The invention relates to a microsphere preparation method for adjusting and controlling the release behavior of risperidone microspheres and for controlling the size thereof, belonging to the technical field of nano-medicaments. The preparation method comprises the steps of: firstly, adding a sustained-release or controlled-release functional material to one or the mixture of dichloromethane, ethyl acetate and acetonitrile, swirling and dissolving to obtain an organic solution of the sustained-release or controlled-release functional material; then adding particles containing risperidone and an alkaline matter to the organic solution of the sustained-release or controlled-release functional material, i.e. stirring or swirling in the oil phase to evenly disperse to form even suspension; and adding the suspension to SPG (Shirasu Porous Glass) membrane emulsion with different bore diameters, enabling the suspension to enter brine containing a surfactant through the membrane emulsion by adjusting the pressure, stirring to form microspheres, and transferring into the brine for solidifying to finish preparation. The biodegradable risperidone microsphere sustained-release preparation prepared by the invention has quick effect taking speed and long drug release time, the particle size of the microspheres is controllable, the envelop rate is high, and the quality of the risperidone microspheres is controllable.