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发明公开
CN101045685A 1－羟基－2－甲基－4－乙酰氧基－2－丁烯的合成方法 失效 - 权利终止

1－羟基－2－甲基－4－乙酰氧基－2－丁烯的合成方法
摘要：
本发明为维生素A乙酸酯的重要中间体1－羟基－2－甲基－4－乙酰氧基－2－丁烯的合成方法。现有方法都很难达到满意的选择性和收率，所用的催化剂不能套用且有损失。本发明的技术方案为：由1－甲酰氧基－2－甲基－4－乙酰氧基－2－丁烯于醇类溶剂中在催化剂碱性阴离子交换树脂的作用下进行酯交换反应，将反应中产生的副产物不断蒸出反应体系，反应完后蒸馏回收溶剂，然后过滤将1－羟基－2－甲基－4－乙酰氧基－2－丁烯的粗品与催化剂分离，回收催化剂。本发明能达到满意的选择性和收率，使用的催化剂可直接套用且基本无损失。
摘要（英）：

This invention relates to a synthetic method of vitamin A acetate important intermedium: 1 - hydroxy -2-methyl-4- acetoxy -2-butylene. Esixting method all could not reach content selectivity AND yield, used catalyzer is not able to recycle and has lost. The technical proposal is: under action of catalyzer alkaline anion exchange resin, 1 - formyloxy -2-methyl- 4- acetoxy - 2-butylene carry out ester exchanging reaction in alcohols solvent, distil off generated byproduct from reaction system continually, distil and recover solvent after reaction, then by lautering to seprate crude product 1 - hydroxy -2-methyl-4 acetoxy - 2-butylene and catalyzer, reclaim catalyzer. This invention can reach content selectivity AND yield, used catalyzer is able to directly reclaim and has no lost.

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