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发明公开
CN102164883A α-三氟甲基-α,β-不饱和酯类的制造方法 失效 - 权利终止

α-三氟甲基-α,β-不饱和酯类的制造方法
摘要：
通过使α-三氟甲基-α-羟基酯类在有机碱的存在下与硫酰氟(SO2F2)反应，可以制造α-三氟甲基-α，β-不饱和酯类。作为原料基质，β位的一个取代基为氢原子，另一个取代基为烷基、取代烷基、烯基、取代烯基、芳香环基或取代芳香环基，并且酯基为烷基酯的情况是更优选的。该原料基质容易获得，可以良好地进行所期望的反应。作为有机碱，更优选1，5-二氮杂双环[4.3.0]壬-5-烯(DBN)或1，8-二氮杂双环[5.4.0]十一碳-7-烯(DBU)。通过使用该有机碱，从而更良好地进行所期望的反应。
摘要（英）：

An [alpha]-trifluoromethyl-[alpha],[beta]-unsaturated ester can be produced by reacting an [alpha]-trifluoromethyl-[alpha]-hydroxy ester with sulfuryl fluoride (SO2F2) in the presence of an organic base. It is preferable that the raw substrate has a hydrogen atom as one [beta]-position substituent group and either an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aromatic ring group or a substituted aromatic ring group as the other [beta]-position substituent group. It is more preferable that an ester moiety of the raw substrate is an alkyl ester. This raw substrate is readily available. Further, the desired reaction can proceed favorably with the use of this raw substrate. It is also preferable to use either 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as the organic base. The desired reaction can proceed more favorably with the use of this organic base.

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