The invention relates to a method for producing compound spice powder, which comprises the following steps of: (1) mixing more than two kinds of spice powder and carriers, and water with a mixer for later use, wherein the carrier is one or multiple of flour, starch, rice flour and corn flour; (2) preheating with a twin screw extruder; (3) adding mixture prepared in step (2) into a feeding hopper of the extruder, starting a screw and regulating the screw at a rotation speed of 50-200r/min; adding the mixture at a constant speed and controlling the feeding speed at 20-100kg/h, wherein the mixture is transmitted and extruded in the extruder, and is extruded out from a mold port of the extruder; and (4) cooling the extruded reaction material to the room temperature and crushing the extruded reaction material with the room temperature by a crusher, and then screening to obtain the spice powder. The spice powder prepared by using the method can improve cooking characteristics while being sterilized. With far fewer losses of aroma components compared with a traditional heating sterilization method, the method can meet the production requirement of essence.