The invention discloses a rolling formation method of a large and medium high-temperature alloy hollow disc-shaped forge piece, which comprises the following steps of: upsetting, compressing and punching a high-temperature alloy rod material into a hollow disc blank; putting the disc blank into a rolling machine to roll; rolling the disc blank for 20s to enable the disc blank to widen at a speed of 9-11mm/s under 4000-4900KN of an axial rolling force at an axial feeding speed of 1.6mm/s; rolling the disc blank for 20-40s to enable the disc blank to widen at a speed of 7-9mm/s under 3000-3500KN of an axial rolling force and 3000-4000KN of a radial rolling force at an axial feeding speed of 0.7mm/s; rolling the disc blank for 40-80s to enable the disc blank to widen at a speed of 4-7mm/s under an axial rolling force of 2500-3000KN and a radial rolling force of 2000-3000KN at an axial feeding speed of 0.5mm/s; and carrying out fire rolling to prepare the hollow disc-shaped forge piece. The method is mainly used for rolling disc-shaped forge pieces with excellent shapes, sizes, textures and performances.