The invention discloses an overall treatment method of starch and starch derivatives, which is performed by carrying out sterilization and bacteriostatic treatment on critical points in a pipeline, a receiver tank, a washer, a separation plant, a drying plant and farinaceous size; specifically the method comprises the following steps: using acid-base sterilization method in combination with disinfectant and employing soaking or slug flow method to sterilize the pipeline, the receiver tank and the washer the farinaceous size flows through; adopting an ultraviolet sterilization lamp to carry out farinaceous size surface sterilization on the receiver tank and a head tank; adopting disinfectant to carry out sterilization on the internal surface of a centrifugal machine; adopting chemical modification self sterilization method and adding disinfectant to carry out sterilization and bacteriostatic treatment on the farinaceous size; adopting the method for cleaning residual powder in combination with air-heater high temperature sterilization for blowing clean the residual dust and then drying the powder. Through a series of overall control methods, the finished product of starch meets therequirements for starch microorganism applied to food and medicine, thus providing an effective microorganism control method for starch production enterprises and enhancing product competitiveness ofsuch enterprises.