The invention discloses a method for preparing a pyrrole derivative. The method comprises the following steps: using primary amine, alkyl glyoxylate and alpha-bromoacetophenone derivative as raw material to reflux and react in organic solvent for 6-12 hours in the presence of pyridine, and obtain the pyrrole derivative through a simple aftertreatment and purification process. The method of the invention has wild reaction conditions, simple process and fast and convenient operation; and the obtained pyrrole derivative has potential and good bioactivity and can be used as the organic synthesis intermediate.