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CN101250201A 一种锝－99m标记的三氮唑双膦酸配合物及其制备方法 无效 - 撤回

一种锝－99m标记的三氮唑双膦酸配合物及其制备方法
摘要：
一种锝－99m标记的三氮唑双膦酸配合物及其制备方法，属于放射性药物和核医学领域。本发明的三氮唑双膦酸配合物为锝－99m标记的2－(1H－1，2，4－三氮唑－1－基)－1－羟基乙烷－1，1－双膦酸配合物(99Tcm－TADP)，该配合物的制备方法是，将配体TADP、还原剂SnCI2·2H2O、pH缓冲液等组成药盒，再将高锝酸(99TcmO4－)溶液加入药盒中反应，即得到锝－99m标记的TADP配合物。本发明的99Tcm－TADP用于核医学诊断显像或治疗类风湿、肿瘤等疾病。本发明产品的骨组织摄取量(Am，骨)(％ID/g)和(Am，骨/Am，血)比文献值高，说明本发明产品具有作为骨显像剂的潜力。
摘要（英）：

A triazole diphosphonic acid complex marked by technetium-99m belongs to the technical field of radiopharmaceuticals and nuclear medicine, wherein the triazole diphosphonic acid complex is 2-(1H-1, 2, 4-triazole-1-group)-1-hydroxy ethane-1, 1-diphosphonic acid complex (99Tc-TADP) marked by technetium-99m. The preparation method comprises using complex TADP, reducer SnCI2 2H2O and pH buffer solution to form a medicine box, adding poly technetium acid (99TcO4-) into the medicine box to be reacted to obtain TADP complex marked by technetium-99m. The 99Tc-TADP can be used for nuclear medicine diagnosis imaging or treating rheumatoid and tumor. The bone tissue absorbed quantities (A, bone)(%ID/g) and (A, bone/A, blood) are higher than literature values, therefore, the invention can be used as bone imaging agent.

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