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CN101747274A 布南色林晶型A的制备方法 无效 - 撤回

布南色林晶型A的制备方法
摘要：
本发明提供一种制备治疗非典型精神病药物2-乙基哌嗪-4-(4-氟苯)-5，6，7，8，9，10-六氢环辛烷并吡啶的晶型A的方法，其特征在于该方法包括以下步骤：使2-乙基哌嗪-4-(4-氟苯)-5，6，7，8，9，10-六氢环辛烷并吡啶在丙酮、异丙醇或乙酸乙酯加热溶解后，通过重结晶得到晶型A。按照本发明方法所得的2-乙基哌嗪-4-(4-氟苯)-5，6，7，8，9，10-六氢环辛烷并吡啶的晶型A的总有关物质(HPLC测定)可以达到0.3％以下，且单个杂质小于0.1％。
摘要（英）：

The invention provides a method for preparing crystal form A of medicament 2-ethylpiperazine-4-(4-fluorobenzene)-5,6,7,8,9,10-hexahydro cyclooctane pyridine for treating atypical psychosis. The method is characterized by comprising the following steps of: ensuring that the 2-ethylpiperazine-4-(4-fluorobenzene)-5,6,7,8,9,10-hexahydro cyclooctane pyridine is dissolved in acetone, isopropanol or ethyl acetate by heating, and then obtaining the crystal form A through recrystallization. The total relevant material (PHLC determination) of the crystal form A of the 2-ethylpiperazine-4-(4-fluorobenzene)-5,6,7,8,9,10-hexahydro cyclooctane pyridine prepared through the method can reach lower than 0.3 percent, and single impurity is lower than 0.1 percent.

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