The invention provides health-care vinegar, a vinegar drink preparation method and anti-alcohol liver-protection application thereof. The method comprises the following steps: (1) grinding rice and kudzuvine root into thick liquid with water, regulating the concentration of starch to be over 10 percent with sterile water or traditional Chinese medicinal extract, and heating the mixture at the temperature of between 125 and 130 DEG C; (2) adding rhizopus, activated dried yeast, aroma-producing yeast and lactic acid bacteria into the sterilized mixture to ferment distilled wort, and stopping alcoholic fermentation when the alcohol content is between 10 and 15 percent; (3) regulating the alcohol concentration to be between 6 and 8 percent with the sterile water or the traditional Chinese medicinal extract, adding acetic acid bacteria solution which is 10 percent of fermentation broth by volume into the mixture at the temperature of between 26 and 34 percent, and stopping fermentation until the acidity of the fermentation broth is between 4 and 6 percent; and (4) ageing the fermented acid solution for over 15 days at the temperature of between 12 and 20 DEG C, and filtering the solution to obtain the health-care vinegar. The invention extracts effective ingredients of traditional Chinese medicament in a flash way to perform alcohol fermentation and acetic fermentation with the kudzuvine root and the rice, not only can effectively maintain the effective ingredients of the traditional Chinese medicament, but also can better play the functions of relieving alcohol, dispelling theeffect of alcohol and protecting liver.