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发明公开
CN102083845A 环丙基聚合酶抑制剂 失效 - 权利终止 复审申请

环丙基聚合酶抑制剂
摘要：
一种式I化合物：其中：R2为氢或C1-C4烷基；R3和R4为独立地选自氢、-C(=O)R5和-C(=O)CHR6-NH2组成的群；或R3为氢和R4为单磷酸酯、二磷酸酯或三磷酸酯；或R3为氢、-C(=O)CHR5或-C(=O)CHR6-NH2和R4为（式2），各R5独立地选自氢、C1-C6烷基和C3-C7环烷基的群；R6为氢或C1-C6烷基；R7为任选经取代的苯基、萘基、或吲哚基；R8和R8’为氢、C1-C6烷基、苄基；或R8和R8’合并形成C3-C7环烷基；R9为C1-C6烷基、苄基或任意经取代的苯基；条件是R2、R3和R4不均为氢；或其药学上可接受的盐类或溶剂合物；具化合物I的药物配制剂；化合物I作为HCV抑制剂的用途，包括其中R2、R3和R4均为氢的式I化合物。
摘要（英）：

A compound of formula I: wherein: R2 is hydrogen or C1-C4alkyl; R3 and R4 are hydrogen, -C(=O)R5, or -C(=O)CHR6-NH2; or R3 is hydrogen and R4 is a monophosphate-, diphosphate-, or triphosphate ester; or R3 is hydrogen, -C(=O)CHR5, or -C(=O)CHR6-NH2 and R4 is (formula 2) each R5 is hydrogen, C1-C6alkyl, or C3-C7cycloalkyl; R6 is hydrogen or C1-C6alkyl; R7 is optionally substituted phenyl; naphthyl; or indolyl; R8 and R8 are hydrogen, C3-C7alkyl, benzyl; or R8 and R8 combined form C3-C7cycloalkyl; R9 is C1-C6alkyl, benzyl, or optionally substituted phenyl; provided that R2, R3 and R4 are not all hydrogen; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations with the compound I; the use of compound I, including the compound of formula I wherein R2, R3 and R4 are all hydrogen, as HCV inhibitors.

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