US11634566B2
The present invention discloses a rubber composition, production method thereof and a rubber product using the same. The rubber composition includes a rubber matrix and essential components. Based on 100 parts by weight of the rubber matrix, the rubber matrix includes a branched polyethylene with a content represented as A, in which 0
US11634561B2
The poor water solubility of high molecular weight chitosan has limited its use in areas such as food and beverage products, post-harvest treatments, cosmetic and pharmaceutical products, medical treatments, and environmental pollution treatments. Disclosed is a high-molecular-weight, solid-state chitosan powder that is completely water-soluble.
US11634554B2
The invention relates to treatment of waste with one or more microorganisms for the purposes of, including but not limited to, degrading waste, bioremediation of waste, enhancing waste stabilization, reducing contaminants in waste, reducing odor in waste, reducing organics in waste, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for uses comprising the above-mentioned uses.
US11634549B2
The present invention provides a method for fabricating patterned cellulose nanocrystal (CNC) composite nanofibers and thin films for optical and electromagnetic sensor and actuator application, comprising the following steps of: selecting materials for fabricating patterned cellulose nanocrystal (CNC) composite nanofibers; and fabricating patterned CNCs composite nanofibers by incorporating secondary phases either during electrospinning or post-processing, wherein the secondary phases may include dielectrics, electrically or magnetically activated nanoparticles or polymers and biological cells mechanically reinforced by CNCs.
US11634543B2
The present disclosure provides a polyimide polymer, which includes a repeating unit represented by formula (I). Formula (I) is defined as in the specification. The present disclosure further provides a polyimide mixture and a polyimide film, wherein the polyimide mixture is prepared by the polyimide polymer, and the polyimide film is prepared by the polyimide mixture.
US11634541B2
Provided is a catalyst for synthesizing a polyethylene oxide polymer, comprising a crown ether as a first component, a quaternary phosphonium salt as a second component, and an alkali metal and/or an alkali metal compound as a third component. The catalyst can reduce the concentration of alkali metal ions in the product and is suitable for high-standard industrial fields. Also provided is a method for synthesizing a polyethylene oxide polymer, comprising carrying out a reaction of a compound containing active hydrogen and ethylene oxide in the presence of the catalyst. The method is simple to operate and environmentally friendly, improves the quality of the synthesized product, and is suitable for high-standard industrial production.
US11634535B2
Provided is a polymer compound having a furan ring having a degree of polymerization of 185 or more and 600 or less. This polymer compound has excellent mechanical strength (flexural strength).
US11634530B2
An object to be achieved by the present invention is to provide a method for producing an artificial leather on a practically usable level without using an organic solvent and without requiring a crosslinking step for a crosslinking agent. The present invention provides a method for producing an artificial leather having a cured product layer of a moisture-curing urethane hot-melt resin composition, wherein the moisture-curing urethane hot-melt resin composition contains a urethane prepolymer having an isocyanate group and does not contain a crosslinking agent having a hydroxyl group and/or an amino group, the method including applying the moisture-curing urethane hot-melt resin composition to a substrate at a coating weight of 0.03 to 0.5 kg/m2 so as to form a cured product layer of the moisture-curing urethane hot-melt resin composition.
US11634528B2
Initiator/mediator chemistry for latent imaging polymers for volume Bragg gratings is provided. Light mediated chemistry including the use of nitroxides allows a first step imaging to occur, where a light induced pattern is recorded in the material, without the grating being apparent. A second bleaching/developing step completes the curing process and reveals the grating.
US11634514B2
A method for producing a fluoropolymer which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer, the surfactant being represented by the general formula (1): CR1R2R4—CR3R5—X-A, wherein R1 to R5 are each H or a monovalent substituent, with the proviso that at least one of R1 and R3 represents a group represented by the general formula: —Y—R6 and at least one of R2 and R5 represents a group represented by the general formula: —X-A or a group represented by the general formula: —Y—R6; and A is the same or different at each occurrence and is —COOM, —SO3M, or —OSO3M. Also disclosed is a surfactant for polymerization represented by the general formula (1), a method for producing a fluoropolymer using the surfactant and a composition including a fluoropolymer and the surfactant.
US11634513B2
Disclosed are support-activators and catalyst compositions comprising the support-activators for polymerizing olefins in which the support-activator includes clay heteroadduct, prepare from a colloidal phyllosilicate such as a colloidal smectite clay, which is chemically-modified with a heterocoagulation agent. By limiting the amount of heterocoagulation reagent relative to the colloidal smectite clay as described herein, the smectite heteroadduct support-activator is a porous and amorphous solid which can be readily isolated from the resulting slurry by a conventional filtration process, and which can activate metallocenes and related catalysts toward olefin polymerization. Related compositions and processes are disclosed.
US11634511B2
The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from γ-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclodextrin comprising, inter alia, reacting γ-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.
US11634501B2
Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
US11634500B2
This invention relates to anti-CD73 antibodies and methods of using them in treating diseases and conditions related to CD73 activity, e.g., cancer.
US11634499B2
The disclosure relates to methods to control trace metals during production of anti-CD38 antibodies, drug substances and drug products generated using the methods, and uses of the generated drug substances and drug products.
US11634494B2
The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
US11634487B2
The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.
US11634481B2
The present disclosure relates to the field of immunology, in particular to a B-cell epitope of Trichinella spiralis cysteine protease inhibitor, a hybridoma cell line, a monoclonal antibody and uses thereof. The present disclosure provides a hybridoma cell line that can generate anti-WN10 antibody, and identifies the specific B-cell epitope of WN10 protein recognized by the monoclonal antibody. These are of great significance for the diagnosis of trichinellosis, for the establishment of competitive ELISA for detecting antibodies and sandwich ELSIA for detecting circulating antigens, for the detection of Trichinella spiralis in different hosts and for the development of subunit vaccines.
US11634480B2
The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.
US11634479B2
The present invention provides an immunological binding partner reactive with a C-terminal epitope of the C5 domain of the α3 chain of collagen Type 6, and a method of immunoassay using the immunological binding partner for detecting and quantifying the C-terminal epitope. The invention also provides a method of investigating the rate of formation of extracellular matrix and a method for identifying a subject suitable for treatment with an insulin sensitizer.
US11634477B2
This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections.
US11634467B2
The present disclosure provides a cytokine-based bioactivatable drug construct (“VitoKine”) platform that aims to reduce systemic mechanism-based toxicities and lead to broader therapeutic utility for proteins and cytokines such as IL-15 and IL-2 for the treatment of cancer, autoimmune diseases, inflammatory diseases, viral infection, transplantation and various other disorders. The novel VitoKine constructs of the present invention comprise: 1) a tissue or disease site targeting moiety D1 domain (“D1”), 2) a bioactivatable moiety D2 domain (“D2”), and a concealing moiety D3 domain (“D3”). Importantly, because the “active moiety” of the VitoKine construct will remain inert until activated locally by proteases that are upregulated in diseased tissues, this will limit binding of the active moiety to the receptors or to the targets in the peripheral or on the cell-surface of non-diseased cells and tissue to prevent over-activation of the pathway and reduce undesirable “on-target” “off tissue” toxicities. Additionally, the inertness of the VitoKine active moiety prior to protease activation will significantly decrease the potential antigen or target sink, and thus, prolong the in vivo half-life and result in improved biodistribution, bioavailability and therapeutic efficacy.
US11634463B2
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
US11634452B2
The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.
US11634451B2
Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
US11634445B2
Provided is a compound comprising a first ligand LA of
US11634438B2
An organic light-emitting device and a heterocyclic compound, the device including a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes a heterocyclic compound represented by Formula 1:
US11634433B2
The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
US11634432B2
The disclosure provides compounds and salts that show high selectivity and inhibitory activity for mTORC1 and uses thereof for the treatment of disease, such as Formula I: or a pharmaceutically acceptable salt thereof.
US11634431B2
The present invention relates to a process for purification of protected polycyclic carbamoylpyridone derivatives and its conversion to polycyclic carbamoylpyridone derivatives or its pharmaceutically acceptable salts thereof.
US11634417B2
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
US11634411B2
Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
US11634410B2
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
US11634393B2
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein A, Q, R1, R2, R3, R4, W and Y are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.
US11634392B2
A high yielding extraction process for the purification of N-(2,4-dichloro-5-(4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)methanesulfonamide (sulfentrazone) by selectively partitioning the desired product from the crude mixture, thereby increasing its purity by decreasing the presence of unwanted impurities and improving the color and particle size distribution of the final sulfentrazone product. The selective partitioning is achieved by the sequential use of an organic solvent, water, aqueous inorganic base and a concentrated aqueous inorganic acid.
US11634386B2
A diphenylsulfone compound containing 4,4′-dihydroxydiphenylsulfone is produced in good yield in a short time and at a relatively low temperature. A diphenylsulfone compound represented by formula (2) below is produced by irradiating, with microwaves, a compound represented by formula (1) below and a sulfonating agent so that a dehydration condensation reaction is carried out.
US11634377B2
Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
US11634370B2
The present disclosure relates to methods for selectively hydrogenating acetylene, to methods for starting up a selective hydrogenation reactor, and to hydrogenation catalysts useful in such methods. In one aspect, the disclosure provides a method for selectively hydrogenating acetylene, the method comprising contacting a catalyst composition with a process gas. The catalyst composition comprises a porous support, palladium, and one or more ionic liquids. The process gas includes ethylene, present in the process gas in an amount of at least 20 mol. %; acetylene, present in the process gas in an amount of at least 1 ppm; and 0 to 190 ppm or at least 600 ppm carbon monoxide. At least 90% of the acetylene present in the process gas is hydrogenated, and the selective hydrogenation is conducted without thermal runaway.
US11634369B2
The present disclosure provides a joint control method for nitrogen and phosphorus emissions in farmlands, comprising: reducing nitrogen and phosphorus input during crop sowing or planting by applying composite organic material and chemical fertilizer, wherein the composite organic material comprises: 200-250 parts of edible fungi residues, 300-350 parts of charcoal and 5-10 parts of rhamnolipid; constructing a nitrogen-phosphorus retention layer by utilizing composite microbial agent in combination with 150 parts of edible fungi residues and 20 parts of straw-based hydrogel; constructing a barrier layer by utilizing composite material, and controlling downward leaching of nitrogen and phosphorus that are not absorbed by crops, wherein the composite material of the barrier layer comprises: 25-35 parts of straw-based hydrogel, 20-30 parts of edible fungi residues, 35-55 parts of bentonite and 5-10 parts of corn flour.
US11634368B2
This document provides compositions comprising (or consisting essentially of or consisting of) one or more water-soluble oils selected from the group consisting of ethoxylated macadamia oil, ethoxylated olive oil, ethoxylated avocado oil, ethoxylated meadowfoam oil, ethoxylated almond oil, ethoxylated corn oil, ethoxylated soybean oil, ethoxylated jojoba oil, ethoxylated seabuckthorn oil (e.g., fruit, berry, or seed oil), ethoxylated emu oil, ethoxylated mink oil, PEG Glyceryl Dimyristate, PEG Glyceryl Dioleate, PEG Glyceryl Distearate, and PEG Glyceryl Palmitate; and one or more agricultural chemical or biological agents. Methods for making and using the compositions also are provided.
US11634358B2
A curable glass coating composition including 5-70 wt % aliphatic polycarbonate diol, 5-60 wt % crosslinker, 1-20 wt % extender, 4-20 wt % fatty alcohol, and 2-30 wt % crystalline or amorphous powder filler material, and optionally 2-20 wt % aliphatic polyester polyol and 2-20 wt % cycloaliphatic epoxy. The coating composition can be applied to a glass substrate and cured to form a decorative cured polyurethane coating layer on the substrate that has improved caustic and UV resistance.
US11634357B2
In embodiments, a precursor glass composition comprises from about 55 wt. % to about 80 wt. % SiO2; from about 2 wt. % to about 20 wt. % Al2O3; from about 5 wt. % to about 20 wt. % Li2O; greater than 0 wt % to about 3 wt. % Na2O; a non-zero amount of P2O5 less than or equal to 4 wt. %; and from about 0.2 wt. % to about 15 wt. % ZrO2. In embodiments, ZrO2 (wt. %)+P2O5 (wt. %) is greater than 3. When the precursor glass composition is converted to a glass-ceramic article, the glass-ceramic article may include grains having a longest dimension of less than 100 nm.
US11634344B2
A fluid-treatment apparatus has a coil structure, a first circuit formed by a rectifier diode and a capacitor in parallel connection, a second circuit formed by a first coil wound on a first section of the coil structure and a second coil wound on a second section of the coil structure, and a third circuit formed by a third coil wound on the second coil and a fourth coil wound on a third section of the coil structure. The first and second coils have a first winding direction, and the third and fourth coils have a second winding direction opposite to the first winding direction. The first and second coils are a first alternate-current (AC) input terminal and the anode of the rectifier diode. The third and fourth coils are connected to a second alternate-current (AC) input terminal and the cathode of the rectifier diode.
US11634342B2
Aluminium-containing iron oxide pigments of the formula Fe2-xAlxO3 with x values from 0.01 to 0.25, characterized in that they possess an a* value of 30.5 to 32.5 CIELAB units and a b* value of 25.5 to 30.5 CIELAB units, measured in each case as full shade in the alkyd resin according to DIN EN ISO 787-25:2007.
US11634336B2
There are provided methods for preparing lithium carbonate. For example, such methods can comprise reacting an aqueous composition comprising lithium hydroxide with CO2 by sparging the CO2 the said composition, thereby obtaining a precipitate comprising the lithium carbonate. The methods can also comprise inserting at least a portion of the precipitate into a clarifier and obtaining a supernatant comprising lithium bicarbonate and a solid comprising the lithium carbonate, separating the solid from the supernatant; and heating the supernatant at a desired temperature so as to at least partially convert the lithium bicarbonate into lithium carbonate.
US11634330B2
The present invention relates to a carbonaceous material which is derived from a plant, having a specific surface area of 1800 to 3000 m2/g as measured by a BET method, a hydrogen element content of 0.42% by mass or less and an oxygen element content of 1.5% by mass or less.
US11634327B2
The present disclosure belongs to the technical filed of new carbon materials and relates to a novel sp2-sp3 hybrid crystalline carbon named Gradia and its preparation process. A novel sp2-sp3 hybrid carbon named Gradia is synthesized using sp2 hybrid carbon as raw materials under high temperature and high pressure. The basic structural units of Gradia are composed of sp2 hybrid graphite-like structural units and sp3 hybrid diamond-like structural units. Gradia disclosed in the present disclosure is a class of new sp2-sp3 hybrid carbon allotrope, whose crystal structure can vary with the widths and/or crystallographic orientation relationships of internal sp2 and/or sp3 structural units.
US11634320B2
A semiconductor oxide plate is formed on a recessed surface in a semiconductor matrix material layer. Comb structures are formed in the semiconductor matrix material layer. The comb structures include a pair of inner comb structures spaced apart by a first semiconductor portion. A second semiconductor portion that laterally surrounds the first semiconductor portion is removed selective to the comb structures using an isotropic etch process. The first semiconductor portion is protected from an etchant of the isotropic etch process by the semiconductor oxide plate, the pair of inner comb structures, and a patterned etch mask layer that covers the comb structures. A movable structure for a MEMS device is formed, which includes a combination of the first portion of the semiconductor matrix material layer and the pair of inner comb structures.
US11634310B2
A container filling assembly that can be used with container filling systems to fill containers during successive filling cycles with the same or different fluid compositions at high rates of speed, with little to no machinery changeover, and/or with little to no fluid waste.
US11634300B2
A method for detecting an entry into an elevator car of an elevator system by a passenger uses a mobile device carried by the passenger. The mobile device has at least one, but in particular a plurality of sensors, with which the mobile device detects and evaluates measured values. An entry into the elevator car is then detected on the basis of comparing the measured values with at least one stored signal pattern.
US11634298B2
Disclosed are systems and methods for feeding welding wire for welding-type applications. The wire-feeder system comprises a base platform, a spool hub, a drive roll assembly, and a wire guide assembly. The spool hub can be mounted to the base platform perpendicular to the base platform and configured to support a wire spool. The drive roll assembly can be mounted to the base platform, and having one or more sets of drive rollers configured to feed wire from the wire spool toward a welding torch. The wire guide assembly can be mounted to the base platform separately from both the wire spool and the drive roll assembly.
US11634287B2
Provided is a drive mechanism capable of withstanding sterilization treatment using a sterilization gas such as hydrogen peroxide and capable of performing positioning operation with heightened accuracy. In a drive mechanism according to the invention, a movable block disposed in the internal space of a partition wall for blocking a sterilization gas is coupled to a movable platform disposed in the external space of the partition wall by means of a magnet coupling mechanism. Further, biasing magnet units are disposed on surfaces, of the movable block and the movable platform, on which no magnet coupling mechanism is disposed, such that the biasing magnet units serve as magnetic poles repelling each other. Repelling force generated by the biasing magnet units serves as biasing force that biases the movable platform toward the partition wall.
US11634281B2
A temporary storage shelf board, a goods shelf, a control method, an apparatus and a system are provided. The temporary storage shelf board is used for providing multiple temporary storage positions. The temporary storage shelf board is provided with fork pockets, and the fork pockets is used for cooperating with a fork arm of a first robot. A goods storage and retrieval channel of the first robot is formed below the temporary storage shelf board, and when goods are stored and retrieved, the first robot is located at the goods storage and retrieval channel, and the fork pockets cooperate with the fork arm on the first robot to store and retrieve the goods. Thus, the efficiency of goods storage and retrieval can be improved.
US11634275B2
A fluid coupling includes a body, a poppet valve assembly, a handle shaft assembly, and a retention member. The body has a fluid conduit, a through-hole extending through a sidewall, and one or more openings that extend between an external surface of the body and an interior of the through hole. The poppet valve assembly is disposed within the fluid conduit and is selectively movable between an open position and a closed position. The handle shaft assembly extends through the through-hole and into the fluid conduit and is interconnected with the poppet valve assembly such that the handle shaft assembly can be actuated to move the poppet valve assembly between the open position and the closed position. The retention member is insertable through the one or more openings and into the through-hole to interact with the handle shaft assembly to selectively hold the handle shaft assembly in the body.
US11634269B1
A spray foam insulator assembly for retaining a pressurized can of spray foam at a preferred temperature includes an insulating sleeve that has a diameter of at least 68.0 mm and a height of at least 245.0 mm to insertably receive a pressurized can of spray foam. The insulating sleeve is comprised of a thermally insulating material to retain the pressurized can of spray foam at an optimal temperature for enhancing functionality of the pressurized can of spray foam. The insulating sleeve has a cut integrated into the insulating sleeve to enhance inserting the pressurized can of spray foam into the insulating sleeve. A closure is integrated into the insulating sleeve for opening and closing the cut. A belt clip is coupled to the insulating sleeve to engage an article of clothing on a user for storing the insulating sleeve.
US11634262B2
An ovenable cooking apparatus for facilitating the cooking of food components while maintaining the separateness thereof may include a first container for holding a first food component, and a second container for holding a second food component. The separation of the first food component from the second food component maintains the surface area for the first and second food components to facilitate heating of the first and second food components. The first food component may have a liquid based content for producing steam when heated, and one or both of the first container and the second container may define a passage for providing airflow and steam flow for contacting the second container and/or the second foodstuff and heating or steaming the second food component. Additionally, the second container may be steam impermeable for cooking bread and the like.
US11634256B2
A flow control insert (102) for a dispensing closure is provided. The insert has a plurality of dispensing slits (that define petals. (120,122,124,126). The petals are formed in an open position and are closed upon assembly of the insert into a dispensing closure.
US11634254B2
Disclosed is a child-resistant beverage lid with a perforated seal strip, wherein a user can peel away the perforated seal strip and remove the child-resistant beverage lid.
US11634250B2
A multi-vessel reservoir assembly is provided. The multi-vessel reservoir assembly comprises a first fluid vessel, a second fluid vessel, and at least one linkage positioned between the first and second fluid vessels. The at least one linkage serves to maintain the first and second fluid vessels in fixed and spaced-apart relationship relative to one another. The first and second fluid vessels are independent and separately operable.
US11634244B2
A system for packaging one or more items includes an order arrangement station where the one or more items can be arranged into a stack with a desired configuration. A dimensioning mechanism determines the outer dimensions of the stack and a converting assembly creates a box template that when erected forms a box that is custom sized to the dimensions of the stack. A crowder assembly holds and maintains the stack in the desired configuration while the box template is at least partially folded around the stack. The box template is secured around the stack in the form of a box.
US11634235B1
A method of operating an electrically powered rotorcraft of the type having a fuselage and a set of N rotors driven by a set of electric motors and coupled to the fuselage, N≥4, under a failure condition preventing ordinary operation of the rotorcraft. The method includes entering a failsafe mode of operation wherein autorotation of at least four of the rotors is enabled. The method also includes using electrical braking associated with a selected group of the rotors to control yaw of the rotorcraft.
US11634228B2
A flow management system for delivering air to a heat load of an aircraft includes a cover having an opening for receiving and directing an airflow, and a duct defining a non-linear fluid flow path. The fluid flow path operably couples the opening and the heat load. A configuration of the fluid flow path reduces a velocity of the airflow therein while minimizing a pressure drop of the airflow.
US11634208B2
A rigid-flexible coupled unmanned aerial vehicle (UAV) morphing wing and an additive manufacturing method thereof are disclosed. A shape memory alloy (SMA) strip/wire for controlling the wing upward deformation and an SMA strip/wire for controlling the wing downward deformation are arranged alternately, and a plurality of reinforcing ribs are arranged at intervals on the SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation are arranged on a flexible substrate, and are wrapped with an insulating covering. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation each are provided with an electric heating element.
US11634202B2
The cooling device for a power source for a ship propulsion device that pumps up cooling water, from which foreign matters with sizes that cause clogging of a cooling water route have been removed, supplies the cooling water to a cooling water passage (30), and discharges the cooling water to outside after cooling a power source (10) includes: a cartridge-type filtration device (40, 73) that is provided at a midpoint of a first water passage (36, 71) in the cooling water route and incorporates a filter (45, 46) for filtrating foreign matters remaining in the cooling water; and a second water passage (38, 72) that is branched from the first water passage and adapted such that a valve member (53) is opened to cause the cooling water to flow in a case in which clogging occurs in the filter.
US11634196B2
A straddle seat assembly having a backrest and a straddle seat is disclosed. The straddle seat has a base structure that has an upper surface to which a resiliently deformable top portion is connected. The resiliently deformable top portion covers at least partially the upper surface. The backrest is selectively connected to the resiliently deformable top portion at either one of at least two positions along a length of the straddle seat such that deformation of the top portions permits movement of the backrest. A personal watercraft having the straddle seat assembly is also disclosed.
US11634182B2
A vehicle front structure includes: a pair of front side members disposed on the front of the vehicle; a pair of damper housings connected to the pair of front side members, respectively; and a connection member connecting the pair of front side members and the pair of damper housings.
US11634178B2
An objective of the present invention is to provide a front pillar outer that has high strength and high rigidity. In an area in which the first door-side flange part and a second door-side flange part overlap with each other, the first door-side flange part and the second door-side flange part are joined to each other. In an area in which the first glass-face-side flange part and the second glass-face-side flange part overlap with each other, the first glass-face-side flange part and the second glass-face-side flange part are joined to each other.
US11634177B2
A sub-frame mounting combination structure of a vehicle body may include a fender apron side member mounted at the rear end portion of a front side member in the longitudinal direction of the vehicle body, a first side extension disposed in the transverse direction of the vehicle body and connected to the inside of the fender apron side member, a second side extension disposed in the transverse direction and connected to the outside of the fender apron side member, a tunnel member disposed in the transverse direction connecting the first side extensions at both sides at the center portion of the vehicle body to each other, and having the same phase as the first side extension, and a cap type bracket disposed to cover the fender apron side member at a portion where the fender apron side member and the first and second side extensions are connected.
US11634162B2
Systems and methods for motion planning by a vehicle computing system of an autonomous vehicle are provided. The vehicle computing system can input sensor data to a machine-learned system including one or more machine-learned models. The computing system can obtain, as an output of the machine-learned model(s), motion prediction(s) associated with object(s) detected by the system. The system can convert a shape of the object(s) into a probability of occupancy by convolving an occupied area of the object(s) with a continuous uncertainty associated with the object(s). The system can determine a probability of future occupancy of a plurality of locations in the environment at future times based at least in part on the motion prediction(s) and the probability of occupancy of the object(s). The system can provide the motion prediction(s) and the probability of future occupancy of the plurality of locations to a motion planning system of the autonomous vehicle.
US11634160B2
Aspects of the disclosure relate to a vehicle having an autonomous driving mode and a manual driving mode. The vehicle may include a steering system having one or more processors configured to control the orientation of the one or more wheels based on control commands. The vehicle may also include an autonomous driving control system configured to control the vehicle in an autonomous driving mode by generating the control commands and to send the control commands to the steering system. In addition, the steering system may thermally derate the steering system based on first temperature information for the steering system when the vehicle is operating in a manual drive mode, and the autonomous driving control system may thermally derate the steering system based on second temperature information for the steering system when the vehicle is operating in the autonomous driving mode.
US11634158B1
A method for generating a trajectory for a vehicle based on an abstract space of control parameters associated with the vehicle may include applying a machine learning model to determine an abstract space representation of the trajectory, which includes a sequence of control parameters associated with the vehicle. For instance, application of the machine learning model may include performing a search of the abstract space parameterized by control parameters that include derivatives of the position of the vehicle. Examples of control parameters include velocity, acceleration, jerk, and snap. A physical space representation of the trajectory may be determined by at least mapping the sequence of control parameters to a sequence of positions for the vehicle. A motion of the vehicle may be controlled based at least on the physical space representation of the trajectory. Related systems and computer program products are also provided.
US11634155B2
Techniques are provided for improving a perception processing pipeline for object detection that fuses image segmentation data (e.g., segmentation scores) with LiDAR points. The disclosed techniques are implemented using an architecture that accepts point clouds and images as input and estimates oriented 3D bounding boxes for all relevant object classes. In an embodiment, a method comprises: matching temporally, using one or more processors of a vehicle, points in a three-dimensional (3D) point cloud with an image; generating, using an image-based neural network, semantic data for the image; decorating, using the one or more processors, the points in the 3D point cloud with the semantic data; and estimating, using a 3D object detector with the decorated points as input, oriented 3D bounding boxes for the one or more objects.
US11634154B2
Disclosed are a driving guide system and method. The driving guide system includes an input unit configured to receive signal information from a signal controller, a memory in which a driving guide program using the signal information is embedded, and a processor configured to execute the program. When it is not possible to recognize a traffic light using a camera, the processor determines a driving behavior using the signal information and then performs autonomous driving according to the driving behavior or provides a notification to a driver.
US11634152B2
Systems and methods are provided to provide a steering indicator to a driver of a vehicle. It is determined whether a first obstacle is in a forward path of the vehicle and whether a second obstacle is present at a side of the vehicle. In response to (a) determining the first obstacle is in the forward path and (b) determining whether the second obstacle is present at the one or more sides of the vehicle, a suggested steering action indicator indicating one or more movements for the vehicle to avoid the first obstacle is provided to a user interface of the vehicle.
US11634134B2
Aspects of the disclosure relate to controlling a first vehicle in an autonomous driving mode. While doing so, a second vehicle may be identified. This vehicle may be determined to be a tailgating vehicle. An initial allowable discomfort value representing expected discomfort of an occupant of the first vehicle and expected discomfort of an occupant of the second vehicle may be identified. Determining a speed profile for a future trajectory of the first vehicle that meets the value may be attempted based on a set of factors corresponding to a reaction of the tailgating vehicle. When a speed profile that meets the value cannot be determined, the value may be adjusted until a speed profile that meets the value is determined. The speed profile that meets an adjusted value is used to control the first vehicle in the autonomous driving mode.
US11634128B2
Methods and systems are provided for a vehicle towing a trailer within a lane of a roadway that include: reconstructing, via a processor onboard the vehicle, lane markings for the trailer using lane markers as sensed via camera data; transforming the reconstructed lane markings, using additional sensor data, to a perspective of the trailer; localizing the trailer within the transformed lane markers using historical camera lane marking information, articulated vehicle dynamics, hitch angle, and trailer dimensions, without needing to add additional trailer lane sensing cameras to the trailer; calculating a time to lane crossing (T-TTLC) value for the trailer and vehicle; generating candidate blended paths of the trailer and the vehicle with a centerline of the lane of the roadway; and controlling operation of the vehicle, the trailer, or both, via instructions provided by the processor to keep the vehicle, the trailer, or both within a lane of travel.
US11634127B2
This document describes near-object detection using ultrasonic sensors. Specifically, when an object is in a near-object range or distance from a vehicle, an object-detection system of the vehicle can utilize raw range measurements and various parameters derived from the raw range measurements. The various parameters may include an average, a slope, and a variation of the range. In the near-object range, using the parameters derived from the raw range measurements may lead to increases in the accuracy and performance of a vehicle-based object-detection system. The increased accuracy in near-object detection capability enhances safe driving.
US11634126B2
A motion planner performs motion planning with collision assessment, using a motion planning lattice that represents configuration states of a primary agent (e.g., autonomous vehicle) as nodes and transitions between states as edges. The system may assign cost values to edges, the cost values representing probability or likelihood of collision for the corresponding transition. The cost values may additionally or alternatively represent a severity of collision, for example generated via a parametric function with two or more parameters and one or more weights. A primary agent and/or dynamic obstacles may be represented as respective oriented bounding boxes. Some obstacles (e.g., road markings, edge of road) may be represented as curves. A trajectory of a primary agent and/or dynamic obstacle may be represented by respective sets of fitted polynomial functions, edges on the planning graph, which represent transitions in states of the primary agent, the system sets value representing a probability of collision, and optionally representing a severity of the collision. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.
US11634103B2
A method of vehicle accident response includes generating, by a mobile device located inside a vehicle, telematics data associated with operation of the vehicle, and transmitting, from the mobile device to one or more processors via wireless communication, the telematics data. The method also includes analyzing the telematics data to determine that an accident involving the vehicle has occurred, analyzing the telematics data to determine a likelihood of injury due to the accident, and generating a communication (i) based upon the telematics data and the likelihood of injury and (ii) in response to determining that the accident has occurred. The method further includes transmitting, to the mobile device, the communication.
US11634102B2
In system and methods for loss mitigation, accident data associated with a vehicle accident involving a driver may be collected. The accident data may be analyzed, and a likely severity of the vehicle accident may be determined based upon the analysis of the accident data. A communication related to emergency assistance or an emergency assistance recommendation may be generated based upon the determined likely severity of the vehicle accident, and transmitted, via wireless communication, from one or more remote servers to a mobile device associated with the driver. A wireless communication from the driver indicating approval or modification of the emergency assistance or emergency assistance recommendation may be received. A third party may be notified, via a communication sent from the remote server(s), of requested emergency assistance as approved or modified by the driver. An estimated insurance claim may also be generated based upon vehicle accident likely severity.
US11634099B2
A breakable portion breaks, as a break start point portion, a portion in a vicinity of a center of a tip end side of a door portion away from a hinge portion on a rotation center side of the door portion when the door portion is opened. A breakable coupling portion in an area of the start point portion is disposed such that a width dimension between the breakable openings which are adjacent to each other in a plan view on a tip end portion away from the hinge portion is smaller than a width dimension on a base portion close to the hinge portion of the door portion.
US11634090B2
A cover device for a side sill of a passenger vehicle includes a sill cover which has a cover element securable on the side sill and a mobile cover element which is disposable in a length region of the side sill below a door opening of the passenger vehicle. The mobile cover element is displaceable between a covering position and an entry position by a drive unit and the drive unit, configured as a pre-assembled structural unit, has a motor and is disposed in a region of the cover element by a holding device. The motor is disposed on an outside of the cover element and protrudes into an interior of the sill cover with a motor shaft.
US11634071B2
A trailer sideswipe avoidance system for a vehicle towing a trailer is disclosed. The trailer sideswipe avoidance system includes a sensor system configured to detect objects in an operating environment of the vehicle. The trailer sideswipe avoidance system may include a controller that processes information received from the sensor system to determine whether the object detected in the operating environment of the vehicle is in the travel path of the towed trailer. A visual display displays a trailer collision alert zone and a trailer collision avoidance zone. The position of the trailer collision avoidance zone on the visual display relative to the position of the trailer collision alert zone on the visual display directionally corresponds with a collision avoidance steering angle of the vehicle relative to a current steering angle of the vehicle when the controller determines that the object is in the travel path of the towed trailer.
US11634068B2
A display device provided in a vehicle that travels autonomously includes: a display unit configured to display information to an outside of the vehicle; a determination unit configured to determine whether a travel state of the vehicle is any one of a deceleration state, a stop state, and a start state, based on a detection result of an internal sensor of the vehicle; and a display control unit configured to display on the display unit the information corresponding to each of the deceleration state, the stop state, and the start state, based on a determination result of the determination unit. In response to the determination unit having determined that the vehicle is in the deceleration state, the display control unit is configured to display on the display unit the information including a display moving from an upper side to a lower side along a vertical direction of the vehicle.
US11634065B2
A control method according to the present disclosure includes: obtaining (receiving) position information (a danger warning signal) indicating a target position where a target object is present; determining whether the vehicle is driving autonomously or is being driven manually; when the vehicle is determined to be being driven manually, inspecting whether the target position is located within a predetermined region of a travel route of the vehicle based on the position information; when the target position is located within the predetermined region, changing the light transmission state of the headlight from a first state to a second state; and when the vehicle is determined to be driving autonomously and/or the target position is not located within the predetermined region, maintaining the light transmission state of the headlight.
US11634063B2
There is provided a tensioning device for tensioning chains to secure loads on a transport vehicle. The tensioning device comprises first and second U-shaped yokes with parallel arms and an open end for coupling to fitments. The first yoke bottom has a threaded hole, while the second yoke bottom has an unthreaded hole. A threaded bolt rotatably extends through the unthreaded hole and engageably extends through the threaded hole, coupling the first and second yokes together. A limiter with a limiter leg is secured to the first yoke at the open end. The leg limits rotation of a fitment relative to the first yoke. The tensioning device includes a drive assembly having a universal type joint releasably coupleable with the threaded bolt, and an extension bar extending therefrom. Actuating the extension bar of the drive assembly rotates the threaded bolt, moving the first yoke relative to the second yoke.
US11634061B2
An apparatus for delivering proppant to a well site includes a plurality of proppant containers. The apparatus also includes a support structure having a bed and a structural framework extending down from the bed. The plurality of proppant container are structurally supported on top of the bed. A bin is disposed within the structural frame work below the bed. A conveyor cooperates with the bin for transporting proppant from the bin to a desired location at the well site. Proppant discharged from one or more of the plurality of proppant containers positioned on the bed above the bin is received in the bin and delivered to the well site by the conveyor.
US11634053B2
To ensure that passengers sleep in a good quality, comfortable and healthy sleep during their bus, airplane and train journeys and to prevent the eclipses occurring in the neck after the journey, a passenger seat sleeping pillow has an angled working principle in accordance with head and neck anatomy. The passenger seat with angle mechanism that can be produced in the system is related to the sleeping pillow and angle mechanism provides two types of assembly (FIG. 1) or (FIG. 2), optionally manual or motorized (FIG. 19), thanks to the variable apparatus enabling the assembly of the passenger seat during or after manufacturing.
US11634051B2
A kinetic seat assembly that rotates based on a force applied on an occupant seated therein is provided. The kinetic seat assembly includes a primary seat cushion frame, a primary seat back frame, a secondary seat cushion frame pivotally connected to the primary seat cushion frame, and a secondary seat back frame pivotally connected to the primary seat back frame. The kinetic seat assembly further includes a front pivot mechanism for damping movement between the primary seat cushion frame and the secondary seat cushion frame in a kinetic seat vertical direction, and an upper pivot mechanism for damping movement between the primary seat back frame and the secondary seat back frame in a kinetic seat longitudinal direction.
US11634047B2
A suspension mat for a vehicle seat comprises a spring element, and a guiding support for at least one electrical cable. The guiding support is molded onto the spring element.
US11634033B2
An electric vehicle braking system including a braking controller, a front braking system, and a rear braking system. The front braking system includes a front friction brake and a front regenerative braking system. The rear braking system includes a rear regenerative braking system and excludes a friction brake. The braking controller is configured to detect the front regenerative braking has reached a maximum force, detect additional deceleration is required, and, in response to detecting the front regenerative braking has reached the maximum force and detecting additional deceleration is required, apply the front friction brake.
US11634032B2
Methods and systems are provided for controlling a high power output direct current to alternating current converter for a vehicle. In one example, a method may include at a vehicle-on event, automatically operating the converter in a first power output mode, and transitioning to a different mode of operation in response to a transition request being received at a controller of the vehicle. In this way, the different mode of operation may be subject to confirmation via an operator of the vehicle, which may improve operational performance of the direct current to alternating current converter.
US11634010B2
The commissioning of an air conditioning system requires a series of manual steps, which leads to inefficient commissioning. A method is therefore provided for commissioning an air conditioning system of a vehicle, including the following: a) Reading in a target data record indicating a target vehicle state; b) Recording an actual data record indicating an actual vehicle state by measuring at least one signal and/or communicating with at least one vehicle component; c) Comparing the actual vehicle state with a target vehicle state; d) Activating at least one function of the air conditioning system only if the actual vehicle state corresponds to the target vehicle state.
US11634009B2
An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.
US11634004B2
An integrated thermal management system for vehicles includes: a first cooling line; a second cooling line; a refrigerant line; and a bypass line configured to diverge from the second cooling line, to be connected to a chiller, and to allow a coolant to bypass a second radiator and to circulate between a high-voltage battery and the chiller.
US11634000B2
Example illustrations are directed to a suspension system for a vehicle, which includes a controller configured to determine a roughness of a ground surface associated with the vehicle. The controller may be further configured to determine a height adjustment parameter for the suspension system based on the roughness determined, and to facilitate modification of the suspension system based on the determined height adjustment parameter. Example methods are provided, which may include determining, using a controller, a roughness of a ground surface associated with a vehicle, the roughness determined based on ride height. The method may also include determining, using the controller, a height adjustment parameter for a suspension system of the vehicle based on the roughness determined.
US11633997B2
Systems are provided for suspensions that deliver desirable wheel kinematics at prescribed conditions. A system includes a vehicle body structure with an engine cradle, and an associated wheel assembly. A suspension system links the wheel assembly with the engine cradle, and includes a link coupled with the engine cradle and coupled with the wheel assembly. A joint at the link includes a flange that has an opening, an edge, and at least one undercut defined in edge of the flange. The joint allows release of the wheel assembly from the engine cradle by designed tearing between the opening and the at least one undercut. The release is initiated only under loads above a select threshold at the joint, to provide select kinematics of the wheel assembly for specific operational cases.
US11633993B2
A tire 2 includes a tread 4, a pair of sidewalls 6, a pair of beads 10, a carcass 12, a belt 14, an inner liner 20, and a pair of insertion layers 22 disposed between the carcass 12 and the inner liner 20. Each insertion layer 22 is disposed between an end of the belt 14 and an end PB of the bead 10. Each insertion layer 22 has a volume resistivity of less than 108 Ω·cm. A complex elastic modulus of the insertion layer 22 is equivalent to or higher than a complex elastic modulus of the inner liner 20. A thickness of each sidewall 6 at a maximum width position PW is not greater than 5.0 mm.
US11633988B2
In a pneumatic tire, a groove depth H1 of each of first and second inclined lug grooves over an entire region from an opening portion to a corresponding one of first or second circumferential main grooves to a terminating end portion within a center land portion has a relationship with a maximum groove depth Hg of the corresponding one of the first or second circumferential main grooves represented by 0.80≤H1/Hg≤1.00. Additionally, a maximum groove depth H2 of each of first and second lateral grooves has a relationship with a groove depth H1e at a terminating end portion of the corresponding one of the first and second inclined lug grooves represented by 0.70≤H2/H1e≤0.90.
US11633981B2
A wheel hub includes a one-piece hub base body configured to surround at least a portion of a rolling-element bearing, the base body having a first axial end region configured to attach to a wheel adapter and/or to a wheel and a second axial end region axially opposite the first axial end region. An annular reinforcing body, which may be a metal band, is mounted on a radially outer surface of the second axial end region and connected to the radially outer surface at a joint.
US11633980B2
A wheel hub unit provided with a radially outer ring, stationary in use, a radially inner ring, rotating in use, at least one row of rolling elements, interposed between the radially outer ring and the radially inner ring, and a sealing assembly, interposed between the radially outer ring and the radially inner ring, which defines cooperating with the radially outer ring or with the radially inner ring a shield of at least one labyrinth seal. The labyrinth seal does not have a circumferential symmetry but comprises an upper portion and a lower portion with respect to a symmetry axis (A) of the wheel hub unit and is provided with an angular interruption of the shield made on its lower portion corresponding to the lower side of the wheel hub unit so as to increase an outflow section thereof from the labyrinth seal itself which facilitates gravity drainage of contaminants present inside the sealing assembly.
US11633973B2
Some embodiments provide a greeting card or a postcard with a practical joke feature. The practical joke feature can include a sound that is repeatedly played for several hours, days, weeks, etc. The card can include a mode of operation configured to allow a purchaser to experience the sound without arming the practical joke feature. The card can include a pouch that contains one or more surprises for card recipients that attempt to open or destroy the card. The card can include one or more features that resist destruction of the card and/or internal components of the card that implement the practical joke feature.
US11633971B2
A ribbon reeling mechanism includes: a gear supporting member that supports a clutch gear rotatably and is configured to move between a mesh position at which the clutch gear supported by the gear supporting member is in mesh with a first reeling-side gear and a non-mesh position at which the clutch gear supported by the gear supporting member is not in mesh with the first reeling-side gear; a clutch impeding spring that causes a clutch impeding force of impeding movement from the mesh position to the non-mesh position to act on the gear supporting member when a feed motor starts rotating in the second rotation direction; a drive member engaged with the gear supporting member; and a clutch drive mechanism that causes the gear supporting member to move to the non-mesh position against the clutch impeding force when the feed motor rotates in the second rotation direction.
US11633963B2
A fixation unit for use in a printing apparatus includes a substantially closed box for enclosing a heated space, the substantially closed box including an entry opening and an exit opening for enabling transport of a print substrate through the substantially closed box, a heating element arranged for heating the heated space enclosed by the substantially closed box, and a transport mechanism for engaging a sheet of the print substrate from the entry opening to the exit opening of the substantially closed box. The transport mechanism includes a nip of two belts that are pressed together and run concurrently and in the same direction, the belts being impermeable to any ink component. A printer includes such a fixation unit and a printing method uses such a fixation unit.
US11633951B2
This disclosure relates to a printing device for printing or dispensing a curable printing composition which is capable of changing color in response to the application of a magnetic field in the non-cured state. The printing device may be a handheld device such as a portable pen. The present disclosure further relates to curable compositions, cartridges and methods which may be used in combination with the aforementioned printing devices or in other applications.
US11633945B2
A shrinkable film capable of being overlapped and heat sealed, a preparation method for the film, and a packaging bag prepared using same, including outer surface layers and a heat sealing layer. Each outer surface layer includes a low-molecular weight compound and is subjected to electron cross-linking treatment, and the low-molecular weight compound is selected from paraffin, oleamide, stearic acid, and one or more of their derivatives. The low-molecular weight compound in each outer surface layer can, during overlapping and heat sealing, be migrated in a polymer under the action of being heated to influence movement of polymer molecular chains, and can be migrated to two molten interfaces to hinder mutual penetration of the polymer molecular chains. Further, by performing electronic cross-linking treatment on the outer surface layers, the outer surface layers form a polymer molecular chain cross-linking structure, and the movement of the polymer molecular chains is reduced.
US11633937B2
There is provided a skin foam-in-place foamed article comprising a pad (15) and a bag-like outer material (20) covering the pad (15). The outer material (20) has a top layer (21) and a liner layer (22) made of a foamed resin. The liner layer (22) has a closed cell structure. A pad-side skin layer (27a) having a density higher than that of a bulk layer (26) is provided on the liner layer (22), on a side of the pad (15). A corona treatment is applied to the pad-side skin layer (27a).
US11633929B2
Disclosed is a bead-apex storage system and a method for handling carriers, each carrier supporting a stack of bead-apexes stacked in a stacking direction and alternated with spacers separating the bead-apexes, wherein the bead-apex storage system includes a plurality of storage stations for storing the carriers and a transfer station for transferring one of the plurality of bead-apexes to a tire building machine, wherein the bead-apex storage system further includes a spacer gripper for lifting one or more of the spacers from one of the carriers in one of the plurality of storage stations and for carrying said one or more lifted spacers to the transfer station, wherein the bead-apex storage system includes a spacer gripper base for supporting the spacer gripper, wherein the spacer gripper base is movable from the transfer station to any one of the plurality of storage stations.
US11633923B2
An apparatus for applying a liquid adhesive according to an embodiment of the present invention includes: a side part including a support surface configured to support one surface of an upright secondary battery; and a lower part including an adhesion space configured to accommodate the liquid adhesive therein and configured to accommodate insertion of a sealing part disposed at the one surface of the upright secondary battery, the lower part having a passage extending from an outer periphery of the lower part to the adhesion space, the passage configured to permit the liquid adhesive to flow from the outer periphery to the adhesion space, wherein the lower part is disposed below the side part.
US11633916B2
A fused deposition modeling printer comprises a head assembly comprising a heating head. The heating head has a top, a bottom, and a conduit extending between the top and the bottom, wherein the surface of the conduit is adapted to guide a flow of material therein. The heating head comprises an electrically conductive layer along the conduit surface that, when powered, generates heat heating the flow of material traveling in the conduit. One realization uses top and bottom electrical contacts. One realization uses several circumferential electrical contacts to power the heating head.
US11633911B2
A printing apparatus is for printing a three-dimensional object. The apparatus includes an operative surface, an energy source for emitting at least one energy beam onto the operative surface and a powder dispensing mechanism for depositing powder onto the operative surface, the powder being adapted to be melted by the or each energy beam. The powder dispensing mechanism is configured to deposit multiple layers of powder onto the operative surface simultaneously.
US11633901B2
An apparatus for heating of thermally deformable sheet material includes a frame consisting of a pair of end beams extending laterally and a pair of side rails secured longitudinally between the end beams in a rectangular arrangement The side rail channels are oriented with their longitudinal openings extending upwardly. A heating tray assembly extends laterally and includes a pair of quick-release cam clamps disposed at opposed ends thereof to engage the respective side rail in a slidable, releasable fashion, so that the tray may be installed/removed at any location and clamped at that location. A sheet support assembly includes similar cam clamps at each end, and may be installed/removed at any location and translated/clamped at that location to maintain planar support of a workpiece.
US11633898B2
Apparatus for heating plastic preforms with a transport device which transports the plastic preforms during their heating along a predetermined transport path, with a first feed transport device which directly transfers the plastic preforms to the transport device in a transfer region, wherein this first feed transport device having a carrier which can be rotated with respect to an axis of rotation and has a plurality of holding devices which hold the plastic preforms, wherein each of these holding devices is in each case assigned an application device, wherein these application devices being arranged on a carrier which can be rotated about an axis of rotation.
US11633887B2
A method of the selection, modification of existing, and/or creation of polyester based polymer materials, which provide improved response to the application of local shear and/or extensional deformation inside the polyester based polymer melt in injection stretch blow molding, is disclosed. A method for manufacturing a polymer article is also provided including injecting a molten polyester based polymer in a preform mold for converting it in a preform while applying shear and/or extensional deformation on the polyester based polymer melt. Applying shear and/or extensional deformation on the polyester based polymer melt includes modifying the flow path of the molten polymer as a function of local pressure profile over at least part of the flow path. The local pressure profile is determined as a function of optimized response of the polyester based polymer melt to the applied local shear and/or extensional deformation over at least said part of the flow path.
US11633882B2
The present invention relates to a method for the production of plastic footwear (10; 100) of the “full plastic” type by means of moulding using a polyurethane mixture (M; P). The method comprises the steps of: —providing a mould (20) having a mould cavity (22) defined by at least two impressions (28, 30) and designed to receive a shoe last (24) so as to define, when the mould (20) is closed, an interspace (26) having the shape and dimensions of the plastic footwear (10; 100) to be produced; —spraying a polyurethane mixture (M, P) onto said at least two impressions (28, 30) of the mould cavity (22); —inserting the shoe last (24) inside said mould cavity (22); —closing the mould cavity (22) so that the sprayed polyurethane mixture (M, P) occupies said interspace (26); —opening the mould (20), once at least the demoulding time (td) for the sprayed polyurethane mixture (M, P) has lapsed, such that the sprayed polyurethane mixture (M, P) has solidified inside the interspace (26) forming said plastic footwear (10, 100); —extracting the shoe last (24) from the mould cavity (22); —removing the plastic footwear (10, 100) from the shoe last (24).
US11633880B2
A cleaning agent composition contains 100 parts by weight of polyethylene oxide; 25 parts by weight to 90 parts by weight of at least one type of fatty acid ester that is selected from glycerin fatty acid ester, polyglycerin fatty acid ester, or sorbitan fatty acid ester; and 15 parts by weight to 45 parts by weight of a metal salt of a fatty acid and/or a hydroxyfatty acid. The cleaning agent composition is used for cleaning a flow channel for resin in a hot runner type mold.
US11633876B2
A slurry scraping mechanism and an applying and scraping device used in an SG abrasive production process includes a scraping master support; a scraper, wherein the scraper is connected with the scraping master support through a suspension component such that the scraper is suspended, and a damping spring is arranged in the suspension component; and a torsion spring adjusting component, wherein the torsion spring adjusting component includes a plurality of torsion springs supported by a torsion spring support shaft, the torsion spring support shaft is fixed to the scraping master support, the torsion spring support shaft is movable up and down relative to the scraping master support, the torsion springs are clamped in a V-shaped plate, an end side of the V-shaped plate is connected with the scraping master support, and a side surface of the V-shaped plate is connected with the scraper.
US11633873B2
A mechanism for adjusting the position of a knife on a rotary cutterhead mounted for rotation about a central axis comprises at least three dynamics positioning points for allowing a user to adjust the knife axially, radially and tangentially with respect to the central axis of the cutterhead.
US11633864B2
A vacuum cup connected to a robotic arm for picking and placing items is disclosed. The vacuum cup includes one or more walls that defines (i) a first internal cavity and (ii) an opening to the first internal cavity, wherein the first internal cavity is defined at least in part by an interior surface adjacent to the opening to the first internal cavity, the interior surface defining an internal ridge positioned to mechanically engage a material drawn into the first internal cavity through the opening at an angle such that the mechanical engagement resists the material being removed from the first internal cavity via the opening. In response to the item being engaged and the suction system controlling the pressure within the first internal cavity to create a vacuum seal between the vacuum cup and the item, at least part of the item is caused to enter the first internal cavity at least during engagement of the vacuum seal.
US11633863B2
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for audio augmentation of physical robot sounds. A robot can determine that a first physically moveable component of the robot is to be actuated and in response, obtain a conditional state of the robot. The robot can obtain an audio object that generates an audio enhancement for the first physically moveable component being actuated, the audio enhancement having one or more characteristics that match the obtained conditional state of the robot. The robot can output the audio enhancement while actuating the first physically moveable component.
US11633860B2
A system and method for machine understanding, using program induction, includes a visual cognitive computer including a set of components designed to execute predetermined primitive functions. The method includes determining programs using a program induction engine that interfaces with the visual cognitive computer to discover programs using the predetermined primitive functions and/or executes the discovered programs based on an input.
US11633859B2
A robot including a robot mechanism including joints and drive units, a control unit controlling the drive units so that an inspection operation to inspect one target drive unit among the drive units is executed by the robot mechanism, and a notification unit notifying maintenance information of the target drive unit based on a current value of a motor of the target drive unit during the inspection operation, or on information associated with the current value, and the inspection operation includes transmitting, to the motor of the target drive unit, control command to rotate a joint as much as a predetermined rotation angle, and thereby moving a tip of the robot mechanism or a tool at the tip, close to an object at a predetermined position from a predetermined start position, to press the object, and separating the tip of the robot mechanism or the tool away from the object.
US11633855B2
To provide a robot controller and a robot control method that do not need a logic command to be associated with a teaching position for a robot, and that are thus capable of executing the logic command at a desired position and a desired timing. A robot controller includes: an operation command interpretation unit that interprets an operation command program describing a teaching operation and a teaching position for a robot, and that generates an operation command; a logic command interpretation unit that interprets a logic command program describing a logic command instructing a machining process to be performed by the robot and an execution position for the logic command, independently from the teaching operation and the teaching position, and that generates the logic command that includes the execution position; and a command execution unit that executes the operation command and the logic command.
US11633851B2
A robot system includes a robot arm driven by an electric motor and a vehicle that is movable and supports the robot arm. A control method includes (a) moving the vehicle to a work station of a first type and (b) driving the robot arm in the work station of the first type. The (a) executes a first operation mode for, in a part of the movement to the work station of the first type, moving the vehicle in a state in which electric power is not supplied to the electric motor, starting supply of the electric power to the electric motor during the movement of the vehicle in the state in which the electric power is not supplied to the electric motor, and arranging the vehicle in the work station of the first type in a state in which the electric power is supplied to the electric motor.
US11633849B2
A soft robot includes a main body configured as a tube inverted back inside itself to define a pressure channel, such that when the channel is pressurized, the main body everts, and inverted material everts and passes out of a tip at a distal end of the main body. A fluidization tube for passing air or other fluid through a core of the main body in the fluidization tube, wherein the fluidization tube engages the main body such that the fluidization tube is ejected as the distal end as the main body everts and joins part of the side of the main body as the main body everts and extends its distal tip.
US11633847B2
A system and a method for controlling a system are described. The system includes a plurality of sensors configured to be worn on a user's body. The plurality of sensors are configured to generate a plurality of signals in response to forces applied by corresponding portions of a user's body. The system also includes a processor configured to receive the plurality of signals. The processor is configured to identify commands from the user based at least partly on the plurality of signals and an operational range and/or null space of the plurality of signals for a task being performed by the user. The processor is configured to control an operation of the system based on the identified commands.
US11633843B2
A percussion tool is used for performing a chiseling operation on a workpiece with a chisel. The percussion tool comprises a housing including a cylinder portion, a tool holder coupled to the cylinder portion for holding the chisel, and a percussion mechanism including a striker supported for reciprocation in the cylinder portion. The percussion mechanism is configured to impart repeated axial impacts to the chisel with the striker. The percussion tool further comprises a flange between the cylinder portion and the tool holder. Movement of the chisel within the tool holder toward the percussion mechanism is stopped by the flange.
US11633842B2
A gas spring-powered fastener driver includes a cylinder, a moveable piston, a driver blade attached to the piston, the driver blade movable with the piston, a lifter including a rotary component operably coupled to the driver blade to move the driver blade from a driven position to a ready position, and a multi-stage planetary transmission. The transmission includes an output shaft operatively coupled to the lifter to provide torque thereto, a first bearing supporting a first portion of the output shaft for rotation, a second bearing supporting a second portion of the output shaft for rotation. The fastener driver also includes a housing having a cylinder support portion in which the cylinder is received and a transmission housing portion in which the first and second bearings are received to rotatably support the output shaft. The cylinder support portion and the transmission housing portion are integrally formed as a single piece.
US11633837B2
A retrofittable auxiliary pliers handle assembly includes a coupler removably coupled to a grip of a pair of pliers. The coupler is positionable between a free end of the grip and a pivot of the pliers. The coupler includes a receiver positioned laterally away from an exterior lateral surface of the grip. An auxiliary handle is positioned in the receiver such that the auxiliary handle is positioned adjacent to the exterior lateral surface and extends away from the pivot. A finger space is defined between the auxiliary handle and the grip. The auxiliary handle comprises a plate that elongated and has a first end, a second end, a first lateral side, a second lateral side, an upper edge and a lower edge. The coupler engages the plate adjacent to the first end such that the first lateral side faces the exterior lateral surface.
US11633832B2
A system for sanding a surface includes a sanding tool, a robotic manipulator to move the sanding tool relative to the surface, and a control unit operatively coupled with the sanding tool and the robotic manipulator. The control unit is operable to: (1) move the sanding tool to a sanding position relative to the surface in which an abrasive surface is in contact with the surface and a sanding force is approximately normal to the surface; (2) set one or more sanding parameters corresponding to a model material removal rate; (3) monitor one or more of the sanding parameters; (4) determine an actual material removal rate, based on one or more of the sanding parameters being monitored; and (5) modify one or more of the sanding parameters until the actual material removal rate is approximately equal to the model material removal rate.
US11633815B2
Provided is a solder paste which uses a conventional flux, and for which long-term preservation is made possible and an easy preservation method can be realized by suppressing changes in the viscosity of the paste over time. This solder paste is provided with a solder powder, a zirconium oxide powder, and a flux, and changes in the viscosity of the paste over time are suppressed.
US11633812B2
A machine learning device performs machine learning on a laser machine including a plurality of galvanometer mirrors for reflection of a laser beam and a plurality of galvanometer motors for driving the galvanometer mirrors to rotate, and scanning the laser beam over a workpiece. The machine learning device includes: input data acquisition unit that acquires at least two detected temperatures from the galvanometer mirrors and the galvanometer motors as input data; label acquisition unit that acquires a coefficient as a label for calculating a machining target position from an actual position of machining with the laser beam on the workpiece; and learning unit that performs supervised learning using a set of the label and the input data as training data to construct a mathematical model for calculating the machining target position from the actual machining position on the workpiece based on the at least two detected temperatures.
US11633802B2
A method for operating a double-action friction stir welding device including a welding tool having a pin member and a shoulder member, a projection/retraction mechanism for causing the pin member to project/retract relative to the shoulder member, a rotation mechanism for rotating a welding tool, and an advancing/retracting mechanism for advancing/retracting the welding tool, the method including cleaning at least one of the outer circumferential surface of the pin member and the inner circumferential surface of a through hole of the shoulder member on the basis of the level of an adhesion parameter correlated with the degree of adhesion of the material of a welding object, caused by friction stir welding, on the outer circumferential surface of the pin member and the inner circumferential surface of the through hole of the shoulder member.
US11633798B1
A process of modifying a passage in a component is provided. The process includes inserting a first material into the passage; blocking at least one end of the passage; inserting an elongated member into the passage through the first material; heat treating the passage, the first material, and the elongated member to form a solid interior in component; and machining through the solid interior to form a modified passage in the component.
US11633795B2
An easily operable, highly durable cutting machine finely adjusts the miter angle of a turntable. A cutting machine includes a turntable supported in a manner rotatable horizontally to a base and including a substantially disk-shaped table body to receive a workpiece and a table extension protruding forward from the table body, a cutting machine body located above the turntable and connected in a manner swingable vertically to the turntable, and a fine angle adjuster that adjusts a rotation angle of the turntable with respect to the base and including a rack on the base, a pinion located in the table body within an area of the table body as viewed from above and engageable with the rack directly or indirectly, and an operation part operable to rotate the pinion.
US11633774B2
A machined article 100 includes a first member 101 including an inner peripheral portion 101a formed by a hole, and a second member including an outer peripheral portion 102a fitted into the inner peripheral portion 101a of the first member 101. At least either an inner peripheral recess 101b to be formed in part of the inner peripheral portion 101a of the first member 101 or an outer peripheral recess 102b to be formed in part of the outer peripheral portion 102a of the second member 102 is formed. A slit 103 penetrating from a front to a back is formed at a position to which the inner peripheral recess 101b or the outer peripheral recess 102b corresponds, between the first member 101 and the second member 102.
US11633769B2
To provide a chassis for a small electronic device that can be formed efficiently by drawing work with low cost, is hard to cause forming failure, and causes no damage on the surface thereof on forming to provide an excellent appearance. The rolled aluminum alloy laminated sheet material is for forming a chassis for a small electronic device by drawing work, and contains a rolled aluminum alloy sheet material having a 0.2% proof stress of 200 MPa or more, and a covering material laminated at least one surface of both surfaces of the rolled aluminum alloy sheet material, and the covering material contains any one of a synthetic resin film, and a laminated material containing a metal foil having synthetic resin films laminated on both surfaces thereof. The rolled aluminum alloy sheet material may have a fibrous crystalline structure extending in a direction perpendicular to a thickness direction thereof.
US11633764B2
A cleaning apparatus includes an end cap assembly for use with an agitator. The end cap assembly includes a stationary end cap, a rotating end cap, and a fragmentor. The stationary end cap is secured to and stationary with respect to a housing of the cleaning apparatus. The rotating end cap is coupled to the agitator and rotates with the agitator relative to the housing. The stationary and rotating end caps define a gap extending radially inward therebetween. The fragmentor is disposed within the gap and is configured to break debris which enters the gap into smaller pieces. The fragmentor may be disposed on a surface of the stationary end cap facing towards the rotating end cap and/or on a surface of the rotating end cap facing towards the stationary end cap. The fragmentor may include a cutting blade and/or an abrasive surface.
US11633763B2
A container inspection system is described herein. The container inspection system includes a camera and a computing system, wherein the camera is configured to capture multiple images of a transparent container as the transparent container is transported along a conveyor. Thus, the camera captures several images of the transparent container when the transparent container is at different positions relative to the camera. The container inspection system detects a defect in the transparent container based upon one or more images in the several images.
US11633760B2
The multilayer coating film formation method for forming a multilayer coating film on a substrate comprises the steps of: applying an undercoat paint composition (X) comprising an antioxidant (a1) to a substrate to form at least one layer of an uncured first coating film; applying a topcoat paint composition (Y) containing a carboxy-containing polymer (b1) and an epoxy-containing acrylic resin (b2) to the first coating film to form an uncured second coating film; and simultaneously heating the uncured first coating film and the uncured second coating film to cure the films.
US11633759B2
Provided is a method for forming a multilayer coating film, the method being capable of forming a multilayer coating film having excellent chipping resistance, adhesion, and finished appearance. The method for forming a coating film uses a 3-coat and 1-bake system in which a three-layered multilayer coating film obtained by sequentially applying a first coloring paint (X), a second coloring paint (Y), and a clear coating paint (Z) onto an object to be coated is heated and cured at the same time, wherein the first coloring paint (X) and the second coloring paint (Y) contain a hydroxyl group-containing resin, and the clear coating paint (Z) contains a hydroxyl group-containing acrylic resin (a) and an aliphatic triisocyanate compound (b1) having a molecular weight within a specific range.
US11633754B2
The present application relates to a fragrance atomization and diffusion device convenient for replacing a fragrance liquid container. The fragrance atomization and diffusion device convenient for replacing a fragrance liquid container comprises a housing, an atomization mechanism, a bottom cover and a top cover respectively located at two ends of the housing and enclosing a chamber, a bracket fixedly mounted within the chamber, a gas supply assembly and a power supply assembly, the atomization mechanism, the gas supply assembly and the power supply assembly each mounted at the bracket; the bracket is provided along the vertical direction with a mount cavity for mounting the atomization mechanism, an end of which extends through the top cover; and the atomization mechanism comprises an atomization head and a liquid storage bottle connected to the atomization head. The present application has the advantage of convenient addition of a fragrance liquid.
US11633749B2
A multicolor powder center supplies at least one powder spraying device with different types of coating powder as required. The multicolor powder center has at least one powder container for receiving coating powder and at least one pump unit comprising at least one powder pump, in particular a dense flow pump or a diluted flow pump. The pressure side of the at least one powder pump is fluidically connected or can be fluidically connected to the powder inlet of a powder spraying device. The at least one powder container has at least one suction channel which is preferably formed in a suction pipe and which has a suction opening that opens into the interior of the powder container and an opposite discharge opening that opens into a connection, wherein the suction side of the at least one powder pump can be fluidically connected to the connection of the powder container.
US11633748B2
A fluid cartridge for a plural component sprayer is configured to receive first and second component materials and purge air from the sprayer and provide the first and second component materials and purge air to a mix chamber for spraying. The fluid cartridge includes a cartridge body, material flowpaths extending from a second end to a cartridge bore, and a purge path extending from the second end to the cartridge bore. Fluid checks are disposed in the material flowpaths and purge path to prevent backflow out of the fluid cartridge. Side seals are disposed in the material paths and are pre-loaded to extend into the cartridge bore and engage a mix chamber within the cartridge bore.
US11633741B2
The invention is directed to a slide chamber comprising a top member (10), a fluidic seal (20), a transparent closure member (30) and base member (40) wherein the top member (10) is provided with at least one examination chamber (11) and a plurality of openings (12) positioned at two sides of the cover member outside of the examination chamber (11); and the base member (40) is provided with interconnecting means (41) complementary to the openings (12) of the top member characterized in that the interconnecting means (41) of the base member (40) and the openings (12) of the top member (10) are configured to mechanically interlock with each other by lateral movement thereby pressing the top member (10) against the transparent closure (30) member in a water-tight manner.
US11633740B2
A reagent vessel, an apparatus and a method for manufacturing a lower part of a reagent vessel for an analytical instrument are disclosed. The reagent vessel is configured to store a liquid reagent. The reagent vessel comprises a cover and a lower part. The lower part comprises a bottom wall, a front wall, a rear wall, two opposing side walls and at least one connection wall. The cover, bottom wall, front wall, rear wall and two opposing side walls define at least one internal volume for storing at least one liquid reagent. The two opposing side walls are at least partially connected to one another by the at least one connection wall located within the at least one internal volume. The connection wall is spaced apart from the bottom wall. The connection wall and at least the two opposing side walls can be injection-molded and are monolithically formed.
US11633738B2
Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.
US11633736B2
This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
US11633734B2
The invention relates to a device for synthesising oligonucleotides, comprising: a reagent container receptacle (1) for holding a reagent container support (17) comprising multiple reagent containers (18); an exchangeable microfluid chip (10) comprising a synthesis chamber, fluid connectors and microfluid valves; a control device (5); fluid connecting means (2); wherein the device can be loaded with the microfluid chip (10) and the reagent container support (17) when in a loading position; a chip receptacle (3). To allow cost-effective and prompt synthesis even of small amounts of oligonucleotides, the invention provides for an actuator device (6) to be provided, with which the reagent container receptacle (1), the microfluid chip (10) and the fluid connecting means (2) can be brought from the loading position to an operating position, in which operating position the reagent container receptacle (1), the chip receptacle (3) and the fluid connecting means (2) are positioned relative to each other such that reagents can be conveyed out of the reagent containers (18) towards the synthesis chamber (14) depending on the valve position of the microfluid valves.
US11633730B2
The present invention relates generally to an apparatus that is able to provide a sealed chamber system including a cell sorter, that allows for various oxygen tensions of choice to be maintained during cell harvest, sorting (and isolation of sub-populations of cells), analysis, etc.
US11633729B2
A polymeric bead having radius R wherein the polymer comprises 0.3% to 20% by weight, based on the weight of the polymer, of polymerized units of one or more multifunctional vinyl monomer and 80% to 99.7% by weight, based on the weight of the polymer, of polymerized units of one or more monofunctional vinyl monomer, (a) wherein the polymerized units of multifunctional vinyl monomer have radial distribution factor MR of 0.9 to 1.1, and (b) wherein some of the vinyl groups in the polymerized units of multivinyl monomer are unreacted, and the unreacted vinyl groups have a radial distribution factor VR of 2.5 or higher.
US11633728B2
Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.
US11633710B2
The invention includes a gas processing system for transforming a hydrocarbon-containing inflow gas into outflow gas products, where the system includes a gas delivery subsystem, a plasma reaction chamber, and a microwave subsystem, with the gas delivery subsystem in fluid communication with the plasma reaction chamber, so that the gas delivery subsystem directs the hydrocarbon-containing inflow gas into the plasma reaction chamber, and the microwave subsystem directs microwave energy into the plasma reaction chamber to energize the hydrocarbon-containing inflow gas, thereby forming a plasma in the plasma reaction chamber, which plasma effects the transformation of a hydrocarbon in the hydrocarbon-containing inflow gas into the outflow gas products, which comprise acetylene and hydrogen. The invention also includes methods for the use of this gas processing system.
US11633709B2
In order to provide a treatment apparatus that can efficiently perform microwave irradiation, a treatment apparatus includes: a vessel made of a microwave-reflecting material, and having a first end and an irradiation opening portion, which is an emitting portion of microwaves that are emitted into the vessel; a first filter located so as to partition the vessel, and configured to separate solids that are to be separated, from the contents of the vessel; and a first reflecting member located closer to the first end than the emitting portion is and so as to partition the vessel, and configured to allow at least the contents having passed through the first filter to pass through the first reflecting member, and to reflect microwaves.
US11633705B2
An agitator for disposition within a cavity of a vessel body containing a particulate includes a weighted portion and a stirring portion. The agitator is positioned and disposed relative to the vessel body to move the stirring portion through the particulate in response to movement of the weighted portion in response to gravitational and/or inertial forces acting on the weighted portion due to movement of the vessel body. Particulate storage vessel arrangements and methods of particulate mixing are also described.
US11633699B2
A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.
US11633698B2
A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
US11633678B2
The embodiments of the present disclosure provide a system for removing particulates from liquid. The system may comprise a base, a tubular body extending upwardly from the base, a liquid quality device located above the base, a sump region located between the base and the liquid quality device, and a plurality of drag-inducing portions positioned in the sump region and projecting inwardly toward a central axis of the sump region. The tubular body may comprise an inlet and an outlet. The plurality of drag-inducing portions may comprise a first set of drag-inducing portions, a second set of drag-inducing portions, a third set of drag-inducing portions, and a fourth set of drag-inducing portions. The first, second, third, and fourth sets of drag-inducing portions may be positioned equidistant from each other and at a same height around a perimeter of the sump region.
US11633677B2
A coalescence method and related system are disclosed herein. A multiphase dispersion feed comprising first and second liquids (i.e. where droplets of the first liquid (dispersed phase) are dispersed in the second liquid (continuous phase)) is passed through a static mechanical droplet-coalescer comprising a channel characterized by a plurality of in-series segments, each segment characterized by a segment-specific-characteristic obstacle size and having geometric features disclosed herein. In embodiments of the invention, the static mechanical droplet-coalescer promotes coalescence between droplets of first liquid to form larger droplets of first liquid. Subsequently, after the dispersion exits the coalescer, the larger droplets are easier to remove from the second liquid (continuous phase) than the smaller droplets that coalesced into the larger droplets.
US11633669B2
Methods and apparatus are disclosed for video transmission. In one example, computer-readable storage media store instructions cause a processor to: generate first motion data; distribute, toward terminal devices of a plurality of viewers via a communication line, the first motion data; receive a web page; receive first operation data from a user interface; generate a second video related to a computer-implemented game on the basis of the first operation data by using the received web page; distribute the second video toward the terminal devices of the plurality of viewer; receive viewer data regarding a plurality of viewers; extract a selected game object out of a plurality of game objects to be used in the game; calculate a control parameter related to the selected game object on the basis of the viewer data; generate the second video including the selected game object; and distribute the second video toward the terminal devices.
US11633668B2
A communication device, method, and computer program product prompt correct face/eye positioning to enable perceived eye-to-eye contact of a user of a video capturing device with camera on a same device side as the viewable display device. A first communication device includes a first display device having a first graphical user interface (GUI). A first image capturing device of the first communication device has a field of view that captures a face of a first user viewing the first GUI. The first image capturing device generates a first image stream of the field of view. A controller of the communication device identifies a look target area of the first GUI proximate to the first image capturing device. The controller presents visual content on the first GUI within the look target area to prompt the first user viewing the first GUI to look towards the look target area.
US11633665B2
An electronic device according to an aspect of the present invention comprises a case formed of an ultra-light fabric material; a frame coupled to the case and supporting the case; and a face pad coupled to the frame, wherein ultra-light fabric material comprises an ultra-light material comprising a thermoplastic resin and a core material dispersed in thermoplastic resin; and a fabric thermo-compressed on at least one side of the ultra-light material by thermoplastic resin.
US11633664B2
A game system includes a mode switching unit switching a play mode between a one-player play mode and a two-player play mode, on the basis of at least one of first operation data from a left controller and second operation data from a right controller, and a control unit controlling a player character and a sub-player character in a virtual space. In the one-player play mode, the control unit switches an operation target between the player character and the sub-player character is set as an operation target, on the basis of the first operation data and the second operation data, and in the two-player play mode, the control unit controls the player character on the basis of the first operation data and controls the sub-player character on the basis of the second operation data.
US11633656B2
Various embodiments for a golf putting training aid having a first stake coupled to a second stake by an upper alignment string and a lower alignment string that collectively establish parallel reference putting lines when the first and second stakes are deployed around a putting surface to train a golfer to properly align their eyes when executing a putt are disclosed.
US11633652B2
A ball bat configured for impacting a ball. The ball bat extends along a longitudinal axis and includes a bat frame and a pivot joint. The bat frame includes a handle portion coupled to a barrel portion. The barrel portions has a distal region. The pivot joint is coupled to the distal region of the barrel portion. The pivot joint movably supports the barrel portion relative to the longitudinal axis such that the distal region of the barrel portion may pivot towards and away from the longitudinal axis about the pivot joint.
US11633650B2
A composite golf club head and a method for manufacturing the same are provided. The composite golf club head has a carbon fiber composite body and a striking face. The carbon fiber composite body is formed by multiple carbon fiber prepreg materials or multiple composite prepreg materials including carbon fiber with stacking, a positive pressure, a vacuum negative pressure, and heating. The striking face is made of a carbon fiber composite or metal material, and is fixedly glued to a front opening portion of the carbon fiber composite body. A weight of the carbon fiber composite body is reduced. Center of gravity and moment of inertia can be adjusted easily according to striking distances or feel of striking of different golf club heads for enhancing a striking performance of the composite golf club head.
US11633646B2
A respiratory treatment device includes a housing, an inlet configured to receive air into the housing, an outlet configured to permit air to exit the housing, and a flow path defined between the inlet and the outlet. A restrictor member positioned along the flow path that is configured to move between a closed position, where the flow of air along the flow path is restricted, and an open position, where the flow of air along the flow path is less restricted. A vane in communication with the flow path rotatable in response to the flow of air along the flow path is configured to move the restrictor member between the closed position and the open position. A protrusion extends in to the housing to limit movement of the restrictor member from the closed position to the open position.
US11633643B2
A rowing exercise apparatus has a linkage assembly that is provided in two boxes. One box includes a forward frame member, a crank rotatably mounted on the forward frame member, and a forward portion of a seat supporting link operatively connected to the crank. Another box includes a rearward frame member, a rocker link pivotally mounted on the rearward frame member, and a rearward portion of the seat supporting link operatively connected to the rocker link. The linkage assembly is made suitable for use by rigidly connecting the two frame members to one another and by rigidly connecting the two portions of the seat supporting link to one another. At least one bracket is rigidly interconnected between the two portions of the seat supporting link. One such bracket is welded onto a rearward end of the forward portion of the seat supporting link to underlie and directly support a proximate end of the rearward portion of the seat supporting link. A seat is mounted on the seat supporting link for movement through at least one elliptical path as the linkage assembly moves through cycles relative to the rigidly interconnected frame members.
US11633640B2
An exercise machine tension device securing system for safely and efficiently securing selectable biasing members to an exercise machine. The exercise machine tension device securing system generally includes an exercise machine including a frame and a carriage movably positioned on the frame. A plurality of tension devices may be connected to the frame at one end; with the other end being removably connected to the carriage by a selection device. The selection device may include a plurality of slots for removably receiving one or more of the tension devices to secure the tension devices selectively to the carriage. A securing member movably connected to the selection device includes projections adapted to selectively enclose the slots so as to secure the tension devices within the slots of the selection device.
US11633636B2
A wireless wild fire defense system network supporting proactive protection of life and property in GPS-specified neighborhoods using GPS-managed delivery of environmentally-clean anti-fire (AF) chemical liquid spray to property before wild fire reaches the neighborhoods. The wireless system network includes a GPS system for providing GPS-location services to each system components in the wireless system network. A wireless communication network supports one or more network databases accessible by systems and devices deployed on the wireless communication network. A fleet of mobile GPS-tracked anti-fire liquid spraying systems are assigned to GPS-specified neighborhoods for spraying anti-fire chemical liquid on combustible property, buildings, and ground cover to inhibit fire ignition and flame spread wherever the anti-fire chemical liquid is sprayed. When allowed to dry, the anti-fire chemical liquid provides fire-protection status to sprayed property that is GPS-tracked and mapped within a network database maintained on the wireless communication network, recording wherever the environmentally-safe anti-fire chemical liquid has been spray applied. The system network includes mobile computing systems, each running a mobile application and deployed to a property owner, spray contractor or other stakeholder, such as firefighters and property insurance inspectors, for remotely monitoring the fire-protection status of property in any GPS-specified neighborhood, at any time on any specified date, along with the status of active wild fires surrounding the neighborhood. A command center deployed on the wireless system network transmits wild fire alerts and notifications and property spray orders, and supports microservices configured for monitoring and managing GPS-tracked spraying operations within GPS-specified neighborhoods. Through GPS-managed delivery of anti-fire chemical liquid spray on property surfaces before arrival of wild fire, fire ignition and flame spread are inhibited, and human and animal life and property are protected.
US11633628B2
A radiotherapy dose rate monitor system includes an electrode configured to be impinged by radiotherapy radiation, and a current measurement circuit configured to measure a current through the electrode. An emission of secondary electrons emitted from the electrode provides a majority of current through the electrode.
US11633622B2
Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.
US11633621B2
A novel photobiomodulation (PBM) system and method that comprehensively directs therapeutic light energy into the brain from a combination of transcranial (through the skull) and intranasal (via the nasal channels) locations. In a preferred embodiment, the PBM device works in combination with a diagnostic tool to provide enhanced treatment of abnormal brain function intelligently, automatically, and unrestricted by geographical distances.
US11633620B2
A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.
US11633618B2
A system, device and method are provided for exposing a patient to therapeutic resonant frequency patterns (RFP) for therapy and treatment of a patient, for example, biological tissue such as muscle, tendon, ligament, and nerve tissue. The resonance frequencies originate from many bioactive substances, pharmaceuticals or other compounds, and key frequencies of the RFP of a compound can be replicated and then delivered to a patient using an electromagnetic catalyst to provide therapeutic benefits. RFPs can be imprinted in a separate device using a plasma imprinting device and method. This separate device can be actively excited by a delivery mechanism that uses electromagnetic or mechanical waves to interact with the device. The actively excited device transmits the RFPs or therapeutic resonant frequency patterns to the patient for similar enhancements and therapeutic benefits.
US11633617B2
The invention relates to a device (10) for generating a plasma jet (P) comprising a first conduit (11) inside a second conduit (12), a first electrode (17) and a second electrode (18) for generating an electric field in a feed gas flow (F) provided in a first flow channel (15) to generate a plasma jet (P), and adapted to provide a curtain gas flow (C) in the space between the first and second conduit (11,12), wherein the first electrode (17) is positioned radially outside of the first flow channel (15), and wherein the radial distance of the second electrode (18) from a longitudinal axis (I) is larger than the radial distance of the first electrode (17) from said longitudinal axis (1).
The invention further relates to an endoscope comprising a device (10), a method for generating a plasma jet (P), a method and a use of the device (10) for manipulating a cavity.
US11633615B2
A method and apparatus generate electrical currents and/or voltage in tissue using particles composed of liquid crystals and magnetic particles.
US11633612B2
A hermetically sealed feedthrough assembly for an active implantable medical device having an oxide-resistant electrical attachment for connection to an EMI filter, an EMI filter circuit board, an AIMD circuit board, or AIMD electronics. The oxide-resistant electrical attachment, including an oxide-resistant sputter layer 165 is disposed on the device side surface of the hermetic seal ferrule over which an ECA stripe is provided. The ECA stripe may comprise one of a thermal-setting electrically conductive adhesive, an electrically conductive polymer, an electrically conductive epoxy, an electrically conductive silicone, an electrically conductive polyimides, or an electrically conductive polyimide, such as those manufactured by Ablestick Corporation. The oxide-free electrical attachment between the ECA stripe and the filter or AIMD circuits may comprise one of gold, platinum, palladium, silver, iridium, rhenium, rhodium, tantalum, tungsten, niobium, zirconium, vanadium, and combinations or alloys thereof.
US11633597B2
Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
US11633591B2
Cochlear implant systems can comprise an implantable subsystem comprising a cochlear electrode, a stimulator, a battery, and a first near field communication interface positioned subcutaneously proximate an ear canal. Cochlear implant systems can further comprise a removable earplug comprising a sensor, a second near field communication interface, and a signal processor. The removable earplug can be inserted into an ear canal to align the first and second near field communication interfaces. Once aligned, the battery can provide electrical power to the removable earplug via the near field communication interfaces. The signal processor can receive input signals from the sensor of the removable earplug and generate a stimulation signal representative of the auditory signals. The signal processor can communicate the stimulation signal to the stimulator via the near field communication interfaces.
US11633590B2
A tip member for inserting into the cochlea, a device comprising: an elongate member including at least one electrode mounted thereon; and a tip member extending distally from a distal end of the elongate member, the tip member comprising a tapered portion tapering distally and a blunt end portion at a distal end of the tapered portion, wherein the tip member is resiliently flexible, and a method for making such a device.
US11633589B2
This specification generally relates to a biphasic injectable electrode which comprises a plurality of solid particles and a transporter phase, wherein both the solid particles and the transporter phase comprise poly(3,4-ethylenedioxythiophene)polystyrene sulfonate. The biphasic injectable electrode, in use in a surgical resection cavity in the brain includes inserting the biphasic injectable electrode into a surgical resection cavity in the brain with a tumor resection margin. A probe is inserted into the electrode and four counter electrodes are implanted in the surrounding brain tissue. A charge delivery device delivers charge to the probe via a wire both of which have also been implanted.
US11633586B2
A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen therethrough. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate. The motor assembly can also comprise a stator assembly disposed about the rotor. The motor assembly can also include a heat exchanger disposed about the stator assembly, the heat exchanger may be configured to direct heat radially outward away from the stator assembly, the rotor, and the chamber.
US11633582B2
An access port for subcutaneous implantation is typically connected to a catheter, a distal portion of which is disposed within a vein or other vessel of the patient. The access port described herein is configured with enhanced fluid handling features to improve fluid flow therethrough while reducing the likelihood of clotting or occlusions in the attached catheter, thus improving system patency. The access port includes a body defining a reservoir, a needle-penetrable septum covering the top opening of the reservoir, a stem including a lumen in fluid communication with the reservoir, and a volume control device positioned in the reservoir. The volume control device includes a floor designed to move from a first position below the side opening to a second position adjacent the bottom surface, and a spring element positioned between the floor and the bottom surface, the spring element biasing the floor in the first position.
US11633580B2
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.
US11633559B2
A respiratory therapy apparatus is operable to deliver multiple types of therapy to a patient. The apparatus includes a main housing and a nebulizer tray that selectively attaches to a bottom of the main housing. The apparatus also includes a filter housing unit having an antenna surrounding a pneumatic passage and a transponder chip coupled to the antenna. The main housing has also has an antenna that surrounds a respective pneumatic passage of a main outlet port of the apparatus. The main housing includes a reader that controls communication between the antennae. The main housing of the apparatus also has a pivotable hose support plate, a firmware upgrade port underneath part of the top wall of the housing, and a graphical user interface (GUI) that displays various user inputs for control of the apparatus and that displays various alert conditions that are detected.
US11633558B2
Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus.
US11633557B2
A non-combustion type flavor inhaler comprising: an atomizer atomizing an aerosol source without burning; and a controller controlling a power output to the atomizer, wherein the controller is configured to start supply of a power output to the atomizer before start of a user's puffing action, and is configured to stop supply of a power output to the atomizer during a user's puffing action.
US11633556B2
There is disclosed an aerosol delivery device comprising: a first aerosol generator to generate a first aerosol from a first aerosol precursor and to introduce said first aerosol into a first fluid flow pathway, wherein said first aerosol is sized for pulmonary penetration; a second aerosol generator to generate a second aerosol from a second aerosol precursor and to introduce the second aerosol into a second fluid flow pathway, wherein said second aerosol generator comprises a Venturi aperture to dispense and aerosolise the in second aerosol precursor in the second aerosol generator, wherein the second aerosol precursor is a liquid, and wherein the second aerosol is sized to inhibit pulmonary penetration; wherein the second aerosol is transmissible within at least one of: a mammalian oral cavity and a mammalian nasal cavity, and the second aerosol comprising an active component for activating at least one of: one or more taste receptors in said oral cavity and one or more olfactory receptors in said nasal cavity.
US11633554B1
Methods and apparatuses for the therapeutic delivery of nicotine for smoking cessation, harm reduction and/or substitution. Furthermore, the devices and methods herein are useful as an alternative, general nicotine delivery system in place of tobacco combustion or high temperature (over 150 degrees C.) products. In addition, the methods and devices herein are useful for the therapeutic delivery of a drug, for reducing the cumulative drug dose and hence its potential toxic side effects, while increasing its neurophysiological and/or physiological effects. Moreover, the devices and methods herein are useful for addiction treatment or reduction. In certain embodiments, the methods are adaptable to a medicament delivery device that determines a sequence of drug doses to be delivered. Dose information may be used to control operation of the device.
US11633541B2
Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.
US11633532B2
A device has a power source having a high voltage terminal and a low voltage terminal, an oil-free gas compressor, a first molecular sieve, multiple ionized gas generators, an outer metal pipe, an inner metal pipe, a dielectric insulating ceramic sheet, and a gas outlet pipe. The first molecular sieve is connected between the oil-free gas compressor and the ionized gas generators, and is capable of filtering out molecules in the gas except for oxygen. The outer metal pipe and the inner metal pipe are electrically connected to the low voltage terminal and the high voltage terminal respectively. The dielectric insulating ceramic sheet is mounted between the outer metal pipe and the inner metal pipe, and forms an ionizing space, which communicates with the ionizing space, with the outer metal pipe.
US11633524B2
A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.
US11633523B2
Provided are a method for producing a cell tissue, including a culturing step of culturing cells capable of serving as a feeder inside opening pores and communicating pores of a porous film having a plurality of the opening pores provided on a surface thereof and the communicating pores communicating mutually adjacent opening pores with one another; and a porous film including a plurality of opening pores provided on a surface thereof and communicating pores communicating mutually adjacent opening pores with one another.
US11633522B1
A bone graft composition comprising a viable, osteogenic cellular material combined with a viscous cryoprotectant that includes a penetrating cryoprotective agent and a non-penetrating cryoprotective agent. The viscosity of the cryoprotectant is such that the composition is malleable, cohesive and capable of being formed into desired shapes.
US11633517B2
The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.
US11633515B2
To provide an aroma diffusing device and a method of controlling an aroma diffusing device that can enable a plurality of functions to be achieved by operation inputs to one operation input part.
Provided is an aroma diffusing device including: a perfume holding part in which a perfume is held; an air blowing source configured to supply air to the perfume holding part; an aroma discharge part through which the air having passed through the perfume holding part is discharged; an operation input part on which an operation input for the air blowing source is performed by a user; and an air blowing source control part configured to control a supply state of the air on the basis of an operation input on the one operation input part.
US11633508B2
A device for increased ultraviolet exposure of fluids. The device includes at least one photonic source for generating and emitting photonic energy in a wavelength or in a range of wavelengths of visible light. The device also includes a lens formed of a fluoropolymer material wherein the at least one photonic source is sealed within an interior and underneath an outer surface of the fluoropolymer material so as to be surrounded by the fluoropolymer material. The at least one photonic source is coupled with the lens such that the photonic energy emitting from the at least one photonic source transmits through and projects beyond the fluoropolymer material. The lens propagates photons in an omnidirectional pattern simultaneously throughout the entirety of the lens. The joining of the at least one photonic source and the fluoropolymer material comprises all components for generating and emitting photonic energy when the photonic source is activated, such that it is an operable source. The operable source is submerged within a containment vessel which holds the fluids to be sanitized by the operable source. The fluid within the system are exposed to the photonic energy within the device for an extended period of time to effectively destroy pathogens and sanitize the target fluids.
US11633505B2
[Problem]
To provide a nuclear magnetic resonance diagnostic agent that has a lower toxicity to organisms and reduced side effects and yet has a site specificity toward a specific cell, tissue, organ, etc.
[Solution]
When ALA or an ALA derivative is administered in vivo, a metabolite thereof is accumulated in a specific cell, tissue, organ, etc. Focusing on this phenomenon, a nuclear magnetic resonance analysis was performed on a site wherein the metabolite of ALA that had been administered in vivo would be possibly accumulated. As a result, it was surprisingly found that ALA and an ALA derivative are useful as a diagnostic agent whereby the aforesaid problem can be solved.
US11633500B2
Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
US11633498B2
Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of a DMPK allele comprising a disease-associated-repeat. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.
US11633496B2
Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload promotes the expression or activity of a functional dystrophin protein. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide, e.g., an oligonucleotide that causes exon skipping in a mRNA expressed from a mutant DMD allele.
US11633493B2
As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LF-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.
US11633486B2
Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.
US11633482B2
A compound for forming a conjugate with an active agent such as an oligonucleotide having a structure represented by Formula (321). The present disclosure also provides a corresponding conjugate. The conjugate of the present disclosure can specifically target hepatocytes, thereby effectively solve the problems associated with delivery of oligonucleotide drugs in vivo, and have low toxicity and excellent delivery efficiency while maintaining high stability for the delivered oligonucleotide.
US11633475B2
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
US11633473B2
Provided herein are Stimulator of Interferon Genes (STING) ligand for use in enhancing immune response and/or as adjuvants in vaccines. In some embodiments, STING ligand is used alone or in combination with Alum in an adjuventation system for early life immunization.
US11633466B2
A novel consortium used as potent vaccine for treating of enteric fever, comprised of isolated Outer Membrane Vesicles (OMVs) taken from two different strains of typhoidal Salmonella species.
US11633465B2
Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.
US11633457B2
A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, progression, proliferation and metastasis in several cancer types.
US11633453B2
The present invention relates to a reconstitutable teverelix-TFA composition having a predefined molar ratio of teverelix to trifluoroacetate which is below the molar ratio required for microcrystal formation. Said composition remains stable during storage e.g. at a temperature around 2-8° C. Upon reconstitution a fixed amount of trifluoroacetate can be added to said composition thereby effectively and simply achieving an exact and desired molar ratio in order to obtain a fluid, milky microcrystalline aqueous teverelix-TFA suspension.
US11633451B2
A topical cleansing composition for stimulating the production of antimicrobial peptides on the skin is disclosed. The topical cleansing composition includes an active ingredient comprising one or more of a natural extract and a polypeptide; one or more surfactants; and water. The topical cleansing composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical topical composition without the active ingredient.
US11633450B2
Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.
US11633447B2
A composition according to an embodiment of the present disclosure includes a banaba leaf extract, a guava leaf extract or a mixture thereof. The composition inhibits photooxidation of A2E due to blue light, inhibits a death of retinal pigment epithelial cells induced by blue light, and inhibits a damage to outer nuclear layers of visual cells in an animal model with blue light-induced macular degeneration, and thus can be beneficially used as a composition for preventing or treating macular degeneration and as a health functional food for preventing or alleviating macular degeneration.
US11633431B2
Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
US11633430B2
The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.
US11633428B2
The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration.
US11633426B2
Provided are methods for administering multiple doses of cells, such as T cells, to subjects for cell therapy. Also provided are compositions and articles of manufacture for use in the methods. The cells generally express recombinant receptors such as chimeric receptors, e.g., chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). The methods generally involve administering a first and at least one consecutive dose of the cells. Timing of the doses relative to one another, and/or size of the doses, in some embodiments provide various advantages such as lower or reduced toxicity and improved efficacy, for example, due to increased exposure of the subject to the administered cells. In some embodiments, the first dose is a relatively low dose, such as one that reduces tumor or disease burden, thereby improving the efficacy of consecutive or subsequent doses, and the consecutive dose is a consolidating dose.
US11633423B2
This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.
US11633418B2
The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
US11633412B2
Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
US11633411B2
The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof.