The invention relates to medicine technical field, in particular to two saponin antimycotics compounds as scabraside A and scabraside B, which molecular formulas are represented as C54H85O26SNa and C54H85O27SNa separated from sea cucumber. The chemical structure and spatial configuration of the compounds are assured by kinds of modern spectrographic analysis, particularly by kinds of advanced two-dimension nuclear magnetic resonance spectroscopy. The compounds can effectively restrain various bacterial strains as candida albicans and aspergillus fumigatus by external antimycotics test. The inventive compounds can be used to prepare antimycotics drug. The invention provides lead compound for preparing new antimycotics drug, with significant value for developing and utilizing sea medical biological resource.