The invention relates to equipment used for an engine test and aims at providing an engine body hydraulic fatigue test system. The system comprises a hydraulic pump station, a hydraulic pulse loading mechanism, a signal measuring and monitoring system and a control system, wherein the hydraulic pulse loading mechanism comprises a hydraulic common-rail module, a hydraulic servo solenoid valve, a hydraulic amplifier and a hydraulic cylinder which are sequentially connected, and the hydraulic cylinder is connected with an engine body to be tested. The engine body hydraulic fatigue test system provided by the invention can be used to substitute the traditional real engine evaluation on engine body fatigue so that test cost is greatly saved, and single cylinder loading and multi-cylinder loading on the engine body are realized. The engine body hydraulic fatigue test system not only can be applied to an engine body fatigue test but also can be applied to an engine parts static loading test, thus realizing the diversification of functions.