The invention discloses an adamantine derivative with anti-avian influenza virus activity. The structure of the derivative is shown in the specification, wherein R1 is Me; and R2 is H. A preparation method for the adamantine derivative comprises the following step of: reacting to obtain the adamantine derivative by taking 1-adamantanecarboxylic acid chloride and amino acid methyl ester hydrochloride as raw materials and an aprotic solvent as a solvent at the temperature of between 0 and room temperature in the presence of triethylamine under anhydrous and oxygen-free conditions. The activity result shows that the compound has a good effect of resisting avian influenza viruses.