The invention provides a compound contraceptive composition, a contraceptive transdermal patch containing the composition and a preparation method. The compound contraceptive composition comprises effective contraceptive quantity of active components dispersed in a skeleton polymer substrate: etonogestrel and estrogen with a contraceptive cooperative function. Drugs are carried out bidirectional regulation by distribution and dispersal in two phases of the skeleton polymer substrate and a pressure sensitive adhesive substrate for drug transdermal release; and a crystallization inhibiting agent is added to a drug warehouse or the pressure sensitive adhesive substrate in order to effectively inhibit the drugs from crystallizing and maintain the long-time continuous transdermal high activity and power of the drugs in the substrates. The contraceptive transdermal patch prepared from the compound contraceptive composition maintains longer (1 to 7 days) stable drug release and blood drug concentration, has better effect, reduces administration frequency, adds user compliance and has obvious advantages in medical application.