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发明公开
CN101654483A 产生嵌合异源多聚体的组合物和方法 无效 - 撤回

产生嵌合异源多聚体的组合物和方法
摘要：
本发明是“产生嵌合异源多聚体的组合物和方法”，提供一种把单体多肽特异性组装成异源多聚体的方法。尤其可用本技术来获得具遗传多样性的异源多聚体如抗原结合单位库。本发明也提供由本发明所述的技术组装的非单链和单链抗原结合单位。本发明也提供重组多核苷酸，载体，宿主细胞以及制造受试抗原结合单位的试剂盒。本发明进一步提供使用受试抗原结合单位的方法。
摘要（英）：

The invention relates to compositions and methods for generating chimeric heteromultimers. The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing thesubject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.

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