The invention discloses a high-strength steel plate for super-thick 80,000-ton large-scale forging press brackets, which comprises the following components in percentage by mass: 0.17 to 0.23 percent of C, 0.15 to 0.40 percent of Si, 1.20 to 1.50 percent of Mn, less than or equal to 0.015 percent of P, less than or equal to 0.010 percent of S, 0.40 percent of to 1.00 Ni, less than or equal to 0.25 percent of Cr, 0.03 to 0.05 percent of Nb, less than or equal to 0.10 percent of Cu, 0.010 to 0.040 percent of Al, 0.002 to 0.004 percent of Ti, 0.50 to 0.55 percent of Mo, 0.001 to 0.005 percent of V, and the balance of Fe and inevitable impurities. Molten steel is subjected to electrosmelting, refining of LF refining furnace, vacuum treatment of VD furnace, off-line stacking and slow cooling after throwing, electroslag remelting for preparing steel ingots, low-speed steel burning, rolling, hydrogen expanding annealing, quenching and tempering treatment so as to be made into finished steel plates. The steel plate completely meets the quality requirements of the high-strength steel plate for super-thick 80,000-ton large-scale forging press brackets, is suitable for manufacturing large-scale forging press brackets, and has good application prospects.