US08003975B2
A semiconductor integrated circuit device includes: a semiconductor layer having a principal surface on which a source electrode, a drain electrode and a gate electrode are formed and having a first through hole; an insulating film formed in contact with the semiconductor layer and having a second through hole; a first interconnection formed on the semiconductor layer through the first through hole and connected to one of the source electrode, the drain electrode and the gate electrode which is exposed in the first through hole; and a second interconnection formed on the insulating film through the second through hole and connected to another of the source electrode, the drain electrode and the gate electrode which is exposed in the second through hole. The first interconnection and the second interconnection face each other and form a microstrip line.
US08003959B2
In an ion implanter, a Faraday cup is utilized to receive an ion beam generated during ion source cleaning. The detected beam has an associated mass spectrum which indicates when the ion source cleaning process is complete. The mass spectrum results in a signal composed of a cleaning agent and the material comprising the ion source. This signal will rise over time as the ion source chamber is being cleaned and will level-off and remain constant once the deposits are etched away from the source chamber, thereby utilizing existing implant tools to determine endpoint detection during ion source cleaning.
US08003937B2
An electrospray ion (ESI) source and method capable of ionizing an analyte molecule without oxidizing or reducing the analyte of interest. The ESI source can include an emitter having a liquid conduit, a working electrode having a liquid contacting surface, a spray tip, a secondary working electrode, and a charge storage coating covering partially or fully the liquid contacting surface of the working electrode. The liquid conduit, the working electrode and the secondary working electrode can be in liquid communication. The electrospray ion source can also include a counter electrode proximate to, but separated from, said spray tip. The electrospray ion source can also include a power system for applying a voltage difference between the working electrodes and a counter-electrode. The power system can deliver pulsed voltage changes to the working electrodes during operation of said electrospray ion source to minimize the surface potential of the charge storage coating.
US08003934B2
Disclosed are methods, apparatus, systems, processes and other inventions relating to: ion sources with controlled electro-pneumatic superposition, ion source synchronized to RF multipole, ion source with charge injection, optimized control in active feedback system, radiation supported charge-injection liquid spray, ion source with controlled liquid injection as well as various embodiments and combinations of each of the foregoing.
US08003931B2
A transparent-front vending machine includes an optical vend-sensing system with an article sensing subsystem arranged athwart a vend space. The article sensing subsystem has two emitter/detector arrays, each having at least one emitter and a plurality of detectors. The emitter/detector arrays are arranged so that at least some electromagnetic radiation emitted by an emitter of the first array can be detected by at least two active detectors of the second array, and at least some electromagnetic radiation emitted by an emitter of the second array can be detected by at least two active detectors of the first array so that articles falling through the vend space will interrupt electromagnetic radiation between an emitter and at least one detector. At least two emitters are active at one time.
US08003927B2
An image projection apparatus of the present invention projects a corrected image according to a projection surface, and includes: an imaging unit for capturing a projected image; a correction parameter calculation unit for calculating a correction parameter, on the basis of the captured image, for correcting an image distortion caused by the projection surface; a correction unit for generating a corrected image by correcting the image using the correction parameter; a reproduction level calculation unit for calculating a reproduction level of the corrected image relative to the original image; an image generation unit for generating a guidance image regarding the reproduction level; and a control unit for controlling projection of the guidance image.
US08003915B2
A system and method for inscribing marks, that will remain non-discernable after tinting, on materials in general, and on plastic ophthalmic lenses in particular. The system uses a laser, which typically performs a heating-type inscription process, such as by use of a CO2 laser. In accordance with a preferred embodiment of the present invention, there is provided an apparatus for producing laser inscription on materials, including laser inscription apparatus for inscribing inscriptions on a surface of the materials, and apparatus for treating a zone of the surface that was affected by the laser inscription beam, to prevent it from absorbing excessive dye relative to other zones, wherein the inscriptions remain non-discernable after applying the dye.
US08003913B2
Electrodes are formed in a predetermined pattern on a base plate. Side face regions of each electrode or certain regions of each electrode, which certain regions contain the side face regions and neighboring regions, have a composition different from the composition of the other region and have insulation characteristics. The base plate with electrodes is produced with a process wherein a conductor layer is formed on the base plate, a resist pattern is formed on the conductor layer, the conductor layer is etched with the resist pattern acting as a mask, the electrodes being thereby formed in the predetermined pattern, and an insulation characteristics imparting processing gas is brought into contact with the electrodes.
US08003903B2
On a pivot bolt which rotatably and pivotally supports a side stand bar on a vehicle-body-side bracket, a switch unit which is constituted of a base and a rotary made of a resin and detects a rotational position of the side stand bar is mounted. A first engaging mechanism which is constituted of a groove and a projection is arranged between a cylindrical portion formed on the rotary and an engaging shaft and, at the same time, a second engaging mechanism which is constituted of a groove and a projection is arranged between the base and the cylindrical portion. The rotary on which a movable contact formed of a leaf spring is mounted allows a positioning pin which is formed on one end portion thereof to be engaged with a pin hole formed in a pivot portion and hence, the rotary is integrally rotated with the side stand bar.
US08003902B1
An apparatus and method for simultaneously operating the horn and light systems of a motorized vehicle is provided. The controller used to operate the systems can be a single controller that operates the horn when a certain range of pressure is applied to the controller and operates the horn and lights systems when a stronger pressure is applied. The system can include a dedicated horn operating system controller independent of the dual function controller to eliminate the need for differing pressures to operate the horn and light systems substantially simultaneously.
US08003883B2
A photovoltaic device that includes a substrate and a nanowall structure disposed on the substrate surface. The device also includes at least one layer conformally deposited over the nanowall structure. The conformal layer(s) is at least a portion of a photoactive junction. A method for making a photovoltaic device includes generating a nanowall structure on a substrate surface and conformally depositing at least one layer over the nanowall structure thereby forming at least one photoactive junction. A solar panel includes at least one photovoltaic device based on a nanowall structure. The solar panel isolates such devices from its surrounding atmospheric environment and permits the generation of electrical power. Optoelectronic device may also incorporate a photovoltaic device based on a nanowall structure.
US08003882B2
Methods and systems for photovoltaic roofing systems are provided. The system includes a back sheet including a length, L, a width, W, and a thickness, T, the back sheet including an overlap portion extending along length L having a width, WO and an active portion extending along length L having a width, WA. The system also includes a photovoltaic cell formed on a surface of the active portion, the photovoltaic cell including a photovoltaic member electrically responsive to an absorption of photons, a negative electrode coupled to a surface of the photovoltaic member, and a positive electrode coupled to the surface of the photovoltaic member, wherein the thickness T is selected such that thickness T plus a thickness of the photoelectric cell substantially match a thickness of a proximate non-photovoltaic roofing member when the photovoltaic roofing system is installed.
US08003871B2
A keyboard apparatus made longitudinally compact while ensuring a pivotal motion range of hammers within a limited space. Common base ends, to which main bodies of white and black keys are connected via vertically extending hinges, are stacked one upon another and fastened to a fastening part of a frame. Hammers are each supported on a hammer pivot shaft such that its rear end is moved upward about the pivot shaft in a key-depression forward stroke. The hammers have their rear ends located forward of rearmost positions of visible parts of black keys. The hammer pivot shafts are located rearward of frontmost positions of the visible parts. A plate portion of the frame, on which key switches are disposed, is located forward of the rearmost positions of the visible parts of the black keys and upward of the fastening part of the frame.
US08003866B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH444919. The invention thus relates to the plants, seeds and tissue cultures of the variety CH444919, and to methods for producing a corn plant produced by crossing a corn plant of variety CH444919 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH444919.
US08003856B2
The present invention provides novel soybean lines having high sucrose content and low phytic acid and low stachyose content. The soybeans are easily digested and provide high energy content for animals and humans. The low phytic acid content permits animal feed to be produced that does not require phytase, yet does not result in significant production of pollution to the environment from excretion by farm animals.
US08003852B2
Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increased salt tolerance, enhanced drought and freeze tolerance. Methods of making such plants are also described.
US08003850B2
Provided is a method for producing a target protein via cultivation of transgenic plant cells comprising a promoter capable of expressing the protein under sugar-free conditions in the response to the depletion of sugar and a gene encoding the target protein, without exchange of a cell growth medium with a sugar-depleted medium comprising the addition of an amino acid mixture to the sugar-rich medium used to grow the plant cells.
US08003849B2
Isolated polynucleotides encoding polypeptides active in lignin, fructan and tannin biosynthetic pathways are provided, together with expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.
US08003836B2
A process has been developed for producing diesel boiling range fuel from renewable feedstocks such as plant oils, animal fats and oils, and greases. The process involves treating a renewable feedstock by hydrogenating and deoxygenating to provide a diesel boiling range fuel hydrocarbon product. If desired, the hydrocarbon product can be isomerized to improve cold flow properties. A portion of the hydrocarbon product is recycled to the treatment zone to increase the hydrogen solubility of the reaction mixture.
US08003835B2
A method for converting solid biomass into hydrocarbons includes contacting the solid biomass with a catalyst in a first riser operated at a temperature in the range of from about 50° C. to about 200° C. to thereby produce a first biomass-catalyst mixture and a first product comprising hydrocarbons; a) separating the first product from the first biomass-catalyst mixture; c) charging the first biomass-catalyst mixture to a second riser operated at a temperature in the range of from about 200° C. to about 400° C. to thereby produce a second biomass-catalyst mixture and a second product comprising hydrocarbons; d) separating the second product from the second biomass-catalyst mixture; e) charging the second biomass-catalyst mixture to a third riser operated at a temperature greater than about 450° C. to thereby produce a spent catalyst and a third product comprising hydrocarbons; and f) separating the third effluent from the spent catalyst.
US08003822B2
A process for continuous carbonylation of carbonylatable reactants with carbon monoxide in the gaseous phase in the presence of a catalyst, wherein said catalyst is a Supported Ionic Liquid-Phase (SILP) catalyst comprising a solution of a Group VIII metal in an ionic liquid confined on a support. The SILP catalyst offers a very large active catalyst area resulting in a very efficient use of catalyst material and a simple apparatus design.
US08003820B2
A process for preparing a bisphosphonate compound comprises reacting a carboxylic acid with a phosphonating agent, in a cresol solvent.
US08003815B2
The present invention provides a method of preparing a cross-condensed compound of an amino-acid derivative and (aminoalkyl)trialkoxysilane using microwave, including: irradiating and heating an amino-acid derivative and (aminoalkyl)trialkoxysilane in a microwave reactor to obtain a reaction product (step 1); and refining the reaction product obtained in the step 1 by removing an unreacted solid material from the reaction product and then leaving the reaction product at room temperature under vacuum to remove excess (aminoalkyl)trialkoxysilane therefrom (step 2). According to the method, since a cross-condensation reaction is performed using microwave, unlike a conventional condensation reaction, economic efficiency is increased due to no catalyst, short reaction time and no solvent. Further, the yield and selectivity of products is increased, and the condensation reaction can be environment-friendly performed because a solvent which can badly influence the environment may not be used.
US08003809B2
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
US08003801B2
A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.
US08003800B2
The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH2CH2—, *—CO—CH2—NH—, wherein the asterisks indicate the bond that is linked to the thiophene group of Formula (I), and R1-R3 are as defined in the claims.
US08003799B2
Compounds of general formula (I): in which n, G, Q1, Q2, X1, X2, Y and Z are as defined in the description, process for preparing these compounds, fungicidal compositions comprising these compounds, processes for treating plants by applying these compounds or compositions.
US08003793B2
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.
US08003791B2
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
US08003789B2
This invention concerns the use of compounds of formula the N-oxides, pharmaceutically acceptable addition salts, quaternary amines, stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl with the attached vinyl group; n is 0 to 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, substituted C1-6alkyl, substituted C1-6alkyloxyC1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6, 5-membered heterocyclic ring; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or —X—R3; Q is hydrogen, C1-6alkyl, halo, polyhalo-C1-6alkyl, optionally substituted amino group; Y represents hydroxy, halo, C3-7cycloalkyl, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono-or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, 13 NHC(═O)R6,—C(═NH)R6, aryl; for the treatment of subjects suffering from HIV infection.
US08003778B1
A real-time reverse transcription-PCR, or NABSA, method (and associated primers) targeting the rbcL gene for the detection and quantitation of the Florida red tide organism, Karenia brevis.
US08003774B2
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
US08003772B2
Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
US08003769B2
The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.
US08003764B2
The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present disclosure relates to methods of diagnosing BHD disease and related conditions, such as spontaneous pneumothorax and kidney cancer, by detection of altered expression of folliculin using folliculin-specific antibodies.
US08003761B2
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
US08003758B2
Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.
US08003757B2
Described is a recombinant receptor comprising an extracellular ligand-binding domain and a cytoplasmic domain that comprises a heterologous bait polypeptide. The recombinant receptor is activated by binding of a ligand to the ligand-binding domain and by binding of a prey polypeptide to the heterologous bait peptide. The invention also discloses a method for detecting compound-compound binding using the recombinant receptor.
US08003750B2
A thermosetting composition comprising (a) 97.9 to 40 percent by weight of at least one bis(dihydrobenzoxazine) prepared by the reaction of an unsubstituted or substituted bisphenol with at least one unsubstituted position ortho to each hydroxyl group, formaldehyde and a primary amine; (b) 2 to 50 percent by weight of at least one organic polyamine; and (c) 0.1 to 10 percent by weight of at least one curing catalyst, selected from the group of carboxylic acids, sulfonic acids and phosphonic acids having at least two acid groups and no other reactive groups; wherein the percent by weight refer to the total amount of components (a), (b) and (c) in the composition, with the proviso that (a), (b) and (c) add up to 100 percent by weight; and (d) and optionally other components. Cured products of these compositions show valuable chemical, physical and mechanical properties.
US08003742B2
An activated, substantially water-soluble polyoxazoline is provided having a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated polyoxazoline and the biologically active agent.
US08003741B2
The present invention relates generally to catalysts, to methods of making catalysts, to methods of using catalysts, to methods of polymerizing, and to polymers made with such catalysts. More particularly, the present invention relates to polyolefin catalysts and to Ziegler-Natta catalysts, to methods of making such catalysts, to methods of using such catalysts, to polyolefin polymerization, and to polyolefins.
US08003735B2
Provided is a thermoplastic resin composition having high impact resistance at low temperature and molded articles with good appearance using the thermoplastic resin composition.The thermoplastic resin composition contains 0.5 to 20 parts by mass of a rubbery elastomer (B) relative to 100 parts by mass of a resin mixture (A) comprising 45 to 97% by mass of a polycarbonate resin (a-1) and 55 to 3% by mass of a fatty acid polyester (a-2), wherein the component (B) is dispersed in the component (a-1).
US08003734B2
The invention relates to low molecular weight polyethylenimines, to vectors for inserting nucleic acids into cells which contain low molecular weight polyethylenimines, and to the preparation and use of the low molecular weight polyethylenimine and the vector.The invention relates to a vector for inserting a nucleic acid into a cell, which vector contains a low molecular weight polyethylenimine (LMW PEI) and a nucleic acid, with the LMW PEI having a molecular weight of less than 50,000 Da.
US08003732B2
An ion conducting polymeric structure suitable for fuel cell applications is provided. The polymeric structure comprises a non-homogenous polymeric layer. The non-homogeneous layer is a blend of a first polymer comprising cyclobutyl moiety; and a second polymer having a non-ionic polymer segment. The weight ratio of the first polymer to the second polymer varies as a function of position within the non-homogenous layer. The blend composition may be cast into an electrolyte membrane that can be used to prepare electrochemical cells such as batteries and fuel cells.
US08003731B2
The invention relates to biodegradable polyester mixture, comprising i) from 5 to 80% by weight, based on the total weight of components i to ii, of at least one polyester based on aliphatic and aromatic dicarboxylic acids and on aliphatic dihydroxy compounds, and ii) from 20 to 95% by weight, based on the total weight of components i to ii, of at least one biodegradable homo- or copolyester selected from the group consisting of polylactide, polycaprolactone, polyhydroxyalkanoates, and polyesters composed of aliphatic dicarboxylic acids and of aliphatic diols, and iii) from 0.1 to 15% by weight, based on the total weight of components i to ii, a) of a copolymer containing epoxy groups and based on styrene, acrylate, and/or methacrylate, b) of a bisphenol A epoxide, or c) of a fatty acid amide or fatty acid ester or natural oil containing epoxy groups; and iv) from 0 to 15% by weight of additive; and v) from 0 to 50% by weight of inorganic or organic filler, and also to processes for their preparation and a method for their use.
US08003728B2
Swellable hydrogel-forming polymers having high permeability Swellable hydrogel-forming polymer comprising at least one hydrophilic polymer of dendritic structure and at least one water-insoluble phosphate, a process for preparing the swellable hydrogel-forming polymer and also its use in hygiene articles.
US08003727B2
Disclosed herein is a scratch resistant flame retardant thermoplastic resin composition comprising: 100 parts by weight of a base resin comprising (A) about 1 to about 99% by weight of a polycarbonate resin and (B) about 99 to about 1% by weight of a modified methacrylate resin; and (C) about 1 to about 50 parts by weight of a flame retardant.
US08003721B2
Polyglycolic acid and polylactic acid having a weight-average molecular weight of at most 50,000 are melt-kneaded in the presence of a thermal stabilizer to obtain a polyglycolic acid-based aliphatic polyester composition. The aliphatic polyester composition alleviates the too fast crystallizability of polyglycolic acid which has been problematic in forming or molding of polyglycolic acid alone or in combination with another thermoplastic resin, thus showing a crystallization speed which has been lowered and can be controlled in a wide range.
US08003720B2
Chemical additives disclosed for reducing “plate-out” which have applications in polymers, such as polyolefins. It is possible to provide for a composition and a process for producing parts, sheet and film from polyolefin extrusion applications wherein the polyolefins are processed with a minimal quantity of “plate-out.” A polyolefin composition may contain a sorbitol-based clarifying system of a derivative of Dibenzylidene, along with one or more co-additives to achieve a reduction in undesirable plate-out.
US08003717B2
The invention is directed to a novel bitumen composition comprising a paraffin wax, wherein the wax has a congealing point of between 85 and 120° C. and a PEN at 43° C., expressed in 0.1 mm, as determined by IP 376 of more than 5.
US08003716B2
Aqueous polymer dispersions based on copolymers of vinyl aromatics and conjugated aliphatic dienes having a mean particle size of from 80 to 150 nm, obtained by free radical emulsion copolymerization of (a) from 19.9 to 80 parts by weight of at least one vinyl aromatic compound, (b) from 19.9 to 80 parts by weight of at least one conjugated aliphatic diene, (c) from 0.1 to 10 parts by weight of at least one ethylenically unsaturated acid, and (d) from 0 to 20 parts by weight of at least one other monoethylenically Unsaturated monomer, the sum of the parts by weight of the monomers (a), (b), (c) and (d) always being 100, in an aqueous medium in the presence of at least one degraded starch having an intrinsic viscosity ηi of less than 0.07 dl/g with the use of at least 0.9% by weight, based on the monomers used altogether, of initiators selected from peroxodisulfates, peroxosulfates, azo initiators, organic peroxides, organic hydroperoxides and hydrogen peroxide, at least 30% by weight of the initiators being initially taken together with the degraded starch in the aqueous medium and the monomers and the remaining initiators being metered into this initially taken mixture under polymerization conditions.
US08003712B2
A polyester resin component having crystallization improved and including a cyclic compound shown by a below-described formula and polyester capable of having a crystal structure: In the formula, each of ring A and a ring B is a benzene ring, and the hydrogen bonded to the benzene rings be substituted with other groups. Additionally, Y is —CONH— or —NHCO— and X is a heterocyclic group or a condensed heterocyclic group including one or more NH or CO.
US08003704B2
Use is disclosed of (a) an AlDH-inhibitory amount of a Trp metabolite, or an analogue or derivative thereof or (b) a bioprecursor thereof, or (c) a potentiator of (a) and/or (b), in the preparation of a medicament for treating alcoholism and/or alcohol dependence.
US08003699B2
Disclosed is an amide compound represented by the following formula (1). (1) (In the formula, X1 represents a fluorine atom or a methoxy group; X2 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A1-CR6R7R8 group, an A2-Cy1 group or an A3-Cy2 group, wherein A1 represents a CH2 group or the like, A2 represents a single bond, a CH2 group or the like, Cy1 represents a C3-C6 cycloalkyl group substituted with a C1-C6 alkoxy group or the like, Cy2 represents a C3-C6 cycloalkyl group which may be substituted with at least one halogen atom or the like, R6 and R7 independently represent a C1-C4 alkyl group, and R8 represents a halogen atom, a hydroxyl group or the like.) The amide compound has excellent plant disease controlling activity.
US08003691B2
The present invention relates to an antiviral and antibacterial pharmaceutical composition comprising cantharidic anhydride-essential oil preparation as effective ingredient and method for preparing thereof. The cantharidic anhydride-essential oil preparation is prepared by dissolving cantharidic anhydride at appropriate temperatures. The clinical trials demonstrate that the cantharidic anhydride-essential oil preparation is effective in the treatment of tuberculosis and various viruses infected diseases. Furthermore, a series of local formulations for external use for treatment and prevention of virus infections can be prepared from the said cantharidic anhydride-essential oil preparations.
US08003687B2
Esters of compounds in the leptomycin family, having a structure according to formula I where R, R10, R11, R12, R13, and R14 are as defined herein, exhibit anti-tumor properties.
US08003686B2
The present invention relates to the use of acyl derivatives of curcumin, desmethoxy curcumin and bisdesmethoxy curcumin and of curcuminisoxazolide as components of animal feed or feed additives for the improvement of animal performance and the new acyl derivatives per se as well as the corresponding animal feed or feed additives containing them.
US08003669B2
The present invention has been made based on the finding that a compound acting on the ORL-1 receptor as an agonist acts as a non-photic entrainment factor, and advances the circadian rhythm phase, and provides a novel therapeutic agent for a sleep disorder such as circadian rhythm sleep disorder, more particularly, an agent for the prophylaxis and/or treatment of a sleep disorder, which contains an ORL-1 receptor agonist, and a novel compound useful as such agent for the prophylaxis and/or treatment.
US08003663B2
The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo [3,4-b]pyridin-5-yl]methyl}-4-({8-[(2-hydroxyethyl) (methyl)amino]octanoyl}amino)benzamide, whose formula is or a salt thereof, such as the monohydrochloride salt thereof. The invention also provides the use of the compound or salt as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, or rhinitis (e.g. allergic and/or non-allergic rhinitis).
US08003662B2
Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
US08003653B2
The present invention is directed to imidazolidinone compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
US08003652B2
The use of acetyl L-carnitine in combination with propionyl L-carnitine and sildenafil is described for the preparation of a medicament and/or dietetic product for the treatment of erectile dysfunction secondary to all those conditions in which there is distress or iatrogenic damage of the lesser pelvis within which the neurovascular bundles of the penis run.
US08003649B2
The invention concerns bicyclic compounds of Formula I wherein the integers X1, X2, X3, Ring A, R4, R5 and m are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of androgen-receptor associated conditions.
US08003648B2
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
US08003647B2
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetrazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.
US08003640B2
The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which in which R1 has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
US08003633B1
Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. Compositions of the present invention inhibit Akt enzymes, iNOS, and increase MAP kinase activity such that cancer cells contacted with the compositions are inhibited.
US08003628B2
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
US08003617B2
The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
US08003613B2
The C-terminal domain of focal adhesion kinase (FAK-CD) was isolated using a Baculoviral system. Using phage display techniques, a phage encoding a 12 amino-acid peptide (peptide 35) and AV3 that binds to FAK-CD were identified. The peptides were also conjugated to TAT-FITC to produce a fluorescently labeled chimeric molecule capable of penetrating cell membranes. Contacting various breast cancer cell lines with these molecule caused detachment, rounding, apoptosis and cell death. These effects were not observed in normal (non-cancerous) breast cells.
US08003610B2
A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH2. Also disclosed are kinestatin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including kinestatin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding kinestatin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides. Kinestatin and analogs thereof (including the prodrugs and multimeric and/or fusion peptides) can be used to treat and/or prevent disorders associated with bradykinin, including cardiovascular disorders, inflammation, asthma, allergic rhinitis, pain, angiogenesis and the like.
US08003599B2
Described is a pharmaceutical composition comprising a compound(s) interfering with the biological activity of L1 and/or ADAM10 or their expression. Also described is the use of said compound(s) for the prevention/treatment of carcinomas like ovarian and endometrial carcinoma. Finally, the diagnosis of highly malignant forms of carcinomas which is based on the determination of the activity/expression of L1 and/or ADAM10 is described.
US08003584B2
There is disclosed a lubricating composition comprising a friction modifier and a base oil comprising less than about 3% by weight of tetracycloparaffins. Methods of making and using the composition are also disclosed.
US08003583B2
Benzo[b]perhydroheterocyclic arylamine compounds have shown to be particularly useful as stabilizers. The compounds may serve as antioxidants, antiozoants, heat stabilizers and ultraviolet light stabilizers and such compounds are oil soluble, thus particularly suited for use as an antioxidant in a lubricating oil composition.
US08003579B2
A process for preparing a binder which comprises a heterocondensate of silicon compounds and metal and/or boron compounds. The process comprises mixing a silicon component which comprises (A), at least one hydrolyzable silicon compound having a non-hydrolyzable polymerizable group, with water to form a hydrolysis product, and 15 s to 15 min after mixing (A) with water, the addition of (B), at least one compound of boron or a metal selected from Al, Ga, In, Tl, Ge, Ga, Sn, Pb, Ti, Zr, Hf, Sc, Y and La.
US08003573B2
A method to remove hydrate plugs in a production system by passing a non-hydrate-forming or a hydrate-forming gas, which forms hydrates at a higher pressure than the existing hydrate, through the flow-restricting hydrate.
US08003570B2
A composition for and a method to kill nematodes, weeds, weed seeds and weed rhizomes in soils.
US08003561B2
The invention aims at providing a platinum black material, without using an expensive and rare material, which is excellent in CO poisoning inhibiting effect, H2S poisoning inhibiting effect, SO4 poisoning inhibiting effect and HCHO poisoning inhibiting effect, and a method for fluorinating platinum black. The platinum black material is characterized by fluorine adsorbed on its surface. The method for fluorinating platinum black is characterized by allowing platinum black to stand in a mixed gas atmosphere of n inert gas and fluorine in a low-pressure chamber to make fluorine adsorbed on the surface of the platinum black.
US08003560B2
Disclosed is a heat-sensitive recording material comprising a support and a heat-sensitive recording layer formed on the support, the heat-sensitive recording layer containing dye precursor-containing composite particles and a developer, the dye precursor-containing composite particles being obtained by dissolving a solute containing a dye precursor in a solvent containing a polyvalent isocyanate compound-containing polymerization component, emulsifying and dispersing the obtained solution in an aqueous medium, and then performing a polymerization reaction of the polyvalent isocyanate compound-containing polymerization component in the presence of polyethyleneimine having a molecular weight of 200 to 1,500. Also disclosed is a method of producing such a heat-sensitive recording material.
US08003555B2
A flame retardant synthetic fiber and a flame retardant fiber composite that satisfy high flame retardance and high fire resistance, a method for producing the flame retardant synthetic fiber and the flame retardant fiber composite, and a textile product are provided. The flame retardant synthetic fiber of the present invention includes a polymer (1) containing 30 to 70 parts by mass of acrylonitrile, 70 to 30 parts by mass of a halogen-containing vinylidene monomer and/or a halogen-containing vinyl monomer, and 0 to 10 parts by mass of a vinyl-based monomer copolymerizable therewith, based on 100 parts by mass of the polymer, and at least one kind of a metal compound (2) that accelerates a dehalogenation reaction of the polymer (1) during burning and a carbonization reaction of the polymer (1) during burning, wherein the flame retardant synthetic fiber has a shrinkage variation of 45% or less when a temperature is raised from 50° C. to 300° C. under a load of 0.0054 mN/dtex.
US08003549B1
A nitrogen-free anti-reflective layer for use in semiconductor photolithography is fabricated in a chemical vapor deposition process, optionally plasma-enhanced, using a gaseous mixture of carbon, silicon, and oxygen sources. By varying the process parameters, a substantially hermetic layer with acceptable values of the refractive index n and extinction coefficient k can be obtained. The nitrogen-free moisture barrier anti-reflective layer produced by this technique improves plasma etch of features such as vias in subsequent processing steps.
US08003544B2
A method of manufacturing a semiconductor device according to an embodiment includes processing a second film 14 formed on a semiconductor substrate to a pattern including a plurality of linear parts and end portions formed in an end of each of the linear parts, having a width wider than the linear parts, forming a first pattern 16 by slimming the pattern, forming a second pattern including a first opening 180 that traverses the end portion 141a of the first pattern 16, etching the second film 14 exposed in the first opening 180, and dividing the end portion 141a into a first end portion 142a close to the linear part 140a and a second end portion 143a apart from the linear part 140a.
US08003543B2
A method of forming hard mask employs a double patterning technique. A first hard mask layer is formed on a substrate, and a first sacrificial pattern is formed on the first hard mask layer by photolithography. Features of the first sacrificial pattern are spaced from one another by a first pitch. A second hard mask layer is then formed conformally on the first sacrificial pattern and the first hard mask layer so as to delimit recesses between adjacent features of the first sacrificial pattern. Upper portions of the second hard mask layer are removed to expose the first sacrificial pattern, and the exposed first sacrificial pattern and the second sacrificial pattern are removed. The second hard mask layer and the first hard mask layer are then etched to form a hard mask composed of residual portions of the first hard mask layer and the second hard mask layer. A fine pattern of a semiconductor device, such as a trench isolation region or a pattern of contact holes, can be formed using the hard mask as an etch mask.
US08003540B2
A method for manufacturing a semiconductor device includes forming an underlying layer over a semiconductor substrate; forming a hard mask layer over the underlying layer; forming first etch patterns over the hard mask layer; forming second etch patterns between the first photoresist patterns; etching the hard mask layer using the first and second etch patterns as an etch mask to form a hard mask pattern; and etching the underlying layer using at least the hard mask pattern. The first and second etch patterns are formed on the same layer.
US08003539B2
A method for making a semiconductor device is provided which comprises (a) creating a data set (301) which defines a set of tiles for a polysilicon deposition process; (b) deriving a polysilicon deposition mask set (311) from the data set, wherein the polysilicon deposition mask set includes a plurality of polysilicon tiles (303); (c) deriving an epitaxial growth mask set (321) from the data set, wherein the epitaxial growth mask set includes a plurality of epitaxial tiles (305); and (d) using the polysilicon deposition mask set and the epitaxial growth mask set to make a semiconductor device (331); wherein the epitaxial growth mask set is derived from the data set by using at least a portion of the tile pattern defined in the data set for at least a portion of the tile pattern defined in the epitaxial deposition mask set.
US08003530B2
The present invention relates to a method for metallizing semiconductor components in which aluminium is used. In particular in the case of products in which the process costs play a big part, such as e.g. solar cells based on silicon, a cost advantage can be achieved with the invention. In addition, the present invention relates to the use of the method, for example in the production of solar cells.
US08003520B2
A hard mask is formed on an interconnect structure comprising a low-k material layer and a metal feature embedded therein. A block polymer is applied to the hard mask layer, self-assembled, and patterned to form a polymeric matrix of a polymeric block component and containing cylindrical holes. The hard mask and the low-k material layer therebelow are etched to form cavities. A conductive material is plated on exposed metallic surfaces including portions of top surfaces of the metal feature to form metal pads. Metal silicide pads are formed by exposure of the metal pads to a silicon containing gas. An etch is performed to enlarge and merge the cavities in the low-k material layer. The metal feature is protected from the etch by the metal silicide pads. An interconnect structure having an air gap and free of defects to surfaces of the metal feature is formed.
US08003513B2
A multilayer circuit includes a dielectric base substrate, conductors formed on the base substrate and a vacuum deposited dielectric thin film formed over the conductors and the base substrate. The vacuum deposited dielectric thin film is patterned using sacrificial structures formed by electroplating techniques. Substrates formed in this manner enable significant increases in circuit pattern miniaturization, circuit pattern reliability, interconnect density and significant reduction of over-all substrate thickness.
US08003511B2
Memory cell formation using ion implant isolated conductive metal oxide is disclosed, including forming a bottom electrode below unetched conductive metal oxide layer(s), forming the unetched conductive metal oxide layer(s) including depositing at least one layer of a conductive metal oxide (CMO) material (e.g., PrCaMnOX, LaSrCoOX, LaNiOX, etc.) over the bottom electrode. At least one portion of the layer of CMO is configured to act as a memory element without etching, and performing ion implantation on portions of the layer(s) of CMO to create insulating metal oxide (IMO) regions in the layer(s) of CMO. The IMO regions are positioned adjacent to electrically conductive CMO regions in the unetched layer(s) of CMO and the electrically conductive CMO regions are disposed above and in contact with the bottom electrode and form memory elements operative to store non-volatile data as a plurality of conductivity profiles (e.g., resistive states indicative of stored data).
US08003510B2
Fabrication methods for nano-scale chalcopyritic powders and polymeric thin-film solar cells are presented. The fabrication method for nano-scale chalcopyritic powders includes providing a solution consisting of group IB, IIIA, VIA elements on the chemistry periodic table or combinations thereof. The solution is heated by a microwave generator. The solution is washed and filtered by a washing agent. The solution is subsequently dried, thereby acquiring nano-scale chalcopyritic powders.
US08003501B2
A method of doping p-type impurity ions in a dual poly gate, comprising: forming a polysilicon layer doped with n-type impurity ions on a substrate with a gate insulation layer being interposed between the polysilicon layer and the substrate; exposing a region of the polysilicon layer; implementing a first doping of p-type impurity ions into the exposed region of the polysilicon layer by ion implantation so with a projection range Rp to a predetermined depth of the polysilicon layer; and implementing a second doping of p-type impurity ions into the exposed region of the polysilicon layer doped with the p-type impurity ions by plasma doping with a sloped doping profile.
US08003491B2
Methods and apparatus provide for forming a semiconductor-on-insulator (SOI) structure, including subjecting a implantation surface of a donor semiconductor wafer to an ion implantation step to create a weakened slice in cross-section defining an exfoliation layer of the donor semiconductor wafer; and subjecting the donor semiconductor wafer to a spatial variation step, either before, during or after the ion implantation step, such that at least one parameter of the weakened slice varies spatially across the weakened slice in at least one of X- and Y-axial directions.
US08003484B2
The present invention provides a method for forming a silicon oxide film, which has excellent insulating properties and higher quality that can enhance a yield in manufacture of semiconductor devices, while keeping advantageous points in a plasma oxidation process. In this method, plasma is generated under a first process condition that a ratio of oxygen in a processing gas is 1% or less and pressure is within a range of 0.133 to 133 Pa, so as to form the silicon oxide film, by oxidizing silicon on a surface of an object to be processed including silicon as a main component, by using the plasma (first oxidation step). Following the first oxidation step, the plasma is generated under a second process condition that the ratio of oxygen in the processing gas is 20% or more and the pressure is within a range of 400 to 1333 Pa, so as to form an additional silicon oxide film, by further oxidizing the surface of the object to be processed, by using the plasma (second oxidation step).
US08003482B2
A method of processing a semiconductor substrate in forming scribe line alignment marks includes forming pitch multiplied non-circuitry features within scribe line area of a semiconductor substrate. Individual of the features, in cross-section, have a maximum width which is less than a minimum photolithographic feature dimension used in lithographically patterning the substrate. Photoresist is deposited over the features. Such is patterned to form photoresist blocks that are individually received between a respective pair of the features in the cross-section. Individual of the features of the respective pairs have a laterally innermost sidewall in the cross-section. Individual of the photoresist blocks have an opposing pair of first pattern edges in the cross-section that are spaced laterally inward of the laterally innermost sidewalls of the respective pair of the features. Individual of the photoresist blocks have an opposing pair of second pattern edges in the cross-section that self-align laterally outward of the first pattern edges to the laterally innermost sidewalls of the features during the patterning.
US08003481B1
A method for forming an HSG (hemispherical grain) layer on a storage electrode of a capacitor formed on a substrate is provided. The method includes a step of introducing a source gas into a reacting chamber to deposit a small amount of HSG nuclei on a conductive layer pattern of a capacitor electrode during a step of stabilizing the substrate temperature. After the substrate temperature is stabilized, a larger amount of source gas is introduced into the chamber to form additional HSG nuclei. Thereafter, a step of annealing is performed to form the HSG layer.
US08003478B2
In one embodiment, a bi-directional diode structure is formed to have a substantially symmetrical current-voltage characteristic.
US08003475B2
A method for fabricating a transistor structure with a first and a second bipolar transistor having different collector widths is presented. The method includes providing a semiconductor substrate, introducing a first buried layer of the first bipolar transistor and a second buried layer of the second bipolar transistor into the semiconductor substrate, and producing at least a first collector region having a first collector width on the first buried layer and a second collector region having a second collector width on the second buried layer. A first collector zone having a first thickness is produced on the second buried layer for production of the second collector width. A second collector zone having a second thickness is produced on the first collector zone. At least one insulation region is produced that isolates at least the collector regions from one another.
US08003471B2
Systems and methods for raised source/drain with super steep retrograde channel. In accordance with a first embodiment of the present invention, in one embodiment, a semiconductor device comprises a substrate comprising a surface and a gate oxide disposed above the surface comprising a gate oxide thickness. The semiconductor device further comprises a super steep retrograde channel region formed at a depth below the surface. The depth is about ten to thirty times the gate oxide thickness. Embodiments in accordance with one embodiment may provide a more desirable body biasing voltage to threshold voltage characteristic than is available under the conventional art.
US08003470B2
In a method for forming a semiconductor device, a gate electrode is formed over a semiconductor body (e.g., bulk silicon substrate or SOI layer). The gate electrode is electrically insulated from the semiconductor body. A first sidewall spacer is formed along a sidewall of the gate electrode. A sacrificial sidewall spacer is formed adjacent the first sidewall spacer. The sacrificial sidewall spacer and the first sidewall spacer overlying the semiconductor body. A planarization layer is formed over the semiconductor body such that a portion of the planarization layer is adjacent the sacrificial sidewall spacer. The sacrificial sidewall spacer can then be removed and a recess etched in the semiconductor body. The recess is substantially aligned between the first sidewall spacer and the portion of the planarization layer. A semiconductor material (e.g., SiGe or SiC) can then be formed in the recess.
US08003456B2
A method for producing a semiconductor component is proposed. The method includes providing a semiconductor body having a first surface; forming a mask on the first surface, wherein the mask has openings for defining respective positions of trenches; producing the trenches in the semiconductor body using the mask, wherein mesa structures remain between adjacent trenches; introducing a first dopant of a first conduction type using the mask into the bottoms of the trenches; carrying out a first thermal step; introducing a second dopant of a second conduction type, which is complementary to the first conduction type, at least into the bottoms of the trenches; and carrying out a second thermal step.
US08003449B2
A gate electrode is formed by forming a first conductive layer containing aluminum as its main component over a substrate, forming a second conductive layer made from a material different from that used for forming the first conductive layer over the first conductive layer; and patterning the first conductive layer and the second conductive layer. Further, the first conductive layer includes one or more selected from carbon, chromium, tantalum, tungsten, molybdenum, titanium, silicon, and nickel. And the second conductive layer includes one or more selected from chromium, tantalum, tungsten, molybdenum, titanium, silicon, and nickel, or nitride of these materials.
US08003438B2
A circuit module includes an electronic component, a ceramic multilayer substrate and a resin wiring substrate. The ceramic multilayer substrate is provided with a wiring layer disposed on top thereof and a cavity in which the electronic component is mounted, wherein a space between the electronic component and the cavity is filled with a thermosetting resin and a surface of the filled cavity is planarized. The resin wiring substrate has an insulating adhesive layer disposed at one side thereof and provided with at least one opening filled with a conductive resin. The ceramic multilayer substrate and the resin wiring substrate are bonded by the insulating adhesive layer, and the wiring layer on the ceramic multilayer substrate is electrically connected with the conductive resin.
US08003430B1
A method for forming a thin film photovoltaic device. The method includes providing a transparent substrate comprising a surface region, forming a first electrode layer overlying the surface region, forming a copper layer overlying the first electrode layer and forming an indium layer overlying the copper layer to form a multi-layered structure. The multi-layered structure is subjected to a thermal treatment process in an environment containing a sulfur bearing species to forming a copper indium disulfide material. The copper indium disulfide material comprising a copper-to-indium atomic ratio ranging from about 1.2:1 to about 2:1 and a thickness of substantially copper sulfide material having a copper sulfide surface region. The thickness of the copper sulfide material is selectively removed to expose a surface region having a copper poor surface comprising a copper to indium atomic ratio of less than about 0.95:1. The method subjects the copper poor surface to a sulfide species to convert the copper poor surface from an n-type semiconductor characteristic to a p-type semiconductor characteristic. A window layer is formed overlying the copper indium disulfide material.
US08003429B2
A method of fabricating an image sensor includes forming a photoelectric transformation device on a substrate and forming a dielectric layer structure on the substrate. The dielectric layer structure includes multi-layer interlayer dielectric layers and multi-layer metal interconnections which are located between the multi-layer interlayer dielectric layers. A cavity which penetrates the multi-layer interlayer dielectric layers on the photoelectric transformation device is formed. A heat treatment is performed on the substrate on which the cavity is formed.
US08003427B2
An example tunable cavity resonator for filtering radiation in the optical and IR wavelengths and an example method for fabricating same. The example resonator includes a pair of reflectors, one in fixed relationship to a substrate and the other formed upon a suspended moveable membrane disposed a cavity length from the one reflector. The resonator also includes a pair of spaced apart electrodes either constituted by the reflectors or juxtaposed therewith, which are electrostatically operable to move the membrane and other reflector relative to the one reflector.
US08003426B2
A package structure of optical devices has a chip, a sealant, a cover, a substrate, a plurality of bonding wires, and a transparent encapsulant. The chip has at least an optical device and a plurality of chip connection pads. The sealant is disposed around the optical elements. The cover is disposed on the sealant. The substrate supports the chip and has a plurality of connection pads. The bonding wires are used for electrically connecting the chip connection pads of the chip to the connection pads of the substrate. The transparent encapsulant is formed over the substrate and the cover, and encapsulates the bonding wires.
US08003424B2
A CMOS image sensor includes a photosensitive device, a floating diffusion region, a transfer transistor, and a pocket photodiode formed in a semiconductor substrate of a first conductivity type. The floating diffusion region is of a second conductivity type. The transfer transistor has a channel region disposed between the photosensitive device and the floating diffusion region. The pocket photodiode is of the second conductivity type and is formed under a first portion of a bottom surface of the channel region such that a second portion of the bottom surface of the channel region abuts the semiconductor substrate.
US08003422B2
According to the present invention, a micro-electro-mechanical system (MEMS) device comprises: a thin film structure including at least a metal layer and a protection layer deposited in any order; and a protrusion connected under the thin film structure. A preferred thin film structure includes at least a lower protection layer, a metal layer and an upper protection layer. The MEMS device for example is a capacitive MEMS acoustical sensor.
US08003420B2
According to one feature of the invention, a region of an insulating film surface at least overlapped with a part of a gate electrode or wiring is coated with an organic agent; a fluid in which conductive fine particles are dispersed in an organic solvent is discharged by a droplet discharging method in the insulating film surface ranging from a region where the organic agent is coated and left to a region where the organic agent is not coated. The organic agent is coated to improve wettability of the fluid in the insulating film surface, and one of each ends of the source electrode and the drain electrode adjacent to each other by interposing the curve therebetween is formed by being curved in a concave and the other end is formed by being curved in a convex.
US08003411B2
Provided is a substrate processing apparatus and a method of manufacturing a semiconductor device, which are hard to cause a defect in processing a substrate owing to that a pressure inside a process chamber is not kept constant, and which enable a better processing of a substrate.
US08003404B2
Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.
US08003403B1
A chemical sensor for detecting organic or inorganic target vapors and comprising a silicon member having a silicon surface with semiconductor pores therein, at least one luminescent sensory material entrapped in the semiconductor pores. The luminescent spectral material is exposed to the target vapors, wherein an excitation of the at least one luminescent sensory material results in a luminescent spectral response due to emission interference. The change in the luminescent spectral response is measured during this exposure.
US08003400B2
The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.
US08003399B2
A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.
US08003389B2
A method for introducing biologically active molecules into animal or human cells using electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution which has a buffer capacity of at least 20 mmol×l−1×pH−1 and an ionic strength of at least 200 mmol×l−1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C. to form a suspension. The method further includes applying an electric voltage to the suspension so as to introduce the biologically active molecules into animal or human cells.
US08003386B1
The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
US08003370B2
This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer heat to and from reaction vessels.
US08003356B2
Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.
US08003347B2
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
US08003344B2
The present invention provides a microbial hydrogen-producing process, comprising: providing at least one Clostridium microbe and at least one Bacillus microbe; and co-culturing said at least one Clostridium microbe and said at least one Bacillus microbe in a fermentation culture system to produce hydrogen. The present invention also provides a microbial hydrogen-producing system, characterized by that the system comprises at least one Clostridium microbe and at least one Bacillus microbe, and it uses an organic waste medium as the substrate to perform a hydrogen-producing fermentation having high efficiency, high stability, and high reproducibility.
US08003339B2
The present invention provides a method for determining endoglycosidase activity, and in particular of the heparanase type, in a sample, and also a method for detecting compounds that modulate the activity of endoglycosidases and in particular endoglycosidases of the heparanase type.
US08003333B2
The present invention provides an improved method of diagnosing a subject having received an organ transplant with Acute Cellular Rejection (ACR). The method comprises obtaining a biological sample from the subject, detecting an amount of at least one protein indicative of ACR in the sample, and comparing the amount of the protein in the sample to a control, wherein a difference between the amount of the protein in the sample relative to the control indicates the subject has or is developing ACR. The difference can be an increase or a decrease. In one version the biological sample comprises a serum sample, and the transplanted organ is selected from a heart, kidney, liver, bone marrow, pancreas, eye, lung or skin. A kit and methods of treating a subject having an organ transplant for ACR and treating an immune suppressed subject are also provided.
US08003332B2
Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the ability to inhibit infection by a virus having a class II viral fusion protein. Additionally provided herewith are aqueous-soluble proteins comprising a portion of a class II viral fusion protein comprising a Domain III of the viral fusion protein.
US08003331B2
A method for identifying a target protein of a compound having a pharmacological action by detecting a tertiary structural change of a target protein by binding a compound having a pharmacological action to a target protein with the use of a molecular chaperone protein having a characteristic of binding to a protein by recognizing a tertiary structural change of the protein is disclosed. Further, a method for screening a therapeutic agent for diabetes using a target protein of biguanide which is a therapeutic agent for diabetes and was found by the identification method, a screening tool which can be used in the screening method and a pharmaceutical composition for treating diabetes containing a substance obtained by the screening method are disclosed.
US08003320B2
The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
US08003317B2
Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
US08003316B2
A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red light when the nanorod is in a first position. The short axis of the gold nanorod scatters green light when the nanorod is in a second position. A polarizing filter filters the red and green light to detect the rotational motion by observing alternating red and green lights. A detection DNA stand (50) is coupled between the gold nanorod and the molecular structure. The detection DNA strand hybridizes with a target DNA strand (58) if the target DNA strand matches the detection DNA strand to form a structural link between the molecular structure and gold nanorod.
US08003308B2
A device manufacturing method is provided. The method includes generating a first patterned beam, projecting the first patterned beam onto a substrate to form a first plurality of spot exposures on the substrate, scanning the substrate in a direction while projecting the first patterned beam, generating a second patterned beam, projecting the second patterned beam onto the substrate to form a second plurality of spot exposures on the substrate, and alternating spot exposures of the first plurality of spot exposures with respective spot exposures of the second plurality of spot exposures.
US08003298B2
Disclosed herein is a printing resist sequentially transferred to a printing plate and a substrate after being applied to a printing roll. The printing resist comprises at least one polymer main chain bound to a tackiness-inducing vinyl group. The surface of the printing resist has tackiness without complete dryness, thus enabling a correct transfer of the printing resist to the printing plate and substrate.
US08003296B2
The present invention provides a chemically amplified positive composition comprising: (A) a resin comprising a structural unit having an acid-labile group and being itself insoluble or poorly soluble in an alkali aqueous solution but becoming soluble in an alkali aqueous solution by the action of an acid, (B) a resin comprising a structural unit represented by the formula (I): wherein R1 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group or a C1-C4 perfluoroalkyl group, Z represents a single bond or —(CH2)k—CO—X4—, k represents an integer of 1 to 4, X1, X2, X3 and X4 each independently represents an oxygen atom or a sulfur atom, m represents an integer of 1 to 3 and n represents an integer of 0 to 3, and a structural unit having a fluorine atom in a side chain, and an acid generator.
US08003294B2
A photosensitive composition comprises: (A) a compound capable of generating an acid represented by formula (I) upon irradiation with actinic ray or radiation; and (B) a resin that decomposes by the action of an acid to its increase solubility in an alkali developer wherein Ra represents an alkyl group substituted with a fluorine atom, or an aryl group substituted with a fluorine atom or a group having a fluorine atom; Rb represents an alkyl group not substituted with a fluorine atom on α-position of the alkyl group, or an aryl group not substituted with a fluorine atom or a group having a fluorine atom.
US08003291B2
A method of charging toner particles in a liquid toner comprising: mixing the toner with an acid; and mixing the toner with a base that reacts with the acid to charge the toner particles.
US08003290B2
A method for manufacturing a developing agent by mixing a resin having a dissociable functional group and an aqueous medium, subjecting the mixture to mechanical shearing, finely pulverizing the pulverized mixture to form resin microparticles, adding a dispersion of colorant particles, causing the resin microparticles and colorant particles to agglomerate, and forming toner particles.
US08003286B2
An object of the present invention is to provide an electrophotographic photoreceptor which is not impaired in electrophotographic properties such as charge potential and residual potential and which is also excellent in repetition stability. The invention relates to an electrophotographic photoreceptor including a conductive support having thereon a photosensitive layer containing a zirconium compound represented by the following general formula (1): and one or more charge transport agents having an arylamino group in its molecule.
US08003283B2
This invention provides the user the ability to accurately nanomachine surfaces with reduced tip induced errors. Nanomaching has two types of errors, a first type of error is brought about by the tip's shape and its aspect ratio. A second type of error due to the tip's deflection as it works the material. Therefore, embodiments of the present invention minimizes tip deflection errors allowing allow high aspect Nano-bits to reliably and accurately nanomachine small high aspect three dimensional structures to repair and rejuvenate photomasks.
US08003278B2
A power generation cell includes a membrane electrode assembly, and first and second separators sandwiching the membrane electrode assembly. The first separator includes an oxygen-containing gas flow field. An inlet buffer area is provided between the oxygen-containing gas flow field and an oxygen-containing gas supply passage, and an outlet buffer area is provided between the oxygen-containing gas flow field and an oxygen-containing gas discharge passage. Plural columnar resistance members are provided within the inlet buffer area and the outlet buffer area. The membrane electrode assembly further includes first and second humidification sections.
US08003274B2
A direct liquid fuel cell is disclosed and wherein the fuel cell includes an anode fluid diffusion layer positioned adjacent to the anode side of the membrane electrode assembly, and which consists of, at least in part, a porous electrically conductive ceramic material which is substantially devoid of predetermined fluid passageways. A source of an aqueous hydrocarbon fuel solution is coupled in direct fluid flowing relation relative to the anode fluid diffusion layer, and the anode fluid diffusion layer substantially evenly distributes the aqueous hydrocarbon fuel solution across the active area surface of the anode side of the membrane electrode assembly.
US08003263B2
Disclosed are a separator for a battery, which is coated with a gel polymer over 40-60% of total separator area, and a rechargeable lithium battery using the separator. The separator partially coated with a gel polymer reduces the battery resistance so that the battery power can be improved. Additionally, the separator increases electrolyte impregnation rate and provides uniform electrolyte impregnation, thereby improving the life, capacity and high-rate discharge property of a battery. Further, the separator permits electrode reactions to be performed uniformly, thereby preventing lithium precipitation and improving the battery safety.
US08003262B2
An object of this invention is to improve battery performance such as a rate capability of a nonaqueous electrolyte solution secondary battery using a separator constituting a thermoplastic resin-based porous film containing a filler.This invention provides a nonaqueous electrolyte solution secondary battery separator which is formed from a porous film containing a thermoplastic resin and a filler contained in the thermoplastic resin and has a ratio of an average pore diameter (μm) to a maximum pore diameter (μm) defined by ASTM F316-86 of 0.6 or more as well as relates to a nonaqueous electrolyte solution secondary battery using this separator.
US08003259B2
A non-aqueous electrolyte secondary battery including: a positive electrode; a negative electrode; a separator interposed between the positive electrode and the negative electrode; a non-aqueous electrolyte; and a porous insulating film adhered to a surface of at least one selected from the group consisting of the positive electrode and the negative electrode, the porous insulating film including an inorganic oxide filler and a film binder, wherein the ratio R of actual volume to apparent volume of the separator is not less than 0.4 and not greater than 0.7, and wherein the ratio R and a porosity P of the porous insulating film satisfy the relational formula: −0.10≦R−P≦0.30.
US08003257B2
The invention relates to an anode for lithium secondary battery comprising vapor grown carbon fiber uniformly dispersed without forming an agglomerate of 10 μm or larger in an anode active material using natural graphite or artificial graphite, which anode is excellent in long cycle life and large current characteristics. Composition used for production for the anode can be produced, for example, by mixing a thickening agent solution containing an anode active material, a thickening agent aqueous solution and styrene butadiene rubber as binder with a composition containing carbon fiber dispersed in a thickening agent with a predetermined viscosity or by mixing an anode active material with vapor grown carbon fiber in dry state and then adding polyvinylidene difluoride thereto.
US08003256B2
A positive electrode active material for a lithium secondary battery according to an aspect of the present invention is a lithium-transition metal compound oxide which is produced by mixing a lithium compound, a transition metal compound, a magnesium compound, and a sulfate and conducting firing and which contains magnesium atoms and sulfate groups, wherein a magnesium halide is used as the magnesium compound.
US08003254B2
Batteries are disclosed. In some embodiments, a battery includes a cathode having a composition that includes a manganese oxide. The composition has an X-ray diffraction pattern with a first peak at about 18 degrees, a second peak at about 22 degrees, and a third peak at about 32 degrees.
US08003248B2
An improved lid for closing the open end of a casing of an electrochemical energy storage device is described. The improved lid comprises a flat region having spaced apart upper and lower planar surfaces joined by a peripheral edge, an angled transition forming a boss protruding from the lower surface, and a bore extending through the boss to the upper surface. An electrical energy storage device is also described, which includes the improved lid secured to the open end of the casing container of the device.
US08003231B2
A member with alumina-based hard coating formed there-on wherein said hard coating contains nitrogen and has a composition represented by the formula (1) below: Al1-xMx(O1-yNy)z (1) (0≦x≦0.5, 00) where, M denotes at least one species of elements selected from those belonging to Group 4, Group 5, and Group 6 (excluding Cr), and such elements as Y, Mg, Si, and B. The hard coating based on γ-alumina, which is formed at temperatures no higher than 1000° C., is superior in wear resistance and heat resistance.
US08003224B2
A method for producing a cellulose acylate composition, which comprises filtering a solution in which cellulose acylate satisfying the following formulae 1 to 3 and having melt viscosity of 150 to 1000 Pa·s at 230° C. is dissolved in a solvent through a filter having a retention particle size of 0.1 to 40 μm, and mixing the filtered solution with a poor solvent to reprecipitate cellulose acylate: 1.5≦A+B≦3 Formula 1 0≦A≦2.0 Formula 2 1.0≦B≦3 Formula 3 where A is a substitution degree for an acetyl group of a hydrogen atom which constitutes a hydroxyl group of cellulose, and B is a substitution degree for an acyl group having 3 to 7 carbon atoms of a hydrogen atom which constitutes a hydroxyl group of cellulose.
US08003223B2
The present invention is directed to a heat-sealable propylene-based polymer composition comprising a propylene polymer composition including a propylene polymer component and propylene/ethylene random copolymer component; an ethylene/α-olefin random copolymer; and a soft propylene polymer composition. The present invention also provides a heat-sealable film using the composition and a packaging bag comprising the film. The heat-sealable film of the present invention has high heat-seal strength, with little decrease in heat-seal strength even after heat treatment. The heat-sealable film also has excellent blocking resistance, rigidity and low-temperature impact resistance.
US08003216B2
A heat-conductive dielectric polymer material having an inter-penetrating-network (IPN) structure includes a polymer component, a curing agent, and a heat-conductive filler uniformly dispersed in the polymer component. The polymer component includes a thermoplastic plastic and a thermosetting epoxy resin. The curing agent is used to cure the thermosetting epoxy resin at a curing temperature. The heat conductivity of the heat-conductive dielectric polymer material is larger than 0.5 W/mK. A heat dissipation substrate including the heat-conductive dielectric polymer material in the present invention has a thickness of less than 0.5 mm and bears a voltage of over 1000 volts.
US08003209B2
Bicomponent fibers comprising a thermoplastic polymer and an elastomeric compound are made which can be continuously extruded from the melt at high production rates. The elastomeric compound has high flow and consists essentially of a selectively hydrogenated block copolymer and a tackifier resin, an alpha-olefin copolymer, an alpha-olefin terpolymer, a wax or mixtures thereof. In one embodiment the block copolymer has at least one polystyrene block of molecular weight from 5,000 to 7,000 and at least one polydiene block of molecular weight from 20,000 to 70,000 and having a vinyl content of greater than 60 mol %. In a second embodiment the block copolymer has a vinyl content of less than 60 mol %. The bicomponent fibers are useful for the manufacture of articles such as woven fabrics, spun bond non-woven fabrics or filters, staple fibers, yarns and bonded, carded webs.
US08003203B2
The present invention provides a porous resinous oil-retaining article, containing lubricating oil, which is excellent in the utilization efficiency of the lubricating oil, has a high mechanical strength, and further allows the resin and the lubricating oil to be combined with each other according to a use and a specification. The present invention also provides a method of producing the resinous oil-retaining article. The resinous oil-retaining article comprises a resinous porous article having interconnected holes which are open to a surface of the resinous porous article; and an oil impregnated into the resinous porous article. The interconnected holes are formed by molding a resin containing a pore-forming substance into a molding and extracting a part of the pore-forming substance from the molding with a solvent which dissolves the pore-forming substance and does not dissolve the resin. An interconnected hole porosity of the resinous porous article is not more than 30%.
US08003201B2
A polyamide molding composition which can be used for production of a printable or printed item contains a) at most 90 parts by weight of a polyamide obtained from a lactam or from an amino carboxylic acid having at least 10 carbon atoms; and b) from 10 to 100 parts by weight of PA1010, wherein a total of components a) and b) is 100 parts by weight.
US08003197B2
The present invention is directed to providing a retroreflective sheet for security that is difficult to be counterfeited, cannot be reused if once released, includes a printed image that can be identified visually regardless of an object to be attached such as a colored glass and also can be identified visually clearly even in the night time, and is directed to providing a method for manufacturing the same. The retroreflective sheet for security of the present invention includes: a surface layer 1; a binder layer 2; high-refractive-index glass beads 3; a print resin layer 4; a focusing layer 5; a metal layer 6; and a pressure-sensitive adhesive layer 7 in this order, wherein the print resin layer 4 forms a mark, the high-refractive-index glass beads 3 are disposed in the binder layer 2, a position for disposing the high-refractive-index glass beads 3 does not coincide with a position of the print resin layer 4, when being observed from the surface layer 1 side in a thickness direction of the retroreflective sheet for security, and the print resin layer 4 is made of a composition containing a room temperature curing resin as a main component.
US08003192B2
A nanodevice including a nanorod and a method for manufacturing the same is provided. The nanodevice according to an embodiment of the present invention includes i) a substrate; ii) at least one crystal that is located on the substrate and includes a plurality of side surfaces forming an angle with each other; and iii) at least one nanorod that is located on the crystal and extends along a direction that is substantially perpendicular to a surface of the substrate.
US08003187B2
An optical medium including a plurality of data layers stacked relative to each other in a dielectric medium. A respective data layer including mark and land regions for having information recorded thereon. A mark region and a land region in the respective data layer are disposed beside each other and have substantially the same optical path length across respective thicknesses of the mark region and the land region. A method and computer program product associated with forming the optical medium which determines whether an admittance curve for a material to be used as the mark region forms an intersection with a desired admittance curve based on the admittance of a land region disposed beside the mark region, and determines a thickness of the material based on the intersection.
US08003184B2
A card sheet includes a top material having weakened separation lines and a carrier material of at least one layer of polymer. The weakened separation lines define the borders of cards. The carrier material is directly applied on an inner surface of the top material. The top material has an outer printable surface. The card sheet is constructed so as to allow the cards to be separated from the carrier material at an interface between the top material and the carrier material to form separate or separable cards after a printing operation on the printable surface.
US08003178B2
A container that has improved release properties for a viscous material configured to minimize residual material remaining in the container upon normal use thereof and also generally maintains the physical stability of a material in the container. The container includes a coating applied to a portion of the inner surfaces thereof that is effective to provide the improved release properties.
US08003175B2
A liquid crystal composition having a nematic phase that includes two components, wherein the first component is a specific five-membered ring compound having a large maximum temperature and a large dielectric anisotropy and the second component is a specific compound having a small viscosity, and a liquid crystal display device containing the composition.
US08003174B2
A method of forming a dielectric film, includes: introducing a siloxane gas essentially constituted by Si, O, C, and H and a silazane gas essentially constituted by Si, N, H, and optionally C into a reaction chamber where a substrate is placed; depositing a siloxane-based film including Si—N bonds on the substrate by plasma reaction; and annealing the siloxane-based film on the substrate in an annealing chamber to remove Si—N bonds from the film.
US08003173B2
The present invention relates to a method for forming a photoresist-laminated substrate including: preparing a laminated substrate having an insulating substrate and a metal layer; coating with an aerosol of metal nanoparticles on the metal layer; laminating a photoresist film on the metal layer coated with the aerosol of metal nanoparticles. The method of the present invention is a environmentally friendly method since an aerosol of metal nanoparticles is used, differentiated from the conventional wet process.
US08003171B2
A grip for the handle of a golf club having at least a polymerized region with two or more polymers. The first and second polymers cooperate to form a pattern on the top surface of the region. The region may be combined with a substrate to form a sheet. The sheet may be formed into a grip interface having any of a number of shapes including a panel shape. In the case of a panel shaped grip interface, the panel is then attached to an underlisting sleeve to form the grip. The grip reduces impact shock and provides a feeling of tackiness in the manner of a spirally wrapped polyurethane-felt grip while allowing the use of multiple colors being polymerized together. The grip may be easily installed onto a golf club shaft and further accommodates the use of polymers including various different characteristics including level of tackiness or durometer.
US08003170B2
A system for controlling the residual moisture in pre-cured binder coated glass fibers. The moisture of the binder coated glass fibers is measured after the process water is extracted in a collection box. Based on the level of moisture found in the coated glass fibers, adjustments are made to the process upstream of the moisture measurements. The adjustments include, but are not limited to, adjusting the amount of water used to make the binder composition; adjusting the amount of heat applied to the binder composition as it is applied to the glass fibers and adjusting the vacuum conditions used to extract the process water from the binder coated glass fibers. Control of the residual moisture in the precured binder coated glass fibers helps ensure proper curing of the binder during the subsequent curing step.
US08003167B2
There is provided a method of making a heat treated (HT) coated article to be used in shower door applications, window applications, or any other suitable applications where transparent coated articles are desired. The method may include heat treating a glass substrate coated with at least a layer of or including diamond-like carbon (DLC) or other type of carbon, with a protective film thereon. In certain example embodiments, the protective film may be of or include a layer of or including SnOx prior to HT. Optionally, a release layer of a material such as zinc oxide may be provided between the SnOx and the DLC. Following and/or during heat treatment the SnOx transforms into SnOy (y>x) so that stress is created due to the SnOx to SnOy transition. Then, during quenching, stress relief may occur which causes the layer to buckle, creating cracks which may act as liquid channels that permit the sacrificial film to be easily removed via washing or the like.
US08003163B2
Provided are a magnetic recording medium and a method of manufacturing the magnetic recording medium. The magnetic recording medium includes a substrate, a soft magnetic underlayer formed on the substrate, a texturing layer formed on the soft magnetic underlayer and including a uniform pattern, and a recording layer including magnetic grains and a non-magnetic boundary region isolating the magnetic grains. The magnetic grains and the non-magnetic boundary region of the recording layer are formed into a regular granular structure by segregation according to the regular pattern of the texturing layer. Therefore, a regular granular structure can be formed in the recording layer without a process such as etching of the recording layer, so that the recording density of the magnetic recording medium can be largely improved.
US08003154B2
This application provides a process for producing a refried bean product. The refried bean product contains both homogenized cooked bean particles and larger sized cooked bean particles and provides a texture typical of refried beans. The present process includes hydrating dried beans in water a period of time sufficient to increase the moisture content of the beans, cooking the hydrated beans in water, coarse grinding the cooked beans to provide a bean slurry, dividing the bean slurry into first and second portions, milling the first bean portion to provide a milled bean portion, homogenizing the milled bean portion with water to provide an homogenized bean portion, combining the homogenized portion and the second coarse ground bean portion with water, spices and lard to provide a combined bean mixture, and mixing the combined bean mixture to provide a refried bean product.
US08003140B1
A herbal medicinal composition, an extract thereof, and a method of manufacturing the same are disclosed. The herbal medicinal composition may be used to induce proliferation of cranial nerve cells, and it includes: 1.5-6 parts by weight of Salvia Radix, 1.5-6 parts by weight of Atractylodis Rhizoma, 1.5-6 parts by weight of Poria, 1.5-6 parts by weight of Glycyrrhizae Radix, 1.5-6 parts by weight of Angelicae Radix, 1.5-6 parts by weight of Paeoniae (Ovatae) Radix Rubra, 1.5-6 parts by weight of Ligustici Rhizoma, 1.5-6 parts by weight of Rehmanniae Radix, 2.5-10 parts by weight of Aconiti Tuber, 1.5-6 parts by weight of Zingiberis Rhizoma, 1.5-6 parts by weight of Scutellariae Radix, 2.5-10 parts by weight of Cinnamon Seed, 10-40 parts by weight of Astragali Radix, 1.5-6 parts by weight of Cinnamomum Ramulus, and 1.5-6 parts by weight of Ginseng Radix.
US08003135B2
The invention relates to a method for producing an extract containing xanthohumol (XN), which is obtained from toasted cereal products, cereal malt, coffee or cocoa. The XN-content in said extract is in the region of 10 mg/kg-2 g/kg xanthohumol. The use of XN-toasted extracts enables the XN-content of foodstuffs and pharmaceutical products to be increased in a natural manner.
US08003130B2
A method for the production of milk with increased melatonin content or a milk product made therefrom. The method comprises dividing the daily cycle of a female mammal into a daytime phase under a first light regime with a proportion of blue light and a night-time phase under a second light regime and milking the mammal at least once during the night-time phase in order to obtain milk with an increased melatonin content. For the second light regime there is used at least one light source which emits light in the wavelength range of 500 nm or above and substantially no light in the wavelength range below 500 nm.
US08003127B2
Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining an antihistamine with a nanoparticulate corticosteroid in a single formulation results in improved efficacy.
US08003125B2
A cyclodextrin polymer-based injectable composition comprising cyclodextrin, a polymer which is capable of forming a hydrogel with the cyclodextrin, and a pharmacologically effective amount of at least one drug. The polymer is selected from poly(ethylene glycol), derivatives thereon or a copolymer with a poly(ethylene glycol) segment. The copolymer with a poly(ethylene glycol) segment may include a polymer selected from the group consisting of polyesters, polyurethanes, polyamides, polyethers, polysaccharides, poly(amino acid)s, polypeptides, and proteins. The composition may be injected subcutaneously, intramuscularly, intradermally, or intracranially.
US08003109B2
Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumors.
US08003108B2
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
US08003097B2
The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.
US08003092B2
The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.
US08003090B2
The present invention relates to the use of IL-6 or a fragment, variant, fusion protein, functional derivative or salt thereof in microvascular complications.
US08003087B1
The present invention is directed to a class of polyesters that have dimethicone copolyol and polysorbate units linked by the reaction of their hydroxyl groups into a polyester by the esterification reaction with succinic anhydride. The polymers and a contribute softness, lubricity and antistatic properties when applied to hair, skin, textile fiber and paper.
US08003081B2
A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.
US08003076B2
The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.
US08003072B2
A seed crystal for the fabrication of a superconductor is grown from a rare-earth oxide having the basic formula XwZtBaxCuyOz, X comprising at least one rare-earth element and Z being a dopant which raises the peritectic decomposition temperature (Tp) of the oxide. In a preferred embodiment, the dopant is Mg. Use of this rare-earth oxide material for seed crystals increases the temperature at which cold-seeding can be performed and thus enables the growth of a wider range of hulk superconductor materials by this process.
US08003069B2
The invention relates to a method for producing carbon black or other flame aerosols, comprising the following steps: the heat is removed from the flame by dissipation and/or radiation; a thin gas boundary layer is formed; the flow formed by the flame and the gas boundary layer is accelerated or expanded; the obtained aerosol is withdrawn; and the cooling surface is cleaned. The invention further relates to a device for carrying out such a method and a black carbon having a maximum pH value of 6.0, a maximum ignition residue of 0.1 percent, and a maximum 5 μm screening refuse of 200 ppm. The inventive black carbon can be used in rubber, plastic, printing inks, inks, inkjet inks, toners, lacquers, dyes, paper, bitumen, concrete, and other construction materials.
US08003068B2
An air pollution control system comprises: a carry-in tank truck that carries in a feedstock, i.e., concentrated hydrochloric acid (35% hydrochloric acid); a hydrogen chloride vaporizer that vaporizes the concentrated hydrochloric acid to obtain hydrogen chloride; a liquid level regulator that separates residual hydrogen chloride from extracted dilute hydrochloric acid discharged as a by-product from the hydrogen chloride vaporizer, and that regulates the liquid level of the hydrogen chloride vaporizer; a concentration regulating tank that regulates the hydrochloric acid concentration of extracted dilute hydrochloric acid 25B from which the residual hydrogen chloride has been separated to a predetermined concentration (e.g., 22%); a by-product tank that stores therein dilute hydrochloric acid regulated to have a predetermined concentration; and a carry-out tank truck that carries out the dilute hydrochloric acid with a predetermined concentration discharged from the by-product tank.
US08003066B2
A method for scrubbing an amine extractant (A) containing an amine added with hydrochloric acid, and an amine binding a metal chloro complex ion, in a scrubbing stage constituting a solvent extraction step, characterized by substituting a chloride ion of the amine, which is added with hydrochloric acid, with sulfuric acid ion, by bringing the amine extractant (A) into contact with a sulfuric acid solution with a concentration of 3 to 10 N, and subsequently, by eliminating a metal by bringing the substituted amine extractant (B) into contact with water.
US08003064B2
The present invention relates generally to a process for controlled leaching and sequential recovery of two or more metals from metal-bearing materials. In one exemplary embodiment, recovery of metals from a leached metal-bearing material is controlled and improved by providing a high grade pregnant leach solution (“HGPLS”) and a low grade pregnant leach solution (“LGPLS”) to a single solution extraction plant comprising at least two solution extractor units, at least two stripping units, and, optionally, at least one wash stage.
US08003061B2
The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.
US08003057B2
A method and apparatus for controlling emissions of acid forming gases such as sulfur dioxide from cement plants is disclosed. Gaseous effluent from the cement plant pyroprocessing chamber is routed to the plant's raw mill to heat and dry the feed meal used in cement production. When the raw mill is in operation microfine lime particles are sprayed into the raw mill using a nozzle system. The spraying of hydrated lime into the raw mill scrubs acid forming gases in the process gaseous effluent. When the raw mill is not operational, microfine lime is sprayed into a gas conditioning tower that is also used to reduce the temperature of the effluent gases to facilitate efficient collection of dust particles prior to emission of the cleansed effluent flow into the atmosphere.
US08003048B2
An automated standards sampling apparatus (50) and method for using such, apparatus are described. The apparatus can be integrated with a liquid analyzer to form a compact, integrated liquid analysis unit. When used in combination with a specially adapted vial se of standard liquids, the apparatus provides a system for automated, substantially error-free periodic calibration and accuracy verification for an online TOC analyzer (52). The automated standards sampling apparatus of this invention facilitates the easy introduction of known concentrations of standard solutions and “grab” samples into online TOC analyzers to satisfy regulatory compliance, calibration, and validation requirements. The automated standards sampling apparatus of this invention also provides substantially improved reliability, higher productivity and better performance when running the critical and regulatory driven System Suitability Test than does any conventional sampling equipment, and it is likely to find wide use in a variety of industrial applications other than its principal intended use in the pharmaceutical industry.
US08003047B2
A vehicle efficacious constituents supply apparatus 10 includes a main unit 13 including an air gun and a subunit 15 including an air gun. A curling ring V1 of air containing aromatic constituents is projected from the main unit 13 towards an efficacious area A, while a curling ring V2 of air is projected from the subunit 15 towards the efficacious area A. A control unit for controlling projection timings of curling rings V1, V2 includes an alarming mode in which a projection interval at which curling rings v1 are projected is set shorter than a projection interval at which curling rings V2 are projected, and by executing this alarming mode, curling rings V2 can be applied to an occupant without causing the curling rings V2 so projected to disappear in the efficacious area A.
US08003043B2
A method and apparatus for accessing a furnace melt are provided. Preferably, the method and apparatus provide for the safe and efficient access to the molten metal melt in a furnace. According to one aspect of the invention used in a steel making process in an electric arc furnace, a furnace aperture plug is reciprocated through a furnace aperture, the furnace aperture plug is retracted from the furnace aperture, access is provided to the molten metal melt in the furnace, and the furnace aperture plug is reinserted into the furnace aperture when the access is concluded.
US08003040B2
The present invention provides a process for producing at least one three-dimensional object, comprising: providing a material to be solidified; delivering electromagnetic radiation and/or synergistic stimulation in a pattern or an image to a building region for solidifying said material; wherein said delivering of electromagnetic radiation and/or synergistic stimulation is performed selectively to a defined area or volume of said material to be solidified; and wherein an energy density of electromagnetic radiation and/or synergistic stimulation is controlled and/or adjusted in a border region of said pattern or image and/or is varied in border regions of patterns or images of different building regions of said material, to have an energy density different from the building region other than said border region(s), wherein the controlling and/or adjustment is dependent on, alone or in combination: (a) intensity of electromagnetic radiation and/or synergistic stimulation delivered to said defined area or volume of said material to be solidified; (b) total shape or contour shape of said defined area or volume of said material to be solidified; (c) size of said defined area or volume of said material to be solidified; and (d) material to be solidified. A device is provided likewise.
US08003037B2
A surface-reinforced article includes a core assembly (12) comprising a foam core (20) with a surface region (22) that includes fine fibers, and an outer reinforcing covering (14) which includes thicker fibers in a resin (30). The fine fibers includes coupling fibers (100) with outer ends (106) embedded in the resin. After the core assembly is molded, the spacers are removed, the core assembly is wrapped in the outer fibrous material, and the wrapped core assembly (120) is placed in the second mold cavity that is formed by the original mold but without the spacers.
US08003034B2
A method and apparatus are provided for forming a composite structure with an automatic placement head, through the use of a non-rotating tooling tablet having first and second substantially oppositely facing surfaces thereof, joined around the peripheries thereof by a side surface of the tablet, with at least one of the first or second surfaces forming a tool surface of the tablet. Layers of pre-impregnated fiber or tape are applied to the tool surface of the tablet by the automated fiber placement head.
US08003032B2
A system for processing materials includes handling and cutting stations positioned at appropriate positions along first and second conveying portions. A crust cutting station is positioned along the first conveyor portion. A crust removal station is positioned to span across the first and second conveying portions. Similarly, a stacking station is also positioned to span across the first and second conveying portions. Further, a first (vertical) cross cutting station is position along the second conveyor portion. Similarly, a second (horizontal) cross cutting station is located along the second conveyor portion. The process of using the disclosed system eliminates the need for specially designed stacking frames or trays and support rods, and improves cutting capacity and reduces processing time by only stacking the materials to be processed once, without de-stacking and restacking steps.
US08003030B2
The process for producing gaskets includes the steps of: forming a metal core material (2) using a stainless steel plate; treating the resulting metal core material (2) with an alkali treating solution; preparing an unvulcanized rubber molded product (1); mounting the metal core material (2) treated in the treating step to the unvulcanized rubber molded product (1); and vulcanizing the rubber-molded product to thereby anchor the elastic material to the metal core material (2) without using an adhesive; characterized in that the alkali treating solution used in the step of alkali treatment includes the following components (A), (B), and (C): (A) an alkali metal hydroxide or an alkaline earth metal hydroxide; (B) an alkali metal silicate or an alkaline earth metal silicate; and (C) a carboxylate salt.
US08003026B2
Method for making carbon-carbon composite friction product, by: fabricating carbon fiber preform; heat-treating the carbon fiber preform; infiltrating the carbon fiber preform with a high carbon-yielding pitch using VPI (vacuum pressure infiltration) or resin transfer molding (RTM) processing; carbonizing the preform with an intermediate heat-treatment at 800-2000° C.; repeating the pitch infiltration and carbonization steps to achieve a final density of >1.75 g/cc; machining the surfaces of the preform; and applying an oxidation protection system. This approach overcomes problems inherent in lower density carbon-carbon composites by employing high carbon-yielding pitches to densify the carbon-carbon composites to a high density. The high carbon yielding pitches may include isotropic pitches, 100% anisotropic (mesophase) pitches, or mixtures of the two. They may be derived from petroleum, coal tar, or synthetic feedstocks.
US08003024B2
Contact lens molds and methods of producing soft cast-molded contact lens products are provided. The methods include placing a soft hydrophilic contact lens-forming composition in a cavity formed between a first mold member and a second mold member, subjecting the composition in the cavity to conditions effective to form a contact lens product from the composition, and repeating the placing and subjecting steps a plurality of times, thereby producing a plurality of soft contact lens products. At least the first mold members, and advantageously all of the first and second mold members, are injection-molded with a nucleated thermoplastic polyolefin resin having a melt flow rate in a range of 10 g/10 min to about 40 g/10 min.
US08003021B2
Embodiments of the present invention are directed to methods of producing PbSexY1-x alloys and methods of producing PbSe/PbY core/shell nanowires. The method of producing PbSexY1-x alloys comprise providing PbSe nanowires, producing a PbY solution where Y═S or Te, adding the PbSe nanowires to an growth solution, and producing PbSexY1-x, nanowire alloys by adding the PbY solution to the heated growth solution comprising PbSe nanowires.
US08003019B2
A silver particle dispersion liquid comprising a silver particle powder having an average particle diameter (DTEM) of 50 nm or less, the surface of the particle being covered with an organic protective material, dispersed in a non-polar or small polar liquid organic medium having a boiling point of 60 to 300° C., wherein the organic protective material is an amine compound having one or more unsaturated bonds in one molecule. The silver particle dispersion liquid can be produced by reducing a silver compound in a liquid including one or more alcohol or polyol acting as a reducing agent, wherein the reduction reaction is conducted in the presence of an amine compound having a molecular weight of 100 to 1,000 and having one or more unsaturated bonds in one molecule.
US08003010B2
A water-stable semiconductor nanocrystal complex that is stable and has high luminescent quantum yield. The water-stable semiconductor nanocrystal complex has a semiconductor nanocrystal core of a III-V semiconductor nanocrystal material and a water-stabilizing layer. A method of making a water-stable semiconductor nanocrystal complex is also provided.
US08003003B2
An improved refrigerant composition, or a kit for an improved refrigerant composition, for use in air conditioners comprising a refrigerant, wherein the refrigerant comprises a hydrofluorocarbon having a GWP of less than about 10 and an ODP of about zero, which is present at a concentration of at least about 50% by weight of the refrigerant composition; a lubricant wherein the lubricant is a polar, oxygenated lubricant; and an acid scavenger comprising a siloxane, an activated aromatic compound, or any mixtures thereof.
US08003002B2
A thermoelectric material of the p-type having the stoichiometric formula Zn4Sb3, wherein part of the Zn atoms optionally being substituted by one or more elements selected from the group comprising Sn, Mg, Pb and the transition metals in a total amount of 20 mol % or less in relation to the Zn atoms is provided by a process involving zone-melting of a an arrangement comprising an interphase between a “stoichiometric” material having the desired composition and a “non-stoichiometric” material having a composition deviating from the desired composition. The thermoelectric materials obtained exhibit excellent figure of merits.
US08002992B2
A method for treating a liquid is disclosed using an apparatus having: (a) a pump volute or hydrocyclone, (b) a throat connected to the pump volute or hydrocyclone head, (c) a parabolic reflector having a vertex, a focus and an opening at the vertex, wherein the opening is connected to the throat such that the vertex and focus are axially aligned with the central axis and the focus is not located within the throat, and (d) a wave energy source having a first electrode within the pump volute or hydrocyclone head that extends into the throat along the central axis of the throat, and a second electrode extending into the parabolic reflector proximate to the focus wherein the second electrode is spaced apart and axially aligned with first electrode. The liquid is supplied to the pump volute or hydrocyclone head and is irradiated by the wave energy source.
US08002990B2
A filter for removing soluble, colloidal, and insoluble particles from a fluid, including lead using a first filter media for filtering soluble material from the fluid, a second filter media, adjacent and in fluid communication with, the first filter media, for filtering soluble material from said fluid, wherein the first and second filter media create a physical non-soluble particle barrier at their interface for capturing non-soluble particles, that when retained at the interface, become soluble over time in the fluid, and are subsequently removed by the second filter media. At least one of the filter media can be fibrillated nanofibers that are loaded with finely subdivided media of powdered ion exchange resins. A third filter media may be placed between the first and second filter media to enhance capturing and dissolving the physical non-soluble particles.
US08002987B2
Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
US08002980B2
A former (11) works, when supplied with wastewater containing heavy metals and hydrogen sulfide, to react heavy metals contained in wastewater with hydrogen sulfide to form sulfide salts, an acquirer (12) works, when supplied with sulfide salts and acid, to acquire hydrogen sulfide and heavy metal ions produced by reactions between sulfide salts and acid, a hydrogen sulfide supply line (13) supplies hydrogen sulfide acquired by the acquirer to the former, and a collection line (20) collects heavy metal ions.
US08002973B2
A lubricant reclamation system having a reclamation device (100) is sectioned into three processing sections: a centralized core section (150), a peripheral filtering section (170), and a base filtering section (190). A series of peripheral conduits (172, 182) are disposed within the peripheral filtering section (170) having an entrance port (174) in communication with an inlet manifold (105) and discharging via an exit port (176) in communication with the base filter (190), a peripheral filtering material (178), or the core filtering section (150). The peripheral conduits (172, 182) can be linear, multi-directional, tapering, and spiraling. The filter is in fluid communication with a series of stacked reclamation members (130, 140). The stacked reclamation members (130, 140) provide processing and/or monitoring of the lubricant via electrical or pneumatic interface.
US08002972B2
A system for producing petroleum products from oil shale includes one or plural kiln lines made up of plural series-connected, indirect-fired, inclined rotary kilns. Plural kiln lines are operated for parallel processing. Oil shale is advanced through kilns in succession and exhausted from each kiln line substantially free of hydrocarbons. Successive kilns along the advancement of oil shale are maintained at successively higher temperatures. A fuel distinct from hydrocarbons in oil shale, such as syngas from a gasifier or hydrogen gas from a separator, drives pyrolysis to extract hydrocarbons. A refining unit located proximate to the kiln lines upgrades extracted hydrocarbons into petroleum products and separates the petroleum products by criteria. A heat extraction unit recovers heat from exhausted oil shale for reuse in kilns. A method involves drying oil shale followed by heating dry oil shale in successively hotter pyrolysis environments.
US08002971B2
Processes and systems associated with hydrodynamic cavitation-catalyzed oxidation of sulfur-containing substances in a fluid are described. In one example method, carbonaceous fluid is combined with at least one oxidant to form a mixture and then the mixture is flowed through at least one local constriction in a flow-through chamber at a sufficient pressure and flow rate to create hydrodynamic cavitation in the flowing mixture having a power density of between about 3,600 kWatts/cm2 and about 56,000 kWatts/cm2 measured at the surface of the local constriction normal to the direction of fluid flow. The creation of hydrodynamic cavitation in the flowing mixture initiates one or more chemical reactions that, at least in part, oxidize at least some of the sulfur-containing substances in the carbonaceous fluid. An example system includes a device configured to mix a carbonaceous fluid and one or more oxidants, at least one cavitation chamber configured to produce cavitation bubbles in the mixture, and at least one elevated pressure zone configured to collapse the cavitation bubbles, thereby catalyzing oxidation of the sulfur-containing substances.
US08002968B2
A process for treating a heavy hydrocarbon feedstock is disclosed. The process involves separating the feedstock into a residue component and a light component, the residue component having a lower API gravity than the light component and treating at least a portion of the light component to produce a synthetic transport diluent suitable for combining with at least a portion of the residue component to produce a product which meets applicable criteria for pipeline transport.
US08002961B2
An electrolyte and method of producing the same. In one embodiment, the electrolyte includes water, ascorbic acid, a phosphorous donor, ammonium perchlorate, ferrous perchlorate, cobalt perchlorate, and a buffering agent.
US08002952B2
A distillation column is disclosed with a folded design. The column includes a plurality of rectification zones and corresponding stripping zones Each rectification zone is linked to a heat pump or a stage of a heat pump. Overhead vapor from the top rectification zone is compressed and used to heat bottoms liquid from the bottom stripping zone. Similarly, overhead vapor from the middle rectification zone is compressed and used to heat liquid from a middle stripping zone and overhead from a lower rectification zone is compressed and used to heat liquid taken from the uppermost or top stripping zone. A single multiple stage heat pump compressor may be utilized as opposed to a plurality of heat pumps Because the heat exchanger from each rectification-stripping zone pair has a lower duty, economical stab-in heat exchangers may be utilized.
US08002949B2
A composition for cellulostic fibers containing amino silicone to impart improved hand feel. The composition may be included in a lotion applied to tissue paper and may include a hydrophilic softener. A carrier for trace substances, fragrances, vitamin E, aloes and colouring agents may also be used. Such carrier may comprise microcapsules.
US08002943B2
A floor tile for a raised floor. The floor tile is defined by a shallow upwardly-opening metal pan defining a shallow compartment in which a main preformed one-piece concrete block is secured. The main concrete block is preferably formed from a plurality of one-piece preformed concrete sub-blocks which are adhesively adhered in sideward abutting relationship to define a plan profile corresponding to the main concrete block. The main concrete block is then adhesively secured within the compartment of the metal pan.
US08002942B2
A triaxial acceleration sensor which has a structure including a cover joined to a substrate including a mechanically operable functional unit to be sealed, is adapted in such a way that the joined state can be reliably obtained so as to not interfere with a displacement of the functional unit. A sealing frame is made of a heated polyimide on a periphery of an upper main surface of a substrate provided with a functional unit, and a sealing layer made of a polyimide is formed over an entire lower main surface of a cover. For integrating the substrate and the cover so as to seal the functional unit, the sealing frame and the sealing layer are joined to each other by heating and pressurizing the sealing frame and the sealing layer at a temperature that is about 50° C. to about 150° C. higher than a glass transition temperature of the polyimide while bringing the sealing frame and the sealing layer into contact with each other. In this case, a recess is formed in the vicinity of a portion of the sealing layer to be brought into contact with the sealing frame so that a bump, generated from the sealing layer which is deformed in the joining step, is prevented from protruding toward the functional unit.
US08002935B2
A method of making a polymeric laminated wafer comprising different film materials that are softenable and formable at different softening temperatures corresponding with the film materials. Also disclosed is a laminated wafer wherein a first layer has different thermal properties than a second layer of the wafer.
US08002929B2
The present invention relates to systems and methods for forming images in solid surfaces, and to solid surfaces containing an image. In particular, the present invention provides systems and methods for forming images in polymeric materials, and polymeric materials containing an image with novel optical density characteristics.
US08002924B2
A continuous splicer includes first and second closely spaced rotating cylinders each having a respective cutting element and tape retaining arrangement disposed on its outer periphery. With a depleting web fed by the first cylinder and a replenishing web fed by the second cylinder, an end of the replenishing web is adhesively joined to the depleting web while in motion and the depleting web is severed by the first cylinder's cutting element in forming a splice of the two webs. As the replenishing web depletes, a third web may be inserted on the first cylinder and automatically or manually spliced to the original replenishing web without stopping or re-configuring the splicer. The splicer is capable of delivering the webs at a constant rate or a rapidly changing and/or dynamic cycling rate, and applies relatively low web tension for operation with delicate, narrow and extensible webs.
US08002919B2
A method of inserting z-axis reinforcing fibers into a multi-layer composite laminate. Layers of material made up of z-axis fiber and y-axis fibers are automatically transported into a z-fiber deposition machine having a housing with upper and lower surfaces. Z-axis apertures are formed in the respective upper and lower surfaces. An elongated solid rod having a tapered front tip is aligned in close proximity to the aperture in the bottom surface. The rod is first rotated by a motor and then actuated upwardly completely through the thickness of the layer of x-y material by an actuator. A first hollow tube having a z-axis is axially aligned with the aperture in the top surface and a fiber bundle is threaded downwardly through a first hollow tube to a position adjacent its bottom end. The z-fiber deposition machine has structure to feed a predetermined length of the fiber bundle downwardly through the first hollow tube so that it follows the pathway in the x-y material formed by the rod which is now withdrawn downwardly through the aperture in the bottom wall. The z-axis fiber is thus deposited into the x-y material. The top end of the z-axis fiber is then severed and the x-y material is then advanced a predetermined distance to complete the cycle and is, thus, set to be repeated.
US08002915B2
A novel compound, used for example, as a gas generating fuel, is defined as a compound having the structural formula of wherein: R4 is a triazine ring; R1 is selected from the group consisting of a tetrazolyl group, CH3, OCH3, —CN, —C2H, NCO, —NHNH2, NO, NO2, OH, Cl, —NHCONH2, —OCOR, NHNO2, substituted tetrazoles, and substituted triazoles; R2 is selected from the group consisting of a tetrazolyl group, CH3, OCH3, —CN, —C2H, NCO, —NHNH2, NO, NO2, OH, Cl, —NHCONH2, —OCOR, NHNO2, substituted tetrazoles, and substituted triazoles; R3 is selected from the group consisting of a tetrazolyl group, CH3, OCH3, —CN, —C2H, NCO, —NHNH2, NO, NO2, OH, Cl, —NHCONH2, —OCOR, NHNO2, substituted tetrazoles, and substituted triazoles.
US08002914B1
A flash powder formulation for use in flash grenades that produces reduced smoke containing from about 10 percent by weight to about 60 percent by weight of zirconium hydride, from about 40 percent by weight to about 90 percent by weight CAN, and from zero percent by weight to about 5 percent by weight of a binder material.
US08002912B2
High temperature aluminum alloys that can be used at temperatures from about −420° F. (−251° C.) up to about 650° F. (343° C.) are described. The alloys are strengthened by dispersion of particles based on the L12 intermetallic compound Al3X. These alloys comprise aluminum, at least one of nickel, iron and chromium; at least one of scandium, erbium, thulium, ytterbium, and lutetium, and at least one of gadolinium, yttrium, zirconium, titanium, hafnium, and niobium.
US08002909B2
Alloy compositions suitable for fabricating medical devices, such as stents, are disclosed. In certain embodiments, the compositions have small amounts of nickel, e.g., the compositions can be substantially free of nickel.
US08002906B2
The present invention provides a rare earth magnet, which is formed through at least hot molding, the rare earth magnet containing grains including an R2X14B phase as a main phase, and a grain boundary phase surrounding peripheries of the grains, in which R is at least one element selected from the group consisting of Nd, Pr, Dy, Tb and Ho, and X is Fe or Fe with a part being substituted by Co; in which an element RH is more concentrated in the grain boundary phase than in the grains, in which the element RH is at least one element selected from the group consisting of Dy, Tb and Ho; and the element RH is present with a substantially constant concentration distribution from the surface part of the magnet to the central part of the magnet.
US08002904B2
A duct system includes at least one duct for communicating air or fluid within a building that has a plurality of openings along the top of the duct along the central axis of the duct. An ingress pipe is coupled to the openings along the top of the duct. A plurality of openings are also provided along the bottom of the duct along the central axis of the duct, with a drain pipe coupled to the opening along the bottom of the duct. A user may inject a fluid into the duct ingress pipe and the fluid is drained and collected from the duct using the drain pipe.
US08002900B2
A method and apparatus 30 are provided for cleaning of bottle filling equipment 10 that has a plurality of elevated valves 18, each valve being in flow communication with filling liquid supply means 14. The method includes storing a manifold 32 that has a plurality of cleaning openings 42 in a configuration resembling that of the valves, in a position that allows clear visibility and access to the operation of the valves. The manifold 32 is lowered relative to the valves 18, so that it is below the valves and is positioned underneath the valves, with each cleaning opening 42 in flow communication with a valve. The valves 18 are rinsed with liquid flowing through the filling liquid supply 14, the valves and the manifold 32. Afterwards, the manifold 32 is removed from the valves 18 and returned to its stored position.
US08002899B2
Aspects of the invention generally provide methods and apparatus for cleaning adhesive residual on a photomask substrate. In one embodiment, the apparatus includes a processing cell, a support assembly configured to receive a photomask substrate disposed thereon disposed in the processing cell, a protection head assembly disposed above and facing the support assembly, and a head actuator configured to control the elevation of the protection head assembly relative to an upper surface of the support assembly. A cleaning device is provided and positioned to interact with the photomask substrate disposed on the support assembly. In another embodiment, a method of cleaning a periphery region of a photomask substrate includes providing a photomask substrate having a periphery portion and a center portion disposed on a support assembly in a processing cell, lowering a protection cover disposed in the processing cell to cover the center portion of the photomask substrate, providing a brush in the processing cell to clean the periphery portion of the photomask substrate.
US08002894B2
In a processing apparatus including a diaphragm valve provided on a process gas discharge line for discharging a process gas from a processing chamber and configured to control the internal pressure of the processing chamber by adjusting the opening of the diaphragm valve, an antistatic agent source is connected to the process gas discharge line at a position upstream of the diaphragm valve. Damage of a diaphragm valve element due to spark discharge resulted from electric charge generated by friction between the gas flowing through the diaphragm valve and the diaphragm valve element can be prevented.
US08002893B2
In a Czochralski (CZ) single crystal puller equipped with a cooler and a thermal insulation member, which are to be disposed in a CZ furnace, smooth recharge and additional charge of material are made possible. Further, elimination of dislocations from a silicon seed crystal by use of the Dash's neck method can be performed smoothly. To these ends, there is provided a CZ single crystal puller, wherein a cooler and a thermal insulation member are immediately moved upward away from a melt surface during recharge or additional charge of material or during elimination of dislocations from a silicon seed crystal by use of the Dash's neck method.
US08002875B1
A hydrogen purification system that is used to separate hydrogen gas from a mixed gas source. The hydrogen purification system includes a hydrogen separator. Within the hydrogen separator is a first chamber into which the mixed gas source is fed. A plurality of tubes extend into the first chamber. Each of the plurality of tubes is permeable only to hydrogen. Gap spaces exist within the first chamber in between any of the plurality of tubes that are arranged in adjacent positions. The mixed source gas passes through the gap spaces as it permeates the first chamber. The mixed gas source spreads thinly over the exterior of the tubes within the confines of the gap spaces. Hydrogen from the mixed gas source permeates thru the tube walls and into the interior of the tubes that are in parallel and the hydrogen is collected in a chamber.
US08002869B2
An air cleaner includes a housing and an access cover. The internal volume of the housing can be reached through an opening in a side wall of the housing. A filter element having fluted filter media is removable and replaceable from the air cleaner. The housing is constructed and arranged to cam the element into sealing engagement with the housing. The access cover includes structure to help support and ensure proper seating of the filter element within the housing. A method of installing the filter element in the air cleaner includes sliding a portion of the filter element against a slide surface in the housing. A method of servicing an air cleaner includes tilting the filter element against a tilt surface in the housing to release a seal between the filter element and the housing. The filter element can have a handle to assist in servicing of the air cleaner. The housing can have a window to allow visual inspection of the internal component of the housing and to determine visually whether a filter element is installed therein.
US08002861B2
Abrasive grain powder, in particular intended for machining silicon ingots, such that the granulometric fraction D40-D60 comprises more than 15% and less than 80%, as percentages by volume, of grains having circularity of less than 0.85.
US08002856B2
The present invention relates to a process for contacting a hydrocarbon and an oxygen-containing gas with a catalyst bed in a reactor at a space velocity of at least 10,000 h−1, said process being characterised in that a) the reactor has a polygonal internal cross-section at least in the section where the catalyst bed is held, b) the catalyst bed is made up of 2 or more layers of catalyst in the form of tiles of polygonal shape, said tiles have at least 4 sides, c) each layer of catalyst comprises at least 4 tiles which tessellate together to form said layer, and d) the edges where 2 tiles meet in one layer do not align with the edges where 2 tiles meet in an adjacent layer.
US08002844B2
A patch for repairing an intra-abdominal defect is disclosed in one embodiment of the present invention as including a mesh layer providing a grid of material perforated by apertures through the mesh. This mesh is used to reinforce an area around an intra-abdominal defect. A containment layer is secured proximate an edge of the mesh layer. A filler is distributed across the apertures of the mesh to contain a fluid from passing through the mesh. The mesh layer, containment layer, and filler are connected to form a chamber to selectively expand upon receipt of a quantity of fluid between the containment layer and the filler.
US08002841B2
A method prepares an ankle joint of a patient for replacement. The patient includes a tibia (20) having a medial portion (22), a talus (40), and an ankle (10) having a medial portion. The method employs a cutting alignment apparatus (50) including a first portion external to the patient and a second portion, and surgically prepares and exposes the medial portion of the ankle for replacement. The second portion of the cutting alignment apparatus is coupled to the tibia, and a cutting guide (90) is disposed with respect to the cutting alignment apparatus. The medial portion of the tibia is detached, a portion of the tibia proximate the talus is cut, and a portion of the talus proximate the tibia is cut. An ankle prosthesis (100) is installed to the ankle, and the medial portion of the tibia is reattached.
US08002836B2
Devices for implantation into an intervertebral disc can include a membrane support member to augment a disc having a defect. A defect in the anulus of a disc can be repaired using a prosthesis such as a barrier. The barrier can include a sealant and an enlarger. The barrier can be implanted into the disc using a delivery cannula, an advancer and at least one control filament to control the positioning of the barrier. A stiffening element can be included within the barrier to impart stiffness to the barrier. The support member can also be connected to an anchor.
US08002835B2
The present invention relates to an intervertebral disc prosthesis preferably comprising at least three pieces including an upper plate (1), a lower plate (2) and a mobile core (3) at least in relation to the lower plate (2), co-operation means (23, 33) allowing to limit or eliminate the movements of the core (3) in relation to the lower plate (2), in translation and in rotation, respectively, about an axis substantially parallel to the lower plate (2) and about an axis substantially perpendicular to the lower plate (2), at least one part of the surface of at least one plate being concave and complementary with a convex surface (30) of the core (3), with which it is in contact, wherein the tip (31) of the convex surface (30) of the core (3) is off centre, in at least one direction, in relation to the centre (32) of this convex surface (30).
US08002828B2
Various polymers are provided that can be polymerized in the lens capsule with the ability to covalently bond an intraocular lens implant to the posterior capsule of the eye such that there is no space available between the intraocular lens implant and the lens capsule for lens epithelial cells to proliferate and thereby significantly reducing posterior capsule opacification.
US08002811B2
A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.
US08002806B2
Anchor assemblies are provided to secure one or more implants along the spinal column that include a retainer in a receiver member. The retainer is configured to distribute the forces exerted on the retainer toward the proximal end of the retainer where it may deform without deforming, distorting or altering the retainer where it supports the anchor member in the receiver member. The desired positioning of the anchor member relative to the retainer and receiver member can thus be attained even when the retainer is subject to deformation forces.
US08002802B2
A spinal implant device includes a spacer region and an attachment region. The spacer region is adapted to be positioned between first and second spinous processes of first and second vertebral bodies to limit movement of the first spinous process and the second spinous process toward one another. The attachment region attaches to the first spinous process via a fastener that extends substantially along a long axis of the spinous process.
US08002800B2
A dynamic stabilization, motion preservation spinal implant system includes an anchor system, a horizontal rod system and a vertical rod system. The systems are modular so that various constructs and configurations can be created and customized to a patient.
US08002792B2
Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.
US08002786B2
A seal assembly for permitting hand assisted laparoscopic procedures is disclosed. The seal assembly includes a seal cap having a seal positioned within a housing. The housing includes a lower seal ring having a track which supports an upper seal ring for relative rotational motion. The seal is supported between the upper seal ring and the lower seal ring for rotation between an open orientation and a closed orientation. A ratchet mechanism is provided for controlling motion of the upper seal ring relative to the lower seal ring. The ratchet mechanism includes a deflection feature and a series of gear teeth, wherein the series of gear teeth are oriented to engage the deflection feature.
US08002769B2
An electrosurgical system includes a generator for generating radio frequency power, and an electrosurgical instrument including at least three electrodes. The generator includes a radio frequency output stage having at least a pair of RF output lines, and a power supply coupled to the output stage for supplying power to the output stage. A controller is operable to limit the radio frequency output voltage developed across the output lines to at least a first predetermined threshold value to produce a cutting RF waveform, and a second threshold value to produce a coagulating RF waveform. In a combined mode, the controller delivers both cutting and coagulating waveforms by alternating discontinuously between the first and second threshold values to form a blended signal. The system also includes means for feeding the waveform to the three or more electrodes such that the cutting RF waveform is delivered between a first pair of the electrodes, and the coagulating waveform is delivered between a second pair of the electrodes.
US08002767B2
A handle used to control movement of a medical instrument. The medical instrument may be coupled to a robotic arm that is connected to a controller. The medical instrument may have a plurality of functions such as wrist locking and motion scaling. One of the functions may be selected through a graphical user interface operated by the end user. The handle may have a plurality of buttons. One of the buttons may allow the end user to control the selected function. For example, when wrist locking/unlocking is selected, depressing the button can toggle the medical instrument wrist between a locked state and an unlocked state.
US08002765B2
A medical valve has a body and a flexible element. The body includes a wall structure defining an internal cavity having an inside and an outside. The body also has a proximal end and a distal end. The proximal end has an opening sufficiently large to receive a tip of a delivery end of a medical implement which transfers fluid through the delivery end. The body has a fluid escape space in its wall structure. The flexible element is adapted to be moved into a compressed state upon insertion of the tip of the medical implement into the opening. The flexible element is sufficiently resilient to return to a decompressed state upon removal of the tip of the medical implement from the opening. The fluid escape space is in fluid communication with the outside of the cavity when the seal is in its compressed state.
US08002763B2
A mandrel includes a mandrel body with a proximal major diameter barrel section, a diameter reducing/tapered portion and a distal minor diameter barrel section. The tapered portion connects the proximal major diameter barrel section and distal minor diameter barrel section. The proximal major diameter barrel section has a major diameter, the distal minor diameter barrel section has a minor diameter, the minor diameter less than the major diameter. The minor diameter is less than a diameter of an inner lumen of a coaxial catheter, and the major diameter exceeds the inner diameter of the outer lumen guidewire exit port of the coaxial catheter, and the tapered portion is sized to form a fluid seal the inner diameter of the outer lumen guidewire exit port. The distal minor diameter barrel section of the mandrel occupies and substantially seals and prevent flow through it to the catheter distal end guidewire entry port.
US08002762B2
A pouch for an absorbent pad is disclosed. The pouch (3) comprises a sheet of waterproof fabric formed into a pouch shape with a base (5) and a side wall (7) that extends from the base and is inwardly turned and defines an opening to insert a pad into the pouch so that the pouch covers the back and sides of the pad. In use, an assembly of the pouch and the pad received in the pouch can be positioned in a crotch region of an adult, child or baby in an operative position of the pad and with the pouch and the skin of the person enclosing the pad and forming a barrier to leakage from the pad.
US08002756B2
Adapters for utilizing a syringe or pen injector with a subcutaneous injection port to deliver a therapeutic substance through the injection port and methods of using the adapters are provided. A syringe adapter has a body having a first end and a second end. The first end of the body is configured to receive and engage the end of a syringe so that the cannula of the syringe is held at a fixed position with the respect to the adapter. The second end of the adapter configured to mate with a mating portion of the injection port. When the second end of the adapter engages the mating portion of the injection port, the adapter assures that the cannula of the syringe is properly aligned with the subcutaneous injection port and assures that the cannula penetrates the injection port to the proper depth. Adapters for use with pen style delivery systems are also disclosed. Additionally, an adapter to facilitate loading a syringe with a therapeutic substance from a vial is disclosed.
US08002744B2
A non-compliant fiber-reinforced medical balloon comprises a first fiber layer and a second fiber layer embedded in a continuous matrix of thermally-weldable polymer material defining a barrel wall, cone walls and neck walls. The fibers of the first fiber layer run substantially parallel to one another and substantially parallel to the longitudinal axis. The fibers of the first fiber layer have a pattern of different lengths and are divisible into a first group and a second group based on length. Each fiber of the first group begins in the neck wall at one end of the balloon, extends continuously in the longitudinal direction and terminates in the neck wall at the opposite end of the balloon. Substantially all of the fibers of the first group have a generally uniform length. Each fiber of the second group begins in the cone wall at one end of the balloon, extends continuously in the longitudinal direction and terminates in the cone wall at the opposite end of the balloon. The length of the fibers of the second group varies progressively in accordance to their proximity to the fibers of the first group; the fibers of the second group closest to the fibers of the first group being longer than the fibers of the second group further from the fibers of the first group. The fiber of the second fiber layer winds circumferentially around the longitudinal axis of the balloon substantially over the entire length of the balloon including the neck walls, the cone walls and the barrel wall.
US08002739B2
The present invention provides a deflectable catheter-based system for assisting in the delivery of therapeutic agents, cellular materials and the like to one or more sites in a target body tissue. The system provides for one or more injections to a predetermined needle insertion depth with a single core needle that can be advanced and retracted from the tip of the catheter. The catheter assembly includes a handle subassembly having a mechanism for setting and limiting the depth of insertion of the needle, a slide for moving the injection needle between retracted and extended positions, a return spring for biasing the needle to the retracted position, and a modified pulley mechanism for compensating for catheter shaft compression when the catheter is deflected.
US08002732B2
Embodiments of the invention provide a suction evacuation system, or smoke evacuation system, for incorporation into hand-held surgical devices. In particular, the system according to embodiments of the invention can be used in hand-held surgical suction-irrigation devices that may also include electrical systems which deliver energy to effect cutting, ablation and coagulation effects at the surgical site. Embodiments of the invention provide a smoke evacuation system that can be incorporated into a hand-held surgical device wherein the smoke evacuation system is structurally and functionally integrated with the suction control system of the device.
US08002731B2
The anti-obesity stent includes a tubular structure having outer and inner surfaces and proximal and distal ends. The tubular structure is sized to fit within a duodenum in substantially coaxial relation therewith. The tubular structure is impervious or semi-permeable to digestive substances and chyme within the duodenum. The anti-obesity stent includes a transport structure at least a part of which is coincident with or connected to the outer surface. The transport structure extends to the distal end of the tubular structure. At least one retainer structure is connected to the tubular structure. The retainer structure secures the tubular structure within the duodenum such that the transport structure is positioned to receive digestive fluids from a papilla of Vater on an inner surface of the duodenum. The transport structure provides a conduit for the digestive fluids therein to flow to the distal end.
US08002720B2
A support for a chest compression system includes a back plate, a front part having a seat for a compression member of a chest compression system, and a side part connecting the back plate to the front part. The side part is adapted to provide adjustable spacing between the seat and the back plate to accommodate patients having different chest heights to allow the support to be snugly placed around the chest of a patient.