The invention discloses a high-speed data encryption/decryption module in a communication link. The module comprises a DB62 input port, a field programmable gate array (FPGA) encryption/decryption processing module, a DB62 output port, a random number generating chip, a Flash storage chip, a configuration and test circuit and a power supply network, wherein the DB62 input port and the DB62 output port are connected with the FPGA encryption/decryption processing module respectively; the DB62 input port receives an uplink differential signal and transmits to the FPGA encryption/decryption processing module; the FPGA encryption/decryption processing module extracts data information and encrypts/decrypts the data; the encrypted/decrypted data is output to the DB62 output port in a form of an LVDS differential signal; the random number generating chip is connected with the FPGA encryption/decryption processing module; the Flash storage chip is connected with the FPGA encryption/decryption processing module; the configuration and test circuit is connected with the FPGA encryption/decryption processing module; and the power supply network is connected with each module in the whole encryption/decryption processing module. The high-speed data encryption/decryption module has wide application prospect in the field of high-speed data communication and information safety.