The invention provides an insulated gate bipolar transistor (IGBT) protection circuit and a motor control system, belonging to the filed of the motor control. The IGBT protection circuit comprises a sampling circuit, a feeding back circuit, a driving circuit and a slow turn-off circuit. The IGBT protection circuit adopts the slow turn-off circuit, thus the turn-off time of the IGBT is prolonged, the current change rate is reduced and the IGBT is protected against damage when the IGBT carries out the over-current protection.