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发明公开
CN101374415A 用于治疗代谢紊乱的化合物 无效 - 撤回

用于治疗代谢紊乱的化合物
摘要：
本发明公开了对治疗诸如胰岛素抵抗综合征、糖尿病、多囊卵巢综合征、高脂血症、脂肪性肝病、恶病质、肥胖症、动脉粥样硬化症和动脉硬化症等各种代谢紊乱有用的试剂，式(I)所示化合物或所述化合物的药学可接受的盐，其中，n是1或2；m是0、1、2、3或4；q是0或1；t是0或1；R1是氢、卤素、羟基、具有1或2个碳原子的烷基、全氟甲基、具有1或2个碳原子的烷氧基和全氟甲氧基；R2是具有1～3个碳原子的烷基；R3是氢、卤素、具有1～3个碳原子的烷基或具有1～3个碳原子的烷氧基；R4和R5之一是氢或羟基，另一个是氢；或者R4和R5合起来为＝O；R6是氢或者具有一个、两个、三个、四个或五个碳原子的烷基。作为选择，所述试剂可以是式(I)的化合物的药学可接受的盐。
摘要（英）：

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I), wherein n is 1 or 2; m is 0, 1, 2, 3, or 4; q is 0 or 1; t is 0 or 1; R<1> is hydrogen, halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; R<2> is alkyl having from 1 to 3 carbon atoms; R<3> is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; one of R<4> and R<5> is hydrogen or hydroxy and the other is hydrogen; or R<4> and R<5> together arc =O; R<6> is hydrogen or alkyl having one, two, three, four or five carbon atoms; or a pharmaceutically acceptable salt of the compound. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).

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