US08546846B2
A nitride semiconductor light emitting device includes n-type and p-type nitride semiconductor layers; an active layer disposed between the n-type and p-type nitride semiconductor layers and having a structure in which a plurality of quantum barrier layers and one or more quantum well layers are alternately stacked; and an electron blocking layer disposed between the active layer and the p-type nitride semiconductor layer. The electron blocking layer has a superlattice structure in which two or more layers having different compositions are alternately stacked. An absolute value of a net polarization mismatch between a material, the material having a composition corresponding to an average composition of the superlattice structure, and a quantum barrier layer adjacent to the electron blocking layer among the plurality of quantum barrier layers is less than ⅔ of an absolute value of a net polarization mismatch between AlxG1-xN(0
US08546825B2
A light emitting device is provided which can prevent a change in gate voltage due to leakage or other causes and at the same time can prevent the aperture ratio from lowering. A capacitor storage is formed from a connection wiring line, an insulating film, and a capacitance wiring line. The connection wiring line is formed over a gate electrode and an active layer of a TFT of a pixel, and is connected to the active layer. The insulating film is formed on the connection wiring line. The capacitance wiring line is formed on the insulating film. This structure enables the capacitor storage to overlap the TFT, thereby increasing the capacity of the capacitor storage while keeping the aperture ratio from lowering. Accordingly, a change in gate voltage due to leakage or other causes can be avoided to prevent a change in luminance of an OLED and flickering of screen in analog driving.
US08546821B2
A display device includes an array of light emitting cells. Banks define each of the light emitting cells. The light emitting cells include a first light emitting cell that is located in a central region of the array and a second light emitting cell that is located in a peripheral region of the array. First and third banks border the first light emitting cell with the first bank being closer to a periphery of the array than the second bank. Second and fourth banks border the second light emitting cell with the third bank being closer to the periphery of the array than the fourth bank. An inclination angle of an innermost sidewall of the third bank that is adjacent the second light emitting cell is different than an inclination angle of an innermost sidewall of the first bank that is adjacent the first light emitting cell.
US08546818B2
Techniques for controlling current flow in semiconductor devices, such as LEDs are provided. For some embodiments, a current-guiding structure may be provided including adjacent high and low contact areas. For some embodiments, a second current path (in addition to a current path between an n-contact pad and a substrate) may be provided. For some embodiments, both a current-guiding structure and second current path may be provided.
US08546817B2
An example sensor that includes a first Schottky diode, a second Schottky diode and an integrated circuit. The sensor further includes a voltage generator that generates a first voltage across the first Schottky diode and a second voltage across the second Schottky diode. When the first Schottky diode and the second Schottky diode are subjected to different strain, the integrated circuit measures the values of the currents flowing through the first Schottky diode and the second Schottky diode to determine the strain on an element where the first Schottky diode and the second Schottky diode are attached.
US08546813B2
A semiconductor substrate includes an AlN layer that is formed so as to contact a Si substrate and has an FWMH of a rocking curve of a (002) plane by x-ray diffraction, the FWMH being less than or equal to 1500 seconds, and a GaN-based semiconductor layer formed on the AlN layer.
US08546812B2
A display panel includes a plurality of pads configured to provide a driver thereon, a plurality of first contacts respectively connected to the plurality of pads, a plurality of second contacts respectively provided so as to be opposed to the plurality of first contacts, a polysilicon layer configured to form a plurality of polysilicon films that are respectively extended to connect the plurality of first contacts and the plurality of second contacts to each other, and a gate metal layer different from the polysilicon layer. Each of a plurality of transistors is formed at a position where the gate metal layer traverses the polysilicon layer, and a plurality of transistor groups are arranged in a zigzag pattern. Each of the plurality of transistor groups include three adjacent transistors of the plurality of transistors.
US08546802B2
An apparatus includes a guide ring, and a bond head installed on the guide ring. The bond head is configured to move in loops along the guide ring. The bond head is configured to pick up dies and place the dies during the loops.
US08546792B2
It is an object to provide a noble anthracene derivative, a light emitting element with a high luminous efficiency, and further a light emitting element with a long lifetime. It is another object to provide a light emitting device and electronic device with a long lifetime by using the light emitting element. An anthracene derivative represented by General Formula (1) is provided. Since the anthracene derivative represented by General Formula (1) has a high luminous efficiency, when the anthracene derivative is used for a light emitting element, the light emitting element can have a high luminous efficiency. Further, when the anthracene derivative represented by General Formula (1) is used for a light emitting element, the light emitting element can have a long lifetime.
US08546789B2
Disclosed herein is a volatile negative differential resistance device using metal nanoparticles, the device includes an organic layer disposed between two metal electrodes, in which the organic layer includes uniformly dispersed metal nanoparticles having a diameter of about 10 nm or less in an organic material. The device of this invention exhibits a volatile negative differential resistance phenomenon at room temperature upon application of a voltage and is thus suitable for use in various switching devices and logic devices, with excellent reproducibility and simple inexpensive processing.
US08546787B2
Group III nitride based light emitting devices and methods of fabricating Group III nitride based light emitting devices are provided. The emitting devices include an n-type Group III nitride layer, a Group III nitride based active region on the n-type Group III nitride layer and comprising at least one quantum well structure, a Group III nitride layer including indium on the active region, a p-type Group III nitride layer including aluminum on the Group III nitride layer including indium, a first contact on the n-type Group III nitride layer and a second contact on the p-type Group III nitride layer. The Group III nitride layer including indium may also include aluminum.
US08546784B2
A phase change memory element and method of forming the same. The memory element includes first and second electrodes. A first layer of phase change material is between the first and second electrodes. A second layer including a metal-chalcogenide material is also between the first and second electrodes and is one of a phase change material and a conductive material. An insulating layer is between the first and second layers. There is at least one opening in the insulating layer providing contact between the first and second layers.
US08546781B2
A resistive random access memory (RRAM) device is provided that includes a first electrode, a second electrode, and a resistance-change film disposed between the first electrode and the second electrode, where the resistance-change film includes an atomic ratio of aluminum, oxygen and nitrogen.
US08546775B2
The invention is directed to a method and an apparatus for stabilizing the source location during the generation of EUV radiation based on a discharge plasma. The object of finding a novel possibility for stabilizing the source location during the generation of EUV radiation which allows changes in position of the source location to be compensated in a simple manner during the operation of the radiation source is met according to the invention in that a first beam aligning unit (7), a second beam aligning unit (4), and a beam focusing unit (5) are arranged in the vaporization beam (3) and are connected to first to third measuring devices (8, 9, 10) and can be adjusted in order to acquire and compensate for direction deviations and divergence deviations of the vaporization beam (3) with respect to reference values.
US08546769B2
A charged particle beam irradiation apparatus includes an accelerator that accelerates the charged particle beam; a first transport line that transports the charged particle beam which is delivered from the accelerator; a plurality of second transport lines that may be provided for each of plurality of irradiation chambers and further transports the charged particle beam to be transported by the first transport line to the respective irradiation chambers; and a line switching unit that may be provided between the first transport line and the second transport lines, wherein the plurality of irradiation chambers may be radially disposed around the line switching unit, the line switching unit has an electromagnet that induces the charged particle beam, and a rotating mechanism that rotates the electromagnet, and the second transport lines of the induction place may be switched by rotating the electromagnet.
US08546764B1
The present invention provides an active X-ray sensing circuit and the sensing method thereof, it is applied in X-ray panel. The X-ray sensing circuit comprises two row of pixel circuit, and the two row of pixel circuit shares one scan line, and each data line connects with two switches. It is compensated the threshold voltage when it switches to the current source. It operates reading when it switches to amplifier. By applying specific scan line signal, the last-row pixel circuit is compensated and the next-row pixel row is read at the same time, so that the sensing circuit array can compensate and sense in one scan to avoid the effect of the leakage current.
US08546751B2
In a tandem mass spectrometer with mass selector spatially separated from a mass analyzer, ions are fragmented in a three-dimensional RF by electron transfer dissociation. The fragment ions are then extracted from the 3D ion trap and introduced into the mass analyzer. The extraction is accomplished by providing, in one of the ion trap end cap electrodes, an aperture with a relatively large area covered by a conductive mesh or formed by closely spaced smaller apertures. The fragment ions are extracted from the RF ion trap by applying a DC voltage to one of the end cap electrodes.
US08546747B2
The rotary encoder includes a rotary scale in which a spiral pattern is formed, and a sensor unit including a light source and a first light-receiving part that detects light entering via the spiral pattern. A first reading area where the first light-receiving part reads the spiral pattern includes at least one cycle of the spiral pattern in a radial direction over an entire rotational angle range of the rotary scale. The first light-receiving part outputs sinusoidal signals corresponding to a radial cycle of the spiral pattern. The signal processor produces a first phase signal from two phase sinusoidal signals produced based on the sinusoidal signals output from the first light-receiving part, and produces, based on the first phase signal, a rotational angle signal showing a rotational angle of the rotary scale.
US08546746B2
A photoelectric encoder includes a scale in which diffraction gratings are formed at predetermined pitches in a measurement axis direction, a detection head which is relatively movable with respect to the scale, and which includes an illuminating portion configured to illuminate the scale, and a light receiving portion configured to receive light reflected by or transmitted through the diffraction gratings of the scale, a signal processing device configured to process a light reception signal output from the light receiving portion of the detection head, and a signal transmitting unit configured to transmit a signal between the detection head and the signal processing device. The signal processing device includes a display unit configured to display information indicating an attachment posture of the detection head with respect to the scale.
US08546744B2
An encoder includes a disc-shaped disk disposed so as to be rotatable about a rotation axis and having at least one ring-shaped track in which a rotating grating is formed and at least one fixed grating which is fixedly disposed opposed to the disk so that the fixed grating and the rotating grating construct a diffraction interference optical system. Each of a plurality of slits included in the at least one rotating grating is formed along a curved line obtained by making each of a plurality of radial lines using the rotation axis as a center curved in the circumferential direction at a predetermined curve degree so that a pitch of the slits can be set to a predetermined value.
US08546729B2
A laminated glazing (e.g. a vehicle windscreen) comprising two panes of glazing material (e.g. glass) having a ply of laminating interlayer extending between them, and one or more wires between the panes of glazing material, each having a conductive central core and an outer dark-colored (e.g. black) sheath, which is substantially resistant to color- and substance-degradation by ultraviolet light. The wires may be in the form of a capacitive sensing plate, an inductive coupling loop, a heating element, an antenna and/or an RFID tag.
US08546725B2
A laser beam machining device includes at least one laser beam source for acting upon at least one workpiece using an annular laser focus. Means are provided for imaging the laser radiation reflected from the workpiece on a sensor unit. A method for adjusting the focal position of an annular laser focus in relation to at least one workpiece is also provided.
US08546707B2
An in-vehicle input device includes a housing including a supporting member; an operating knob including a shaft hole (supported part) and supported by the supporting member in such a manner that the operating knob rocks; and a switch (a moving contact of a bulge and a fixed contact of a main substrate) operated by rocking the operating knob, wherein the operating knob has a notch defining an opening intersecting with a rocking axis on a first side intersecting with the rocking axis, and wherein a rotary knob, which is an operating (second operating knob) corresponding to another switch, is disposed in the notch.
US08546703B2
An enclosure of an electronic device includes a chassis, a sliding plate slidably disposed on the chassis, and a pivot member. A number of vent holes and a location hole are defined in the chassis. A number of teeth are formed on a sidewall bounding the location hole. A through slot is defined in the sliding plate. A toothed rack is formed on a sidewall bounding the through slot. The pivot member extends through the through slot and the location hole. The pivot member includes a toothed portion engaging with the toothed rack and the teeth, and a smooth neck. When the toothed portion disengages from the teeth, the neck is pivotably received in the location hole, the pivot member is pivoted to drive the sliding member to slide relative to the chassis by the toothed portion rolling on the toothed rack, thereby exposing or covering the vent holes.
US08546698B2
A wiring board has a first rigid wiring board having a first wiring layer on a first main surface, a second rigid wiring board having a second wiring layer on a second main surface, a first connection portion connecting the first wiring layer and the second wiring layer, and a first interlayer insulation layer formed on the first wiring layer, the second wiring layer and the first connection portion. In such a wiring board, the first rigid wiring board and the second rigid wiring board are positioned in such a way that the first main surface and the second main surface are set at substantially the same level, and the first wiring layer and the second wiring layer are electrically connected by the first connection portion.
US08546695B2
A grommet includes an inner tube and an outer tube coupled to the inner tube by an annular coupling section. A slant wall section of the outer tube has a curved portion at a position having an outer diameter equal to an inner diameter of a through-hole in a vehicle body panel. The curved portion has a different inclination angle from the slant wall section. An inclination angle of the slant wall section at a larger diameter side with respect to the curved portion is set to be smaller than an inclination angle at a smaller diameter side with respect to the curved portion. The slant wall section is provided on an inner peripheral surface at the smaller diameter side with a bending stress absorbing portion of which an inner surface is recessed annularly to be a smaller thickness.
US08546691B2
A differential signal transmission cable includes a pair of differential signal lines arranged in parallel to each other, an insulation for bundle-covering the pair of differential signal lines, and a shield conductor wound around an outer periphery of the insulation. The insulation is configured such that an outer circumference thereof in a cross section perpendicular to a longitudinal direction thereof has an oval shape formed with a continuous convex arc-curve. The oval shape has a width in a first direction along the arrangement direction of the pair of differential signal lines being larger than a width in a second direction orthogonal to the first direction.
US08546686B2
A solar collector utilizes multiple reflections of light passing down a tapered, pyramidal-type structure made of highly-reflective mirrored surfaces. A right-angled truncated reflective pyramidal structures have been discovered to have many properties which make them superior to existing concentrator geometries. The use of a tapered, pyramidal-type structure creates multiple reflections which appear at the collector output in the form of a Buckminster-Fullerene display, providing improved collector efficiency and amplification when compared to prior art “concentrators” of the Fresnel lens or parabola type.
US08546683B2
The electrically conductive glass is obtained by providing a transparent electrically conductive film 12 such as ITO or FTO on a glass plate, and providing a grid including a film of a passivated metal on this transparent electrically conductive film. An insulating, fine oxide film formed on the surface of the passivated metal prevents leakage current from flowing from the grid to an electrolyte. In addition, leakage current is prevented from flowing from the transparent electrically conductive film to the electrolyte by providing a diffusion-preventing film including titanium or titanium oxide between the transparent electrically conductive film and the grid.
US08546676B2
A pedal device for an electronic percussion instrument, including: a base; a foot board supported at its first end portion to the base and configured to pivot by depression; an arm rotatably supported at its first end at a pivot point located near to a second end portion of the foot board, the arm being pivotable about the pivot point; a mass portion provided near to a second end of the arm; a regulating portion for regulating a locus of displacement of the mass portion when the foot board is moved from a depression start position to a depression end position; and a stopper portion provided on the base for defining the depression end position by contacting the mass portion in a forward stroke of depression, the regulating portion regulating the locus of the displacement of the mass portion so as not to contain a downward component in the forward stroke.
US08546672B1
Disclosed are various embodiments for an apparatus for playing a stringed instrument that has a surface facing multiple strings. The apparatus includes an input device and a carriage assembly having multiple picks configured to sound strings of the stringed instrument. In response to data received from the input device, the picks are configured to move across the strings from a first position, with the strings between the picks and the surface of the stringed instrument, to a second position, with the picks between the strings and the surface of the stringed instrument.
US08546671B2
An accessory for a string instrument including a body portion and a clamping portion that is coupled to the body portion by a connecting portion having at least one point of connection. The body portion includes at least one surface capable of altering the position or sound of one or more strings of an instrument. The body portion can include a slide, a capo, both, and/or other surfaces or features configured to alter the sound or position of the instrument's strings.
US08546669B1
A novel maize variety designated X08B800 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B800 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B800 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B800, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B800. This invention further relates to methods for producing maize varieties derived from maize variety X08B800.
US08546662B2
The invention provides seed and plants of tomato hybrid PX 02461111 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PX 02461111 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08546658B1
A novel soybean variety, designated XB38AL11 is provided. Also provided are the seeds of soybean variety XB38AL11, cells from soybean variety XB38AL11, plants of soybean XB38AL11, and plant parts of soybean variety XB38AL11. Methods provided include producing a soybean plant by crossing soybean variety XB38AL11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB38AL11, methods for producing other soybean varieties or plant parts derived from soybean variety XB38AL11, and methods of characterizing soybean variety XB38AL11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB38AL11 are further provided.
US08546633B2
A method for producing an alkylated aromatic compound includes a step (i) of producing a reaction product (a1) containing the alkylated aromatic compound and water by the reaction of an aromatic compound, a ketone, and hydrogen using a metal component containing at least one metallic element of copper, nickel, cobalt, and rhenium and a solid acid substance; a step (ii) of forming a dehydrated product (a2) from at least a portion of the reaction product (a1) by removing at least a portion of the water in the reaction product (a1); and a step (iii) of producing a reaction product (a3) containing the alkylated aromatic compound by bringing at least a portion of the dehydrated product (a2) into contact with a solid acid substance.
US08546629B2
Embodiments of methods for co-production of linear alkylbenzene and biofuel from a natural oil are provided. A method comprises the step of deoxygenating the natural oils to form a stream comprising paraffins. A first portion of the paraffins are dehydrogenated to provide mono-olefins. Then, benzene is alkylated with the mono-olefins under alkylation conditions to provide an alkylation effluent comprising alkylbenzenes and benzene. Thereafter, the alkylbenzenes are isolated to provide the alkylbenzene product. A second portion of the paraffins is processed to form biofuel.
US08546624B2
Provided are azeotropic and azeotrope-like compositions of 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf) and hydrogen fluoride (HF). Such azeotropic and azeotrope-like compositions are useful as intermediates in the production of 2,3,3,3-tetrafluoropropene (HFO-1234yf).
US08546623B2
The invention relates to a process for preparing a C3-6 hydrofluoroalkene comprising dehydrohalogenating a C3-6 hydrohalofluoroalkane in the presence of a zinc/chromia catalyst.
US08546619B2
The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, bringing the reaction to completion and separating bronopol from the aqueous reaction mixture.
US08546618B2
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
US08546611B2
A method for preparing succinic acid, including producing a modified palladium-containing catalyst by using an acid and liquid-phase hydrogenation of unsaturated acid compounds on the modified catalyst at an increased temperature and pressure; separating the catalyst from the succinic acid; wherein the modification of the catalyst is performed on a substrate having the palladium-containing catalyst delivered thereon, the delivery being performed in an oxygen-free atmosphere; the delivery being performed in an aqueous medium of succinic, maleic or fumaric acids and/or their mixtures at a Pd2+/acid ratio of 1:1-1:100; hydrogenating the liquid-phase unsaturated acid compounds selected from maleic, fumaric acids or their anhydrides or their mixtures; and crystallizing the succinic acid from an aqueous solution containing 0.001-0.01 wt. % succinic acid seed.
US08546607B2
Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize unconventional phenol derivatives as cross-coupling partners. Embodiments of the invention can be used to synthesize a variety of useful organic compounds, for example the anti-inflammatory drug flurbiprofen.
US08546605B2
The invention provides a multistage process for continuously preparing organic, distillable polyisocyanates, preferably diisocyanates, more preferably aliphatic or cycloaliphatic diisocyanates, by reacting the corresponding organic polyamines with carbonic acid derivatives and alcohols to low molecular mass monomeric polyurethanes, and thermally cleaving said polyurethanes, in which at defined reaction stages the polyisocyanates prepared and unusable residues are separated off, and reusable by products and intermediates are recycled to upstream stages.
US08546591B2
The present invention relates to a process for the preparation of cis-2-(2-methylprop-1-enyl)-4-methyltetrahydropyran comprising the catalytic hydrogenation of 2-(2-methylprop-1-enyl)-4-methylenetetrahydropyran in the presence of hydrogen and a heterogeneous catalyst comprising ruthenium on a support and subsequently bringing the compounds obtained in this way into contact with a strongly acidic cation exchanger.
US08546580B2
Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
US08546577B2
The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
US08546576B2
There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.
US08546573B2
The present invention relates to process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin hydrochloride trihydrate and process for the isolation of 1-chlorocarbonyl-4-piperidinopiperidine and novel crystalline form of 1-chlorocarbonyl-4-piperidinopiperidine and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin.
US08546572B2
The present invention relates to an improved process for preparing morphinane analogues of formula (1) wherein the substituents R1, R2, R3, R4, R5 and Y have the same meanings as defined in the specification.
US08546570B2
A process is described for the synthesis of a cationic [rhodium diolefin phosphorus ligand] complex comprising the steps of: (a) reacting a rhodium-diolefin-1,3-diketonate and an acid in a ketone solvent, (b) adding a stabilising olefin to form a stabilised cationic rhodium compound, and (c) mixing a phosphorus ligand with the solution of the stabilised cationic rhodium compound to form a solution of the cationic [rhodium diolefin phosphorus ligand] complex. The solution may be used directly or the complex recovered. In one embodiment, the solution may be combined with a co-solvent and the ketone removed to give a new catalyst solution, from which the complex may be recovered.
US08546569B2
The use of a compound of formula I Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring is a 6 membered aromatic ring or is a 5 or 6 membered heteroaromatic ring; Z and Z′ are provided that both are not N; R1, R2, R3, R3a, R4, R8 and Ra are specified organic groups and n and p are independently 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
US08546568B2
There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).
US08546566B2
The present invention relates to an improved process for manufacturing dihydropteridinones of general formula (12) as well as intermediates thereof, wherein the groups R1, R2, R3, R4, and R5 have the meanings given in the claims and specification.
US08546565B2
Novel quinazolinamide derivatives of the formula (I), in which R1-R5 and X have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
US08546562B2
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
US08546559B2
Cationic hydrophobically modified galactomannan ethers having a cationic degree of substitution (DSC) from 0.01 to 0.5 and hydrophobic degree of substitution (DSH) below 0.001 are readily soluble in aqueous systems and useful to thicken, stabilize and condition cosmetics, detergent compositions and household cleaning products; they further improve the deposition of other ingredients on the treated surface (skin, hair or fabric).
US08546551B2
The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid.
US08546550B2
Compositions that include immunostimulatory nucleic acids are disclosed, along with the use of such compositions to induce immune responses.
US08546546B2
An antibody that binds to Mucin17 (Muc17) is disclosed. The antibody of the present invention preferably binds to the peptide of SEQ ID NO:3 and does not bind to the peptide of SEQ ID NO:4 or the peptide of SEQ ID NO:5. Also disclosed are an anti-cancer agent, preferably an anti-cancer agent for pancreatic cancer, which comprises the antibody of the present invention, as well as a method of diagnosing cancer using the antibody of the present invention, preferably the antibody of the present invention that does not bind to the secreted-form of Muc17.
US08546541B2
The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
US08546531B2
Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less. The reagent can be prepared to yield a predetermined stoichiometric ratio of the functional groups on the scaffold such that the probe has a fixed stoichiometric ratio of the functional groups.
US08546529B2
The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
US08546525B2
The invention relates to a nucleic acid molecule selected from the group comprising a) a nucleic acid molecule having one of the nucleotide sequences presented in SEQ ID:NO 4 to SEQ ID:NO 8, b) a nucleic acid molecule that codes for a peptide having one of the amino acid sequences presented in SEQ ID:NO 12 to SEQ ID:NO 16, c) a nucleic acid molecule, the complementary strand of which hybridizes to a nucleic acid molecule according to a) or b) and which codes for a peptide having antimicrobial activity, and d) a nucleic acid molecule, the nucleotide sequence of which deviates from the nucleotide sequence of a nucleic acid molecule according to c) because of the degenerated genetic code.
US08546520B2
The present invention relates to a method of reducing allergenicity of natural rubber latex products caused by allergens by reducing extractable protein levels found for said products, said method comprising the steps of: subjecting said products to a wash in a strong alkaline solution to deteriorate the allergens, and a system for reducing allergenicity of natural rubber latex products caused by allergens by reducing extractable protein levels found for said products, and a product, such as a glover or condom, manufactured from natural rubber latex.
US08546518B2
A method is provided for producing a polyarylene sulfide by reacting a sulfidizing agent with a dihalogenated aromatic compound in an organic polar solvent in the presence of an alkali metal hydroxide, the method includes : carrying out the reaction in such a manner that the polymerization time in a temperature range of 230° C. to less than 245° C. (T1a) is not less than 30 minutes and less than 3.5 hours and that the conversion ratio of the dihalogenated aromatic compound at the end of the step is 70 to 98 mol. % and : carrying out the reaction in such a manner that the polymerization time in a temperature range of 245° C. to less than 280° C. (T2) is not less than 5 minutes and less than 1 hour.
US08546517B2
The present invention generally relates to a poly(bisoxalamide) and a process for preparing and article comprising the poly(bisoxalamide).
US08546515B2
A subject for the invention relates to processes for producing a polycarbonate containing a plant-derived starting material and to molded articles thereof, the polycarbonate having excellent mechanical strength, heat resistance, a low refractive index, a large Abbe number, low birefringence, and excellent transparency. The invention relates to a process for producing a polycarbonate which includes a step in which one or more dihydroxy compounds including a dihydroxy compound having at least one linking group —CH2—O— in the molecule thereof are reacted with a carbonic acid diester in the presence of a polymerization catalyst, wherein the dihydroxy compound having at least one linking group —CH2—O— in the molecule thereof has a formic acid content lower than 20 ppm. The invention further relates to a molded article constituted of a polycarbonate or a composition of the polycarbonate, the polycarbonate being a polycarbonate which contains constituent units derived from a dihydroxy compound having at least one linking group —CH2—O— in the molecule thereof and has an Abbe number of 50 or larger and a 5% weight loss temperature of 340° C. or higher.
US08546513B2
The disclosure relates to methods and materials useful for polymerizing a monomer. In one embodiment, for example, the disclosure provides a method for polymerizing a monomer containing a plurality of electrophilic groups, wherein the method comprises contacting the monomer with a nucleophilic reagent in the presence of a guanidine-containing catalyst. The methods and materials of the disclosure find utility, for example, in the field of materials science.
US08546503B2
This invention deals with an approach to control anionic polymerization. The anionic polymerization is conducted by adding a kind of initiator ligand compound, directly or in the form of solution into the monomer or initiator at the same or different time, or at different stages. The metal atoms in the ligand can form the association with the initiator cations, while the alkyloxy groups in the initiator ligand can restrict the entering channel of the addition of the monomers due to their relatively large volume or steric hindrance. Therefore, the initiator ligand compound can restrict the rate of anionic polymerization, restrain the side reaction, and make the anionic polymerization possible to be conducted at room or even higher temperature. The molar ratio of initiator ligand compound to initiator is from 0.01:1 to 20:1. Compared with present technologies, the method of this invention can control and adjust the homopolymerization and copolymerization rate, side reactions and the polymerization temperature, and make it possible to industrialize.
US08546501B2
This invention relates to Group 4 catalyst compounds containing di-anionic tridentate nitrogen/oxygen based ligands. The catalyst compounds are useful, with or without activators, to polymerize olefins, particularly α-olefins, or other unsaturated monomers. Systems and processes to oligomerize and/or polymerize one or more unsaturated monomers using the catalyst compound, as well as the oligomers and/or polymers produced therefrom are also provided.
US08546499B2
Ziegler-Natta catalyzed linear low density polyethylene which satisfies the following conditions:a) a density, according to ISO 1183, of from 900 to 925 kg/m3,b) a C4-C10-comonomer content, determined by Fourier transform infrared spectroscopy, of 1 to 16 wt %c) a weight average molecular weight Mw, determined by gel permeation chromatography, of at least 200 000,d) wherein the linear low density polyethylene comprises, by Crystallisation Analysis Fractionation (CRYSTAF) an amorphous fraction soluble at a temperature below 30° C. of at most 10 wt % and a fraction crystallising between 60 to 75° C. of at least 35 wt % ande) by temperature rising elution fractionation (TREF) analysis, at least 70 wt % of a crystallising polymer component having an elution temperature range from 60° C. to 94° C. and less than 10 wt % of a crystallising polymer component having an elution temperature range from 30° C. to 60° C. and,f) by Gel Permeation chromatography coupled with Fourier transform infrared spectroscopy detector (GPC-FTIR), a substantially constant short chain branching profile across the molecular weight distribution (MWD) org) by Gel Permeation chromatography coupled with Fourier transform infrared spectroscopy instruments (GPC-FTIR), a reverse short chain branching profile across the molecular weight distribution (MWD),the linear low density polyethylene being produced in the presence of a special Ziegler-Natta procatalyst and a halogenated aluminium alkyl cocatalyst of the formula (IV) (C1-C4- alkyl)m-Al-X3−m, wherein X is chlorine, bromine, iodine or fluorine and m is 1 or 2.
US08546496B2
The present invention relates to a process for preparing a bimodal polyethylene product in a single loop reactor, comprising polymerizing ethylene monomer and optionally one or more olefin co-monomers in the presence of a single heterogeneous polymerization catalyst consisting of a metallocene-alumoxane catalyst immobilized on a porous support wherein said metallocene comprises only one transition metal. Said polymerization catalyst consists of two physically different fractions of support particles onto which said metallocene-alumoxane catalyst is immobilized.
US08546492B2
The present invention provides a surface treatment method for a water-absorbing resin comprising three steps of: 1) a humidifying and mixing step for mixing a base polymer and a surface cross-linking agent solution to obtain a “humidified substance”; 2) a pretreatment step for raising temperature of said humidified substance to obtain a “pretreated substance”; and 3) a surface cross-linking reaction step for cross-linking said pretreated substance to obtain a surface cross-linked “water-absorbing resin”; wherein dew point in the pretreatment step of the above 2) is from 50° C. to 95° C., and temperature of said humidified substance is raised from temperature below the dew point up to a temperature of 10° C. higher than the dew point.
US08546489B2
Provided are filled polyimides that can be used in films and articles comprising the films. The films are useful in coverlay applications and have advantageous optical properties. Also provided are blends of polyimide precursor, polyacrylonitrile, and cellulosic polymer which can be used to obtain the filled polyimides.
US08546475B2
The present invention provides an inexpensive infrared reflecting black pigment which comprises Fe and Mn but comprises no harmful elements, and exhibits an excellent infrared reflecting property. The infrared reflecting black pigment according to the present invention comprises a compound comprising Fe, Mn and at least one element selected from the group consisting of Mg, Al, Ca, Si, Sr and Ba, and has a blackness (L* value) of not more than 30 and a solar radiation reflectance of not less than 15%.
US08546474B2
Thermally-stable silicone elastomers are prepared from organopolysiloxane compositions by polyaddition, polycondensation or vulcanization reactions in the presence of peroxide; the thermal stability of the silicone elastomers is achieved by the inclusion of an additive derived from an iron (III) complex.
US08546472B2
The present invention relates to a polyester comprising repeat units based on at least one aliphatic dicarboxylic acid or an ester-forming derivative thereof (component A1), at least one aromatic dicarboxylic acid or an ester-forming derivative thereof (component A2), at least one diol (component B), optionally at least one sulfo-containing compound (component A3) and optionally at least one trifunctional crosslinking agent as component C1 and/or at least one difunctional chain extender as component C2, component A1 comprising 2-methylsuccinic acid or an ester-forming derivative thereof, to a process for preparing the inventive polyester, to the mixtures comprising the inventive polyester, to the use of the inventive polyesters or of the inventive mixtures for production of moldings, films, adhesives, foams or fibers, and to moldings, films, adhesives, foams or fibers comprising at least one inventive polyester or at least one inventive mixture.
US08546470B2
A cellulosic inclusion-thermoplastic composition that includes cellulosic inclusions and a thermoplastic polyolefin that forms a matrix in which the cellulosic inclusions are dispersed. A maleated polymer and a polar thermoplastic polymer resin of a polyamide or polyester are provided to improve adhesion between the cellulosic inclusions and the thermoplastic polyolefin. The polar thermoplastic polymer resin is characterized by a melting temperature greater than that of the thermoplastic polyolefin. The composition as provided has increased break tensile strength relative to a composition devoid of the polar thermoplastic polymer resin but otherwise is unchanged. The break tensile is measured at 23° Celsius and at an elongation rate of 50 millimeters per minute.
US08546468B2
The present invention relates to a method for the continuous production of a polymer by radical polymerization, wherein at least three materials are mixed with microstructures in one or more mixers and are then polymerized in at least one reaction zone.
US08546460B2
A prosthetic device may comprise an insert having a first surface configured to contact a first prosthetic component and a bearing surface configured to articulate against a second prosthetic component. The insert comprises an ultra-high molecular weight polyethylene and vitamin E. The vitamin E may have a concentration in the range of 0.02 to 0.12 wt % first mixed with the ultra-high molecular weight polyethylene and then molded with the ultra-high molecular weight polyethylene at a temperature greater than the melting point of the ultra-high molecular weight polyethylene. The ultra-high molecular weight polyethylene and vitamin E may be gamma irradiated with a dosage of radiation between 5 and 20 Mrad. The insert may be machined prior to gamma irradiating the insert in air such that the gamma irradiation, at suitably high dosages, may also sterilize the insert.
US08546454B2
Disclosed herein is a process for the production of fuel grade DME from carbonaceous fuels, including a pressurized multi-stage progressively expanding fluidized bed gasifier and an oxyblown autothermal reformer to produce a synthesis gas (syngas) with desirable hydrogen to carbon monoxide molar ratio, which then undergoes gas-phase DME one-step direct synthesis in a fluid pluralized bed reactor over an attrition resistant bifunctional catalyst. The crude DME thus obtained is purified in a two column distillation unit to produce a fuel grade DME having a purity greater than 99.98 mole %.
US08546449B2
Methods and compositions for the generation of a peroxyacetic acid sanitizer in proximity to the point-of-use are disclosed. These methods comprise introducing a hydrogen peroxide-acetyl precursor solution to water, mixing, and then adding an aqueous source of a alkali metal or earth alkali metal hydroxide. Triacetin is a preferred acetyl precursor and is converted rapidly and with a high conversion rate into peracetic acid. These methods produce solutions with a high level of peracetic acid. Methods for preparing the hydrogen peroxide-acetyl precursor solution are also provided. Also disclosed are solid compositions comprising a liquid acetyl precursor, a water-soluble source of hydrogen peroxide, and a water-soluble source of alkalinity. The solid composition is a freely-flowable solid that is used as a bleaching agent and a stain remover for the treatment of articles such as fabrics, dentures, textile garments, and equipment used in the food and beverage industry.
US08546441B2
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.
US08546432B2
Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
US08546428B2
The present invention relates to the fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
US08546422B2
Compounds of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
US08546420B2
The present invention relates to 4,5-ring annulated indole derivatives of formula (I), compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient, wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R1, R2, R3, R6, R7 and R10 are as described herein.
US08546410B2
Heteroaryl-fused macrocyclic 2,4-diaminopyrimidine compounds of formula (I) wherein W, G1, G2, A1 and R1 are defined in the description, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
US08546402B2
The present invention relates to chromone derivatives, their preparation, their pharmaceutical compositions and their application as D3 dopaminergic ligands as a medicament for disorders of the central nervous system.
US08546400B2
Oxazole derivatives are described. The inventive compounds are useful as kinase inhibitors, and may be used in the treatment of cancer, such as prostate cancer, lung cancer, breast cancer, colon cancer, leukemia, CNS cancer, melanoma, ovarian cancer, and renal cancer.
US08546393B2
The disclosure relates to compounds of formula (I): wherein , A, W, X, and Ra are as defined in the disclosure, and salts thereof, and to pharmaceutical compositions comprising said compounds, to processes for preparing them, and to their use as medicaments, in particular as MET inhibitors.
US08546388B2
The invention relates to compounds of formulae I(a)-I(d): and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof.
US08546386B2
Provided are additives of formula I for use in hydrocarbonaceous compositions, such as petroleum or liquid fuels: (I) wherein R1, R2, R3, R4, and R5 are as defined herein. The additives improve the corrosion resistance of the compositions. The additives also enhance the antimicrobial efficacy of any added biocides contained in such compositions.
US08546383B2
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
US08546382B2
Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor cell proliferation in individuals with bone marrow aplasia are also described. The methods involve administering an agent that inhibits adipogenesis, adipocyte growth, adipocyte differentiation and/or adipocyte proliferation.
US08546367B2
Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
US08546364B2
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free acid or as a compound such as an ester. Specifically disclosed are methods for preventing the isomerization of hydrocortisone 17-butyrate into hydrocortisone 21-butyrate through the use of safflower oil.
US08546361B2
Provided is a pseudolipid complex mixture comprising a pseudoceramide and a stearic acid and an external skin application composition comprising the same. The complex mixture has improved phase stability and a structure similar to that of the stratum corneum which can retain water and other beneficial materials, and accordingly the composition comprising the same can be used as an external skin application composition having improved moisturization and barrier repair capabilities.
US08546360B2
A method of treating a citrus plant is provided to reduce the incidence of one or more insect-vectored bacterial infections such as citrus greening. The method comprises the step of applying a treatment composition one or more times to the plant, wherein the treatment composition comprises an effective amount of aluminum tris(O-ethyl phosphonate).
US08546358B2
The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:
US08546354B2
The instant invention relates to decasaccharides of formula (I): wherein Ac represents an acetyl group and R represents a group of formula —OH or —OSO3−, in their acid form or in the form of any one of their pharmaceutically acceptable salts, and to their process of preparation. The oligosaccharides of formula (I) are useful as antithrombotic agents.
US08546352B2
The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.
US08546350B2
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
US08546346B2
The present invention relates to a method of modulating splice site selection, splicing and alternative, the method comprising the step of hybridizing an oligonucleotide-protein conjugate to a target pre-mRNA molecule in a cell or cell extract, wherein the oligonucleotide-protein conjugate comprises an oligonucleotide moiety which comprises at least two distinct sequence elements: (i) a nucleic acid sequence that is complementary to a specific region upstream of the splice site in the target pre-mRNA molecule; and (ii) an extension containing a protein binding site sequence element for covalently binding a protein; wherein the protein moiety comprises a protein capable of modulating splicing of the splice site upon binding with the protein binding site.
US08546344B2
The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.
US08546341B2
A composition for the treatment of bruising is disclosed. The composition can include an antioxidant, one or more citrus flavanoids, as active agents along with a pharmaceutically acceptable excipient or filler. The compositions are nutriceutical formulations having the capacity to reduce the number of bruises that occur over time and that reduce the healing time of bruises. The compositions are preferably in tablet form for oral consumption one or more times per day. A method of reducing bruising is also disclosed in which a patient in need of a treatment for bruising or at risk of developing bruises is identified. The composition can then be administered orally to the patient.
US08546340B2
A soothing cosmetic or pharmaceutical composition that includes at least one peptide that activates human HMG-CoA reductase general formula (I): R1-(AA)n-X1-Gly-Glu-Leu-Ser-X2-X3-(AAp-R2 in a physiologically suitable medium is disclosed. The invention further applies to a cosmetic treatment method intended to combat skin irritations. Additionally, methods of treating skin irritations with such a composition are described.
US08546329B2
The present invention relates to an erythropoietin-containing solution preparation containing a poloxamer and having a pH of 6.5 to 7.5. The present invention also relates to a method for quantifying a protein in a trace amount, the method including the following steps: binding a protein sample to a high-intensity fluorescent dye; separating a desired analyte from the obtained sample by an appropriate separation means; and quantifying the desired analyte and converting the amount of the analyte into the amount of the protein.
US08546327B2
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
US08546320B2
Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or in a DDS without having any adverse side effects. It is found that Hsp90 alone cannot exhibit its function as a chaperone in assisting the refolding of a protein such as survivin, but can exhibit this function when Hop (which is one of the partner proteins of Hsp90) binds to Hsp90. Thus, specifically disclosed herein is a chimeric peptide comprising of an Hsp90 TPR domain binding peptide and a cell-penetrating peptide.
US08546317B2
The present invention relates to a hard surface cleaning composition comprising a polybetaine polymer, wherein said polybetaine polymer comprises a zwitterionic unit A or a mixture thereof, wherein said unit A comprises a betaine group or a mixture thereof and wherein said betaine group of said unit A is a sulphobetaine group or a mixture thereof, and a vinylpyrrolidone homopolymer or copolymer, wherein said polybetaine polymer and said vinylpyrrolidone homopolymer or copolymer are present in said composition at a weight ratio of polybetaine polymer to vinylpyrrolidone homopolymer or copolymer of at utmost 1.5:1.
US08546314B2
A surface treatment composition comprising from about 6% to about 20%, by weight of the composition, of cationic polymer; from about 6% to about 40%, by weight of the composition, of anionic surfactant; and from about 4% to about 15%, by weight of the composition, of a shielding salt, wherein the weight ratio of anionic surfactant to cationic polymer is between about 0.5:1 and about 4:1. The shielding salt is defined by having a molecular weight of from about 25 to about 500 and being incapable of lowering the surface tension of water below 50 mN/m when added to water at concentrations of up to 0.01M.
US08546313B1
The invention relates to methods and products enabling decontamination of chemical warfare agents and/or toxic industrial chemicals. More particularly, the invention pertains to improvements of surface decontamination processes using novel sorbents such as nanotubular titania.
US08546308B2
The present disclosure relates to novel triple tag sequences that may comprise a 6× histidine tag, a c-myc tag and a V5 tag. The present disclosure also provides polynucleotides, proteins, vectors and host cells that comprise the triple tag sequence of the present disclosure, including libraries of such polynucleotides, proteins, vectors and host cells. The novel triple tag sequences of the present disclosure may be used in phage display vectors and phage libraries and in methods for detection, screening, capture, purification, quantitation, and/or recovery of proteins of interest to which they are linked. Proteins of interest include antibodies such as single chain antibodies, single chain antibodies, and Fab fragments of antibodies or peptides such as non-antibody peptides.
US08546300B2
A thermosensitive recording material including: a support; an undercoat layer containing at least a water-soluble resin; a thermosensitive coloring layer containing a leuco dye and a developer; and a protective layer containing a water-soluble resin and a fluorescent whitening agent, wherein the undercoat layer, the thermosensitive coloring layer, and the protective layer are formed in this order over the support, wherein the undercoat layer has a single layer structure or a multilayer structure, and the protective layer has a single layer structure or a multilayer structure, and wherein the undercoat layer has an air permeance of 150 mL/min or less.
US08546299B2
Provided is a recording material with a superior heat resistance and having a low content of a dihydroxydiphenylsulfone derivative, and a color-developing composition for producing the recording material. With the use of this color-developing composition, a recording material with a superior heat resistance at the background part can be provided and the content of a dihydroxydiphenylsulfone derivative, such as 4,4′-dihydroxydiphenylsulfone, in the color-developing composition can be reduced to 2% by mass or less, or further to 1% by mass or less.
US08546298B2
An odor filtration media having a chemical reagent which removes odor causing fluid contaminants from a fluid stream through the use of granular or shaped media have a chemical composition including permanganate is provided. A method of producing the odor absorbing media having a chemical reagent is also provided and comprises the steps of mixing H2O, KMnO4, and at least one salt adding ions or ionic compounds selected from the group consisting of Na+, Li+, K+, NH4+, Cl−, SO42−, BO32−, CO32−, PO43−, NO3− and combinations thereof, or from the group consisting of Na+, Li+, K+, NH4+, Mg2+, Ca2+, Cl−, BO32−, NO3− and combinations thereof, forming an impregnating solution. The impregnating solution is heated and combined with a support material to form a coherent mass.
US08546281B2
A light emitting device includes: a first substrate; a second substrate; a light emitting unit interposed between the first substrate and the second substrate; and a sealing material bonding the first substrate to the second substrate and sealing the light emitting unit. The sealing material comprises V+4. In addition, a glass frit, a composition for forming a sealing material, and a method of manufacturing a light emitting device using the composition for forming a sealing material are provided to obtain the light emitting device. The sealing material of the light emitting device can be easily formed by coating and irradiation of electro-magnetic waves, so that manufacturing costs are low and deterioration of the light emitting unit occurring when sealing material is formed can be substantially prevented. The sealing material has good sealing properties and thus a light emitting device including the sealing material has a long lifetime.
US08546278B2
A composite board including: at least one glass fiber mat having an upper surface and a lower surface; a foam layer attached to the glass fiber mat; and a first binding composition applied to the upper surface of the at least one glass fiber mat and a second binding composition applied to the lower surface of the at least one glass fiber mat, the first and second binding compositions being the same or different compositions.
US08546271B2
A method for selective oxidation of silicon containing materials in a semiconductor device is disclosed and claimed. In one aspect, a rapid thermal processing apparatus is used to selectively oxidize a substrate by in-situ steam generation at high pressure in a hydrogen rich atmosphere. Other materials, such as metals and barrier layers, in the substrate are not oxidized.
US08546265B2
A method for manufacturing a silicon structure according to the present invention includes, in a so-called dry-etching process wherein gas-switching is employed, the steps of: etching a portion in the silicon region at a highest etching rate under a high-rate etching condition such that the portion does not reach the etch stop layer; subsequently etching under a transition etching condition in which an etching rate is decreased with time from the highest etching rate in the high-rate etching condition; and thereafter, etching the silicon region under a low-rate etching condition of a lowest etching rate in the transition etching condition.
US08546263B2
Embodiments of the invention generally relate to methods for fabricating devices on semiconductor substrates. More specifically, embodiments of the invention relate to methods of patterning magnetic materials. Certain embodiments described herein use a reducing chemistry containing a hydrogen gas or hydrogen containing gas with an optional dilution gas at temperatures ranging from 20 to 300 degrees Celsius at a substrate bias less than 1,000 DC voltage to reduce the amount of sputtering and redeposition. Exemplary hydrogen containing gases which may be used with the embodiments described herein include NH3, H2, CH4, C2H4, SiH4, and H2S. It has been found that patterning a magnetic tunnel junction with an oxidizer-free gas mixture comprising hydrogen maintains the integrity of the magnetic tunnel junction without producing harmful conductive residue.
US08546255B2
The present invention relates to a method for forming vias in a semiconductor substrate, including the following steps: (a) providing a semiconductor substrate having a first surface and a second surface; (b) forming a groove on the semiconductor substrate; (c) filling the groove with a conductive metal; (d) removing part of the semiconductor substrate which surrounds the conductive metal, wherein the conductive metal is maintained so as to form an accommodating space between the conductive metal and the semiconductor substrate; and (e) forming an insulating material in the accommodating space. In this way, thicker insulating material can be formed in the accommodating space, and the thickness of the insulating material in the accommodating space is even.
US08546252B2
A structure and method to create a metal gate having reduced threshold voltage roll-off. A method includes: forming a gate dielectric material on a substrate; forming a gate electrode material on the gate dielectric material; and altering a first portion of the gate electrode material. The altering causes the first portion of the gate electrode material to have a first work function that is different than a second work function associated with a second portion of the gate electrode material.
US08546250B2
A vertically integrated semiconductor device includes multiple continuous single crystal silicon layers vertically separated from one another by a dielectric layer or layers. Semiconductor devices are disposed on an underlying single crystal silicon substrate and the continuous single crystal silicon layers. The individual devices are interconnected to one another using tungsten or doped polysilicon leads that extend through openings formed in the continuous single crystal silicon layers. The method for forming the structure includes forming a dielectric material over the single crystal silicon layer or substrate and forming an opening extending down to the surface of the single crystal silicon material to act as a seed layer. An epitaxial silicon growth process begins at the seed location and laterally overgrows the openings. Growth fronts from the various seed locations meet to form a continuous single crystal silicon layer which is then polished.
US08546238B2
A method for transferring a micro-technological layer includes preparing a substrate having a porous layer buried beneath a useful surface, forming an embrittled zone between it and the surface, bonding the substrate to a supporting substrate, causing detachment at the porous layer by mechanical stress to obtain a first substrate remnant, and a bare surfaced detached layer joined to the supporting substrate, performing technological steps on the bared surface of the detached layer, bonding the detached layer, by the surface to which the technological steps had been applied, to a second supporting substrate, causing detachment, at the embrittled zone, by heat treatment to obtain a detached layer remnant joined to the second supporting substrate, and the detached layer remnant joined to the first supporting substrate.
US08546231B2
Some embodiments include methods of forming memory cells. A stack includes ovonic material over an electrically conductive region. The stack is patterned into rails that extend along a first direction. The rails are patterned into pillars. Electrically conductive lines are formed over the ovonic material. The electrically conductive lines extend along a second direction that intersects the first direction. The electrically conductive lines interconnect the pillars along the second direction. Some embodiments include a memory array having first electrically conductive lines extending along a first direction. The lines contain n-type doped regions of semiconductor material. Pillars are over the first conductive lines and contain mesas of the n-type doped regions together with p-type doped regions and ovonic material. Second electrically conductive lines are over the ovonic material and extend along a second direction that intersects the first direction. The second electrically conductive lines interconnect the pillars along the second direction.
US08546220B1
A method for fabricating buried bit lines comprises steps of: defining a plurality of parallel masked regions and a plurality of first etched regions each forming between any two neighboring masked regions on a surface of a substrate, and wherein the masked region is wider than the first etched region; etching the first etched regions to form a plurality of first trenches and a plurality of first pillars; forming two bit lines respectively on two sidewalls of each first trench; etching the first pillars to form a plurality of second pillars corresponding to the bit lines. The present invention uses a two-stage etching process to prevent pillars from bending or collapsing due to high aspect ratio. Moreover, the present invention has a simple process and is able to reduce cost and decrease cell size.
US08546216B2
A nonvolatile semiconductor memory device includes a first insulating layer, charge storage layers, element isolation insulating films, and a second insulating layer formed on the charge storage layers and the element isolation insulating films and including a stacked structure of a first silicon nitride film, first silicon oxide film, intermediate insulating film and second silicon oxide film. The first silicon nitride film has a nitrogen concentration of not less than 21×1015 atoms/cm2. Each element isolation insulating film includes a high-temperature oxide film formed along lower side surfaces of the charge storage layers between the charge storage layers and a coating type insulating film. The first silicon nitride film is formed on an upper surface of the high-temperature oxide film in upper surfaces of the element isolation insulating films and not on the upper surface of the coating type insulating film.
US08546213B2
A high voltage ESD protective diode having high avalanche withstand capability and capable of being formed by using manufacturing steps identical with those for a high voltage transistor to be protected, the device having a structure in which a gate oxide film is formed over a substrate surface at a PN junction formed of an N type low concentration semiconductor substrate constituting a cathode region and a P type low concentration diffusion region constituting an anode region, and a gate electrode which is disposed overriding the gate oxide film and a field oxide film is connected electrically by way of a gate plug with an anode electrode, whereby an electric field at the PN junction is moderated upon avalanche breakdown to obtain a high avalanche withstand capability. Further, the withstand voltage can be adjusted by changing the length of the field oxide film.
US08546212B2
A manufacturing method of a semiconductor device includes the following steps. First, a substrate is provided. At least one gate trench and a first inter-layer dielectric layer are formed on the substrate. A work function metallic layer is then formed in the gate trench. A first contact hole is then formed in the first inter-layer dielectric layer. A main conductive layer is formed in the gate trench and the first contact hole simultaneously.
US08546209B1
A method of forming a semiconductor device structure includes forming an interlevel dielectric (ILD) layer over a semiconductor substrate and a dummy transistor gate structure formed on the substrate; infusing a shallow gas cluster ion beam (GCIB) layer in a top portion of the ILD layer; and removing at least one layer from the dummy transistor gate structure, wherein the at least one layer comprises a same material as the ILD layer and wherein the GCIB layer has a slower etch rate with respect to the ILD layer.
US08546207B2
The invention describes a method for fabricating silicon semiconductor wafers with the layer structures from III-V semiconductor layers for the integration of HEMTs based on semiconductor III-V layers with silicon components. SOI silicon semiconductor wafers are used, the active semiconductor layer of which has the III-V semiconductor layers (24) of the HEMT design (2) placed on it stretching over two mutually insulated regions (24a, 24b) of the active silicon layer. An appropriate layer arrangement is likewise disclosed.
US08546197B2
A method of manufacturing a thin film transistor includes: forming a gate electrode on a substrate; forming a gate insulating layer on the gate electrode; forming an organic semiconductor layer on the gate insulating layer; forming an organic semiconductor pattern by selectively removing part of the organic semiconductor layer by means of a laser ablation method; and forming source and drain electrodes on the organic semiconductor pattern.
US08546194B2
A method of manufacture of an integrated circuit packaging system includes: providing a base carrier; forming a conductive post on the base carrier, the conductive post having a top protrusion with a protrusion top side; mounting a base integrated circuit over the base carrier; and forming a base encapsulation over the base integrated circuit, the base encapsulation having an encapsulation top side and an encapsulation recess with the conductive post partially exposed within the encapsulation recess, the encapsulation top side above the protrusion top side.
US08546185B2
Provided is a method for manufacturing a semiconductor device which includes: providing a plurality of semiconductor substrates formed with through holes which penetrate between main surfaces of the substrates and are filled with porous conductors; stacking the plurality of semiconductor substrates while aligning the porous conductors filled in the through holes; introducing conductive ink containing particle-like conductors into the porous conductors of the plurality of stacked semiconductor substrates; and sintering the plurality of stacked semiconductor substrates.
US08546178B2
According to one embodiment, a semiconductor light emitting device includes a substrate, a first semiconductor layer, a light emitting layer, a second semiconductor layer, and a translucent electrode. The substrate includes a first region provided along periphery of a first major surface and a second region provided on center side of the first major surface as viewed from the first region. The first semiconductor layer is provided on the first major surface of the substrate. The light emitting layer is provided on the first semiconductor layer. The second semiconductor layer is provided on the light emitting layer. The translucent electrode is provided on the second semiconductor layer. A reflectance in the second region is higher than a reflectance in the first region.
US08546173B2
A photoelectric conversion device comprises a high-refractive-index portion at a position close to a photoelectric conversion element therein. And, the high-refractive-index portion has first and second horizontal cross-section surfaces. The first cross-section surface is at a position closer to the photoelectric conversion element rather than the second cross-section surface, and is larger than an area of the second cross-section surface, so as to guide an incident light into the photoelectric conversion element without reflection.
US08546171B2
Disclosed is a method of fabricating a thin film solar cell. A separation process (‘P4’ process) of insulating a thin film solar cell from the outside is integrally performed with a transparent electrode patterning process (‘P1’ process) and a metallic electrode patterning process (‘P3’ process). This may reduce the fabrication costs and enhance spatial efficiency as the ‘P4’ process and equipment for the ‘P4’ process are not required.
US08546169B1
A pressure sensor device is assembled by forming cavities on a surface of a metal sheet and then forming an electrically conductive pattern having traces and bumps over the cavities. An insulating layer is formed on top of the pattern and then processed to form exposed areas and die attach areas on the surface of the metal sheet. The exposed areas are plated with a conductive metal and then electrically connected to respective ones of the bumps. A gel is dispensed on the die attach areas and sensor dies are attached to respective die attach areas. One or more additional semiconductor dies are attached to the insulating layer and bond pads of these dies are electrically connected to the exposed plated areas. A molding compound is dispensed such that it covers the sensor die and the additional dies. The metal sheet is removed to expose outer surfaces of the bumps.
US08546163B2
Provided is a group-III nitride semiconductor laser device with a laser cavity allowing for a low threshold current, on a semipolar surface of a support base in which the c-axis of a hexagonal group-III nitride is tilted toward the m-axis. First and second fractured faces 27, 29 to form the laser cavity intersect with an m-n plane. The group-III nitride semiconductor laser device 11 has a laser waveguide extending in a direction of an intersecting line between the m-n plane and the semipolar surface 17a. In a laser structure 13, a first surface 13a is opposite to a second surface 13b. The first and second fractured faces 27, 29 extend from an edge 13c of the first surface to an edge 13d of the second surface 13b. The fractured faces are not formed by dry etching and are different from conventionally-employed cleaved facets such as c-planes, m-planes, or a-planes.
US08546158B2
A method for distributing phosphor particulates on an LED chip, includes steps of: providing a substrate having an LED chip mounted thereon; dispensing an adhesive on the chip, wherein the adhesive have positively charged phosphor particulates doped therein; providing an upper mold and a lower mold for producing an electric field through the adhesive and moving the upper mold to press the adhesive, wherein the phosphor particulates are driven by the electric field to move to a top face of the chip; and curing the adhesive and removing the upper mold and the lower mold.
US08546155B2
Method form via chain and serpentine/comb test structures in kerf areas of a wafer. The via chain test structures comprise a first via chain and a second via chain in a first kerf area. The via chain test structures are formed such that geometrically shaped portions of the first via chain and geometrically shaped portions of the second via chain alternate along the length of the first kerf area. The methods perform relatively low (first) magnification testing to identify a defective geometrically shaped portion that contains a defective via structure. The methods then perform relatively high (second) magnification testing only within the defective geometrically shaped portion. The first magnification testing is performed at a lower magnification relative to the second magnification testing.
US08546154B2
An apparatus and method to inspect a defect of a substrate. Since a recess of an under layer of a substrate is darker than a projection of a top layer, a ratio of a value of a secondary electron signal (of an SEM) of the under layer to a value of the top layer may be increased to improve a pattern image used to inspect an under layer defect. Several conditions under which electron beams are irradiated may be set, and the pattern may be scanned under such conditions. Secondary electron signals may be generated according to the conditions and converted into image data to display various pattern images. Scan information on the images may be stored with positional information on the substrate. Each of scan information on the pattern images may be calculated to generate a new integrated image.
US08546148B2
A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.
US08546146B2
Process for evaluating a plurality of refinery feedstocks, by providing an array of refinery feedstocks, the array having at least a plurality of different refinery feedstocks, and fractionating each of the refinery feedstocks in the array, either in parallel or in a rapid serial fashion, to produce a further array having a plurality of fractions with different chemical and/or physical properties, each fraction being representative of a process stream that might be present in a refinery. Each of the plurality of fractions is analyzed to determine one or more chemical and/or physical properties of the fractions, the analyzes being performed at least partially in parallel.
US08546144B2
By way of summary, the present invention meets some or all of the above needs by providing in a first aspect a method comprising contacting red blood cells in a suspension medium containing mannose under conditions such that the concentration of S-Alc glycated hemoglobin is increased to greater than about 6 percent by weight of the hemoglobin in the red blood cells. Preferably the suspension medium is an aqueous suspension medium. In preferred embodiments, the method is performed at about ambient temperature, 18° C. to about 23° C.
US08546142B2
The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold.
US08546126B2
The present teachings provide methods for increasing protein secretion, e.g., chymosin in filamentous fungi by co-expressing certain chaperone(s) and/or foldase(s). The present teachings also provide filamentous fungi containing certain chaperone(s) and/or foldase(s) and a protein of interest for increased secretion.
US08546120B2
An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
US08546119B2
An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
US08546111B2
The object is to provide a novel glycosyltransferase and the use thereof, the glycosyltransferase catalyzes transglucosylation of maltotriose units under conditions which can be employed for the processing of foods or the like. Provided is a maltotriosyl transferase which acts on polysaccharides and oligosaccharides having α-1,4 glucoside bonds, and has activity for transferring maltotriose units to saccharides, the maltotriosyl transferase acting on maltotetraose as substrate to give a ratio between the maltoheptaose production rate and maltotriose production rate of 9:1 to 10:0 at any substrate concentration ranging from 0.67 to 70% (w/v).
US08546107B2
Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“PI3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant PI3K, and/or mutant B-Raf in a sample and for treating disorders or conditions related to the presence of mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described. Methods of treating tumors containing mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described.
US08546106B2
The present invention relates to methods for producing a secreted polypeptide having biological activity, comprising: (a) transforming a fungal host cell with a fusion protein construct encoding a fusion protein, which comprises: (i) a first polynucleotide encoding a signal peptide; (ii) a second polynucleotide encoding at least a catalytic domain of an endoglucanase or a portion thereof; and (iii) a third polynucleotide encoding at least a catalytic domain of a polypeptide having biological activity; wherein the signal peptide and at least the catalytic domain of the endoglucanase increases secretion of the polypeptide having biological activity compared to the absence of at least the catalytic domain of the endoglucanase; (b) cultivating the transformed fungal host cell under conditions suitable for production of the fusion protein; and (c) recovering the fusion protein, a component thereof, or a combination thereof, having biological activity, from the cultivation medium.
US08546105B2
Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.
US08546087B2
The present invention relates to compounds, compositions, methods and/or kits for determining and/or predicting and/or diagnosing and/or treating restenosis in a patient.
US08546083B2
Methods and compositions are provided for determining polypeptide-nucleic acid interactions.
US08546082B2
The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.
US08546079B2
According to one embodiment, there is provided a reporter gene construct. The reporter gene construct comprises a transcriptional regulatory sequence and a reporter gene that is functionally bound to downstream of the transcriptional regulatory sequence. The reporter gene construct is activated dependently of environment and the reporter gene codes for a protein producible of producing a free radical by the activation of the transcriptional regulatory sequence.
US08546076B2
The invention concerns novel mutations or mutational profiles of HIV-1 protease cleavage sites (CS) in the Gag region correlated with a phenotype causing alterations in sensitivity to anti-HIV drugs. The present invention also relates to the use of genotypic characterization of a target population of HIV and the subsequent association, i.e., correlation, of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention further relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design and clinical management.
US08546064B2
A method for fabricating a flowfield for a fuel cell includes the steps of: providing a substrate; providing a plurality of radiation sources configured to generate a plurality of radiation beams; disposing a radiation-sensitive material on the substrate; placing an imaging mask between the plurality of radiation sources and the radiation-sensitive material; and exposing the radiation-sensitive material to the plurality of radiation beams through a first portion of the radiation-transparent apertures and a second portion of the radiation-transparent apertures in the imaging mask to form the plurality of truss elements and the plurality of wall elements in the radiation-sensitive material, the truss elements forming a plurality of trusses configured to support an adjacent diffusion medium layer, and the wall elements defining a fluid path along a length of the substrate.
US08546063B2
Provided is a pattern-forming method including, in the following order: (1) a process of forming a film with an actinic ray-sensitive or radiation-sensitive resin composition comprising a resin which contains an acid-decomposable repeating unit and is capable of decreasing the solubility in an organic solvent by the action of an acid; (2) a process of exposing the film with an electron beam or an EUV ray; and (4) a process of developing the film with a developer containing an organic solvent.
US08546052B2
An electrophotographic photosensitive member having a surface layer containing a polymeric product obtained by polymerizing a specific adamantane compound, a process cartridge and an electrophotographic apparatus which have the electrophotographic photosensitive member, and a process for producing the electrophotographic photosensitive member.
US08546050B2
The present invention is an electrophotographic photosensitive member including a conductive support, an intermediate layer which is placed on the conductive support, and a photosensitive layer which is placed on the intermediate layer, wherein the intermediate layer comprises a metal-oxide particle and a compound having a structure represented by the following formula (1):
US08546047B2
Provided are a reflective mask blank and a reflective mask which are capable of improving the contrast for inspection light having a wavelength of 200 nm or less in an inspection, capable of improving the contrast for exposure light in use of the mask, and capable of forming a high-resolution fine pattern. A reflective mask blank 10 includes a substrate 1, and a multilayer reflective film 2 adapted to reflect exposure light, a protective film 6 composed mainly of ruthenium (Ru) or its compound on the multilayer reflective film 2, and an absorber film 4 adapted to absorb the exposure light, which are formed in this order on the substrate. The absorber film 4 has a laminated structure including an uppermost layer 4b and a lower layer 4a. The uppermost layer 4b is formed of a material composed mainly of a nitride, an oxide, an oxynitride, a carbide, a carbonitride, or an oxycarbonitride of at least one or more elements selected from Si and Cr. A reflective mask 20 is obtained by forming a transfer pattern in the absorber film of the reflective mask blank.
US08546046B2
A method for fabricating a bi-polar plate of a fuel cell and the bi-polar plate thereof are presented. A graphite film is formed first. Next, a polymeric material added with electrically conductive powder is coated on a surface of a metal substrate. The graphite film is disposed on the polymeric material and the polymeric material is hardened to form an adhesive layer, such that the graphite film is attached on the surface of the metal substrate.
US08546040B2
In forming a fuel cell stack by stacking a plurality of fuel cell units, in order to provide a fuel cell in which the fuel cell stack can be stably bound, the supply of fuel and conduction of respective cells can be surely performed, and stable power generation is possible, the fuel cell includes a fuel cell stack 2 formed by stacking a plurality of fuel cell units 3 having a fuel electrode 33 and an oxidizer electrode 43. The oxidizer electrode has, in a plane orthogonal to a stacking direction of the fuel cell units, an elastic member (an oxidizer electrode diffusion layer) 41 that is arranged in parallel to a rigid supporting member 14 and has electrical conductivity.
US08546039B2
A solid polymer fuel cell that utilizes liquid fuel such as methanol should prevent generated water from residing in a ventilation port close to an anode, to thereby suppress degradation of a MEA. The fuel cell includes an anode, an anode-side collecting electrode, a sealing material located along a perimeter of a solid polymer electrolytic membrane and interleaved between the electrolytic membrane and the anode-side collecting electrode, and a discharging device that discharges a product generated through electric reaction on the anode. The sealing material is provided in a frame-shape around the anode. The discharging device is a ventilation port formed on the sealing material, and a water repellent material is provided at least one of inside the ventilation port and between the ventilation port and the anode.
US08546032B2
The fuel cell device has a control device for conducting, at the time of startup, a partial oxidation reforming reaction (POX) inside the reformer, then an auto-thermal reforming reaction (ATR) inside the reformer, then a steam reforming reaction (SR) inside the reformer; a water supply device is provided with a pump for intermittently supplying extremely small amounts of water to the reformer using pulsed control; the control device controls the fuel supply device, the reforming air supply device, and the water supply device to respectively supply target supply flow rates of fuel, reforming air, and water based on the outputs of various sensors; and, in the ATR region, the control device suppresses changes in the flow rate of fuel supplied by the fuel supply device during at least a predetermined interval following the supply of water by the pump.
US08546031B2
A hydrogen generation device and a fuel cell using the same are provided. The hydrogen generation device includes a first containing groove, a cover, a second containing groove, and a rotating device. The first containing groove contains liquid water. The cover is fixed on the first containing groove and covers the liquid water. The cover has an opening for exposing the liquid water. The second containing groove is stacked on the cover and divided into a plurality of containing compartments, wherein each containing compartment contains a solid fuel. The opening is aligned with one containing compartment so that the corresponding solid fuel reacts with the liquid water generate hydrogen. The rotating device is connected with the first or the second containing groove. The opening is moved and aligned with another containing compartment when the rotating device drives the first containing groove and the second containing groove to relatively rotate.
US08546024B2
A lithium secondary battery has an anode, a cathode, a separator between the anode and the cathode and a non-aqueous electrolyte. The non-aqueous electrolyte includes a lithium salt; and a non-linear carbonate-based mixed organic solvent in which (a) a cyclic carbonate compound, and (b) a propionate-based compound are mixed at a volume ratio (a:b) in the range from about 10:90 to about 70:30, and optionally (c) a vinylene carbonate; and an inhibitor against a reaction between the anode and the propionate-based ester compound. The cathode has a current density in the range from about 3.5 to about 5.5 mA/cm2 and a porosity in the range from about 18 to about 35%. This battery may be manufactured as a high-loading lithium secondary battery.
US08546020B2
Embodiments of the present invention generally relate to lithium-ion batteries, and more specifically, to a system and method for fabricating such batteries using thin-film processes that form three-dimensional structures. In one embodiment, an anodic structure used to form an energy storage device is provided. The anodic structure comprises a flexible conductive substrate, a plurality of conductive microstructures formed on the conductive substrate, comprising a plurality of columnar projections and dendritic structures formed over the plurality of columnar projections and a plurality of tin particles formed on the plurality of conductive microstructures. In another embodiment, the anodic structure further comprises a tin nucleation layer comprising tin particles formed on the flexible conductive substrate between the flexible conductive substrate and the plurality of conductive microstructures.
US08546017B2
Provided is a composite for anode material, a method of manufacturing the composite for anode material, and a cathode and a lithium battery that includes the composite for anode material, and more particularly, to a composite for anode material that has a large charge and discharge capacity and a high capacity retention, a method of manufacturing the composite for anode material, and a cathode and a lithium battery that includes the composite for anode material. Also, the composite for anode material in which Si or Si and carbon are distributed in silicon oxide particles is provided.
US08546015B2
This invention provides a battery can allowing for a reduced amount of gas forming therein, thus realizing lower production cost. The cathode can 11 of an alkaline battery is cylindrically shaped and closed-bottomed, comprising an opening 15, a body 17 and a bottom 18, with the body 17 being divided into an opening sealing section 31 and an electrode mixture container section 33 which are arranged in order from the opening 15, with the plate thickness t0 set for the electrode mixture container section 33, which is not less than 80% of the plate thickness t1 of the opening sealing section 31, with the plate thickness t3 of the electrode mixture container section 33 gradually reducing in the region starting at the topmost point of the electrode mixture container section 33 and ending at the set plate thickness t0.
US08546010B2
An assembled battery with a high capacity, comprising a plurality of unit cells electrically connected with one another in parallel, the unit cells each having a through-hole and being of toroidal shape, and the plurality of unit cells are arranged in a nested manner such that one unit cell is disposed within another unit cell. The problem that toroidal batteries with high capacity, high power density and small thickness may have a large volume and low energy density is solved by connecting in parallel a plurality of unit cells nested within one another, and heat dissipation of the battery is also further improved. A toroidal cell having heat dissipating fins is also provided.
US08546008B2
Provided is an electronic device, comprising: a casing, comprising an accommodation space that a battery is detachably assembled therein. The battery comprises a hook extending towards the casing, a first and a second urging surfaces that a step connected there between; and a latching module, disposed in the casing and moving back and forth between a first and a second positions. When the latching module moves from the first position towards the second position, the hook, the first urging surface, the step, and the second urging surface are sequentially located in a moving path of a urging portion of the latching module. When the latching module is located at the first position, the urging portion is buckled to the hook. When the latching module is located at the second position, the urging portion is limited by the step and rests on the second urging surface.
US08546003B2
A secondary battery having a bare cell and a protective circuit module disposed over the bare cell and electrically connected to the bare cell via a first lead plate, in which the first lead plate includes a first plate, a second plate connected to the first plate, and a third plate arranged opposite to the first plate and connected to the second plate.
US08545998B2
Embodiments of the current invention describe a method of plating platinum selectively on a copper film using a self-initiated electroless process. In particular, platinum films are plated onto very thin copper films having a thickness of less than 300 angstroms. The electroless plating solution and the resulting structure are also described. This process has applications in the semiconductor processing of logic devices, memory devices, and photovoltaic devices.
US08545978B2
To provide a composite film having low-temperature flexibility. The composite film including an acrylic polymer and a urethane polymer, in which the acrylic polymer includes an acryl component containing at least an acrylic acid-based monomer and a monofunctional acrylic monomer whose homopolymer has a glass transition temperature (Tg) of 273 K or more; the content of said acrylic acid-based monomer in said composite film is from 0.5 to 15 wt %; the glass transition temperature (Tg ac) of the acrylic polymer is 273 K or more; the glass transition temperature (Tg ur) of the urethane polymer is 273 K or less; and the glass transition temperature (Tg) of the composite film is 269 K or less.
US08545977B2
Polymer concrete electrical insulation including a hardened epoxy resin composition filled with an electrically non-conductive inorganic filler compositions. The polymer concrete electrical insulation system optionally may contain additives. The epoxy resin composition is based on a cycloaliphatic epoxy resin. The inorganic filler composition can be present within the range of about 76% by weight to about 86% by weight, calculated to the total weight of the polymer concrete electrical insulation system. The inorganic filler composition includes a uniform mixture of (i) an inorganic filler with an average grain size within the range of 1 micron (μm) to 100 micron (μm) [component c(i)], and (ii) an inorganic filler with an average grain size within the range of 0.1 mm (100 micron) to 2 mm [component c(ii)]. The inorganic filler with an average grain size within the range of 1 micron (μm) to 100 micron (μm) [component c(i)] can be present in an amount within the range of 22% to 42%, calculated to the total weight of the polymer concrete electrical insulation system; and (e) the inorganic filler with an average grain size within the range of 0.1 mm to 2 mm [component c(ii)] is present within the range of 41% to 61% by weight, calculated to the total weight of the polymer concrete electrical insulation; and method of producing said electrical insulation.
US08545975B2
A solvent cast film comprises a polyimide comprising structural units derived from polymerization of a dianhydride component comprising a dianhydride selected from the group consisting of 3,4′-oxydiphthalic dianhydride, 3,3′-oxydiphthalic dianhydride, 4,4′-oxydiphthalic dianhydride, and combinations thereof, with a diamine component comprising 4,4′-diaminodiphenylsulfone; wherein the polyimide has a glass transition temperature from 190° C. to 400° C.; and wherein the film has a coefficient of thermal expansion of less than 60 ppm/° C., a thickness from 0.1 to 250 micrometers, endless than 5% residual solvent by weight.
US08545965B2
A method for manufacturing a lightweight structural trim part is comprising the following steps: (A) inserting a plurality of layers into a molding tool comprising a first molding half (6) and a second molding half (7). The second molding half (7) comprises a plurality of cup-like indentation (8). The plurality of layers at least comprises a first air permeable skin layer (1) facing the first molding half (6), a second air tight skin layer (3,4) facing the second molding half (7), and a film layer (2) between the two skin layers. (B) Closing the molding tool and discharging gas from one side in order to press the first skin layer against the first molding half. (C) Shaping and consolidating the first porous skin layer. (D) Charging with pressurized air the first space in order to press the second skin layer against the second molding half. (E) Shaping and consolidating the second skin layer. (F) Meanwhile bonding the first and second skin layer to each other in the area between the cup-like indentations, in order to form an acoustic body comprising a plurality of cup-like cavities.
US08545961B2
A ballistic-resistant molded article comprising a compressed stack of sheets comprising reinforcing elongate bodies and an organic matrix material, the direction of the elongate bodies within the compressed stack being not unidirectionally, wherein the elongate bodies are tapes with a width of at least 2 mm and a thickness to width ratio of at least 10:1 with the stack comprising 0.2-8 wt. % of an organic matrix material.
US08545958B2
A block including at least one glass ply at least partially covering an outer surface of a core made from composite material. A method for reinforcing a block made from a composite material, including a glass ply placed in a mold, such as to cover the base of the mold; the block is positioned in the mold; the edges of the glass ply are folded such that the glass ply is molded to the outer edge of the block; the mold is closed with a cover; the block housed inside the mold is cured in an oven such as to polymerize the glass ply; and the glass-ply-covered block is recovered.
US08545957B2
An optical information recording medium including a substrate; two or more recording layers provided on the substrate; and a protective layer provided on the recording layers, wherein the surface of one of the side of the substrate and the protective layer is a light irradiation plane, at least one of the recording layers other than the recording layer at the deepest position from the light irradiation plane includes W, Pd, and Cu oxides as the principal components, and the ratio of W, Pd, and Cu that are respectively included in the W, Pd, and Cu oxides satisfies the relationship 0.17≦x1 (where x1=a/(b+0.8c), where a: atomic ratio of W with respect to the total of W, Pd, and Cu, b: atomic ratio of Pd with respect to the total of W, Pd, and Cu, and c: atomic ratio of Cu with respect to the total of W, Pd, and Cu).
US08545955B2
[Problem to be solved]To obtain a display strip to which bags can be attached with sufficient holding force and from which the bags can be removed smoothly, keeping the removed surface of the bag clean.[Solution]The display strip for arranging and attaching a plurality of product-enclosed bags comprises a laminate having at least a substrate layer and a sealant layer, wherein the sealant layer comprises an olefin resin layer [(a) layer] containing no polymer grafted with a vinyl monomer and an easily peelable resin layer [(b) layer] containing an olefin-based polymer grafted with a vinyl monomer, and the (a) layer is the outermost layer of the display strip.
US08545952B2
A polyester container with enhanced gas barrier properties includes a polyester composition having an IV of 0.65 dL/g to 1.0 dL/g and including a polyester and a reactive organic gas barrier enhancing additive. The polyester is made using at least one first polycondensation catalyst, non-limiting examples of which include metals in Groups 3, 4, 13, and 14 of the Periodic Table and includes a catalyst residue remaining in the polyester from formation of the polyester. The catalyst residue includes at least a portion of the at least one first polycondensation catalyst.
US08545947B2
A transparent substrate with optical compensation ability comprises polyimide having the following chemical formula: wherein A and A′ are cyclic aliphatic or aromatic compounds, B and B′ are cyclic aliphatic or aromatic compounds. In particular, the refractive index of the transparent polyimide is nx=ny>nz, that is, it has ability of adjusting the negative type c-plate phase difference, wherein nx represents the lateral refractive index, ny represents the longitudinal refractive index, nz represents the vertical refractive index along the thickness direction, and m and n are between 10 and 10,000.
US08545943B2
A painting device for painting a curved surface (102) of an object (101), with a paint material ejection device (103), with a guide device (104, 105) and with a control device. The paint material ejection device (103) is designed for ejecting paint material. By means of the guide device (104, 105) the paint material ejection device (103) can be mechanically guided along a curved surface of an object. By means of the control device the paint material ejection device (103) and the guide device (104, 105) can be controlled in such a way that by means of guiding the paint material ejection device (103) along a predefinable path and by means of predefinable ejection of paint from the paint material ejection device (103) along the predefinable path a curved surface (102) of an object (101) to be painted can be painted.
US08545941B2
In an oven used for printing machine and the like, drying is rendered possible to be conducted without decreasing traveling speed (120 m/min or more) by a short and compact drying zone for a coating liquid agent which is made aqueous as well as oily coating liquid agent. A plurality of hot air blow-off nozzles 222 are provided in the drying portion 220 of the first printing unit 200. Heating guide rolls 223a are provided at the former portion, and cooling guide rolls 223b are provided at the latter portion, so that they meet the hot air blow-off nozzles 222. Liquid delivery pipes 224a for injecting hot water are connected to the heating guide rolls 223a, and liquid delivery pipes 224b for injecting cooling water are connected to the cooling guide rolls 223b. Introduced raw web 1 is heated to the boiling point of solvent or higher than that by the heating guide rolls 223a.
US08545940B2
A reactor configured to subject a substrate to alternately repeated surface reactions of vapor-phase reactants is disclosed. The reactor may include a reaction chamber that defines a reaction space and a gas flow control guide structure; and a substrate holder. The gas flow control guide includes one or more channels. Each of the channels widens as the channel extends from the inlet to the reaction space. At least one of the channels is configured to generate a non-uniform laminar flow at a first portion of the periphery of the reaction space such that the laminar flow includes a plurality of flow paths that provide different amounts of a fluid. The reaction chamber may include a reactor base and a reactor cover detachable from each other; and a driver configured to independently adjust at least three portions of the reactor base to provide a substantially perfect seal to the reactor space.
US08545937B2
A spray nozzle is disclosed that produces a flat spray pattern for liquid coating material, the spray pattern having a generally uniform flow distribution of quantity of coating material across the spray pattern. The spray nozzle may include a rectangular cut spray orifice to produce such a spray pattern. The spray pattern may further have distinct edges so that the pattern exhibits substantially reduced tailings of coating material outside these edges. In one embodiment, the spray pattern produces a “rectangular” drip pattern. In another embodiment, the spray pattern may include a middle region having reduced flow of coating material as compared to side regions of the spray pattern.
US08545934B2
A method of preparing composite materials by (a) containing particulates to which an adhering material is to be made to adhere, in a rotary body having a bottom surface and a side wall; (b) rotating the rotary body so as to apply centrifugal forces to the particulates in the rotary body; and (c) varying the inclination of the rotary body to an arbitrary inclination angle in the range from an angle at which the bottom surface of the rotary body forms a horizontal surface perpendicular to the direction of gravity to an angle at which the bottom surface forms a vertical surface parallel to the direction of gravity, and supporting the rotary body at the arbitrary inclination angle.
US08545933B2
A method of cooling a device, by applying a molecular fan thin film to a heat sink surface of the device, dissipating heat from the device by emitting infrared radiation, and cooling the device.
US08545931B2
A coating system with an applicator that has an air cylinder with a needle valve. A control has a timer that provides a string of electrical pulses to a solenoid. With each pulse, the solenoid applies pressurized air to a cylinder piston, thereby opening the needle valve and permitting coating material to flow past the needle valve. The needle valve is closed for durations of time between pulses, and the coating material is ejected from a dispensing needle in response to closings of the needle valve.
US08545930B2
A manufacturing method of mechanical elements comprises providing (210) of a mechanical element having a rough curved surface preferably with a surface roughness of more than Sa=0.1 μm. The method is characterized by tribochemically depositing (214) solid lubricant substance directly onto the rough curved surface in transverse directions. A mechanical element has a curved surface. The curved surface has a surface layer of a tribochemically deposited solid lubricant substance. The mechanical element is obtainable by the above method. A tool for manufacturing of such a mechanical element comprises a support portion, at least one tool working surface, means for providing a force pressing the tool towards the curved surface and driving means for moving said at least one tool working surface in two different directions along said curved surface. The working surface comprises an oxide, carbide and/or suicide of an element capable of forming a stable sulfide.
US08545928B2
A method and system for including a double layer security mark in digital document data defining an image of a document to be printed and in the printed document. A fluorescence mark region including a fluorescence mark is defined using first and second metameric colorant mixtures. Variation in colorant spatial coverage between the first and second metameric colorant mixtures results in colorant-free areas that define the fluorescence mark due to substrate fluorescence under UV illumination. The fluorescence mark region is modified to define a double layer fluorescence mark region including the fluorescence mark and also including at least one visible light object defined by a third colorant mixture. The third colorant mixture is added to the fluorescence mark region by masking the colorant-free areas of the fluorescence mark region to prevent writing of the third colorant mixture data to the colorant-free areas to avoid disturbing the colorant-free areas.
US08545918B2
A ham product and method for production thereof described herein separate bone-in hams into smaller pieces. Accordingly, pieces of bone-in ham, even those spirally-sliced, will be available to consumers in smaller portions. Unlike conventional methods, however, the ham product provides three or four pieces of essentially equal size that each have a nearly equal meat-to-bone ratio. Furthermore, when a spiral cut ham is separated into pieces, each piece includes a portion of the femur and retains attachment of the slices to the femur so that the slices stay intact during handling and packaging and so that the pieces retain the natural shape and easy handling desired by consumers.
US08545909B2
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species, ovine species and caprine species; Camelidae species such as Camelus dromedarius; porcine species; or Equidae species. The recombinant enzymes are used in milk coagulating compositions in cheese manufacturing based on cow's milk and milk from any animal species which are used in cheese manufacturing including camel's milk.
US08545902B2
Compositions for improved delivery of plant-derived cathartics are disclosed. In one aspect, the compositions comprise a plant-derived cathartic and an effervescence coupling system that, when dissolved into an aqueous medium such as water, produce an effervescent liquid cathartic composition. In another aspect, the compositions comprise a solid dosage form that dissolves or disperses in an aqueous medium to produce a liquid composition that is administered to an individual. The liquid compositions are not only more appealing to a consumer, but also improve the amount and bioavailability of active cathartic components. The cathartic composition is administered to an individual alone or in combination with one or more agents that promote additional laxation, digestion or gastrointestinal health, and/or improve the effectiveness of the plant-derived cathartic composition.
US08545898B2
A composition for a broad-spectrum antiviral agent with excellent preservation stability, which comprises a pure chlorine dioxide solution comprising a chlorine dioxide gas dissolved therein, a chlorite, and a pH adjuster.
US08545886B2
The invention is directed to a Pharmaceutical extended release system, particularly for oral administration, of a pH-dependent water-soluble active substance, comprising or essentially consisting of a) flibanserin or a pharmaceutically acceptable derivative thereof as active substance; b) one or more pharmaceutically acceptable pH-dependent polymers; c) one or more pharmaceutically acceptable pH-independent polymers; d) one or more pharmaceutically acceptable acids; and e) optionally one or more additives. The present invention provides a release profile of flibanserin which is independent on the pH in the gastrointestinal tract when administered orally resulting in a significantly improved bioavailability.
US08545883B2
An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
US08545873B2
A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is ⅓ times by mass to 4 times by mass as that of the rosin-based resin.
US08545871B2
Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.
US08545870B2
The invention concerns a medicinal tablet to be sucked made with boiled sugar of solid consistency designed to dissolve in the buccal cavity, comprising at least an active principle. The invention is characterized in that it further comprises at least a matrix agent for slowing down the release of the active principle(s) which therefore remain in prolonged contact with the region of the mouth and the pharynx, the dissolving time in the buccal cavity being at least 15 minutes.
US08545867B2
According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
US08545863B2
Controlling insects of the superfamily of the Psylloidea in horticultural and/or agricultural crops, by using bicarbonate and carbonate salts.
US08545861B2
A fibrous web, in particular tissue web treated with a lotion composition based on an O/W emulsion comprising: (A) at least one oil; (B) an (O/W) emulsifier or (O/W) emulsifier combination; and (C) 6 to 30 weight % of water; wherein the weight % values relate to the total weight of the lotion composition. Since in the above lotion composition the external phase is aqueous, a web treated therewith can easily be wet by water and does not float on the water if it is to be disposed in a toilet.
US08545856B2
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
US08545853B2
It refers to a recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, comprising a deletion in the stem domain, wherein at least one heterologous sequence is inserted in a region selected from the group consisting of regions defined by amino acid position of 108 to 151, 1 to 5, 288 to 293, 43 to 48, 235 to 240, 92 to 97, 31 to 36,or 156 to 161 of SEQ ID NO: 1, with the proviso that, if the heterologous sequence contains five or more consecutive histidines the moiety of the heterologous sequence other than the moiety of five or more consecutive histidines has a minimum length of 11 amino acids; or a variant thereof comprising 1-50 amino acids added, substituted or deleted in SEQ ID NO. 1 and the activity to form oligomers and to bind to lipidic bilayers. It also provides a medicament and vaccine comprising said recombinant polypeptide.
US08545832B2
The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.
US08545827B2
The present invention is related to an aqueous conditioning composition for hair comprising at least one alkyl glyceryl ether and at least one arylated silicone. Conditioning composition of the present invention can be in the form of a shampoo, cleansing—conditioning composition, or in the form of a conditioner used after washing hair with cleansing compositions. It has surprisingly been found out that a composition comprising at least one alkyl glyceryl ether and at least one arylated silicone gives hair shine, and hair treated with such a composition looks attractive and has its natural excellent shine, volume and body, elasticity, smoothness and it is easily manageable. Accordingly, the present invention is on a conditioning composition for hair comprising at least one alkyl glyceryl ether and at least one arylated silicone.
US08545823B2
A cosmetic composition for caring for and/or making up the skin, lips and/or body in the form of a film, which is non-transferable, long-lasting with a comfortable feeling of use to consumers over long periods of wear time. The composition contains graftable POSS which forms a film when it cures in situ. The invention also relates to using such film for preparing a cosmetic composition and a makeup process and makeup kit comprising the product.
US08545815B2
Certain surfactants suitable for use alone to dissolve a water-insoluble component in compositions is described for providing VOC-free compressed gas aerosol compositions. The compositions include water-insoluble component(s), a surfactant and water. The water-insoluble component(s) can be active agent(s), such as fragrance(s) and/or an insecticide(s). The surfactant is present as a single surfactant which, in the absence of a solvent, dissolves or disperses the water-insoluble component(s) and provides a homogenous blend in water which provides a stable compressed gas emulsion. The surfactant is an anionic surfactant or a nonionic surfactant, in particular nonionic alkylpolyglycosides; nonionic cocoglucoside; nonionic alkylene oxide extended chain alkylpolyglycosides; anionic sodium lauryl ether sulfate (SLES), nonionic C13-C15 oxoalcohol ethoxylate with 8 ethylene oxides (EO), nonionic C12-C14 secondary alcohol ethoxylate with 7EO or 12EO, polyethylene glycol (PEG) hydrogenated castor oil wherein the PEG is PEG-60 or PEG-40, polyglyceryl-10 laurate and polyglyceryl-6 caprylate.
US08545811B2
The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
US08545803B2
Modified molecular sieve characterized by improved sodium-resisting contamination activity and preparation method thereof are provided. The method comprises: adding molecular sieve in phosphorus-containing organic solution, and reacting for 10-200 minutes at temperature of 70-200° C. and pressure of 0.2-1.2 MPa, and then filtering, drying and calcining. The said modified molecular sieve contains 90-99 wt. % molecular sieve as dry basis and 1-10 wt. % phosphorus as oxide. The said method can improve the capability of sodium-resisting contamination effectively, and its technology is simple and fits the existing catalyst production apparatus and process. The said modified molecular sieve has high sodium-resisting contamination activity, and the model catalyst by sodium contamination has high activity retention.
US08545801B1
This disclosure is directed to a method for preparing a new crystalline molecular sieve designated SSZ-87, which is synthesized using an N,N′-diisopropyl-N,N′-diethylbicyclo[2.2.2]oct-7-ene-2,3:5,6-dipyrrolidinium dication as a structure directing agent.
US08545796B2
The invention is directed to compositions and processes for the production of silica-stabilized ultrafine anatase titanias and which may further comprise tungsten and vanadia. The surface stabilization may be by treatment of the TiO2 particles with a low molecular weight and/or small nanoparticle form of silica such as, in preferred embodiments, a tetra(alkyl)ammonium silicate or silicic acid, which serves to efficiently maintain the anatase phase and prevent crystal growth under severe thermal and hydrothermal conditions, even in the presence of vanadia. The vanadia catalysts produced from the novel titanias have equal or improved catalytic activity for selective catalytic reduction of NOx compared to conventional vanadia supported silica-titania based catalysts. The invention is further directed to diesel emission catalytic devices comprising the novel titania-based catalyst compositions.
US08545786B2
Methods for producing porous tricalcium phosphate net-shaped material are provide. The methods involve preparing a reactant mixture comprising calcium oxide and phosphorus pentoxide in a mole percent ratio that allows the mixture to form tricalcium phosphate upon combustion thereof, forming this mixture into a desired final shape in a die with compression, and carrying out a combustion synthesis therewith. Net-shaped TCP materials of the combustion synthesis, comprising alpha tricalcium phosphate or mixtures of alpha and beta tricalcium phosphate, are optionally further treated to effect transition of the alpha phase to the beta phase. The net-shaped TCP materials can have a uniform or non-uniform porosity.
US08545783B2
There is provided an acid gas absorbent having excellent performance of absorbing acid gas such as carbon dioxide, and an acid gas removal device and an acid gas removal method using the acid gas absorbent. An acid gas absorbent of an embodiment contains at least one type of tertiary amine compound represented by the following general formula (1). (In the above formula (1), the cycle A represents a cyclic structure whose carbon number is not less than 3 nor more than 8. R1, R2 and R3 each represent an alkyl group whose carbon number is 1 to 4, and R4 represents a hydroxyalkyl group. R1 and R2 are groups coupled to carbon atoms adjacent to a carbon atom forming the cycle A and coupled to a nitrogen atom.)
US08545782B1
A CO2 recovery apparatus includes a desulfurization tower which includes a desulfurization unit and a cooling unit, an absorption tower which includes a CO2 absorption unit and an acid washing unit, a regeneration tower, and an acid water production device configured to produce acid water by causing exhaust gas yet to be introduced into the desulfurization to come into contact with water. In the CO2 recovery apparatus, the water to be come in contact with the exhaust gas is condensed water that is generated in the desulfurization tower, the absorption tower, or the regeneration tower.
US08545781B1
The carbon dioxide adsorbent composition relates to a material that will adsorb carbon dioxide gas from the atmosphere and that is made by the treatment of oil fly ash with ammonium hydroxide. In order to make the carbon dioxide adsorbent, oil fly ash is first mixed with ammonium hydroxide. This mixture is then refluxed and cooled. Additional ammonium hydroxide is added to the cooled mixture of oil fly ash and ammonium hydroxide to form a secondary mixture. This forms an amine-functionalized fly ash composition, which is then filtered from the secondary mixture to be used as a carbon dioxide adsorbent composition. The carbon dioxide adsorbent composition is then dried and may be used as a carbon dioxide adsorbent for gas streams, such as flues and exhaust systems, containing carbon dioxide.
US08545780B1
A catalyst material including a catalyst carrier including a porous alumina support and a hindrance layer on the alumina support, the hindrance layer comprising one or more of a sulfate, carbonate, hydroxide, or oxide of barium, strontium, or calcium is described. The catalyst carrier further includes a rare earth oxide. The catalyst material can further comprise a platinum group metal. The catalyst material is useful for methods and systems of abating pollutants from automotive exhaust gas.
US08545776B2
The invention provides a method of inhibiting the accumulation of DSP scale in the liquor circuit of Bayer process equipment. The method includes adding one or more particular silane based small molecules to the liquor fluid circuit. These scale inhibitors reduce DSP scale formation and thereby increase fluid throughput, increase the amount of time Bayer process equipment can be operational and reduce the need for expensive and dangerous acid washes of Bayer process equipment. As a result, the invention provides a significant reduction in the total cost of operating a Bayer process.
US08545774B2
An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.
US08545769B2
A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.
US08545768B2
A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample.
US08545763B2
A catalytic converter substrate structure includes an outer peripheral wall having a first end and a second end. A plurality of cells are defined by walls that are disposed within the outer peripheral wall and are interconnected to the outer peripheral wall. The plurality of cells extend axially along a length of the outer wall and have a varying density.
US08545761B2
The present disclosure provides a sensor device. The sensor device may include an intake port for an air sample connected to a mixing chamber. The mixing chamber may contain at least one device for the introduction of a liquid or gel detection improvement agent, or at least one mechanical dispersal device for the introduction of a solid detection improvement agent. The detection improvement agent may be operable to interact with a chemical or biological agent in the air sample. The mixing chamber may also include at least one heating or cooling plate and at least device for the introduction of water or an aromatic solvent into the air sample as well as at least one detection element able to detect a chemical or biological agent in the air sample. The mixing chamber may be connected to an exhaust port.
US08545753B2
An ultra-violet lamp and reflector/shield assembly designed to be mounted in a commercial HVAC, and to other types of A/C units is described herein. The reflector/shield includes a reflective inner surface creating an illumination pattern and an outer surface shielding the UV lamp from the air flow. An orienting and securing assembly for a UV lamp is also described herein.
US08545749B2
The invention comprises a method of making a cement-based object or structure having a compressive strength greater than about 1,000 psi. The method comprises placing a cement-based material in an insulated concrete form, wherein the insulated concrete form has an R-value of at least 1.5, wherein the cement-based material comprises approximately 10% to approximately 80% by weight portland cement, and at least one of approximately 10% to approximately 90% by weight slag cement and approximately 5% to approximately 80% by weight fly ash. The invention also comprises a method of making a cement-based object or structure. The invention further comprises objects or structures made by the foregoing methods.
US08545746B2
A method of making a substrate having multi-layered structures thereon, the method comprising the steps of (a) applying a mold having an imprint forming surface to the substrate to form an array of imprint structures that projects from the substrate; and (b) applying a lateral force that is substantially normal to said projecting imprint structures to cause said imprint structures to move angularly towards said substrate and thereby form a pattern of multi-layered structures thereon.
US08545741B2
Provided are methods of manufacturing microstructures, in which at least one viscous composition each containing at least one active ingredient is disposed directly or indirectly on a first substrate and/or a second substrate and the viscous composition(s) is elongated between the first and second substrates. The methods are simpler and more cost-effective.
US08545733B2
Disclosed is a process for the manufacture of glass-crystalline particles comprising a glass component and a crystalline component comprising the steps of: a) providing a precursor solution comprising a solvent, a glass component composition, and a crystalline component composition; b) forming an aerosol comprising finely divided droplets of the precursor solution, wherein the droplet concentration which is below the concentration where collisions and subsequent coalescence of the droplets results in a 10% reduction in droplet concentration; c) heating the aerosol wherein, upon heating, glass-crystalline particles are formed, wherein the glass-crystalline particles comprise a glass component and a crystalline component, and wherein the crystalline component comprises one or more metal oxides; and d) isolating the glass-crystalline particles.
US08545717B2
The present invention relates to a composition comprising a curable dichroic dye and a curable liquid crystal compound, which are used to prepare an optical component that is vertically oriented to give a narrow viewing angle, to form an optical component, and an optical component comprising an optical component layer prepared using the same. There is provided a composition for forming an optical component comprising 0.1-90 parts by weight of a dichroic dye and 10-98.85 parts by weight of a curable liquid crystal compound, and there is also provided an optical component comprising an optical component layer in which a curable liquid crystal compound and a curable dichroic dye are vertically oriented. The optical component comprising an optical component layer in which a curable dichroic dye and a curable liquid crystal compound are vertically oriented and which is made of the composition comprising a curable dichroic dye and a curable liquid crystal compound for forming an optical component has excellent physical properties such as heat resistance, durability to high temperature and high moisture, vertical orientation and dichroic ratio, and also adjust a narrow viewing angle. The durability in the high temperature and high moisture is due to the cross linking shape of the optical component layer.
US08545697B2
A device for the treatment of waste material in a waste water collection system includes an inner core and an outer portion partially surrounding the inner core such that at least one surface of the inner core is exposed. The inner core has a greater water solubility than the outer portion.
US08545694B2
An improved aromatics saturation process for use with lube oil boiling range feedstreams utilizing a catalyst comprising a hydrogenation-dehydrogenation component selected from the Group VIII noble metals and mixtures thereof on a mesoporous support having aluminum incorporated into its framework and an average pore diameter of about 15 to less than about 40 Å.
US08545685B2
Provided is a cleaning process of producing lactic acid. Firstly saccharification liquid is prepared through saccharated materials, then fermented with nutritive materials and lactic acid bacteria, and liquid alkali is used to adjust the pH. The fermentation broth is filtrated with porous membrane, and the lactic acid bacteria in the interception liquid are then reintroduced into the porous membrane for recycling. The permeate from porous membrane is subjected to nanofiltration to be decolored and purified. The concentrated solution from nanofiltration and the cleaning liquid from fermentation tank and its affiliated equipment are filtrated and sterilized by using ceramic membrane, and then are reintroduced into the fermentation unit for recycling. The permeate from nanofiltration is then subjected to bipolar electrodialysis system to prepare lactic acid, and the liquid alkali produced at the same time is reintroduced into the fermentation tank for recycling. The lactic acid is finally concentrated by using vacuum distillation. The process recycles the bacteria in the liquid alkali and matured fermentation broth, and is characterized by low material consumption and emission, low pollution, reduced cost and cleanness and environmentally protection of the whole production process.
US08545684B2
Disclosed herein is a method of making a sensing element comprising forming an electrically conductive element, wherein the sensing element comprises a metal selected from the group consisting of Pd and alloys and combinations comprising Pd; and wherein the electrically conductive element is thermally stable at temperatures as high as 1,200° C.
US08545679B2
A system for recovering hydrocarbons from tar sands includes a heated enclosure 66, one or more input conveyors 60, 67 move tar sands through the heated enclosure, provide a flow line with a temperature gradient of at least 150 F.°, and mechanically move the tar sands along the flow line. A heated rotary drum 74 is in fluid communication with the flow line, and condenser unit 94, 98 receive vapors from the flow line and the rotary drum and output hydrocarbons. One or more discharge conveyors 76 discharge stripped sands from the rotary drum. Control valves 80, 82 seal a vacuum downstream from the discharge conveyors, and control valves 34, 46 seal vacuum upstream from the one or more input conveyors. Various types of vacuum pumps may be used to maintain a selected vacuum between the control valves.
US08545662B2
An apparatus and method in which an insert with an undercut is mechanically coupled to a lay up mold for translated movement between an engaged position for molding with an undercut engaging the material to be molded and a remote position in which a resultant molded product maybe removed and the material may be laid up without interference with the undercut, preferably with the mechanical coupling allowing for hinged movement of the insert relative the lay up mold.
US08545657B2
A method for forming a composite structure according to one embodiment includes forming a first ply; and forming a second ply above the first ply. Forming each ply comprises: applying a bonding material to a tape, the tape comprising a fiber and a matrix, wherein the bonding material has a curing time of less than about 1 second; and adding the tape to a substrate for forming adjacent tape winds having about a constant distance therebetween. Additional systems, methods and articles of manufacture are also presented.
US08545646B1
The present disclosure relates to a high-density rocket propellant and associated recoilless launching systems and methods with tungsten powder added providing substantial mass to the propellant for additional impulse, absorption of sound, optimization of back blast and carry weight, and the like. In an exemplary embodiment, the high-density rocket propellant includes tungsten mass percentages of between about 70%-about 80%, equivalent to about 17%-about 26% by volume.
US08545629B2
Bulk single crystals of AlN having a diameter greater than about 25 mm and dislocation densities of about 10,000 cm−2 or less and high-quality AlN substrates having surfaces of any desired crystallographic orientation fabricated from these bulk crystals.
US08545628B2
The present invention relates to methods and apparatus that are optimized for producing Group III-N (nitrogen) compound semiconductor wafers and specifically for producing GaN wafers. Specifically, the methods relate to substantially preventing the formation of unwanted materials on an isolation valve fixture within a chemical vapor deposition (CVD) reactor. In particular, the invention provides apparatus and methods for limiting deposition/condensation of GaCl3 and reaction by-products on an isolation valve that is used in the system and method for forming a monocrystalline Group III-V semiconductor material by reacting an amount of a gaseous Group III precursor as one reactant with an amount of a gaseous Group V component as another reactant in a reaction chamber.
US08545626B2
A method for efficiently producing a plate-like nitride semiconductor crystal having the desired principal plane in a simple method is provided. A raw material gas is fed to a seed crystal in which a ratio (L/W) of length L in a longitudinal direction and maximum width W, of a plane of projection obtained by projecting a crystal growth face on the seed crystal in a growth direction is from 2 to 400, and the maximum width W is 5 mm or less, thereby growing a plate-like semiconductor crystal on the seed crystal.
US08545620B2
The invention relates to an inorganic binder system comprising a) calcium silicate cement, b) calcium aluminate cement, c) at least one trifunctional polyalkylene glycol and d) optionally calcium sulphate. Additionally disclosed is the use of at least one polyalkylene glycol as an accelerator for an inorganic binder system comprising a) calcium silicate cement, b) calcium aluminate cement and d) optionally calcium sulphate.