US08604516B2
A first group III nitride semiconductor layer has a low carbon concentration region having a carbon concentration of less than 1×1017 cm−3, and located in a region under an edge of a gate electrode closer to a drain electrode, a thickness d2 of the low carbon concentration region satisfies Vm/(110·d1)≦d2
US08604514B2
The present teachings provides a bipolar semiconductor device comprising: a main cell region consisting of a trench gate type element region; and a sense cell region including a planar gate type element region.
US08604512B2
A bidirectional switch includes a semiconductor element and a substrate potential stabilizer. The semiconductor element includes a first ohmic electrode and a second ohmic electrode, and a first gate electrode and a second gate electrode, which are sequentially formed on the first ohmic electrode between the first ohmic electrode and the second ohmic electrode. The substrate potential stabilizer sets a potential of the substrate lower than higher one of a potential of the first ohmic electrode or a potential of the second ohmic electrode.
US08604508B2
A high power LED lamp has a GaN chip placed over an AlGaInP chip. A reflector is placed between the two chips. Each of the chips has trenches diverting light for output. The chip pair can be arranged to produce white light having a spectral distribution in the red to blue region that is close to that of daylight. Also, the chip pair can be used to provide an RGB lamp or a red-amber-green traffic lamp. The active regions of both chips can be less than 50 microns away from a heat sink.
US08604499B2
Provided is a light-emitting device provided with a light reflection layer which has a high light reflectivity and which is less susceptible to deterioration of the reflectivity due to corrosion, and having an improved light extraction efficiency.A light-emitting device comprising a substrate having a conductor layer formed on its surface and a light-emitting element disposed on the conductor layer, characterized in that an overcoat layer is formed between the conductor layer and the light-emitting element, and the overcoat layer is a borosilicate glass which comprises, as represented by mol % based on oxides, from 62 to 84% of SiO2, from 10 to 25% of B2O3, from 0 to 5% of Al2O3 and from 0 to 5% in total of at least one of Na2O and K2O, provided that the total content of SiO2 and Al2O3 is from 62 to 84%, and may contain from 0 to 10% of MgO and at least one of CaO, SrO and BaO in a total content of at most 5%.
US08604490B2
An organic EL device includes a first substrate and a plurality of organic EL elements above a first portion of the first substrate. A first inorganic layer covers the plurality of organic EL elements. An active layer is above a second portion of the first substrate that is different than the first portion. The active layer comprises a material that is at least one of hygroscopic and oxidizable. A second inorganic layer covers the active layer. A second substrate is opposite the first substrate, with the plurality of organic EL elements being between the first and second substrates. A seal extends between the first and second substrates to define a sealed space between the first and second substrates. The second inorganic layer includes through-holes that expose the active layer to the sealed space that is defined by the first substrate, the second substrate, and the seal.
US08604489B2
A mask frame assembly for thin film deposition includes a frame including an opening portion, and a plurality of unit mask strips that are fixed to the frame after a tensile force is applied to both of end portions of the unit mask strips in a lengthwise direction of the unit mask strips. Each of the plurality of unit mask strips includes a plurality of unit masking pattern portions each including a plurality of opening patterns. Before the tensile force is applied to both of the end portions of the unit mask strips in the lengthwise direction and the unit mask strips are fixed to the frame, a width of each of the unit masking pattern portions in a widthwise direction perpendicular to the lengthwise direction increases as a function of a closeness of a portion of the unit masking pattern portion where the width is measured to a central portion of each of the unit masking pattern portions.
US08604477B2
A pixel structure and a manufacturing method thereof are provided. In the pixel structure, an electrode of a storage capacitor is formed when an active layer is formed, and the electrode and the active layer are made of the same material. The material of the electrode and the active layer can be an oxide semiconductor with high transmittance. Therefore, a stable display frame of the pixel structure can be provided by the storage capacitor, an aperture ratio of the pixel structure can be improved, and power consumption can be further reduced.
US08604474B2
One type of a semiconductor device integrating with a monitoring device is disclosed. The device includes a plurality of gate fingers, two of which arranged in a center of the device has a space wider than a space between any other fingers to suppress the heat concentration on the center of the device. The monitoring region is arranged in this wider space to monitor the temperature dependence of the device.
US08604473B2
An object is to provide a UV sensor with high accuracy, which can be manufactured at low cost and formed over a flexible substrate. A semiconductor device includes a transistor having an oxide semiconductor film, and a voltage source electrically connected to a gate of the transistor, in which a threshold voltage of the transistor is changed by irradiating the oxide semiconductor film with UV rays; a change in the threshold voltage of the transistor is dependent on a wavelength of the UV rays with which the oxide semiconductor film is irradiated, and the voltage source adjusts a voltage output to the gate of the transistor.
US08604470B2
An oxide thin film transistor (TFT) and a fabrication method thereof are provided. The method for fabricating an oxide thin film transistor (TFT) comprises: forming a gate electrode on a substrate; forming a gate insulating layer on the substrate with the gate electrode formed thereon; forming an active layer made of oxide semiconductor on the gate insulating layer; forming a contact layer on the substrate with the active layer formed thereon and forming source and drain electrodes, which are electrically connected with source and drain regions of the active layer through the contact layer, on the contact layer; forming a protective layer on the substrate with the source and drain electrodes formed thereon; forming a contact hole by removing the protective layer to expose the drain electrode; and forming a pixel electrode electrically connected with the drain electrode through the contact hole, wherein the contact layer is made of oxide including a different metal or conductivity with that of the source and drain electrodes, to adjust a threshold voltage according to the difference in a work function.
US08604467B2
An organic electro-optical component, with an electrode, counter-electrode, and organic region made up of one or more organic materials, which is in electrical contact and in an active region overlapping with the electrode and the counter-electrode, wherein the electrode and/or the counter-electrode have part electrodes which extend from a part electrode connecting section which is arranged outside of the active region, a distal electrode section is electrically connected via a proximal electrode section to the part electrode connecting section, the distal electrode section is formed at least in sections within the active region, and the proximal electrode section is formed outside of the active region and by means of an electrical pathway, the pathway length of which is larger than the shortest distance between an end of the distal electrode section facing the part electrode connecting section and the part electrode connecting section.
US08604461B2
A semiconductor device may include a doped semiconductor region having a modulated dopant concentration. The doped semiconductor region may be a silicon doped Group III nitride semiconductor region with a dopant concentration of silicon being modulated in the Group III nitride semiconductor region. In addition, a semiconductor active region may be configured to generate light responsive to an electrical signal therethrough. Related methods, devices, and structures are also discussed.
US08604454B2
An energy modulator for use with a particle source that provides a beam of particles includes a first block moveable between a first position and a second position, wherein when the first block is at the second position, it is in a path of the beam, and a second block moveable relative to the first block, wherein the second block and the first block are offset from each other in a direction of the beam, wherein the first block has a first energy absorption characteristic, and the second block has a second energy absorption characteristic that is different from the first energy absorption characteristic.
US08604435B2
A radiation sensor (27) includes a radiation sensor chip (1) including first (7) and second (8) thermopile junctions connected to form a thermopile (7,8). The first thermopile junction is disposed in a floating portion of a dielectric membrane (3) thermally insulated from a silicon substrate (2) of the chip, and the second thermopile junction is disposed in the dielectric membrane directly adjacent to the substrate. Bump conductors (28) are bonded to corresponding bonding pads (28A) coupled to the thermopile (7,8) to physically and electrically connect the chip to conductors on a printed circuit board (23). The silicon substrate transmits infrared radiation to the thermopile while blocking visible light.
US08604434B2
A radiological image imaging apparatus includes: a radiation detection unit configured to detect radiation; a housing configured to contain the radiation detection unit; and a photo timer fixing member configured to fix a photo timer light receiving unit for measuring the radiation dose to the housing; wherein the photo timer fixing member is positioned such that the photo timer light receiving unit can be detached by separating cover members that form the surface of the housing.
US08604433B2
An apparatus for analyzing, identifying or imaging an target including first and second laser beams coupled to a pair of photoconductive switches to produce CW signals in one or more bands in a range of frequencies greater than 100 GHz focused on and transmitted through or reflected from the target; and a detector for acquiring spectral information from signals received from the target and using a multi-spectral heterodyne process to generate an electrical signal representative of some characteristics of the target. The lasers are tuned to different frequencies and a frequency shifter in the path of one laser beam allows the terahertz beam to be finely adjusted in one or more selected frequency bands.
US08604430B2
The inspection apparatus disclosed generates an electron beam, an acceleration electrode accelerates the electron beam, a convergence lens converges the electron beam, an electron beam deflector scans the beam over a sample, an objective lens converges the electron beam on the sample, a detector located between the sample and the objective lens detects charged particles emitted from the sample, a power supply applies a retarding voltage to the sample for decelerating the electron beam to the sample, an electrode is disposed between the objective lens and the sample, and a voltage is generated between the sample and the electrode by said electrode, the voltage being determined depending on the sample. The apparatus solves problems encountered in conventional inspection systems.
US08604428B2
A method of controlling particle absorption on a wafer sample and charged particle beam imaging system thereof prevents particle absorption by grounding the wafer sample and kept electrically neutral during the transfer-in and transfer-out process.
US08604426B2
Radical anions for use in the fragmentation of positively charged biopolymer ions by means of electron transfer are produced from substances previously unknown for use as ETD production substances. The inventive substances produce radical anions that lead to electron transfer dissociations with a high yield of fragment ions. The substances have high volatility that allows them to be kept in unheated containers outside the vacuum system and transported into the vacuum system to an in vacuum electron attachment ion source via unheated lines and low molecular weights that allow the measurement of even very light fragment ions. In one embodiment, a suitable substance is 1-3-5-7-cyclooctatetraene.
US08604418B2
A method is provided for reducing particle contamination in an ion implantation system, wherein an ion implantation system having source, mass analyzer, resolving aperture, decel suppression plate, and end station is provided. An ion beam is formed via the ion source, and a workpiece is transferred between an external environment and the end station for ion implantation thereto. A decel suppression voltage applied to the decel suppression plate is modulated concurrent with the workpiece transfer, therein causing the ion beam to expand and contract, wherein one or more surfaces of the resolving aperture and/or one or more components downstream of the resolving aperture are impacted by the ion beam, therein mitigating subsequent contamination of workpieces from previously deposited material residing on the one or more surfaces. The contamination can be mitigated by removing the previously deposited material or strongly adhering the previously deposited material to the one or more surfaces.
US08604406B2
The low power image sensor includes: an image sensing unit which senses light from an object, converts the light into an electric signal, and outputs the electric signal; a comparing unit which receives an electric signal from the image sensor, compares a voltage level of the electric signal with a reference voltage, and outputs an image signal as a 1 bit signal per pixel; and an effective image adjuster which compares bit value distribution of an image signal output from the comparing unit with a preset effective range, and adjusts the reference voltage to output an effective image. Further, an optical pointing device includes: an image sensor which senses light from an object and outputs an image signal; and a motion computing unit which receives the image signal and compares before and after images to calculate a motion vector.
US08604402B2
An afterbody device for a spacecraft fitted with at least one rocket engine at the rear of the craft includes at least one movable cover element designed to take a first position, masking and reducing the vehicle's rear drag, where it prolongs the vehicle's fuselage around at least one part of a rocket engine nozzle of the vehicle and extends beyond the rear of the vehicle's fuselage, and to take a second position fully deployed, increasing the vehicle's aerodynamic drag.
US08604401B2
A microwave heating construct for preparing a food item having a periphery that is desirably browned and/or crisped includes a substantially planar base and a plurality of side walls extending upwardly from a periphery of the base. The base and side walls define an interior space for receiving the food item. The base includes a plurality of movable portions for being moved out of the plane of the base into the interior space towards the periphery of the food item. A microwave energy interactive material may be joined to at least a portion of the base including the movable portions. The microwave energy interactive material may be operative for converting at least a portion of impinging microwave energy into heat.
US08604392B1
A hydration system comprises a bladder assembly defining a bladder chamber, a hose assembly, and a heating system comprising a heating element defining a loop portion. Liquids flow from the bladder chamber to the hose assembly. The loop portion is arranged within the hose assembly such that current flowing through the heating element inhibits freezing of liquids within at least a portion of the hose assembly.
US08604389B2
A welding system is disclosed in which the rate of advancement of wire electrode is determined automatically. The device can include a control circuit that determines the rate of advancement of the wire electrode in response to a signal from the voltage selection device of the welding system. Depending upon the operator selected voltage which is selected via the voltage selection device, the control circuit will determine the appropriate rate of wire electrode advancement and control the advancement mechanism (e.g., electric motor) accordingly. Linking of the voltage level and wire-feed speed controls facilities easy of use for more novice operators and, furthermore, facilitates single-handed adjustment of two operational parameters during a welding process.
US08604384B2
Methods and systems for creating and controlling an AC output for welding, plasma cutting or heating are provided. One embodiment of the present disclosure achieves a desired square wave AC output and reduces the number of circuit components needed by combining components of a buck converter and a full bridge inverter. Current flow paths through a power control circuit that are generated via switching of transistors in the circuit on and off are provided. In one embodiment, a pulse width modulation leg, which controls the level of current flow through an inductor, is provided. Certain embodiments include a bidirectional buck converter that converts an unregulated DC flow to a regulated DC flow through an inductor. In one embodiment, a steering leg is provided, which controls a direction of current flow through the inductor. Additionally, an output clamp circuit, which suppresses the parasitic load inductance during polarity reversal is provided.
US08604377B2
Disclosed is an automatic transfer switch. According to the exemplary embodiment of the present invention, the automatic transfer switch alternatively supplying power from a commercial power terminal and an emergency power terminal to load terminals by moving a pair of movable contactors, wherein at least one of the pair of movable contactors are integrally formed with the commercial power terminal or the emergency power terminal through a wire made of a flexible material.
US08604376B2
An electrical switch has a fixed contact and a moving contact moving between a first position in contact with the fixed contact and a second position not in contact with the fixed contact. An operating mechanism moves the moving contact and includes a resiliently biased presser resiliently pressing upon the moving contact while riding in opposite first and second directions past a barrier associated with the moving contact, and a spring having first and second parts acting on first and second sides of the presser to maintain the presser in a neutral position and providing extra biasing force to assist the presser in moving faster upon riding past the barrier.
US08604374B2
An energy transfer system absorbs impact forces and/or energy from a moveable conductive blade directly attached to a moveable contact in a circuit breaker. The energy transfer system includes a rotatable member and a biasing member. The rotatable member has an axis of rotation about which the rotatable member is rotatable between a first position and a second position. The rotatable member further includes a protrusion. The protrusion has an initial curved engagement surface portion, a planar engagement surface portion next to the initial curved engagement surface portion, and a final curved engagement surface portion next to the planar engagement surface portion. The biasing member biases the rotatable member towards the first position. The movable conductive blade impacts the initial curved engagement surface portion to cause the rotatable member to begin to rotate about the axis of rotation such that the moveable conductive blade then contacts the planar engagement surface portion and then the final curved engagement surface portion.
US08604373B2
An electronic device includes a housing and a power button assembly mounted on the housing. The housing defines an assembly hole and an assembly portion around the assembly hole, and the assembly portion includes a side wall. The power button assembly includes a pressing button received in the assembly hole, a printed circuit board, and a support plate connected to the printed circuit board. The support plate is fixed on the housing, such that the printed circuit board is positioned opposite the pressing button. The support plate includes a plurality of positioning portions bent towards the printed circuit board along an imaginary outline corresponding to the side wall, respectively, and the positioning portions are inserted in the assembly portion and abut the side wall correspondingly.
US08604372B2
A push button for mounting on a shell includes a button body depressibly engaged in a through hole defined in the shell, a flexible circuit board, a rigid plate attaching to the shell and a conductive spring tab. The flexible circuit board is arranged between the a button body and the rigid plate. The flexible circuit board is brought into contact with the rigid plate. The flexible circuit board is electrically connected to a connector and includes a pair of normally-open contacts. The conductive spring tab is fixed to the flexible circuit board and aligned with the button body. The conductive spring tab is deformable. The button body is configured for being manually depressed so as to urge the conductive spring tab to deform and contact the pair of normally-open contacts, thereby generating a signal transmittable through the flexible circuit board to the connector.
US08604361B2
A thermally insulated electronic component package and an instrument suitable for process conditions in a high temperature environment are disclosed. The component package includes a thin electronic component, a thermally insulating outer enclosure, and an insert made of a thermally insulating material that is sized and shaped to fit within the outer enclosure. The insert includes an inner cavity sized and shaped to receive the thin electronic component. In the instrument, the outer enclosure can be configured to mount to a substrate.
US08604360B2
A sealing body for a cable sleeve for an optical fiber cable is disclosed. The sealing body has a central, cylindrical sealing body segment. The central, cylindrical sealing body segment has, on an outer casing surface, a plurality of cutouts distributed over the circumference thereof, in each case one cylinder-segment-like sealing body segment being capable of being inserted into each of the cutouts of the central sealing body segment, and in each case one cable insertion opening for receiving and individually sealing off in each case one single cable being formed between the central sealing body segment and each cylinder-segment-like sealing body segment. Each of the cylinder-segment-like sealing body segment has a gel-like sealing element, which can be compressed individually independently of the sealing elements of other cylinder-segment-like sealing body segments in order to individually seal off the cable inserted into the respective cable insertion opening.
US08604359B2
A package substrate includes a core board, a first dielectric layer, a second circuit pattern, a first solder mask and an insulating layer. A first circuit pattern is disposed on a first surface of the core board. The first dielectric layer covers the first circuit pattern. The second circuit pattern is located on the first dielectric layer and the second circuit pattern includes an interconnection circuit pattern within a chip mounting area. The first solder mask covers a portion of the second circuit pattern outside the chip mounting area. The insulating layer covers the chip mounting area and the interconnection circuit pattern. A plurality of embedded bump pads are located on an upper surface of the insulating layer.
US08604348B2
A packaged microelectronic element includes connection component incorporating a dielectric layer (22) carrying traces (58) remote from an outer surface (26), posts (48) extending from the traces and projecting beyond the outer surface of the dielectric, and pads (30) exposed at the outer surface of the dielectric layer, the pads being connected to the posts by the traces. The dielectric element overlies the front surface of a microelectronic element, and contacts (74) exposed on the front surface of the microelectronic element are connected to the pads by elongated leads (76) such as wire bonds. Methods of making the connection component are also disclosed.
US08604344B2
A cable clamp includes a board and a cover. The board forms a block on a top surface and at a first end of the board, and an L-shaped inserting portion on a bottom surface. A hook extends out from a second end of the board. The cover has a first end pivotably connected to the second end of the board, and a second end detachably engaged with the block.
US08604333B2
Glass reflectors for concentrating sunlight in a solar energy system are disclosed. A concave mold is used to shape the glass reflectors in which the surface of the mold that contacts the float glass has a grooved surface profile comprising a plurality of cusps. The surface of the mold also has a plurality of concave valleys. Glass reflectors are preferably manufactured by heating a sheet of float glass positioned over the mold until the sheet of glass sags to contact the mold. If necessary, the glass may also stretch to conform to the shape of the mold. In the case of large monolithic glass reflectors, the edges of the dish-shaped glass are rolled around the periphery of the mold. The glass reflector is then silvered to create a dish-shaped mirror that reflects solar radiation to a focus.
US08604328B2
A method of generating data for controlling a rendering system includes obtaining data representative of a recording of at least intervals of an event, the recording having at least two components obtainable through different respective modalities. The data is analyzed to determine at least a dependency between a first and a second of the components. At least the dependency is used to provide settings for a system for rendering in perceptible form at least one output through a first modality in dependence on at least the settings and on at least one signal for rendering in perceptible form through a second modality.
US08604327B2
There is provided an information processing device including a storage unit that stores music data for playing music and lyrics data indicating lyrics of the music, a display control unit that displays the lyrics of the music on a screen, a playback unit that plays the music and a user interface unit that detects a user input. The lyrics data includes a plurality of blocks each having lyrics of at least one character. The display control unit displays the lyrics of the music on the screen in such a way that each block included in the lyrics data is identifiable to a user while the music is played by the playback unit. The user interface unit detects timing corresponding to a boundary of each section of the music corresponding to each displayed block in response to a first user input.
US08604320B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH327446. The invention thus relates to the plants, seeds and tissue cultures of the variety CH327446, and to methods for producing a corn plant produced by crossing a corn plant of variety CH327446 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH327446.
US08604314B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH379150. The invention thus relates to the plants, seeds and tissue cultures of the variety CH379150, and to methods for producing a corn plant produced by crossing a corn plant of variety CH379150 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH379150.
US08604309B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH967642. The invention thus relates to the plants, seeds and tissue cultures of the variety CH967642, and to methods for producing a corn plant produced by crossing a corn plant of variety CH967642 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH967642.
US08604306B2
According to the invention, there is provided seed and plants of the corn variety designated CV344925. The invention thus relates to the plants, seeds and tissue cultures of the variety CV344925, and to methods for producing a corn plant produced by crossing a corn plant of variety CV344925 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV344925 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV344925.
US08604297B2
The cotton variety FM 1773LLB2 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety FM 1773LLB2 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of FM 1773LLB2 and to plants of FM 1773LLB2 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from FM 1773LLB2.
US08604293B1
A soybean cultivar designated 12004711 is disclosed. The invention relates to the seeds of soybean cultivar 12004711, to the plants of soybean cultivar 12004711, to the plant parts of soybean cultivar 12004711, and to methods for producing progeny of soybean cultivar 12004711. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 12004711. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 12004711, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 12004711 with another soybean cultivar.
US08604291B1
A soybean cultivar designated S110139 is disclosed. The invention relates to the seeds of soybean cultivar S110139, to the plants of soybean cultivar S110139, to the plant parts of soybean cultivar S110139, and to methods for producing progeny of soybean cultivar S110139. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110139. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110139, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110139 with another soybean cultivar.
US08604285B2
A soybean cultivar designated S100107 is disclosed. The invention relates to the seeds of soybean cultivar S100107, to the plants of soybean cultivar S100107, to the plant parts of soybean cultivar S100107, and to methods for producing progeny of soybean cultivar S100107. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100107. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100107, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100107 with another soybean cultivar.
US08604282B2
A soybean cultivar designated S090098 is disclosed. The invention relates to the seeds of soybean cultivar S090098, to the plants of soybean cultivar S090098, to the plant parts of soybean cultivar S090098, and to methods for producing progeny of soybean cultivar S090098. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S090098. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S090098, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S090098 with another soybean cultivar.
US08604274B2
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a GSBP-like polypeptide (GSBP: GT-Pase activating protein SH3 domain binding Protein). The present invention also concerns plants having modulated expression of a nucleic acid encoding a GSBP-like polypeptide, which plants have enhanced yield-related traits relative to control plants.
US08604273B1
A novel maize variety designated X85B703 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X85B703 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X85B703 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X85B703, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X85B703. This invention further relates to methods for producing maize varieties derived from maize variety X85B703.
US08604270B2
An absorbent core includes a width, a length, an elongate liquid holding formation and an outer region of fibrous material located outward of the liquid holding formation. The outer region of the absorbent core has, in cross-section taken across the width of the absorbent core, a first thickness. The liquid holding formation has, in cross-section taken across the width of the absorbent core, second and third thicknesses. The second and third thicknesses of the liquid holding formation are greater than the first thickness of the outer region.
US08604266B2
A dressing for covering a wound. The dressing including: a first component having a first shape; a second component releasably attached to a first surface of the first component to maintain the first component in a second shape different from the first shape; and an adhesive disposed on a surface of the first component different from the first surface for attaching the first component to the wound such that the second component can be released from the first component to allow the first component to take the first shape to apply a pressure to portions of the skin surrounding the wound to close the wound; wherein the second component is a mechanical device.
US08604265B2
Dressings, systems, and methods for treating a tissue site on a patient involve allowing liquids from the tissue site or a priming fluid to evaporate and exit the dressing through a liquid-impermeable, vapor-permeable membrane. The dressing is able to process more liquids than would otherwise be possible without evaporation and potentially to create reduced pressure. Other dressings, systems, and methods are disclosed.
US08604262B2
A process for reforming a hydrocarbon stream is presented. The process involves splitting a naphtha feedstream to at least two feedstreams and passing each feedstream to separation reformers. The reformers are operated under different conditions to utilize the differences in the reaction properties of the different hydrocarbon components. The process utilizes a common catalyst, and common downstream processes for recovering the desired aromatic compounds generated.
US08604254B2
Convert an alkylene to a product stream that comprises an alkanol by subjecting a gaseous combination of a) an alkylene selected from ethylene, propylene or a combination thereof, b) carbon monoxide, c) hydrogen and, optionally, d) at least one hydrocarbon or gas diluent other than ethylene or propylene to reductive hydroformylation conditions in combination with a solid phase, sulfided, heterogeneous catalyst.
US08604247B2
This disclosure relates to chrysene compounds with deep blue emission that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a chrysene compound.
US08604237B2
Subject of the invention is a method for the production of L-carnitine, comprising the steps of (a) providing a solution comprising at least 5% (w/w) carnitine in a first solvent, wherein the carnitine is a mixture of D- and L-carnitine, (b) optionally seeding the solution with L-carnitine crystals, (c) adding an second solvent, in which the L-carnitine is not soluble or has a low solubility, (d) isolating crystals comprising L-carnitine.
US08604236B2
A continuous carbonylation process for high turnover carbonylation, and a carbonylation reaction medium and product stream thereof. The process comprises carbonylating an ethlenically unsaturated compound with carbon monoxide in the presence of a source of hydroxyl groups and a catalyst system. The catalyst system comprising: (a) a bidentate phosphine, arsine or stibine ligand; and (b) a catalytic metal selected from a group VIB or group VIIIB metal or a compound thereof. The catalytically active concentration of said catalytic metal, measured as the ACCF (product Kg·hr−1·Dm−3), is maintained at less than 0.5.
US08604232B2
The invention relates to method for producing mono amino-functionalised dialkylphosphonic acids esters and salts, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, the salt or ester thereof (II), b) the alkylphosphonous acid, the salt or ester thereof (II) produced above is reacted with an allylamine of formula (V) in the presence of a catalyst B to give mono amino-functionalised dialkylphosphinic acid derivatives (III) where, R1, R2, R3, R4, R5, R6, R7, R8, R9 independently=amongst others, H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl and X═H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and Y=a mineral acid, a carboxylic acid, a Lewis acid or organic acid, where n=a whole or fractional number from 0 to 4, catalyst A is a transition metal and/or transition metal compound and/or catalyst system comprising a transition metal and/or a transition metal compound and at least one ligand and catalyst B is compounds forming peroxides and/or peroxide compounds and/or azo compounds.
US08604225B2
The present invention relates to a method of producing 5-hydroxymethylfurfural by dehydration of fructose and/or glucose and/or mannose.
US08604223B2
The reaction of alcohols with oxocarboxylates to form acetals or ketals is catalyzed by unexpectedly low levels of protic acids. By employing low acid catalyst levels compared to amounts conventionally used, rapid formation of acetal or ketal is facilitated while the formation of oxocarboxylate esters is minimized. Further employing a significant molar excess of oxocarboxylate in conjunction with low acid catalyst level gives rise to the rapid and clean formation of acetals and ketals from oxocarboxylates and alcohols.
US08604222B2
The present invention provides an improved process for the synthesis of nebivolol or its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). The present invention further provides a new Form T1 of nebivolol and its pharmaceutically acceptable salts.The present invention also provides pharmaceutical compositions and process for the preparation of a solid oral dosage form of nebivolol hydrochloride of formula (I), without the use of wetting agent, and optionally using binder and/or disintegrant.
US08604221B2
Disclosed is a method for producing a halogen-substituted phthalide, which includes a reaction step of reacting a halogen-substituted phthalic anhydride with sodium borohydride.
US08604219B2
Disclosed is a process for the preparation of N-alkyl carbazole. Said process comprises: a) chlorinating cyclohexanone to form 2-chlorocyclohexanone; b) reacting 2-chlorocyclohexanone with N-ethyl aniline to form 2-(N-ethyl anilino)cyclohexanone; c) cyclizing 2-(N-ethyl anilino) cyclohexanone by refluxing with simultaneous water removal to obtain 9-ethyltetrahydrocarbazole; d) treating 9-ethyl-tetrahydrocarbazole with concentrated hydrochloric acid followed by water wash for removing N-ethyl aniline; e) dehydrogenating 9-ethyltetrahydrocarbazole by heating 9-ethyltetrahydrocarbazole in a solvent, in presence of a catalyst to obtain N-alkyl carbazole.
US08604213B2
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
US08604212B2
Septic shock is known to lead to, at the end stage, systematic inflammatory reaction syndrome and multiple organ failure (MOF) and cause the patients' death. In both diseases, the patient dies finally of MOF, and the infiltration by inflammatory cells plays a key role for MOF. Thus, development of therapeutic agents for septic shock by suppressing the infiltration by inflammatory cells has been desired.To provide a therapeutic or preventive agent for shock, comprising as an active ingredient a diaminotrifluoromethylpyridine derivative represented by the formula (I) or its salt: wherein X is a cycloalkylcarbonyl group, an alkenylcarbonyl group, a thiophenecarbonyl group or a benzoyl group which may be substituted by a halogen atom; and Y is an alkylsulfonyl group.
US08604211B2
Molecules according to Formula One: and their uses are disclosed herein.
US08604204B2
The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
US08604203B2
The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
US08604202B2
The present invention relates to compounds of formula (I) wherein R1, R2 and B1, B2 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
US08604201B2
The invention relates to the use of cyclovinyl phosphine compounds in the form of complexes with copper, as catalysts for reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds. The invention also relates to complexes of copper with at least one cyclovinyl phosphine, as well as to the method for creating a carbon-carbon or a carbon-heteroatom bond catalysed by a cyclovinyl phosphine/copper complex.
US08604188B2
The invention relates to a process for extracting an impurity from an organic phase comprising caprolactam, comprising extracting the impurity by washing said organic phase as a discontinuous phase with an aqueous phase as a continuous phase, the ratio of the flow of the aqueous phase in m3/hr, to the flow of the organic phase in m3/hr, being 0.05 or less. Further the invention relates to a caprolactam production plant, wherein use can be made of a process of the invention.
US08604187B2
The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis C.
US08604183B2
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
US08604177B2
The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
US08604172B2
Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
US08604170B2
The present invention provides antibodies specific for the CSF-1R, compositions comprising said antibodies and methods of treatment using such compositions.
US08604159B2
The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.
US08604155B2
In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having two or more sites that can initiate polymerization. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups and a high percentage of carbonate linkages. The compositions are further characterized in that they contain polymer chains having an embedded polyfunctional moiety linked to a plurality of individual polycarbonate chains.
US08604154B2
A water-soluble or water-dispersible carbodiimide compound is hydrophilicized by incorporating methyl glycolate or methyl lactate, which serves a moiety similar to the moiety which aqueous urethane resin, aqueous acrylic resin, or the like possesses, into an end of a starting carbodiimide compound. The invention provides a carbodiimide compound and a carbodiimide composition, which, when added as a cross-linking agent to aqueous resin, can enhance water resistance, solvent resistance, and adhesion of the resin, while maintaining the conventionally attained pot life, and an aqueous coating composition containing the carbodiimide compound or composition.
US08604151B2
A bodied siloxane resin comprises M, Q, and T-propyl units and is capped with additional M units. The bodied siloxane resin contains less silanol groups than the bodied siloxane resin before being capped with additional M units.
US08604150B2
The present invention has an object to provide a curable composition for transfer materials. The curable composition is applicable to a UV nanoimprint process capable of forming micropatterns with high throughput, is applicable to a thermal nanoimprint process in some cases, and is capable of forming a micropattern having high selectivity on etching rates regarding a fluorine-based gas and an oxygen gas. A curable composition for transfer materials of the present invention contains a curable silicon compound produced by subjecting a silicon compound (A) having a Si—H group and a compound (B) having a curable functional group and a carbon-carbon double bond other than the curable functional group to a hydrosilylation reaction.
US08604148B2
This invention relates to a polymer of a cyclic olefin and a vinyl terminated macromonomer, and processes for the production thereof.
US08604144B2
Disclosed are procatalyst compositions having an internal electron donor which includes a substituted amide ester and optionally an electron donor component. Ziegler-Natta catalyst compositions containing the present procatalyst compositions exhibit improved catalyst activity and/or improved catalyst selectivity and produce propylene-based olefins with broad molecular weight distribution.
US08604132B2
A polymer composition comprising star macromolecules is provided. Each star macromolecule has a core and five or more arms, wherein the number of arms within a star macromolecule varies across the composition of star molecules. The arms on a star are covalently attached to the core of the star; each arm comprises one or more (co)polymer segments; and at least one arm and/or at least one segment exhibits a different solubility from at least one other arm or one other segment, respectively, in a reference liquid of interest.
US08604128B2
Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group.
US08604122B2
A curable composition useful as a thermosetting binder, comprising a polycarboxy polymer or copolymer, a glycerol derivative, and, optionally, a phosphorous containing compound.
US08604115B1
The ethylene/propylene copolymer nanocomposite is a copolymer prepared by inclusion of a filler of nanoparticles of titania doped with iron that permits control over, and variation of, the overall polymeric properties. Through the addition of the TiO2/Fe nanofiller, the concentration of polypropylene in the copolymer is increased and the overall crystallinity is decreased. In order to make the copolymer, a TiO2/Fe titania-iron nanofiller is first mixed with a polymerization catalyst (a vanadium (III) complex bearing bidentate salicylaldiminato ligands) in a reactor. The reactor is then charged with solvent (e.g., toluene) and heated to a temperature suitable for polymerization, e.g., about 30° C. Following heating, a mixture of ethylene and propylene gases (in selected molar ratios) is fed into the reactor at a fixed pressure, and methyl aluminum dichloride co-catalyst (MADC) is added to initiate polymerization. Polymerization is quenched to yield the ethylene/propylene copolymer nanocomposite, which is then washed and dried.
US08604114B2
Provided is a process for making non-phthalate plasticizers, by acylating an aromatic compound with a succinic anhydride to form a keto-acid, and then esterifying the keto-acid with C4-C13 OXO-alcohols to form a plasticizer compound. The aromatic rings of the aromatic compound may also be optionally hydrogenated.
US08604112B2
The invention relates to a composition containing a particulate solid, a plastic material (such as a thermoplastic polymer) and a compound capable of having dispersant properties. The compound may be obtained/obtainable by reacting a fatty acid with either (i) a hydroxy-C4-5-alkylene carboxylic acid, or (ii) a lactone. The invention further relates to novel compounds, and the use of the compound as a dispersant.
US08604111B2
A composition is formed from a polymeric acid precursor, such as polylactic acid (PLA), that is a least partially dissolved within a polymer dispersing solvent. An emulsion may be from polymeric acid precursor that is at least partially dissolved within a solvent and a liquid that is substantially immiscible with the solvent. In certain cases, the molecular weight of the polymeric acid precursor may be reduced in forming the solution. The solution may be used in treating a formation penetrated by a wellbore.
US08604108B2
The invention relates to a method for producing mono-hydroxyfunctionalized dialkylphosphinic acids and esters and salts thereof by means of acroleins, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivatives (IV) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivatives (VI) are reacted to yield a mono-hydroxyfunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C, wherein R1, R2, R3, R4, R5, R6, R7 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C6-C18 aralkyl, C6-C18 alkylaryl, and X stands for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and the catalyst A and C are formed by transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B is formed by compounds forming peroxides and/or peroxo compounds and/or azo compounds and/or alkali metals and/or alkaline earth metals, alkali hydrides, alkaline earth hydrides and/or alkali alcoholates and alkaline earth alcoholates.
US08604101B2
The present invention relates to a process for producing aqueous dispersions of thermoplastic polymers which have a plurality of ester groups and/or carbonate groups in the main polymer chain and which have an acid number of less than 5 mg KOH/g, in particular at most 3 mg KOH/g, and which have a zero-shear viscosity η0 (180° C.) of at least 60 Pa·s at 180° C. The invention also relates to the polymer dispersions obtainable by said process, and to the use thereof.
US08604098B2
Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides structure to the lens. The masking compound is capable of blocking polymerization or crosslinking of the prepolymer, until photoisomerization of the compound is triggered, and the compound is converted from a first isomer to a second isomer having a different absorption profile. The prepolymer is a composition that can undergo a polymerization or crosslinking reaction upon photoinitiation to alter one or more of the properties of the lenses.
US08604097B2
The present invention relates to a process for preparing radiation-curing binders containing allophanate groups by reacting, at temperatures of ≦130° C., A) one or more compounds containing uretdione groups with B) one or more OH-functional compounds which contain groups which react, with polymerization, with ethylenically unsaturated compounds on exposure to actinic radiation (radiation-curing groups), C) optionally NCO-reactive compounds other than B), in the presence of D) a catalyst containing at least one zinc compound, to form allophanate groups by opening the uretdione ring. The present invention also relates to the binders obtained by the process of the invention and to coating compositions containing these binders.
US08604095B2
A radiation-curable ink composition contains (A) aminoacrylate at 1 mass % to 10 mass %, inclusive, (B) phenoxyethyl acrylate at 20 mass % to 50 mass %, inclusive, and (C) tetraethylene glycol diacrylate at 1 mass % to 20 mass %, inclusive, in its reaction component, as well as (E) bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide at 3 parts by mass to 8 parts by mass, inclusive, (F) 2,4,6-trimethylbenzoyl-diphenyl-phosphine oxide at 3 parts by mass to 5 parts by mass, inclusive, in 100 parts by mass of the reaction component, and (G) diethylthioxanthone at 1 part by mass to 3 parts by mass, inclusive, in 100 parts by mass of the reaction component.
US08604082B2
The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the invention relates to treatment of premature ejaculation in humans.
US08604080B2
The present invention provides for a method of treating OCD or an Obsessive-Compulsive Spectrum Disorder (OCSD), such as BDD or ADHD, using a high-dose glycine treatment.
US08604073B2
An antimicrobial composition comprising (a) a cationic surfactant derived from the condensation of fatty acids and esterified dibasic amino acids, such as lauric arginate and (b) an antibiotic, such as of β-lactam antibiotics, polypeptides, quinolones. The composition may be used as a stand alone antimicrobial formulation, or in combination with medical articles or medical devices.
US08604063B2
The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.
US08604057B2
The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.
US08604052B2
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
US08604049B2
The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising —O—R3, —NR3R4, —CR3R4R5, -(ethyne)-R3, —S—R3, —SO—R3, and SO2—R3, or R1 represents a group B selected from among the group comprising: —C6-10-aryl; —a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; —a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and —a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.
US08604048B2
Pyridocarbazole-type compounds of formula (I): are provided as a medicament, and more particularly for application in anticancer chemotherapy. Also provided is a pharmaceutical composition with the compound and methods for preventing and/or treating neurodegenerative-type pathologies, such as Alzheimer's disease and schizophrenia, parasitoses, such as malaria, or glaucomas.
US08604047B2
Methods and compositions are described for the treatment of very severe acne vulgaris, including nodulocystic acne and conglobate acne. Compounds which inhibit either or both type 1 and type 2 isoforms of steroid 5α-reductase are administered daily in either oral or topical formulations to patients suffering from severe forms of acne vulgaris. Very high dosages of such compounds can effectively be administered oral just once a week and be successful.
US08604045B2
The present invention relates to the use of pyrimidylaminobenzamide derivatives for the preparation of a drug for the treatment of non-cancerous, benign brain tumors, especially for the curative and/or prophylactic treatment of NF, and to a method of treating non-cancerous, benign brain tumors, especially for the curative and/or prophylactic treatment of NF.
US08604044B2
The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below. These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.
US08604043B2
The present invention relates to the Janus kinase (JAK) inhibitors 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octanenitrile or 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]heptanenitrile, as well as its compositions and methods of use, which is useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, skin disorders, cancer, and other diseases.
US08604042B2
The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
US08604041B2
The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
US08604035B2
Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
US08604033B2
The present invention relates to novel compounds of Formula (I), wherein M, P, X, A and (B)n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
US08604027B2
A method of contraception is provided which involves delivery of 21 to 27 consecutive days of a progestin in the absence of an estrogen or other steroidal compound, followed by 1 to 7 days without an effective amount of an active agent. Also described is a pharmaceutically useful kit to facilitate delivery of this regimen.
US08604024B2
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein X is selected from the group of CH2, O, and NR2; m=0 or 1; R1 at each instance is selected from the group of halogen, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is a bond, —NHCO—, —NH—, or L and Z together can be absent; Z is a C6-C10-aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, haloC1-4 alkoxy, 4-methoxyphenyl, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; R2 is selected from the group of hydrogen, benzyl, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, acetyl, and methanesulfonyl; and R3, R4 and R5 are independently selected from hydrogen or C1-4alkyl.
US08604012B2
The present invention relates to methods and compounds for increasing serum iron in a subject.
US08604003B2
The present invention provides an agent which induces acceleration of hard tissue formation, acceleration of cell differentiation and increase in cellular alkaline phosphatase activity, by directly acting on the cell. Specifically, it provides a hard tissue formation promoter, a cell differentiation inducer and a cellular alkaline phosphatase activity reinforcing agent comprising, as an active ingredient, a glycosaminoglycan or a salt thereof that keeps sulfate group and has the characteristics of the following (1) and (2): (1) a basic structure is a disaccharide repeating structure consisting of a hexuronic acid residue and a glucosamine residue, (2) one or less of the position among a 2-position hydroxyl group of a hexuronic acid residue, a 6-position hydroxyl group of a glucosamine residue and a 2-position amino group of the glucosamine residue in the basic structure of the aforementioned (1) does not have the sulfate group. In this connection, it is preferable that the hexuronic acid residue is a glucuronic acid residue or an iduronic acid residue.
US08604001B2
This invention relates to the use of a preparation comprising sulfated oligosaccharides which trap spermine or spermidine or both, as an active slimming ingredient in a cosmetic, pharmaceutical and/or nutraceutical composition. One of the objectives of the invention is to supply a cosmetic, pharmaceutical or nutraceutical composition with a slimming effect.
US08604000B2
The present invention relates to the use of a taste masking agent selected from the group of cellulose; starch; xanthan gum; gellan gum; alginate; galactomannans such as fenugreek, guar gum, tara gum, locust bean gum, and cassia gum; gum karaya; gum tragacanth; carrageenan; and mixture thereof, for improving one or more of mouth feel, taste, aftertaste and smell of a liquid aqueous nutritional composition comprising a nucleotide and/or a nucleoside. It also relates to a nutritional composition comprising an unsavory nucleotide and/or a nucleoside component, having improved sensory characteristics such as improved mouth feel, taste, aftertaste and smell. In particular, it relates to a composition comprising said un-savory nucleotide and/or a nucleoside component, in particular comprising an uridine-containing nucleotide and/or a nucleoside in combination with an unsavory edible oil, such as a fish oil.
US08603998B2
In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.
US08603997B2
The present inventors discovered that siRNAs targeting the 17AA site of the WT1 gene not only suppress the expression of the WT1 gene, but also demonstrate remarkable cell growth-suppressing effects and cell death-inducing effects in cancer cell lines.
US08603984B2
This invention provides methods of controlling pain in a canine comprising transdermally administering a composition comprising fentanyl, a penetration enhancer, and a volatile liquid, wherein the composition is a solution. The invention also provides a single unit dose of the composition.
US08603979B2
The present invention relates to a von Willebrand Factor for use in the treatment and/or prevention of a bleeding event associated with a thrombopathy induced by substances inhibiting thrombocytes. Furthermore, the present invention relates to a method of treating and/or preventing a disorder related to a bleeding event associated with a thrombopathy induced by substances inhibiting thrombocytes comprising administering a pharmaceutically effective amount of a von-Willebrand-Factor (vWF) to a patient in need thereof. The present invention also relates to a composition comprising vWF and a composition comprising FVIII for simultaneous, separate or sequential use for use in the treatment and/or prevention of a bleeding event associated with a thrombopathy induced by substances inhibiting thrombocytes.
US08603975B2
The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
US08603973B2
The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.
US08603969B2
The present invention relates to novel Pancreatic Polypeptide Family (“PPF”) polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50% sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.
US08603961B2
The instant disclosure relates to methods of making compositions comprising glycerol esters and a fabric softening active. Methods of using such compositions are also disclosed.
US08603950B2
This invention relates to methods for the generation of polynucleotide seed libraries and the use of these libraries in generating novel mutants of recombinant proteins and, more particularly, for generating focused libraries of recombinant human antibodies and screening for their affinity binding with target antigens.
US08603947B2
A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
US08603943B2
A proposed heat-sensitive recording material comprises a substrate, a heat-sensitive recording layer containing color formers and color acceptors, and a protective layer covering this heat-sensitive recording layer. The heat-sensitive recording layer has, as color acceptor, at least 66⅔ percent by weight of 4,4′-dihydroxydiphenyl sulfone based on the total percentage of color acceptors in the heat-sensitive recording layer, and the protective layer has, as binder, at least 60 percent by weight of diacetone-modified polyvinyl alcohol based on the total percentage of binder in the protective layer.
US08603939B2
The present provides a high-efficiency amide compound production catalyst to be used in producing an amide compound through hydration of a nitrile compound and a production method using it. The amide compound production catalyst is for producing an amide compound through reaction of a nitrile compound and water, and comprises a manganese oxide catalyst containing bismuth and further containing yttrium or vanadium. The method for producing an amide compound comprises reacting a nitrile compound and water in a liquid phase in the presence of the amide compound production catalyst.
US08603926B2
The invention relates to a textile fabric having a coating composed of two layers of thermoplastic hot-seal adhesives of differing compositions applied one on top of the other, the second hot-seal adhesive, which is applied to the first, having a melting point of >135° C. and a melt flow index (MFI) value of 50 to 250 g/10 minutes (190° C./2.16 kg). The invention further relates to a method for producing a textile fabric, comprising the following steps: a) producing a textile fabric using a textile fabric manufacturing technique; b) applying a layer of a first hot-seal adhesive to the textile fabric; and c) applying a layer of a second hot-seal adhesive to the textile fabric so as to d) form a layer of the second hot-seal adhesive over the layer of first hot-seal adhesive, the second hot-seal adhesive used having a melting point of >135° C. and a melt flow index (MFI) value of 50 to 250 g/10 minutes (190° C./2.16 kg). The textile fabrics may be used as interlining or lining material which can withstand stress during care treatment.
US08603907B2
Apparatus having a dielectric containing scandium and gadolinium can provide a reliable structure with a high dielectric constant (high k). In an embodiment, a monolayer or partial monolayer sequence process, such as for example atomic layer deposition (ALD), can be used to form a dielectric containing gadolinium oxide and scandium oxide. In an embodiment, a dielectric structure can be formed by depositing gadolinium oxide by atomic layer deposition onto a substrate surface using precursor chemicals, followed by depositing scandium oxide onto the substrate using precursor chemicals, and repeating to form a thin laminate structure. A dielectric containing scandium and gadolinium may be used as gate insulator of a MOSFET, a capacitor dielectric in a DRAM, as tunnel gate insulators in flash memories, as a NROM dielectric, or as a dielectric in other electronic devices, because the high dielectric constant (high k) of the film provides the functionality of a much thinner silicon dioxide film.
US08603900B2
Methods of improving the anti-reflection properties of one or more dielectric layers and reducing surface recombination of generated carriers of a solar cell are disclosed. In some embodiments, dopants are introduced into the dielectric layers to improve their anti-reflection properties. In other embodiments, species are introduced into the dielectric layers to create electrical fields which repel the minority carriers away from the surface and toward the contacts. In another embodiment, mobiles species are introduced to the anti-reflective coating, which cause carrier to be repelled from the surface of the solar cell. By creating a barrier at the surface of the solar cell, undesired recombination at the surface may be reduced.
US08603899B2
At present, a forming process of a base film through an amorphous silicon film is conducted in respective film forming chambers in order to obtain satisfactory films. When continuous formation of the base film through the amorphous silicon film is performed in a single film forming chamber with the above film formation condition, crystallization is not sufficiently attained in a crystallization process. By forming the amorphous silicon film using silane gas diluted with hydrogen, crystallization is sufficiently attained in the crystallization process even with the continuous formation of the base film through the amorphous silicon film in the single film forming chamber.
US08603897B2
A method for manufacturing a bonded wafer including bonding together a bond wafer and a base wafer each having a chamfered portion at an outer circumference and thinning the bond wafer, wherein the thinning of the bond wafer includes: a first step of performing surface grinding on the bond wafer such that a thickness of the bond wafer reaches a first predetermined thickness; a second step of removing an outer circumference portion of the ground bond wafer; and a third step of performing surface grinding on the bond wafer such that the thickness of the bond wafer reaches a second predetermined thickness.
US08603892B2
A semiconductor device includes groove-like regions that are formed between two adjacent bit lines among a plurality of bit lines each having upper and side surfaces covered with a cap insulating film and a side-wall insulating film, respectively, a SiON film that contains more O (oxygen) than N (nitrogen) and continuously covers inner surfaces of the groove-like regions, and a silicon dioxide film formed by reforming polysilazane and filled in the groove-like regions with the SiON film interposed therebetween.
US08603889B2
A method of forming an integrated circuit structure includes: forming a vent via extending through a shallow trench isolation (STI) and into a substrate; selectively removing an exposed portion of the substrate at a bottom of the vent via to form an opening within the substrate, wherein the opening within the substrate abuts at least one of a bottom surface or a sidewall of the STI; and sealing the vent via to form an air gap in the opening within the substrate.
US08603888B2
A variable-resistance material memory array includes a series of variable-resistance material memory cells. The series of variable-resistance material memory cells can be arranged in parallel with a corresponding series of control gates. A select gate can also be disposed in series with the variable-resistance material memory cells. Writing/reading/erasing to a given variable-resistance material memory cell can include turning off the corresponding control gate, while turning on all other control gates. Various devices can include such a variable-resistance material memory array.
US08603887B2
A method for depositing a silicon oxide layer on a substrate including a silicon region and a silicon-germanium region, including the steps of: forming a very thin silicon layer having a thickness ranging from 0.1 to 1 nm above silicon-germanium; and depositing a silicon oxide layer on the substrate.
US08603883B2
Methods of fabricating bipolar junction transistors, bipolar junction transistors, and design structures for a bipolar junction transistor. A first portion of the intrinsic base layer is masked while a second portion of an intrinsic base layer is etched. As a consequence of the masking, the second portion of the intrinsic base layer is thinner than the first portion of the intrinsic base layer. An emitter and an extrinsic base layer are formed in respective contacting relationships with the first and second portions of the intrinsic base layer.
US08603879B2
A method for fabricating a super-junction semiconductor power device with reduced Miller capacitance includes the following steps. An N-type substrate is provided and a P-type epitaxial layer is formed on the N-type substrate. At least a trench is formed in the P-type epitaxial layer followed by forming a buffer layer on interior surface in the trench. An N-type dopant layer is filled into the trench and then the N-type dopant layer is etched to form a recessed structure at an upper portion of the trench. A gate oxide layer is formed, and simultaneously, dopants in the N-type dopant layer diffuse into the P-type epitaxial layer, forming an N-type diffusion layer. Finally, a gate conductor is filled into the recessed structure and an N-type source doped region is formed around the gate conductor in the P-type epitaxial layer.
US08603878B2
In a vertical-type memory device and a method of manufacturing the vertical-type memory device, the vertical memory device includes an insulation layer pattern of a linear shape provided on a substrate, pillar-shaped single-crystalline semiconductor patterns provided on both sidewalls of the insulation layer pattern and transistors provided on a sidewall of each of the single-crystalline semiconductor patterns. The transistors are arranged in a vertical direction of the single-crystalline semiconductor pattern, and thus the memory device may be highly integrated.
US08603874B2
A method of manufacturing a semiconductor device includes, forming an isolation region defining a first region and a second region, injecting a first impurity of a first conductivity type into the first region and the second region, forming a first gate insulating film and a first gate electrode over the first region, forming a second gate insulating film and a second gate electrode over the second region, forming a first mask layer over a first portion of the second region to expose a second portion of the second region and the first region, and injecting a second impurity of the first conductivity type into the semiconductor substrate from a direction diagonal to a surface of the semiconductor substrate.
US08603872B2
The field effect device comprises a sacrificial gate electrode having side walls covered by lateral spacers formed on a semiconductor material film. The source/drain electrodes are formed in the semiconductor material film and are arranged on each side of the gate electrode. A diffusion barrier element is implanted through the void left by the sacrificial gate so as to form a modified diffusion area underneath the lateral spacers. The modified diffusion area is an area where the mobility of the doping impurities is reduced compared with the source/drain electrodes.
US08603868B2
A method includes providing a substrate containing at least first and second adjacent gate structures on a silicon surface of the substrate; etching a V-shaped groove through the silicon surface between the first and second adjacent gate structures, where the V-shaped groove extends substantially from an edge of the first gate structure to an opposing edge of the second gate structure; implanting a source/drain region into the V-shaped groove; and siliciding the implanted source/drain region. The etching step is preferably performed by using a HCl-based chemical vapor etch (CVE) that stops on a Si(111) plane of the silicon substrate (e.g., a SOI layer). A structure containing FETs that is fabricated in accordance with the method is also disclosed.
US08603863B2
This IC card is provided with a module having an inlet, an adhesive layer covering the module, and a first base material and second base material sandwiching the module with interposition of the adhesive layer. The module is disposed on one face of the first base material with interposition of a viscous layer which has a thickness that varies according to the thickness at each area of the module, and its two ends are narrower than its other parts when viewed from the outer face side of the first base material or the outer face side of the second base material. According to this IC card, it is possible to offer the IC card with a flat surface, and without occurrence of strain in the embedded IC chip.
US08603859B2
A method of manufacture of an integrated circuit packaging system includes: providing a substrate; mounting a top integrated circuit on a first side of the substrate; mounting a bottom integrated circuit on a second side of the substrate; forming a top encapsulation over the top integrated circuit and a bottom encapsulation over the bottom integrated circuit simultaneously; and forming a bottom via through the bottom encapsulation to the substrate.
US08603850B2
To provide a method for manufacturing a solar cell, whereby solar cells can be mass-produced by a simple process at low cost. A first conductivity-type silicon powder (11) is prepared, a silicon powder layer (11a) is formed by disposing the powder in the form of a layer, the powder layer is melted by heating the powder layer to the melting point of silicon or higher, and a first conductivity-type silicon layer (11b) is formed by cooling the melted layer. A second conductivity-type silicon powder (12) is prepared, a second conductivity-type silicon powder layer (12a) is formed by disposing the powder in the form of a layer on the first conductivity-type silicon layer (11b), the powder layer is melted by heating the powder layer to the melting point of silicon or higher, and a second conductivity-type silicon layer (12b) is formed by cooling the melted layer.
US08603847B2
An improved method of fabricating a semiconductor light emitting diode (LED) is disclosed. The current blocking layer and the contact area for the n-type layer are implanted at the same time. In some embodiments, a dopant, which may be an n-type dopant, is implanted into a portion of the p-type layer to cause that portion to become either u-type or n-type. Simultaneously, the same dopant is implanted into at least a portion of the exposed n-type layer to increase its conductivity. After this implant, the dopant in both portions of the LED may be activated through the use of a single anneal cycle.
US08603845B2
An array substrate for an organic electroluminescent display device includes a substrate including a display area and a non-display area; a gate line and a data line; a thin film transistor including a semiconductor layer of polycrystalline silicon, a gate insulating layer, a gate electrode, an inter insulating layer, a source electrode, and a drain electrode; auxiliary lines formed of a same material and on a same layer as the data line; a passivation layer of organic insulating material and including a drain contact hole exposing the drain electrode, and an auxiliary line contact hole exposing one of the auxiliary lines; and a first electrode and a line connection pattern on the passivation layer, wherein the first electrode contacts the drain electrode and the line connection pattern contacts the one of the first auxiliary pattern.
US08603844B2
A method for manufacturing a pixel structure is provided. A thin film transistor is formed on a substrate and an insulating layer is formed to cover the substrate and the thin film transistor. The insulating layer is patterned by a half-tone mask to form a protruding pattern, a sunken pattern connecting the protruding pattern, and a contact window inside the sunken pattern. A transparent conductive layer is formed to cover the protruding pattern and the sunken pattern, and filled in the contact window. A passivation layer is formed to cover the transparent conductive layer. A pixel electrode pattern is formed from the transparent conductive layer by removing a part of the passivation layer located on the protruding pattern, a part of the transparent conductive layer on the protruding pattern, and a part of the passivation layer located within the contact window. A pixel structure manufactured by the method is provided.
US08603842B2
Disclosed is a package substrate for an optical element, which includes a base substrate, a first circuit layer formed on the base substrate and including a mounting portion, an optical element mounted on the mounting portion, one or more trenches formed into a predetermined pattern around the mounting portion by removing portions of the first circuit layer so that the first circuit layer and the optical element are electrically connected to each other, and a fluorescent resin material applied on an area defined by the trenches so as to cover the optical element, and in which such trenches are formed on the first circuit layer so that the optical element and the first circuit layer are electrically connected to each other, thus maintaining the shape of the fluorescent resin material and obviating the need to form a via under the optical element. A method of manufacturing the package substrate for an optical element is also provided.
US08603840B2
To improve the reliability in an electric inspection of a semiconductor device. When a movable pedestal 15 is being positioned relative to an arrangement direction of a plurality of second contact pins 13a by a positioning pin 13b which a socket 12 includes, a substrate conduction test is performed by bringing a first contact pin 14a into contact with a pre-stack land 5c of a wiring substrate 5 and of the a lower package 2 and moreover bringing the second contact pin 13a into contact with a solder ball 7, and thus the electric inspection can be performed by precisely positioning the first contact pin 14a side and the second contact pin 13a side. Then, the reliability of the electric inspection can be improved.
US08603838B2
The invention relates to a method for producing a contact for solar cells (30) arranged in a laminated solar panel (1), wherein the solar cells (30) are coated on both sides of the main surfaces thereof with at least one layer and before a lamination step the solar cells (30) are connected with electrically-conducting connectors (31, 33), the electrically conducting connectors (31, 33) being arranged in the solar panel for laminating such as to be completely laminated within the solar panel (1) after the lamination step. After the lamination step a contact region (35) of the electrically-conducting connector (33) is exposed, wherein at least one of the layers covering the solar cells is completely punched through in the corresponding region, in particular by stripping. The contact region (35) of the electrically-conducting connector (33) can then be contacted by means of an externally-accessible contact element. The incorporation of the connector (31, 33) can be automated as the electrical connector (31, 33) can be laid essentially flat in the corresponding plane of the layer system and no complex through holes are made before lamination. The position of the electrical connector (31, 33) within the layer system is possible to be more accurately deigned than the position of connectors extending from the layer system which significantly simplifies contacting the contact region (35) of the connector (31, 33), in particular with an automated solution.
US08603837B1
Combinatorial workflow is provided for evaluating cleaning processes after forming a gate structure of transistor devices, to provide optimized process conditions for gate stack formation, including metal gate stack using high-k dielectrics. NMOS and PMOS transistor devices are combinatorially fabricated on multiple regions of a substrate, with each region exposed to a different cleaning chemical and process. The transistor devices are then characterized, and the data are compared to categorize the potential damages of different cleaning chemicals and processes. Optimized chemicals and processes can be obtained to satisfy desired device requirements.
US08603828B2
Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.
US08603827B2
A tracer system comprising a tracer compound for a fluid system, the tracer compound comprising one or more polyether alcohol compounds. The one or more polyether alcohol compounds is arranged for being placed in contact with a first part of said fluid system. The one or more polyether alcohol compounds is truly monodisperse. The polyether alcohol compounds comprises one or more functional groups. The one or more truly monodisperse polyether alcohol compounds is arranged for being detected in a second part of the fluid system in fluid communication with said first part of said fluid system. The tracer compound is detectable in very low concentrations.
US08603825B2
A sensor for measuring gas permeability of a test material, comprising: an electrically conductive sensing element that comprises a water and/or oxygen sensitive material, wherein the reaction of said material with water or oxygen when the sensing element is contacted with water and/or oxygen results in a change in the electrical conductivity of the sensing element, and two electrodes electrically connected to the sensing element.
US08603821B2
A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.
US08603820B2
A synthetic cell culture surface, prepared from a mixture of at least three (meth)acrylate monomers where one of the monomers has an N-hydroxysuccinimide moiety is provided, which supports the growth of cells including undifferentiated human embryonic stem cells in defined media. Methods for preparing the cell culture surface is also provided.
US08603819B2
The present disclosure provides compositions comprising musculoskeletal cells and mesenchymal stem cells in discrete regions. The present disclosure provides systems comprising a subject composition; and methods of using a subject composition to generate cartilage, bone, tendon, muscle, intervertebral disc, or other musculoskeletal tissues.
US08603812B2
The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
US08603809B2
This invention relates to isolated pluripotent adult stem cells which are obtained from exocrine glandular tissue as well as methods of isolating and culturing these pluripotent stem cells.
US08603804B2
An apparatus and method for increasing the efficiency of finding a field of focus, and for increasing the accuracy of field of view in reading slides with fluorescent microscopy technology, including tuberculosis slides.
US08603803B2
Methods for electrochemically synthesizing polymers are provided in which a cleavable linker is coupled to the surface of at least one electrode of an array of electrodes on a substrate and a polymer coupled to the cleavable linker is synthesized through a series of monomer addition cycles. Polymers that are synthesized include nucleic acids and peptides. Cleavable linkers include linkers that can be cleaved under conditions such as reducing, oxidizing, acidic, and or basic conditions. Additionally, provided are devices that comprise an array of individually addressable electrodes having surface-attached cleavable linker molecules.
US08603802B2
A method of extracting fibers from decorticated plant bast skin involves pre-treating decorticated plant bast skin of a fiber plant with an aqueous solution containing trisodium citrate having a pH in a range of about 8-14 at a temperature of about 90° C. or less; and subsequently treating recovered fibers with a protease at alkaline pH.
US08603798B2
The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal subtype with fed-batch fermentation in a chemically-defined medium. The plasmid DNA production process described herein can generate record quantities of plasmid DNA when said highly productive clonal subtypes are cultivated on an industrial scale. The disclosed method can be used for the production of pharmaceutical grade DNA for use in polynucleotide vaccination and gene therapy treatment regimens.
US08603793B2
The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
US08603785B2
A dihydrolipoamide dehydrogenase (DLD) in a germ is recombined. The new DLD is applied in a solution to degrade an ether bond of an organic polymer. With the present invention, bioremediation is accomplished without secondary pollution of compounds which have environmental hormones.
US08603782B2
The present invention provides methods of producing isolated heat stable polypeptides by expressing the polypeptides in a prokaryotic host cell and subjecting the host cell to heat lysis. The invention further provides screening methods by producing a plurality of isolated heat stable polypeptides by expressing each of the plurality of polypeptides in a prokaryotic host cell and subjecting the host to heat lysis.
US08603767B2
A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent.
US08603762B2
TAS2R46 was identified as a dextromethorphan-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of dextromethorphan are provided.
US08603760B2
Provided is a recombination protein which binds specifically to troponin I derived from human myocardium. The recombinant protein includes a light chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 63; and a heavy chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 65.
US08603753B2
An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.
US08603750B2
The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.
US08603748B2
The phylogeny of twelve Campylobacter species was determined based on partial (1020-bp) gyrB gene sequences. Methods have been described for detection and speciation of Campylobacter, including 16S rRNA sequence analysis. However, gyrB provides a better resolution than the 16S rDNA gene for Campylobacter species with interspecies sequence similarities ranging from 58.3 to 89.2% compared to those reported for the 16S rRNA gene (ranging from 89 to 99%). A universal primer set, designed to amplify a 960-bp fragment of the gyrB gene in Campylobacter spp., was developed and used for (PCR-RFLP) of 19 strains representing twelve Campylobacter species and resulted in unique digest patterns for all twelve Campylobacter species. PCR assays for amplification of regions of the gyrB gene specific for each Campylobacter species were also developed. Using these PCR and PCR-RFLP methods results in unambiguous identification of the majority of Campylobacter species.
US08603744B2
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
US08603743B2
The present invention relates to methods and systems for single molecule based clonal amplification and subsequent detection of nucleic acid molecules, and particularly to the determination of SNPs, mutations, and to the diagnosis of diseases associated with the changes of these nucleic acid molecules.
US08603732B2
There is disclosed a resist underlayer film-forming composition comprising, at least: a resin (A) obtained by condensing a compound represented by the following general formula (1) with a compound represented by the following general formula (2) by the aid of an acid catalyst; a compound (B) represented by the general formula (1); a fullerene compound (C); and an organic solvent. There can be a resist underlayer film composition in a multi-layer resist film to be used in lithography, which underlayer film is excellent in property for filling up a height difference of a substrate, possesses a solvent resistance, and is not only capable of preventing occurrence of twisting during etching of a substrate, but also capable of providing an excellently decreased pattern roughness; a process for forming a resist underlayer film by using the composition; and a patterning process.
US08603727B2
An active light ray sensitive or radioactive ray sensitive resin composition which satisfies high sensitivity, high resolution, good pattern configuration, and good line edge roughness at the same time to a great extent, while having sufficiently good outgassing performance during exposure, and an active light ray sensitive or radioactive ray sensitive film formed by using the composition, and a pattern-forming method, are provided.The active light ray sensitive or radioactive ray sensitive resin composition according to the present invention includes a resin (P) containing a repeating unit (A) which decomposes by irradiation with active light ray or radioactive ray to generate an acid, and a repeating unit (C) containing a primary or secondary hydroxyl group.
US08603726B2
A radiation-sensitive resin composition including (A) a polymer that includes a repeating unit (a1) and a fluorine atom, and (B) a photoacid generator, the repeating unit (a1) including a group shown by any of the following formulas (1-1) to (1-3).
US08603723B2
The present invention relates to an image transfer process. The process includes the steps of: a) providing an image carrying device including at least one photoluminescent surface; b) displaying a luminous image on a display surface of a light-emitting medium; and c) positioning the display surface of the light-emitting medium that is displaying the luminous image at a distance from the at least one photoluminescent surface of the image carrying device shorter than a predetermined effective distance, for a predetermined period of time.
US08603715B2
A toner including a core particle and projections at a surface of the core particle is provided. The core particle includes a binder resin and a colorant. The binder resin includes a crystalline resin as a major component. Each of the projections consists of a fine resin particle. An average length of long sides of the projections is not less than 0.15 μm and less than 0.5 μm. A standard deviation of lengths of the long sides of the projections is 0.2 or less. A surface coverage of the toner with the projections is within a range of 30 to 90%.
US08603713B2
A toner including a colorant, a thermoplastic resin (a) comprising an amorphous polyester resin having a main chain having a polyhydroxycarboxylic acid skeleton, and a thermoplastic resin (b) is provided. The toner is manufactured by a method including mixing the colorant with the thermoplastic resin (a) to prepare a preliminary mixture, and mixing the preliminary mixture with the thermoplastic resin (b).
US08603711B2
To obtain a pigment dispersion and a yellow toner having high coloring power and high dispersibility of a pigment in a dispersion medium, a pigment dispersion containing a compound represented by general formula (1) and a yellow pigment represented by general formula (2) are provided in a dispersion medium.
US08603709B2
A photoconductor that includes a backing layer, a supporting substrate thereover, a photogenerating layer, and at least one charge transport layer of at least one charge transport component, and wherein the backing layer is in contact with the supporting substrate on the reverse side thereof, and the outermost layer of the backing layer is comprised of a polyurethane comprised of a dendritic polyester polyol and a polyisocyanate.
US08603701B2
A fuel cell component including a body disposed along a plane and having a boundary past which a reactant and water flows is provided. The boundary has a discontinuous edge adapted to militate against a pinning of the water at the edge. The fuel cell component may be a bipolar plate having a port hole with the discontinuous edge. The fuel cell component may be a subgasket for a fuel cell having a boundary with the discontinuous edge. The discontinuous edge facilitates a transportation of water from an upper surface of the fuel cell component to a lower surface of the fuel cell component.
US08603693B2
An output limiting device for a fuel cell, including: an inlet coolant temperature sensor detecting an inlet coolant temperature at a coolant inlet of the fuel cell; an outlet coolant temperature sensor detecting an outlet coolant temperature at a coolant outlet of the fuel cell; and an output limiter limiting power or current extracted from the fuel cell according to the detected inlet coolant temperature and the detected outlet coolant temperature.
US08603681B2
The present invention relates to a novel porous film material which comprises at least one carbonaceous semimetal oxide phase, and to a process for production thereof. The invention also relates to the use of these porous film materials as a separator layer or for production of such separator layers in electrochemical cells, particularly in lithium cells and especially in lithium secondary cells.The inventive porous film material comprises: a) at least one carbonaceous (semi)metal oxide phase A of silicon, of aluminum, of titanium or of zirconium, which has hydrocarbon groups bonded covalently to the (semi)metal of said (semi)metal oxide phase A; b) optionally one or more organic polymer phases B, said carbonaceous (semi)metal oxide phase A forming essentially continuous phase domains in which the pore phase present in the film material and the optionally present organic polymer phase(s) B are intercalated, the mean distance between two phase boundaries of adjacent domains of identical phases being not more than 50 nm, preferably not more than 10 nm, particularly not more than 5 nm and especially not more than 2 nm.
US08603677B2
A method for producing a coated nickel hydroxide powder suitable as a cathode active material for alkaline secondary battery includes the steps of: dispersing a nickel hydroxide powder in water to prepare a suspension, an aqueous alkali solution to the suspension with stirring to keep a pH of the suspension at 8 or higher as measured at 25° C., and supplying an aqueous cobalt salt solution to the suspension to coat a surface of each particles of the nickel hydroxide powder with cobalt hydroxide crystallized out by neutralization.
US08603667B1
An electrochemical device includes a container, a storage element, and a structure. The container includes a container main body including a first inner surface, and a lid including a second inner surface opposed to the first inner surface. The lid is bonded to the container main body. The container contains an electrolyte. The storage element includes first and second electrode layers respectively adhered to the first and second inner surfaces and a separator provided between the first and second electrode layers to retain the electrolyte, and is sandwiched between the first and second inner surfaces. The structure is provided in at least either one of the first and second inner surfaces. The structure compresses and deforms the storage element to form, in an area of the separator sandwiched between the first and second electrode layers, a thin wall portion thinner than in a peripheral area around the area.
US08603665B2
Disclosed herein is a battery pack wherein a rectangular battery having an electrode assembly and an electrolyte contained therein in a sealed state is received in a pack case, and an insulating material is filled in a space defined between the inner surface of the upper end of the pack case and the upper end of the battery, whereby the battery pack is manufactured with a reduced thickness, the assembly process of the battery pack is very simple, and short circuit of the battery pack or suspension of power supply from the battery pack, which may occur as the battery is moved, is effectively prevented even when the battery pack falls down or external impacts are applied to the battery pack.
US08603663B2
A battery pack includes a plurality of battery modules, each battery module including a plurality of battery units with positive and negative electrode terminals, and each battery unit including a plurality of battery cells, a plurality of bus bars connecting positive electrode terminals to negative electrode terminals of adjacent battery units, battery modules adjacent to each other in a horizontal direction being electrically connected to each other via the bus bar to form a loop, and a connection member electrically connecting battery modules adjacent to each other in a vertical direction.
US08603661B2
A battery connection plate has a plurality of bus bars provided on a base plate section and is to be attached to a battery assembly containing a stacked plurality of batteries so that the bus bars are connected to terminals on the batteries. The base plate section has a wiring member attachment section to which a plurality of signal output wires connected to the bus bars can be wired, and window sections through which bosses can be inserted are formed on wiring paths of the signal output wires at the wiring member attachment section. The signal output wires are wired so as to bypass or wind around the bosses inserted into the window sections, and then the bosses are pulled out from the window sections, and thereby surplus length sections are formed on the signal output wires.
US08603658B2
An activation mechanism for a reserve battery cell generally includes a housing with a chamber containing an electrolytic solution and a delivery device configured to discharge the electrolytic solution from the housing. The delivery device includes a compressed spring configured to be released in response to an external force to initiate the discharge of the electrolytic solution from the housing.
US08603657B2
A battery pack is loaded and unloaded to and from a battery mounting portion while sliding one surface thereof in the battery mounting portion. The one surface is provided with a pair of insertion guide grooves extending along the sliding direction and spaced from each other in the sliding direction. Each of the insertion guide grooves has an end portion fronting on a side surface of a battery main body.
US08603656B2
A rechargeable battery includes a housing comprising at least two cells that can be filled with an electrolyte. The rechargeable battery includes a cover and a degassing system having openings provided therein. The cover and the degassing system are arranged such that the openings provided in the cover and the degassing system are located above the cells of the rechargeable battery. A sealing plug is provided in each of the openings, the sealing plug having an upper part and a lower part having a splash basket. The upper part covers the openings on the outside of the cover and the lower part extends in the direction of the cells. The splash basket surrounds a cavity and has slots distributed over its circumference, the slots continuing as far as a free end of the splash basket.
US08603651B2
A perpendicular magnetic recording medium that is excellent in terms of electromagnetic conversion characteristics and can achieve the demand for the recording density growth, and a magnetic recording and reproducing apparatus provided with the perpendicular magnetic recording medium are provided. The perpendicular magnetic recording medium has at least a backing layer, an underlayer, an intermediate layer, and a perpendicular magnetic recording layer sequentially laminated on a non-magnetic substrate, in which the backing layer includes at least a soft magnetic film having an amorphous structure; the underlayer includes a first underlayer and a second underlayer laminated from the non-magnetic substrate side; the first underlayer is an fcc-structured alloy layer including an fcc-structured element and a bcc-structured element, the second underlayer includes a NiW alloy; and the intermediate layer includes Ru or a Ru alloy.
US08603648B2
A reflective film laminate is provided with high productivity and at low cost in which a protective film with minimized pinholes is provided to improve the alkali resistance and warm water resistance of the reflective film laminate including a pure Al film or an Al-based alloy film so that a reflectivity reduction resulting from the elution or oxidization of the Al film in an alkaline or warm water environment is less likely to occur. The reflective film laminate of the present invention includes, over a substrate, a pure Al film or an Al-based alloy film as a first layer, and an oxide film of a metal containing one or more elements selected from the group consisting of Zr, Cr, Y, Nb, Hf, Ta, W, Ti, Si, and Mo as a second layer over the first layer. The thickness of the second layer is 0.1 to 10 nm.
US08603647B2
Disclosed is a composition including an anthracene derivative and a solvent and a method for fabricating a light-emitting element using the composition. The anthracene derivative has a diphenylanthracene moiety and a carbazole moiety linked to one of the phenyl groups of the diphenylanthracene moiety. The use of the composition enables the formation of a light-emitting element by a wet type method such as an ink-jet method, a spin coating method, and a dip coating method.
US08603632B2
Embodiments of the invention include articles comprising a diamond like carbon coating or doped diamond like carbon coating on one or more surfaces of a plastic substrate or a plastic enclosure. Embodiments of the DLC or doped DLC coatings reduce the gas permeation of the coated plastic or thermoplastic to hydrogen or helium compared to the permeability of the plastic alone. The DLC or doped DLC coatings coating provides a surface resistivity of from about 107 to about 1014 ohm/square and have a transmittance that range from about 0% to about 70% less than the transmittance of the underlying plastic substrate in the range of about 300 nm to about 1100 nm. The DLC coated plastic can be used in environmental enclosures for protecting environmentally sensitive substrates such as semiconductor wafers and reticles.
US08603631B2
Disclosed are formaldehyde-free, thermally-curable, alkaline, aqueous binder compositions. The disclosed binder compositions may be cured to substantially water-insoluble thermoset polyester resins, including formaldehyde-free, substantially water-insoluble thermoset polyester resins. Uses of the disclosed binder compositions as binders for non-woven fibers and fiber materials are also disclosed.
US08603627B2
A housing is provided which includes an aluminum or aluminum alloy substrate, an aluminum layer and a corrosion resistant layer formed on the aluminum or aluminum alloy substrate in that order. The corrosion resistant layer is an Al—O layer. Then, Gd ions are implanted in the Al—O layer by ion implantation process. The atomic percentages of O in the Al—O gradient layer gradually increase from the side of Al—O gradient layer near the aluminum or aluminum alloy substrate to the other side of Al—O gradient layer, away from aluminum or aluminum alloy substrate. Therefore the housing has a high corrosion resistance. A method for making the housing is also provided.
US08603616B1
The invention relates to a lightweight transparent armor laminate comprising layers of borosilicate glass, layers of transparent glass-ceramics and a polymer spall layer of polycarbonate and/or polymethyl methacrylate. The layers are bound by polyurethane and/or polyvinylbutyral interlayer films.
US08603608B2
A graphene laminate including a substrate, a binder layer on the substrate, and graphene on the binder layer, wherein the graphene is bound to the substrate by the binder layer.
US08603598B2
In an embodiment, a multi-layer insulation (MLI) composite material includes a first thermally-reflective layer and a second thermally-reflective layer spaced from the first thermally-reflective layer. At least one of the first or second thermally-reflective layers includes a plurality of through openings configured to at least partially obstruct transmission therethrough of infrared electromagnetic radiation having a wavelength greater than a threshold wavelength. A region between the first and second thermally-reflective layers impedes heat conduction between the first and second thermally-reflective layers. Other embodiments include a storage container including a container structure that may be at least partially formed from such MLI composite materials, and methods of using such MLI composite materials.
US08603591B2
A plasma processing tool is used to deposit material on a workpiece. For example, a method for conformal deposition of material is disclosed. In this embodiment, the plasma sheath shape is modified to allow material to impact the workpiece at a range of incident angles. By varying this range of incident angles over time, a variety of different features can be deposited onto. In another embodiment, a plasma processing tool is used to etch a workpiece. In this embodiment, the plasma sheath shape is altered to allow ions to impact the workpiece at a range of incident angles. By varying this range of incident angles over time, a variety of differently shaped features can be created.
US08603588B2
Disclosed is a composition comprising a hydrolysate of an alkoxysilane compound, a hydrolysate of a siloxane compound represented by Formula (1), a surfactant, and an element having an electronegativity of 2.5 or less. In Formula (1), RA and RB independently represent a hydrogen atom, a phenyl group, —CaH2a+1, —(CH2)b(CF2)cCF3 or —CdH2d−1, RA and RB are not both hydrogen atoms simultaneously, RC and RD independently represent a single bond that links a silicon atom and an oxygen atom to form a cyclic siloxane structure, or each independently represent a hydrogen atom, a phenyl group, —CaH2a+1, —(CH2)b(CF2)cCF3, or —CdH2d−1, a represents an integer of 1 to 6, b represents an integer of 0 to 4, c represents an integer of 0 to 10, d represents an integer of 2 to 4, and n represents an integer of 3 or greater.
US08603580B2
A method for vaporizing a liquid for subsequent thin film deposition on a substrate. The method comprises vaporizing a liquid which is disposed within a tubular porous metal body. The porous metal body comprises a first surface defining a first carrier gas flow path and a second surface defining a second carrier gas flow path in a substantially opposite direct to the first carrier flow path. Vapor is generated from the liquid and added to a carrier gas that passes sequentially in direct contact along the first and second surfaces of the porous metal body to form a gas/vapor mixture with the carrier gas first flowing along the first surface and then along the second surface thereby providing a gas/vapor mixture for thin film deposition.
US08603579B2
A tubular body includes a tubular fiber-reinforced carbonaceous substrate and an SiC layer. The tubular fiber-reinforced carbonaceous substrate includes an aggregate formed of ceramic fibers, and a carbonaceous material filled in interstices between the ceramic fibers. The SiC layer is formed at least on an outer surface of the tubular fiber-reinforced carbonaceous substrate in which silicon atoms are diffused from a boundary region between the fiber-reinforced carbonaceous substrate and the SiC layer to an inside of the fiber-reinforced carbonaceous substrate.
US08603559B2
The present invention provides stable whippable or prewhipped food products comprising exudate gums in combination with proteins and optionally comprising cellulosic hydrocolloids; triglycerides; sweetener/bulking agents and water. The whippable liquid product is free of fat-based emulsifiers. The product is stable through processing and freeze/thaw and when whipped the resulting product can be used as icing, topping and filling in a dessert. The prewhipped product further comprises non-hydrogenated fat based emulsifiers but is free of other fat based emulsifiers. This product can be stored frozen and when thawed, can be directly applied as icing, topping and filling.
US08603557B2
Containers and methods are provided for dispensing a liquid concentrate utilizing one or more desirable properties including a generally consistent discharge across a range of squeeze forces, a generally consistent discharge with the same force without significant dependence on the amount of liquid concentrate in the container, a substantially dripless or leak proof outlet opening, a jet that minimizes splashing when the liquid concentrate impacts a target liquid, and a jet that maximizes mixing between the liquid concentrate and the target liquid to produce a generally homogenous mixture without the use of extraneous utensils or shaking. Also provided are liquid beverage concentrates that can be cold filled during packaging while maintaining shelf stability for at least about three months at ambient temperatures. Concentrates are provided having low pH, with or without alcohol, and with buffers to allow for increased acid content at a selected pH.
US08603554B2
Methods of preparing cheese products are described. The methods may include the step of converting at least a portion of a protein containing starting milk into discrete curd particles, and forming the curd particles into a cheese precursor. The cheese precursor may be combined with a slurry to form an admixture. The admixture may be processed into the cheese product. Also described are continuous methods of making a cheese product. The methods may include suppressing formation of a coagulum in a starting milk while adding a coagulation agent. The starting milk may be passed along a flow path, and one or more of the temperature and the pH may be adjusted to allow the formation of curd particles within the flow. The curd particles may be formed into a cheese precursor, which is combined with a slurry to form an admixture that may be processes into the cheese product.
US08603547B2
A cocoa extract obtainable by the extraction of non-defatted cocoa beans which have not been fermented or have been allowed to ferment for no more than three days, having a polyphenol content of more than 25% by weight, may be used in weight management.
US08603542B2
Methods and compositions for treating skin conditions in animals, which tend to have higher skin pH than humans, including wounds, ulcers, rashes, burns, abrasions, and other irritations and relevant injuries are provided. The invention contemplates the use of an aqueous or emollient medium having non-occlusive properties with one or more pH raising ingredients in a composition specifically designed to deliver oxygen to the skin's surface.
US08603540B2
The invention provides an insect repellent that repels flies, gnats, mosquitoes, lice, ticks, and fleas. The insect repellent comprises an avian-based extract, in particular an extract isolated from birds of the order Psittaciformes (parrots). The invention also provides an insect repellent composition about 5 volume % to about 75 volume % of the avian-based extract and about 95 volume % to about 25 volume % of a carrier vehicle.
US08603532B2
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
US08603527B2
Provided herein are pharmaceutical formulations, comprising 4-((9-((3S)-tetrahydro-3-furanyl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)-trans-cyclohexanol, including pharmaceutically acceptable salts, solvates, isomers, isotopologues, tautomers and racemic mixtures thereof, and a pharmaceutically acceptable excipient; and their use for treating or preventing disease.
US08603525B2
An orally disintegrating multilayer tablet comprising at least two discrete layers, one of which comprises at least one active agent that promotes the oxidation of opioids, preferably acetaminophen, and the other of which contains granules including an inert core which is coated with at least one opioid and at least one binder, wherein said opioid coating is coated with a subcoat comprising a compound soluble in gastric fluids, said subcoat being coated with a taste-masking coating comprising a polymer or copolymer comprising dialkylaminoalkyl(meth)acrylate units and a pore-forming agent.
US08603523B2
The present invention relates to a pharmaceutical composition including loratidine, its use in the treatment of upper respiratory mucosal congestion and a method of administration of the composition. Particularly, though not exclusively, the invention relates to a pharmaceutical composition including loratidine in an amount suitable for administration a maximum of 4 times a day, and a second active that is a hydroxyl-α-[(methylamino) methyl]-benzenemethanol, such 3-hydroxyl-α-[(methylamino) methyl]-benzenemethanol (phenylephrine), or salt thereof.
US08603515B2
The invention relates to pharmaceutical formulations, and more particularly to formulations containing cannabinoids for administration via a pump action spray. In particular, the invention relates to pharmaceutical formulations, for use in administration of lipophilic medicaments via mucosal surfaces, comprising: at least one lipophilic medicament, a solvent and a co-solvent, wherein the total amount of solvent and co-solvent present in the formulation is greater than 55% wt/wt of the formulation and the formulation is absent of a self emulsifying agent and/or a fluorinated propellant.
US08603510B2
The present invention relates generally to polymer devices impregnated with semichemical attractants for termites. The materials for delivering the semiochemicals are preferably cellulose-free. Devices of the subject invention are placed in soil and provide a slow-release and permeation of the semiochemicals into the adjacent soil so that termites tunneling in the vicinity are directed toward the chemical sources. Because the semiochemicals are impregnated in the polymer, the device also protects the semiochemicals so that they do not degrade rapidly under field conditions. In a preferred embodiment, the subject invention comprises a durable station housing, preferably with a removable bait, wherein the body of the station housing itself is impregnated with a semiochemical attractant.
US08603508B2
Disclosed is an oil-in-water emulsion comprising about 2-3% w/w of a combination of glyceryl stearate, arachidyl alcohol, PEG-100 stearate, and arachidyl glucoside.
US08603506B2
A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.
US08603501B2
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
US08603482B2
The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
US08603479B1
The present invention provides compositions and methods of use of humanized, chimeric or human Class I anti-CEA antibodies or fragments thereof, preferably comprising the light chain variable region CDR sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and the heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6). The Class I anti-CEA antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express CEACAM5 and/or CEACAM6 antigens. The Class I anti-CEA antibodies or fragments are also of use for interfering with specific processes, such as metastasis, invasiveness and/or adhesion of cancer cells, or for enhancing sensitivity of cancer cells to cytotoxic agents and have favorable effects on the survival of subjects with cancer.
US08603477B2
Uses of anti-CS1 antibodies, alone or in combination with other agents, for the treatment of rare lymphomas, such as NK lymphomas, NK/T-cell lymphomas, and angioimmunoblastic lymphomas.
US08603476B2
The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
US08603475B2
Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
US08603473B2
The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
US08603472B2
The present invention relates generally to methods and compositions for treatment of, including reversing, pre-diabetes. More specifically, the present invention relates to the administration of a fusion protein comprising at least one immunoglobulin having one or more diabetogenic epitopes including, inter alia, GAD2, inserted within a variable region thereof, for treating or reversing pre-diabetes in a subject.
US08603471B2
The present invention relates generally to methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes. More specifically, the present invention relates to the administration of a fusion protein comprising at least one immunoglobulin having one or more diabetogenic epitopes inserted within the variable region, for suspending, preventing or delaying the onset of type 1 diabetes in a pre-diabetic subject.
US08603461B2
The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.
US08603437B2
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that in normal tissues. Alternatively, the enzyme is conjugated to a targeting moiety such as an antibody or a receptor-binding molecule.
US08603435B2
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. The present invention represents a step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
US08603419B2
The invention concerns a method of treating an alkaline granular carbonatable material which contains aluminium metal and which has in particular a pH of at least 10. The method comprises an oxidation step wherein at least a portion of said aluminium metal is oxidized by contact with moisture. The aluminium should be oxidized to avoid swelling problems when using the granular material as aggregate. In the method according to the invention this oxidation is accelerated by providing at least one oxidizing agent in said moisture, which oxidizing agent has a higher redox potential than the water contained in said moisture. The method further comprises a carbonation step wherein the granular carbonatable material is at least partially carbonated to lower the pH thereof. In this way the formation of ettringite, which may also release aluminium ions which causing further swelling problems, can be avoided in the granular material or any ettringite present therein can be destabilized.
US08603417B2
Tube and cap assemblies for retaining an aliquot of fluid suitably for transferring such samples within a laboratory or between laboratories include a tube portion having at least one sidewall defining an open top. A flange extends outwardly from the open top and includes a top surface and a bottom surface. At least one channel is provided in the top surface of the flange, and an internal closed bottom extends from the at least one sidewall. The cap includes at least one peripheral wall, a hub inset from the at least one peripheral wall, and a plurality of ribs extending from the hub to the at least one peripheral wall to strengthen it against forces inward toward the hub. The cap further includes a neck having at least one bubble ring, a rim extending from the neck, and at least one sealing rib extending from the rim. In the assembly, where the cap is secured to the transfer tube, the neck extends into the open top of the transfer tube and the at least one bubble ring sealingly contacts the at least one sidewall, and the at least one sealing rib extends into the at least one channel.
US08603414B2
A micro-cassette 1 stores a sample, a reagent, and an additive, and comprises a sensor measures the component of measurement item. Analysis device 2 comprises liquid control unit controls each liquid in micro-cassette 1. Mixing controller 33 mixes the sample and the additive sent to sample processing unit 13, and generates the first sample includes a formed element. Isolation unit 14 generates the second sample from the first sample sent from sample processing unit 13. Sensor 18 measures the compound liquid of the second sample and reagent, and generates the analysis signal.
US08603404B2
A Low Temperature Conversion apparatus composed of tri-tubes which simultaneously carries out the functions of vessel and heat exchanger is provided. The apparatus is capable of thermally decomposing any kind of organic material to obtain coal, oil, water and non-condensable gases, and also decontaminating soils and residues contaminated with organochlorides and dioxins and comprises: an outer box (2) with a hermetic lid (19); a thermal insulation layer (5) disposed throughout the inner surface of the outer box (2) and lid; and at least a structure with three concentric tubes disposed internally, positioned substantially vertically and with a wall width suitable for heating by means of gases from an inner side and outer side of said structure. An associated process for thermal decomposition using the apparatus is also provided.
US08603402B2
A microwave-excited plasma device is proposed. The device comprises of a plurality of microwave plasma reaction units which are capable of generating plasma independently such that a large-area plasma is able to be generated by all of the units. Besides, the high cost of the large-area microwave coupling window and its deformation together with possible breakage caused by atmospheric pressure can be prevented. Moreover, when a plurality of permanent magnets is assembled upon each of the plasma reaction units, the microwave-excited plasma device is improved to be a large-area electron cyclotron resonance (ECR) plasma device.
US08603401B2
The present invention relates to a selective catalytic reduction (SCR) reactor assembly for removing fine particles that interfere with SCR catalyst activity in biomass fuel applications. The selective catalytic reduction (SCR) reactor assembly includes at least one turning vane disposed in a plenum chamber of the reactor, at least one rectifier layer disposed downstream of the at least one turning vane, and at least one active catalyst layer for removing particulate matter. The turning vane is adapted to impart a directional turn to the flue gas flowing through the reactor, and the at least one rectifier ensures even flow distribution.
US08603398B2
The invention provides a fragrance delivery system comprising: a control unit for controlling a release mechanism to release at least one selected fragrance, said control unit comprising a selection unit for selecting said selected fragrance from at least two fragrances and controlling said release mechanism to release said selected fragrance, and a switching element for switching said release mechanism between an first state and an second state or vice versa, in which first state said release mechanism releases said selected fragrance at a higher rate than in said second state. The invention further provides a kit of parts comprising said device and a at least two fragrance reservoirs filled with a fragrance chemical. In addition, the invention relates to the use of a control unit for controlling a release mechanism to release a selected one of at least two fragrances in a fragrance delivery system, which control unit comprises a selection unit for selecting said selected fragrance and controlling said release mechanism to release said selected fragrance, and a switching element for switching said release mechanism between an active state and an inactive state or vice versa, and to the use of the present fragrance delivery system to deliver a fragrance to a space which is at least periodically occupied by an individual.
US08603394B2
An analysis system is provided which comprises an integrated analysis device and a test strip magazine, for determining an analyte in a body fluid, wherein the analysis system comprises a first group comprising reusable components and a second group of components comprising a plurality of disposable articles. The second group includes non-electronic and electronic components, with critical interfaces configured between two or more such components, wherein non-electronic components can be disconnected from electronic components at a disconnection point. In one embodiment, critical interfaces are produced and tested during production of the analysis system.
US08603387B2
A water-cooled cover for a treatment vessel for metal melts, wherein the preferably refractorily lined treatment vessel serves in particular for the treatment of liquid metal, in particular of steel, by blowing in solids or gases, or inductive stirring at atmosphere or in vacuum. The cover is formed dome-like, wherein the ratio of inner clear height (h) to inner clear diameter (D) of a flange of the cover is at least 0.2. On the side facing the metal melt, an inner wall of the cover is formed substantially smooth and free of grooves and gaps. Cooling channels arranged on the outer side of the inner wall so that the surface temperature of the inner wall is maintained at a temperature of maximum 350° C.
US08603377B2
A process and method for retreading a heavy duty tire with a polyurethane tread where, after a tire carcass is inspected, cleaned and the worn tire tread is removed, the tire carcass receives a tube fitted therein and is installed in a mold cavity, between top and bottom mold rings. The mold rings each include spaced segments that inter-digitate and will form equal spaced tread voids in a finished recapped tire. The bottom mold ring inner edge top includes a continuous sealing lug, and the top ring is open to pass a flow of polyurethane materials, that is received off of a lower edge of a cone shaped spreader positioned onto the tire carcass top side wall and slides, as a sheet, into the mold, filling the mold cavity from bottom to top, forcing air from the mold ahead of the fill and forming the recapped tire tread.
US08603375B2
A new procedure for constructing cryogenic storage tanks involves erecting a freestanding metal liner. The liner is sized and configured to withstand the hydraulic forces the concrete wall of the tank being poured without the need for temporary stiffeners on the inside surface of lower portions of the liner. Lateral tension ties can be connected to anchor ties on an outward surface of the liner and used to tie the liner to outer formwork. These ties may be spaced up to about 2 m apart. Studs can also be provided on the outer surface of the liner, and a cylindrical ring of cryogenic steel can be integrated into the liner.
US08603368B2
Disclosed are new compound semiconductors which may be used for solar cells or as thermoelectric materials, and their application. The compound semiconductor may be represented by a chemical formula: InxMyCo4-mAmSb12-n-z-pXnQ′pTez, where M is at least one selected from the group consisting of Ca, Sr, Ba, Ti, V, Cr, Mn, Cu, Zn, Ag, Cd, Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu; A is at least one selected from the group consisting of Fe, Ni, Ru, Rh, Pd, Ir and Pt; X is at least one selected from the group consisting of Si, Ga, Ge and Sn; Q′ is at least one selected from the group consisting of O, S and Se; 0
US08603366B2
In an electric contact material of silver matrix capable of resisting arc erosion and containing no cadmium-composite, an Ag—(SnO2+In2O3) composite containing 9˜11% of (SnO2+In2O3) or an Ag—Cu oxide, composite containing 15˜25% of Cu oxide is used. The electrical contact material has a contact resistance of 5˜60 milliohms (mohm) and an arc erosion resistance capability up to 2*103˜10*103 times provided that the Vickers hardness (Hv) of the material is 100˜150, the measured current is 1˜5 amperes, and the measured voltage is 10˜20 volts. Two electrical contacts maintain an arc erosion resisting capability at the condition of a low contact resistance when the electrical contact material is formed on a surface of a metal substrate of an electric connector.
US08603364B2
A phosphor includes semiconductor nanoparticles formed of compound semiconductor, and conductive transparent compounds. The semiconductor nanoparticles may be dispersed in or on the conductive transparent compounds. The resistivity of the conductive transparent compounds is preferably less than or equal to 10 Ωcm.
US08603353B2
A thermal insulation material comprising a precipitated silica having a modified tapped density of less than or equal to 70 g/l.
US08603351B2
An object to be processed is reliably cut along a line to cut. An object to be processed is irradiated with laser light while locating a converging point at the object, so as to form a modified region in the object along a line to cut. The object formed with the modified region is subjected to an etching process utilizing an etching liquid exhibiting a higher etching rate for the modified region than for an unmodified region, so as to etch the modified region. This can etch the object selectively and rapidly along the line to cut by utilizing a higher etching rate in the modified region.
US08603350B2
A manufacturing method is provided for manufacturing a substrate for information storage media having various properties that are demanded for a next generation of information storage media substrate purposes exemplified by perpendicular magnetic recording systems, etc., and above all, having high fracture toughness and a smooth surface at low cost. The method of manufacturing a substrate for information storage media includes a step of preparing glass material of a plate shape containing SiO2 component, Al2O3 component, and R′2O component, R′ being at least one selected from Li, Na, and K, and the step of lapping includes at least one sub-step of lapping the glass material with a diamond pad.
US08603349B2
Methods of manufacturing a nanoimprint stamp are provided. The method may include forming a pattern on a surface of a master substrate, depositing an etch barrier layer on a surface of a stamp substrate, coating a photoresist on one of the surfaces of the master substrate and the stamp substrate on which an etch barrier layer is formed, forming a photoresist pattern by pressing the master substrate against the stamp substrate, forming a hard mask by etching the etch barrier layer using the photoresist pattern, and etching the stamp substrate using the hard mask as an etch mask.
US08603346B2
Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.
US08603343B2
The device described in the present invention can separate fine solid particles in suspension in a viscous liquid, withdrawing a clear liquid from the top of the device, and a dense liquid charged with solid particles is withdrawn from the bottom. The invention also concerns the application of this device to the separation of catalyst particles in a liquid phase Fischer-Tropsch synthesis process.
US08603342B2
The present invention relates to an apparatus and method for collecting solid microparticles floating in water, and more particularly, to a safe, ease to use, and environmental friendly collecting apparatus and method adapted for collecting radioactive solid microparticles floating and depositing in a cooling water tank of nuclear facility or a tank for storing radioactive materials.
US08603340B2
A process for preparing a reverse osmosis membrane that includes (A) providing a polyamine, a polyfunctional acid halide, and mono-hydrolyzed trimesoyl chloride; (B) combining the polyamine, polyfunctional acid halide, and mono-hydrolyzed trimesoyl chloride on the surface of a porous support membrane; and (C) interfacially polymerizing the polyamine and the polyfunctional acyl halide on the surface of the porous support membrane to form a reverse osmosis membrane comprising (i) the porous support membrane and (ii) a discrimination layer comprising a polyamide. The reverse osmosis membrane is characterized by a flux that is greater than the flux of the same membrane prepared in the absence of the mono-hydrolyzed trimesoyl chloride.
US08603329B2
A wastewater treatment apparatus of the present invention is configured to biologically filter wastewater through multimedia by consecutively performing two stages (the first and second stages) for a multimedia biological filtration process. A carbon source and coagulant are respectively injected during the first and second multimedia biological filtration processes. The first stage multimedia biological filtration process is carried out in anoxic conditions and the second stage multimedia biological filtration process is carried out in aerobic conditions. The media for the first and second stage biological filtration processes are arranged in large-middle-middle large-small size. Thus, the present invention can secure excellent treated water while minimizing loss of water-head by maximizing reflux capability of solids.
US08603327B2
Systems, methods and compositions for the separation and recovery of hydrocarbons from particulate matter are herein disclosed. According to one embodiment, a method includes contacting particulate matter with at least one analogue ionic liquid. The particulate matter contains at least one hydrocarbon and at least one solid particulate. When the particulate matter is contacted with the analogue ionic liquid, the hydrocarbon dissociates from the solid particulate to form a multiphase system.
US08603326B2
Systems, methods and compositions for the separation and recovery of hydrocarbons from particulate matter are herein disclosed. According to one embodiment, a method includes contacting particulate matter with at least one ionic liquid. The particulate matter contains at least one hydrocarbon and at least one solid particulate. When the particulate matter is contacted with the ionic liquid, the hydrocarbon dissociates from the solid particulate to form a multiphase system.
US08603324B2
The present invention relates to a method of hydro-upgrading inferior gasoline through ultra-deep desulfurization and octane number recovery. The method comprises the following steps: cutting inferior full-range gasoline into light fraction gasoline and heavy fraction gasolines; contacting the light fraction gasoline successively with a catalyst for selective diene removal and a catalyst for desulfurization and hydrocarbon multi-branched-chain hydroisomerization; contacting the heavy fraction gasoline with the catalyst for selective hydrodesulfurization in a first reactor, and contacting the reaction effluent from the first reactor with a catalyst for supplemental desulfurization and hydrocarbon aromatization/single-branched-chain hydroisomerization in a second reactor; and blending the treated light fraction gasoline and the heavy fraction gasoline to obtain the ultra-clean gasoline product. The hydro-upgrading method of the invention is suitable for hydro-upgrading inferior gasoline, especially for hydro-upgrading inferior FCC gasoline with ultra-high sulfur content and high olefin content to obtain excellent hydro-upgrading effects.
US08603322B2
The purpose of the invention is to provide a method for accurately quantifying a chemical substance by a substitutional stripping voltammetry technique. A method is provided for quantifying a chemical substance contained in a sample solution, and the method comprises preparing a measurement system. The measurement system comprises a pair of working electrodes (a first and a second electrodes), a counter electrode, and a gel-coated electrode. This gel-coated electrode comprises an electrode surface, a stripping gel, and a protection gel, and the protection gel covers the stripping gel.
US08603318B2
An electrolyte solution, methods, and systems for selectively removing a conductive metal from a substrate are provided. The electrolyte solution comprising nanoparticles that are more noble than the conductive metal being removed, is applied to a substrate to remove the conductive metal selectively relative to a dielectric material without application of an external potential or contact of a processing pad with a surface of the substrate. The solutions and methods can be applied, for example, to remove a conductive metal layer (e.g., barrier metal) selectively relative to a dielectric material and to a materially different conductive metal (e.g., copper interconnect) without application of an external potential or contact of a processing pad with the surface of the substrate.
US08603299B2
A method for forming a web of transversely extensible fibrous material includes the steps of subjecting a fluid-permeable endless conveyor belt of elastic material, of thickness increasing from its longitudinal axis to its edges, to a localized transverse stretching operation, achieved by temporarily withdrawing a longitudinal band thereof from the surface on which it naturally slides and maintaining it in contact, in this stretched condition, with at least a part of the surface of a support member; depositing a web of pliable fibrous material having a liquid content between 3% and 70% by weight against that portion of the conveyor belt of elastic material which has been transversely stretched; and with vacuum, maintaining the web of pliable fibrous material adhering to the conveyor belt of elastic material during its return to its original configuration, to cause the transverse contraction of the web and the simultaneous partial removal of liquid therefrom.
US08603295B2
A process for separating the components of lignocellulosic biomass for the purpose of producing a pure reactive cellulose is disclosed. The process has two stages. In the first stage, the lignocellulosic biomass is pretreated with steam, with or without an acid catalyst, and then pressed, with or without the presence of an eluent, to remove hemicellulose and other impurities. In the second stage, the pretreated biomass is extracted with a solvent such as ethanol with or without acid catalysts in order to remove lignin and release a purified cellulose stream. The extracted cellulose is then rapidly decompressed to rupture the fibrous structure. The process provides a purified cellulose stream that is relatively easy to hydrolyze with enzymes and ferment to biofuels and other chemicals such as ethanol.
US08603292B2
A five-sided quartz window configured to be mounted on a degas chamber as a UV-transmissive window. The quartz window is made of synthetic quartz and has a uniform thickness. The shape of the quartz window is defined by an upper surface, a lower surface and a sidewall therebetween. The sidewall has five straight sections interconnected by five arcuate sections. The quartz window has four arcuate recesses extending into the sidewall.
US08603291B2
Acrylic resin is used as a protection film of a polyvinyl alcohol polarizer film to compose a polarizer plate, wherein the glass transition temperature of the acrylic resin is higher than 50° C. A preparation method of the polarizer plate is also disclosed.
US08603284B2
A fluid dispensing subassembly, includes a first set of plates including a diaphragm to be operated on by a transducer, a second set of plates including at least one manifold plate to direct ink to an aperture plate forming an exterior surface of the second set of plates, and a polymer compliant film arranged in between the first and second sets of plates to attach the first and second sets of plates together to form the fluid dispensing subassembly. A method of manufacturing a fluid dispensing subassembly includes forming a first structure of at least a diaphragm and a gap plate adjacent to at least one side of a polymer compliant film, the gap plate further including an air gap integrally formed within the gap plate, forming a second structure of at least a manifold body sealed on at least one side by the polymer compliant film, placing the polymer compliant film between the first and second structures, and using the polymer compliant film as an adhesive to attach the first and second structures of plates together, forming a fluid dispensing subassembly.
US08603280B2
The invention relates to a method for producing hollow bodies from thermoplastic material, comprising the molding of at least two sheet-like, web-shaped preforms of plasticated thermoplastic material in a multi-part tool forming a cavity to form two complementary shells, and also the joining together of the shells to form a substantially closed hollow body, wherein the preforms are brought between open parts of the tool which each have part-cavities, the parts of the tool are then closed against a tool separator arranged between the preforms, and the preforms are inserted into the part-cavities with the use of differential pressure and molded. In a subsequent separate method step, the tools are reopened and internal components of the hollow body to be produced are fastened to the shells. Finally, the shells are joined together by reclosing the tools to form a closed hollow body.
US08603275B2
In a process of manufacturing pneumatic tires, a carcass sleeve is made which includes at least one carcass ply provided with axially opposite flaps turned up around annular anchoring structures, so as to form respective loops. An outer sleeve is positioned around the carcass sleeve and the latter is radially expanded in order to cause application of same against a radially internal surface of the outer sleeve. After each of the end flaps has been turned up and before radial expansion, only a portion belonging to each of the loops and extending substantially parallel to the respective annular anchoring structure is submitted to a step of carrying out heating under pressure, to make each loop integral with the annular anchoring structure and prevent the turned-up ply/plies from even partly slipping off, during the subsequent radial-expansion step of the carcass sleeve and vulcanization step of the tire.
US08603273B2
The invention relates to a method of producing a friction lining whereby a friction paper is displaced with a latex based on an elastomer and fibers of the friction paper are then bonded one another due to precipitation of the elastomer out of the latex. A non-surface active protective colloid is added to the latex as a suspension agent before applying it to the friction paper.
US08603272B2
A multilayer film comprises a layer consisting essentially of a fluorinated copolymer resin film and a layer consisting essentially of a blend of two ethylene copolymers. The first ethylene copolymer comprises copolymerized units of ethylene, optionally a first olefin having the formula CH2═C(R1)CO2R2, and a second olefin having the formula CH2═C(R3)COOH. The second ethylene copolymer consists essentially of copolymerized units of ethylene, optionally a first olefin having the formula CH2═C(R1)CO2R2, and a third olefin having the formula CH2═C(R4)D. R1, R3 and R4 represent hydrogen or an alkyl group; R2 represents an alkyl group; and D represents a moiety containing an epoxy group. The multilayer film is useful as an integrated frontsheet or backsheet for photovoltaic modules. Methods for preparing the multilayer film and the photovoltaic modules are also included.
US08603269B2
A corrosion resistant waste-water disposal or chemical injection screen is fabricated from extruded, double cold pilgered N06625 or N07716 nickel alloy in a standard oilfield tubular length. After providing each end with a premium thread for a box and a pin end, and slotting the body of the well screen with slits no wider than 0.015 inches and no longer than 2.5 inches, the well screen is ready for deployment in a well. Other types of oilfield tubulars in standard OCTG lengths could be fabricated in the manner described herein.
US08603264B2
A method for imparting wear- and corrosion-resistance to a metal component comprising overlaying the component with a ductile Co-based alloy comprising between about 0.12 wt % and about 0.7 wt % C, between about 20 wt % and about 30 wt % Cr, between about 10 wt % and about 15 wt % Mo, between about 1 wt % and about 4 wt % Ni, and balance of Co, without forming cracks during the alloy's solidification.
US08603262B2
A cleaning apparatus may include a flow source such as a fan which creates air flow through a ventilation duct or other structure to be cleaned. A projectile source projects projectiles such as dry ice pellets proximate the structure to dislodge debris particles therefrom and introduce the dislodged debris particles into the air flow. An electrostatic precipitator removes the particles from the air flow. An upstream sensor may be used to detect the particles upstream of the electrostatic precipitator and determine if the structure is clean using a controller. A downstream sensor may be used to detect the particles downstream of the electrostatic precipitator and determine the efficiency of the electrostatic precipitator using the controller. Carbon dioxide within the air flow may also be detected.
US08603260B2
A dishwasher is provided that allows the dishes that are to be cleaned that have been placed in a cleaning container to be washed and dried efficiently from an economic perspective while keeping the energy consumption associated therewith as low as possible. The dishwasher includes a washing container and a conduit system that is connected in an air-conveying manner to the washing container. A heat tube of the conduit system is used for both cooling, and thus drying, and heating air penetrating the washing container and both ends of the heat tube protrude into the washing container.
US08603255B2
A dishwasher, in particular a domestic dishwasher, having at least one substantially closed water circuit in which washing liquor is recirculated in a first direction in accordance with a program control unit, with the washing liquor being conveyed through a filter element during recirculation in order to filter impurities. Provision is made of a device for reversing the direction of flow, and this allows recirculation of the washing liquor in a second direction, which runs counter to the first direction, in order to flow through and eliminate impurities from a first screen, with the first screen being arranged in the water circuit in such a way that liquid forcibly flows through the first screen during recirculation of the washing liquor both in the first and in the second direction.
US08603253B2
A method to preparing Cadmium telluride surface before forming metal back contact is disclosed. The method can include removing carbon from Cadmium telluride surface.
US08603246B2
A method for synthesis of silicon nanowires provides a growth reactor having a decomposition zone and a deposition zone. A precursor gas introduced into the decomposition zone is disassociated to form an activated species that reacts with catalyst materials located in the deposition zone to deposit nano-structured materials on a low melting point temperature substrate in the deposition zone. A decomposition temperature in the decomposition zone is greater than a melting point temperature of the low melting point temperature substrate. The silicon nanowire are grown directly on the low melting point temperature substrate in the deposition zone to prevent the higher temperatures in the decomposition zone from damaging the molecular structure and/or integrity of the lower melting point temperature substrate located in the deposition zone.
US08603244B2
A vapor deposition device includes a base, a hollow rod, a bracket, four bearing seats, and an ion source. The base defines a through hole and four grooves in one surface thereof. The hollow rod is inserted in the through hole and defines four vents in the circumferential direction thereof. The vents point to the upper space of the grooves correspondingly. The hollow rod includes a closed end and an opposite opened end. The bracket is connected to the closed end. The bearing seats are fixed to the bracket so that the bearing seats face the grooves respectively. The ion source is coupled to the opened end. Ions emitted by the ion source are guided by the hollow rod to the vents and the upper spaces of the grooves respectively.
US08603242B2
One embodiment of the present invention is a method for producing a silicon (Si) and/or germanium (Ge) foil, the method including: dissolving a Si and/or Ge source material in a molten metallic bath at an elevated temperature T2, wherein the density of Si and/or Ge is smaller than the density of the molten metallic bath; cooling the molten metallic bath to a lower temperature T1, thereby causing Si and/or Ge to separate out of the molten metallic bath and to float and grow as a Si and/or Ge foil on a top surface of the molten metallic bath; and separating the floating Si and/or Ge foil from the top surface of the molten metallic bath.
US08603231B2
Inorganic-organic composite articles and methods for producing them using inorganic acidic/alkaline precursor components as inorganic adhesives is provided. Articles prepared therefrom provide improved flexibility, zero flame spread, no release of volatile organic compounds, and low carbon foot print.
US08603229B2
Multi-Element Structured Arrays (MESAs) present an effective approach to utilizing high pressure drop media that previously were cost prohibitive for use in a traditional filter element. The operational velocity is significantly slowed by the incorporation of numerous elements; thus, eliminating the Darcian flow resistances of the media. The MESAs are readily fitted with two or more replaceable “filter elements” that are able to employ commercially available media, microfibrous entrapped catalyst/sorbent media, unique multilayers and more. A model capable of estimating pressure drop for flow through a pleated filter is able to be used as a design tool to predict minimum initial pressure drop, maximum filtration area, and preferred media properties with respect to permeability versus thickness thus allowing the filtration system's dirt holding capacity, filtration efficiency and operational energy cost and filtration operational and total ownership costs such as blower energy, filter procurement and shipping, maintenance personnel, filter disposal, inventory and storage, cost of money and more to be improved.
US08603223B2
A water desalination system including at least one pair of evaporators, said pair including a high pressure and a low pressure evaporator, each for evaporating saline water to produce water vapor; at least three adsorption beds in selective vapor communication with each evaporator, said adsorption beds arranged to reversibly adsorb the water vapor from the corresponding evaporator; said adsorption beds in selective vapor communication with a condenser, and in heat transfer communication with a heat source for selectively desorbing the adsorbed water vapor; said condenser arranged to condense the water vapor to desalinated water; wherein said system is arranged to sequentially connect, for a pre-determined period, each evaporator to a corresponding adsorption bed, and the heat source to the third bed.
US08603221B2
A rapid cycle, gas permeable, adsorbent-containing (“RCA”) paper suitable for separating at least a portion of a first gas from a second gas in a gas mixture to produce a product stream enriched in the first gas. The RCA paper contains p-aramid fibrids and zeolite.
US08603212B2
In an iron-based powder, 0.01% to 5.0% by mass of a flaky powder having an average particle size of longitudinal size of 100 or less, a thickness of 10 μm or less, and an aspect ratio (longitudinal size-to-thickness ratio) of 5 or more with respect to the iron-based mixed powder is contained, whereby the flowability of an iron-based mixed powder is increased, the density of a green compact is increased, and ejection force is greatly reduced after compaction, thereby accomplishing an increase in product quality and a reduction in production cost.
US08603209B2
An example filter assembly prevents particles from entering a control valve and defines an airflow path between an inlet and outlet. An inlet tube extends from an inlet and defines an inlet passage into a filter housing. Openings within the inlet tube open into an interior space of a filter housing. An outer housing defines a cavity within which the filter housing is secured. The filter housing includes an open top portion that engages a cap that covers and seals the outer housing. The cap holds the filter housing to prevent movement of the filter housing.
US08603205B2
Fuel processors, methods of using fuel processors, and the like, are disclosed.
US08603202B2
A device for producing a product gas from biomass includes a reactor which is delimited by a base part and reactor walls. The reactor walls include a circumferential wall and an upper wall. The reactor includes a supply opening for the supplying of biomass, and also at least one riser for the chemical conversion of supplied biomass to a product gas and a solid substance. The riser is attached within the circumferential wall and includes an upper end and a lower end. The reactor also has a discharge opening for the discharging of the product gas. The riser is fastened to at least one reactor wall. The base wall of the reactor has a through-opening through which the lower end of the riser movably extends.
US08603198B2
A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles.
US08603193B2
A method for producing a prismatic secondary cell housing a flat electrode assembly includes disposing a first current-collecting member onto a first to-be-welded portion at a flat portion of an edge of the electrode assembly where a core-body exposed portion of the first electrode protrudes. A first receiving member is disposed onto a plane opposing the flat portion. The first current-collecting member, the core-body exposed portion, and the first receiving member are resistive-welded with the core-body exposed portion between the other members. A second current-collecting member is disposed onto a second to-be-welded portion at a position of the flat portion distanced from the first to-be-welded portion while avoiding contact between the collecting members. A conductive connecting member is placed between the collecting members or between the receiving members. The conductive connecting member and its abutting members are welded. One of the members is electrificably connected to an external output terminal.
US08603191B2
There is provided an aqueous solution containing (a) a preservative and (b) at least one azo compound represented by the following Formula (1) or a salt thereof, in which the content of (b) is 1% by mass to 25% by mass. (In Formula (1), G represents a nitrogen atom or —C(R2)═. R2 represents a hydrogen atom, a sulfo group, a carboxyl group, a substituted or unsubstituted carbamoyl group or a cyano group. X1, X2, X3, X4, X5, X6 and X7 each independently represents a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 each independently represents a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 may be bonded with each other to form a ring. All of Y2, Y3 and Y4 do not represent hydrogen atoms at the same time. M each independently represents a hydrogen atom or a monovalent countercation.)
US08603184B2
A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.
US08603183B2
A bilayered bone graft device includes a core portion comprising deminernalized gelatin and a shell portion surrounding the core portion. The shell portion includes a calcium silicate and the deminernalized gelatin in a range of 1 to 30 weight percent, and the calcium silicate has a molar ratio of calcium to silicon ranging from 10 to 0.1. The core portion and the shell portion are bound by the deminernalized gelatin without using a binder. In one embodiment of the present invention, the core portion is configured to provide buffering for receiving an insertion, and the shell portion is configured to provide a load-bearing structure.
US08603177B2
An interbody implant (20) includes first and second members (22, 24) that are configured to allow the members (22, 24) to be inserted into a disc space separately and then connected together in the disc space to form the interbody implant (20). This allows for a larger interbody implant (20) because the combined size of the members (22, 24) can exceed the size of an access opening into the disc space, with each of the members (22, 24) being sized to pass separately through the access opening before being connected together in the disc space.
US08603173B2
A space keeper for insertion between two vertebrae which has a variable axial length is provided. The space keeper possesses a sleeve-like first member (2) and a second member (3) guided in the latter and movable relative to the first member in the axial direction for adjusting an overall length. In order that adjustability during operating is facilitated the two members (2, 3) are connected to one another by a lever (7, 8), wherein one center of motion (16) of the lever is connected to one member (3) and the other center of motion (18) is connected in terms of action to the other member (2).
US08603172B2
A cage interposed between a pair of vertebral bodies, wherein both left and right side surfaces of a cage body are formed in a smooth surface, both upper and lower surfaces of the cage body are provided with a large number of projections arranged in a longitudinal direction and a lateral direction, tip end surfaces of the large number of projections substantially match with a virtual arc curved surface formed around an axis in the longitudinal direction, and angles of inner end edges of the projections close to left and right side surfaces are more acute. A longitudinal through hole is formed in the cage body in its longitudinal direction so as to penetrate the cage body, and both left and right side surfaces and both upper and lower surfaces of the cage body are provided with communication holes which are in communication with the longitudinal through hole. The communication holes are circular holes having a common diameter.
US08603162B2
An artificial mitral valve has a ring, an anterior cusp-side region, a posterior cusp-side region and a valve leaflet connected along an outer edge of the ring. The valve leaflet includes an anterior cusp forming member connected to the anterior cusp-side region and a posterior cusp forming member connected to the posterior cusp-side region. The anterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion. The upper edge is made up of a pair of right and left edges that incline inward and upward from the right and left sides, and a curved edge interposed between the inclined edges that curves along the anterior cusp-side region. The posterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion.
US08603160B2
A method for endovascularly replacing a heart valve of a patient. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor in an unexpanded configuration within a catheter to a vicinity of the heart valve; deploying the anchor from the catheter; expanding the anchor to contact tissue at an anchor site; and retrieving the anchor into the catheter. The invention also includes an apparatus for endovascularly replacing a heart valve, including: a catheter; a replacement valve configured to be disposed within the catheter for delivery to a vicinity of the heart valve; and an expandable anchor configured to be disposed within the catheter for delivery to a vicinity of the heart valve, to be deployed from the catheter, to be expanded to contact tissue at an anchor site and to be retrieved back into the catheter after having been expanded.
US08603159B2
A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchor may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand within the deficient native valve, and the anchor engages the lumen wall.
US08603158B2
An expandable stent for use within a body passageway having a body member with two ends and a wall surface disposed between the ends. The body member has a first diameter to permit delivery of the body member into a body passageway and a second expanded diameter. The surface of the stent is coated with a biological agent and a polymer which controls the release of the biological agent.
US08603152B2
An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.
US08603149B2
A substantially radiolucent cranial stabilization pin is adapted for use with a fixture for immobilizing a patient's head during a medical procedure. The pin includes a tip and a body, which are secured together to form the pin. The tip and body are constructed from non-ferrous, non-magnetic materials that are biocompatible. The tip and body are safe for use with, and compatible with, imaging techniques including MR imaging and CT imaging. In some examples the tip is a titanium insert and the body is molded within and around at least a portion of the tip. In some versions, the tip includes a hollow portion and one or more openings providing access to the hollow portion. The molded body flows into and around portions of the tip creating a secure pin suitable to withstand torque and axial forces observed in use.
US08603145B2
A poly-axial bone fastener assembly having a collar and a bone fastener can be coaxially locked to prevent poly-axial movements of the collar relative to the bone fastener while permitting the collar to rotate about an axis of the bone fastener, thereby combining the functions and advantages of a poly-axial bone screw and a fixed angle bone screw. Some embodiments of a coaxial locking mechanism may include a c-clip with a locking pin, a c-clip with hooks, a split ring with square corners, a pin that spins inside the collar, pins that travel about a neck of the bone fastener, a coaxially locking top that screws into the collar over a head of the bone fastener, and a top nut that threads onto the head of the bone fastener inside the collar to trap a flange of the collar between a shoulder of the bone fastener and the top nut.
US08603143B2
An implantable device and method for fixation of spinous processes is presented. The device has first and second spaced plates configured for attachment to portions of adjacent spinous processes. The device can also have an implant configured for insertion between two adjacent spinous processes, but need not necessarily. The method has the steps of assembling the components of the implantable device and otherwise inserting them into position onto, between, and/or adjacent two desired spinous processes.
US08603142B2
An implantable device and method for fixation of spinous processes is presented. The device has first and second spaced plates configured for attachment to portions of adjacent spinous processes. The device also has an implant configured for insertion between two adjacent spinous processes. The method has the steps of assembling the components of the implantable device and otherwise inserting them into position onto, between, and/or adjacent two desired spinous processes.
US08603136B2
An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.
US08603122B2
A device capable of capturing and facilitating the removal of a thrombus in blood vessels (or stones in biliary or urinary ducts, or foreign bodies) uses a soft coil mesh with the aid of a pull wire or string to engage the surface of a thrombus, and remove the captured thrombus. The soft coil mesh is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical elements forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. The use of multiple coil mesh elements, delivered through a single lumen or multiple lumens, preferably with separate control of at least one end of each coil, provides a firm grasp on a distal side of a thrombus, assisting in non-disruptive or minimally disrupted removal of the thrombus upon withdrawal of the device.
US08603121B2
Medical system and methods are provided for forming an Anastomosis, such as an intestinal bypass anastomosis for treatment of obesity or diabetes. The medical devices and methods are minimally invasive and reduce complications. One embodiment of the method includes forming a first opening in the first section and forming a second opening in the first section. A proximal portion of the second section is moved to a position adjacent the first opening, and a distal portion of the second section is moved to a position adjacent the second opening. In this manner, an intermediate portion of the second section extends along the first section and an anastomosis can then be formed between the first section and the second section.
US08603120B2
A surgical implant adapted to treat a prolapse in a patient is provided. The implant comprises a knitted mesh having a mass density of less than 25 g/m2. The knitted mesh includes at least one biocompatible polypropylene filament and openings. The implant is configured to be implanted in a region of the prolapse, wherein the prolapse is selected from the group consisting of urethrocoele prolapse, cystocoele prolapse, vault prolapse, uterine prolapse, enterocoele prolapse, and rectocoele prolapse. Methods of using a surgical implant are also provided.
US08603115B2
A soft tissue fixation device for use in ACL or CrCL, reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface. The teeth members are positioned so that when the affixing member is attached to the base member the teeth members will extend across and into the notched section of the top surface of the base member. The opposite ends of the affixing member is shaped to fit into aligned notches positioned along perimeter sections of the base member bottom surface for attaching the clip member to the base member.
US08603113B2
Improved medical suturing devices, systems, and methods may hold a suture needle at a fixed location relative to a handle of the device, allowing the surgeon to grasp and manipulate the handle of the suturing device to insert the needle through tissues in a manner analogous to use of a standard needle gripper. Cycling the handle from a closed position to an open position and back to the closed position may alternate the device between gripping the needle with a first clamp (for example, along a proximal portion of the needle) to gripping the needle with a second clamp (for example, along a distal portion of the needle) and optionally back to gripping with the first clamp, with the needle often staying at a substantially fixed location relative to the suturing device body. Related single-clamp needle grasping devices can be bent plastically by a surgeon, and/or have bodies that are grasped by a hand while a portion of the hand actuates a handle.
US08603107B2
A tissue anchor applicator includes an end effector assembly having first and second jaw members. The first jaw member includes a pair of spaced-apart arms configured to releasably retain a fastening member thereon. The second jaw member is configured for releasably retaining an anchor member thereon. One (or both) of the first and second jaw members is moveable with respect to the other from a spaced-apart position to an approximated position for securing tissue between the fastening member and the anchor member.
US08603105B2
A uterine manipulator includes a sound and a body. The sound has a selectively actuatable anchor disposed proximate a distal end and an operating mechanism spaced from the anchor for controlling actuation of the anchor. The body has a passage therethrough adapted to receive the sound passed proximally through the body to a position in which the operating mechanism is accessible proximally of the body and the anchor extends distally.
US08603104B2
A medical retrieval device, and related method, uses a basket formed by one or more legs to retrieve material such as calculi. At least one of the legs has at least an inner and an outer surface. The outer surface is an atraumatic surface such as a curved surface. The atraumatic surface can include one or more radii. The inner surface can be flat such that the leg has a D-shaped cross section. Other shapes are possible for the inner surface including a pointed shape that enhances the basket's stone crushing or breaking ability. The inner surface, whatever its shape, can have a rough surface (e.g., serrated, etched, toothed, etc.) for further enhancing the basket's ability to capture stones and other calculi.
US08603103B2
There is provided an intraocular lens insertion device capable of appropriately regulating the motion of a rear supporting portion during a process of moving an intraocular lens, and reducing the possibility of reoperation being required after the intraocular lens is inserted into an eye. An intraocular lens insertion device 1 comprises a main body 2, and a slider 3 and a plunger 4 that are attached to the main body 2. Further, the intraocular lens insertion device 1 is of a preset type in which an intraocular lens 5 is placed inside the main body 2 in advance. The slider 3 includes a first abutting portion 21 for pushing up a supporting portion 7 (rear supporting portion 7a) arranged on a rear side of an optical part 6 with respect to a lens advancement axis A, and second abutting portions 22a, 22b abutting against an outer edge of a rear portion of the optical part 6.
US08603101B2
The present disclosure provides a provisional tibial prosthesis system for a set of prosthetic knee joints for implantation in a natural knee, the provisional tibial prosthesis system including a bearing component and a bearing support, the spacing of the bearing component from the bearing support is adjustable to allow for representation of a variety of different sized final tibial prostheses. In this system, only one provisional bearing component corresponding to each level of constraint is needed and shims are used to adjust the spacing of the bearing component from the bearing support. The shims are slidably insertable between the bearing component and the bearing support in an anterior/posterior direction to allow for adjustment of the spacing of the bearing component from the bearing support. The number of provisional components needed during knee surgery is reduced and adjustment of the system only requires the knee joint to be distracted by a distance equal to the height of a particular shim.
US08603099B2
A method of assembling an implant in one embodiment includes aligning the connection features of a first implant component with the connection features of a second an implant component, placing an implant engagement surface of an impactor device and the first implant component in contact, striking an impaction surface of the impactor device, transferring force from the impaction surface to an impactor shaft, diverting the transferred force within the shaft, focusing a portion of the diverted force, and transferring the focused force from the shaft to the first implant component which brings the connection features on the first implant component into engagement with the connection features on the second implant component.
US08603098B2
Provided is a system and devices for use in the treatment and repair of moveable skeletal joints in the body of a subject. In particular, the present invention relates to the complete or partial posterior modular disc replacement of damaged or diseased fibrocartilage intervertebral discs in a subject wherein the replacement disc is capable of rotation and translation articulation.
US08603097B2
The present invention provides a minimally invasive surgical applicator device. The device is useful in the application of bone wax during surgical procedures to halt or reduce bone bleeding. The device may be sterilized for re-use or may be made disposable.
US08603096B2
A device for dispensing biomaterial includes a handle configured to receive a syringe, the syringe including a biomaterial and a threaded plunger, and an engagement pin retained within the handle and slidable between a first position and a second position. The engagement pin is configured to engage the threaded plunger in the first position, the engagement pin is further configured to disengage from the threaded plunger in the second position.