The invention relates to a quick-release medicinal composition, which contains indiplon and pharmaceutically acceptable carrier. The oral quick-release composition prepared from the indiplon and the quick-release carrier can provide a new convenient medicament administration mode and a new dosage form for oral medicaments under the special conditions that the medicaments are difficult to swallow and inconvenient to drink water. Compared with a common oral preparation, because the mucosa of the gastrointestinal tract is widely covered by rapidly-disintegrated medicament, the medicinal composition has quick response. If the medicament can be absorbed through the mucosa of the oral cavity, the medicinal composition has no first-pass effect so as to improve the bioavailability and reduce the stimulation to the stomach and intestine.