The invention relates to a negative pressure drainage device for an odontogenic jaw cyst, which is used in the clinical treatment of a large odontogenic jaw cyst. The negative pressure drainage device consists of an outer hollow inverted frustum-shaped body and a frustum-shaped movable plug; the frustum-shaped movable plug comprises a positive frustum structure and an inverted frustum structure; the upper surface of the positive frustum structure is provided with a sliding stop lever; the coronal surface of an inner wall of an inner opening is provided with eudipleural smooth stop lever sliding chutes which are longitudinal in the vertical direction; a spring is arranged between the sliding stop lever and the bottom of the inner wall of the inner opening of the outer body; a row of soft tissue alae are arranged at the middle upper position of the outer surface of the outer body; and the middle lower part of the outer surface of the outer body is a uniform screw-in threaded region. The odontogenic jaw cyst negative pressure drainage device of the invention is made of a medicinal metallic material with a small volume, can be implanted into the jaw for long-term use and can be used for drainage and forming negative pressure in the cyst so as to greatly shorten the treatment period, reduce the probability of infection and improve the clinical effect for treating the odontogenic jaw cyst.