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发明授权
CN101985449B 一种香豆素衍生物及其制备方法和作为抗癌药物的用途 失效 - 权利终止

一种香豆素衍生物及其制备方法和作为抗癌药物的用途
摘要：
本发明属于药物与化工领域，公开了一种香豆素衍生物及其制备方法和作为抗癌药物的用途。该香豆素衍生物的结构式为：其中R1为H、OBn或O(CH2)nNR3；R2为H或O(CH2)nNR3；但R1或R2中至少有一个为O(CH2)nNR3；n＝1、2、3、4或5。NR3表示C1-6的烷基胺、C3-6的环烷基胺、哌啶基、吗啉基、哌嗪基或吡噁啉基。本发明同时公开了该香豆素衍生物的制备方法及其作为抗癌药物的用途。该香豆素衍生物对端粒DNA及c-myc等原癌基因DNA的表达有很强的抑制作用，对多种癌细胞株具有显著的抑制作用，且对正常细胞毒性小，在制备抗癌药物上有着广阔的应用空间。
摘要（英）：

The invention belongs to the fields of medicaments and chemical industry, and discloses a coumarin derivative, and a preparation method and use thereof as an anti-cancer medicament. The coumarin derivative has a structural formula shown in the specification, wherein R1 is H, OBn or O(CH2)nNR3; R2 is H or O(CH2)nNR3; at least one of R1 and R2 is O(CH2)nNR3; n is equal to 1, 2, 3, 4 or 5; and NR3 is alkylamine with 1 to 6 carbon atoms, ring alkyl amine with 3 to 6 carbon atoms, piperidyl, morpholinyl, piperazinyl or a pyraoxaline base. The invention also discloses the preparation method of the coumarin derivative and use thereof as the anti-cancer medicament. The coumarin derivative has a good suppression effect on the expressions of oncogene DNA consisting of telomere DNA, c-myc and on thelike, a remarkable suppression effect on a plurality of cancer cell lines, and low toxicity to normal cells, and is widely applied to the preparation of the anti-cancer medicaments.

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